Click here to switch to the map view.

The map label for this gene is prk [H]

Identifier: 37521865

GI number: 37521865

Start: 2459272

End: 2460267

Strand: Direct

Name: prk [H]

Synonym: gvip313

Alternate gene names: 37521865

Gene position: 2459272-2460267 (Clockwise)

Preceding gene: 37521857

Following gene: 37521866

Centisome position: 52.79

GC content: 58.84

Gene sequence:

>996_bases
ATGGTCAGTACGTTGGACCGAGTGGTCCTGATCGGTGTCGGTGGGGATTCGGGTTGCGGCAAGTCGACATTCCTCAGGCG
GCTTAAAGATCTGTTCAGCAAGGAGCTTGTCACGGTCATCTGCCTCGATGACTACCACTCGCTCGACCGCAAGCAGCGCA
AAGAAACGGGTATTACCGCCCTCGACCCGCGCGCCAACAATTTTGATCTAATGGCCGAGCAGGCGACCGCCCTCAAGGTC
GGCCAGTCGATCATGAAGCCCATCTACAACCACGAGACGGGCAAAATCGACCCGCCCGAGCTGATCGAGCCCACTCCGAT
CGTCATTCTCGAAGGGCTGCATCCTTTTTACGACGCGCGCGTGCGCAACCTATTTGACTTCAAGATCTACTTCGACCTAT
CCGATCCGATCAAGATTCAGTGGAAGATCCAGCGCGACATGGCCGAGCGCGGCCACACCTACGAAGATGTCCTCAAGCAG
ATCGAATCGCGCCGCCCGGACTTTTCGGCCTACATCGACCCGCAGAAGCAGTACGCCGATGTGGTGCTGCAGATTCTGCC
CAGTGAGCTTCCTGAAAAAGCAGGCGGTATCAAGCGCGTCAAAGCCTGCATGGTGCAGGTGGACGGCATCCCCAACTACG
ACGCGCCCTACCTGTTCGACCGGGCCATTTCCGATGTGTGCTGGAAGCCCAATTTTCCCAACTCGGATGAAGAGCTGACC
TTCTGCTACGGCACCCAGGATTACTTCGGCCGCCCGGCGTCCTACCTGTCGATCGACGGCGAGTTTGCTCCGGAGGATTC
TCCCGAACTGGAGGAGAAGCTGCGCAACACCAGCGAGACGCGCTACGGCGAACTCGCCTCGCTCATCCTCAAGCACACCG
ATTACCCCGGCTCCCGCGACGGCACCGGCTTTTTCCAGGTGCTCATGAGCCTCAAGTTCCGCGCCATCTACGAAGCGCTT
ACCGCCCAATTGCTGACGGCTTCCAAGGCCAAGTAG

Upstream 100 bases:

>100_bases
TTACCATTGGGGGGCATTTTTTGCTTGCCCCGTGGGCATTTGAGCTTGGTGGGCGAGTGGCGGGTGGTCCAGTCAGGGAA
GCCAGTCCAAGGAGAACGCG

Downstream 100 bases:

>100_bases
CGCGCCGCGCCCACCTTTCGCGACAGGAAGTATCCATGACTGGCACTTTGCTTGACAAGACCGCCGCCCAGTTGGACGAG
TTGAGCGTCAATACCATCCG

Product: phosphoribulokinase

Products: NA

Alternate protein names: PRK; PRKase; Phosphopentokinase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVSTLDRVVLIGVGGDSGCGKSTFLRRLKDLFSKELVTVICLDDYHSLDRKQRKETGITALDPRANNFDLMAEQATALKV
GQSIMKPIYNHETGKIDPPELIEPTPIVILEGLHPFYDARVRNLFDFKIYFDLSDPIKIQWKIQRDMAERGHTYEDVLKQ
IESRRPDFSAYIDPQKQYADVVLQILPSELPEKAGGIKRVKACMVQVDGIPNYDAPYLFDRAISDVCWKPNFPNSDEELT
FCYGTQDYFGRPASYLSIDGEFAPEDSPELEEKLRNTSETRYGELASLILKHTDYPGSRDGTGFFQVLMSLKFRAIYEAL
TAQLLTASKAK

Sequences:

