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The map label for this gene is tkt [H]

Identifier: 37521866

GI number: 37521866

Start: 2460303

End: 2462315

Strand: Direct

Name: tkt [H]

Synonym: glr2297

Alternate gene names: 37521866

Gene position: 2460303-2462315 (Clockwise)

Preceding gene: 37521865

Following gene: 37521867

Centisome position: 52.81

GC content: 63.14

Gene sequence:

>2013_bases
ATGACTGGCACTTTGCTTGACAAGACCGCCGCCCAGTTGGACGAGTTGAGCGTCAATACCATCCGTTTTTTGGCCGTTGA
TGCTGTCCAGAAGGCCAACTCCGGTCACCCCGGCCTGCCGATGGGGGCCGCCCCGATGGCCTACGTGATCTGGACGAAGT
TCCTCAAGCACAATCCCACCAACCCGAAGTGGTTCGACCGCGATCGGTTCATCCTTTCGGCGGGTCACGGTTCGATGCTG
CTCTACGCCCTGCTGCACCTGACCGGTTACGACCTGGCCATAGATGATCTCAAGCAATTTCGCCAGCTGCACTCGAGAAC
CCCAGGCCACCCGGAGAACTTCATGACCCCGGGGGTGGAGGTGACCACCGGCCCCCTCGGTCAGGGCCTCGGCAACGGCA
TCGGTATCGCTGTCGCCGAAGCGCACCTCGCGGCCCGTTACAACCGTCCCGGCCACGAGATTATCGACCATACCACCTAC
GCCATCGTCTCCGACGGCGACCTGATGGAAGGGGTAGCTTCCGAGGCCGCTTCGCTCGGGGGCCACCTGGGTCTGGGCAA
GGTCATCTATCTCTACGACGACAACCACATCTCGATCGACGGCGAGACCGAGTTGTCCTTTACCGAAGACCGCATGCAGC
GCTTCGACGCCTACGGCTGGCACACCCAGGCGGTGGCCGACGGCAATGATATCGCCGCCATCGAGCAGGCCATCCACAAC
GCCCGCGCCGTCACCGACAAGCCTTCGATCATCGCCGTGCGCACGATCATCGGTTACGGTTCACCCAACAAAGCCAACAG
CCACGACGTGCACGGCTCGCCCCTGGGTGGGGACGAAGTCAAAGCGACCAAAGAAAACCTCAAGTGGCCCCTGGAGCCCG
AGTTTTATATTCCCGAGGAGACCCTCGCCCAGTTTCGCAAAGCCGTTGAGGCGGGCAAAGAAGCCGAAGCGGACTGGAAT
GCCCGCTTTGCCGCCTACAAAGCCGAATTTCCAGAACTGGCCGCTGAACTCGAATCGCTCATCGAAGGCCGTCTGCCGGA
AGGCTGGGAGTCGTCCCTGCCCAGCTTCAGCCCCGCCGACAAGCCGCTTGCCACCCGCGCCGCCTCAGGCAAAGTGCTCA
ATGCCGTCACTGCCGCCCTCCCTGGCCTGATTGGCGGCTCGGCGGACCTGGCGCCCTCCAACAACACCTACGTCAAAGCC
TTCGTAGACTTTCAAAAAGCGACTCCCGAGGGCCGCAACTTCCACTTCGGCGTGCGCGAGCACGGCATGGGGGCGGTCAT
GAACGGCATGGCCATGCACGGCGGACTCAAAGTTTACGGCGGCACCTTTCTCATCTTCATGGACTACATGAAGGGGGCTG
TGCGCGTTGCGGCGCTTTCGCACTCGCCGGTGGTCTACGTGTTCACCCACGATTCAATCGGCCTCGGTGAAGACGGTCCC
ACGCACCAGCCGGTCGAGCAGATTCTCACCCTGCGCGCCACACCGCAGCTCACGGTCATCCGCCCCGGCGACGCCGTCGA
GACGGTCGGTGCCTGGAAGGTGGCCATCGAGAGCAATCGCGACCCGGTCGCCCTCATCCTCACCCGCCAGAATCTGCCCA
TCCAGCCCGGCTCTACGGTCGAGGCGGTGGCAAAGGGCGCCTACACGCTGGTGGAAGCCGACAATCCCGAAATCATCCTG
ATTGGCACCGGCTCCGAGGTGCAACTGGTGGTCGAAGCCCAAAAGCAACTGGCCGAGCAGGGCATCGCTGCCCGCGTCGT
CTCCTTCCCGAGCTGGGAACTGTTCGAAGCCCAGCCCCAGGAGTATAAAGACAGCGTCCTCACCCCCGGCGTCAAGCGCC
TGGCGGTGGAAGCGGGCACCAGCCTGGGCTGGCACAAGTACGTCGGCCTCGAAGGGGCGGTGATTGGCGTCGATCGCTAC
GGCGCTTCGGCTCCGATCAAAGCGGTCATGCCCGAGTACGGATTTACGATCGACAATGTCGTCGCCCATGCCCTGAAGGT
GCTGGGCCGCTAG