>Translated_331_residues
MVSTLDRVVLIGVGGDSGCGKSTFLRRLKDLFSKELVTVICLDDYHSLDRKQRKETGITALDPRANNFDLMAEQATALKV
GQSIMKPIYNHETGKIDPPELIEPTPIVILEGLHPFYDARVRNLFDFKIYFDLSDPIKIQWKIQRDMAERGHTYEDVLKQ
IESRRPDFSAYIDPQKQYADVVLQILPSELPEKAGGIKRVKACMVQVDGIPNYDAPYLFDRAISDVCWKPNFPNSDEELT
FCYGTQDYFGRPASYLSIDGEFAPEDSPELEEKLRNTSETRYGELASLILKHTDYPGSRDGTGFFQVLMSLKFRAIYEAL
TAQLLTASKAK
>Mature_331_residues
MVSTLDRVVLIGVGGDSGCGKSTFLRRLKDLFSKELVTVICLDDYHSLDRKQRKETGITALDPRANNFDLMAEQATALKV
GQSIMKPIYNHETGKIDPPELIEPTPIVILEGLHPFYDARVRNLFDFKIYFDLSDPIKIQWKIQRDMAERGHTYEDVLKQ
IESRRPDFSAYIDPQKQYADVVLQILPSELPEKAGGIKRVKACMVQVDGIPNYDAPYLFDRAISDVCWKPNFPNSDEELT
FCYGTQDYFGRPASYLSIDGEFAPEDSPELEEKLRNTSETRYGELASLILKHTDYPGSRDGTGFFQVLMSLKFRAIYEAL
TAQLLTASKAK

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoribulokinase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=179, Percent_Identity=30.1675977653631, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI57863312, Length=179, Percent_Identity=30.1675977653631, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI18699734, Length=187, Percent_Identity=25.1336898395722, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI13899253, Length=190, Percent_Identity=25.7894736842105, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87082034, Length=193, Percent_Identity=33.160621761658, Blast_Score=98, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17539892, Length=186, Percent_Identity=27.9569892473118, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=180, Percent_Identity=28.3333333333333, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71981181, Length=197, Percent_Identity=27.9187817258883, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28573516, Length=180, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573514, Length=180, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573512, Length=180, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550449, Length=180, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221458995, Length=188, Percent_Identity=28.1914893617021, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24649624, Length=188, Percent_Identity=28.1914893617021, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006082
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.19 [H]

Molecular weight: Translated: 37556; Mature: 37556

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00567 PHOSPHORIBULOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTLDRVVLIGVGGDSGCGKSTFLRRLKDLFSKELVTVICLDDYHSLDRKQRKETGITA
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCEE
LDPRANNFDLMAEQATALKVGQSIMKPIYNHETGKIDPPELIEPTPIVILEGLHPFYDAR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEECCCCHHHHHH
VRNLFDFKIYFDLSDPIKIQWKIQRDMAERGHTYEDVLKQIESRRPDFSAYIDPQKQYAD
HHHEEEEEEEEECCCCEEEEEEEEHHHHHCCCCHHHHHHHHHHCCCCCEEEECCHHHHHH
VVLQILPSELPEKAGGIKRVKACMVQVDGIPNYDAPYLFDRAISDVCWKPNFPNSDEELT
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEE
FCYGTQDYFGRPASYLSIDGEFAPEDSPELEEKLRNTSETRYGELASLILKHTDYPGSRD
EEECCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
GTGFFQVLMSLKFRAIYEALTAQLLTASKAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVSTLDRVVLIGVGGDSGCGKSTFLRRLKDLFSKELVTVICLDDYHSLDRKQRKETGITA
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCEE
LDPRANNFDLMAEQATALKVGQSIMKPIYNHETGKIDPPELIEPTPIVILEGLHPFYDAR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEECCCCHHHHHH
VRNLFDFKIYFDLSDPIKIQWKIQRDMAERGHTYEDVLKQIESRRPDFSAYIDPQKQYAD
HHHEEEEEEEEECCCCEEEEEEEEHHHHHCCCCHHHHHHHHHHCCCCCEEEECCHHHHHH
VVLQILPSELPEKAGGIKRVKACMVQVDGIPNYDAPYLFDRAISDVCWKPNFPNSDEELT
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEE
FCYGTQDYFGRPASYLSIDGEFAPEDSPELEEKLRNTSETRYGELASLILKHTDYPGSRD
EEECCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
GTGFFQVLMSLKFRAIYEALTAQLLTASKAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1660882; 8905231 [H]