Upstream 100 bases:

>100_bases
TCAAGTTCCGCGCCATCTACGAAGCGCTTACCGCCCAATTGCTGACGGCTTCCAAGGCCAAGTAGCGCGCCGCGCCCACC
TTTCGCGACAGGAAGTATCC

Downstream 100 bases:

>100_bases
TCGACGAGTACTGCCGATCGACCGGGGGAGTGCAGGCCACTCCCCCGGTTTGTTTTTGCAGCCTGTTGGATGCGCCCGTG
GCACAATCGACTCTCAATAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MTGTLLDKTAAQLDELSVNTIRFLAVDAVQKANSGHPGLPMGAAPMAYVIWTKFLKHNPTNPKWFDRDRFILSAGHGSML
LYALLHLTGYDLAIDDLKQFRQLHSRTPGHPENFMTPGVEVTTGPLGQGLGNGIGIAVAEAHLAARYNRPGHEIIDHTTY
AIVSDGDLMEGVASEAASLGGHLGLGKVIYLYDDNHISIDGETELSFTEDRMQRFDAYGWHTQAVADGNDIAAIEQAIHN
ARAVTDKPSIIAVRTIIGYGSPNKANSHDVHGSPLGGDEVKATKENLKWPLEPEFYIPEETLAQFRKAVEAGKEAEADWN
ARFAAYKAEFPELAAELESLIEGRLPEGWESSLPSFSPADKPLATRAASGKVLNAVTAALPGLIGGSADLAPSNNTYVKA
FVDFQKATPEGRNFHFGVREHGMGAVMNGMAMHGGLKVYGGTFLIFMDYMKGAVRVAALSHSPVVYVFTHDSIGLGEDGP
THQPVEQILTLRATPQLTVIRPGDAVETVGAWKVAIESNRDPVALILTRQNLPIQPGSTVEAVAKGAYTLVEADNPEIIL
IGTGSEVQLVVEAQKQLAEQGIAARVVSFPSWELFEAQPQEYKDSVLTPGVKRLAVEAGTSLGWHKYVGLEGAVIGVDRY
GASAPIKAVMPEYGFTIDNVVAHALKVLGR

Sequences:

>Translated_670_residues
MTGTLLDKTAAQLDELSVNTIRFLAVDAVQKANSGHPGLPMGAAPMAYVIWTKFLKHNPTNPKWFDRDRFILSAGHGSML
LYALLHLTGYDLAIDDLKQFRQLHSRTPGHPENFMTPGVEVTTGPLGQGLGNGIGIAVAEAHLAARYNRPGHEIIDHTTY
AIVSDGDLMEGVASEAASLGGHLGLGKVIYLYDDNHISIDGETELSFTEDRMQRFDAYGWHTQAVADGNDIAAIEQAIHN
ARAVTDKPSIIAVRTIIGYGSPNKANSHDVHGSPLGGDEVKATKENLKWPLEPEFYIPEETLAQFRKAVEAGKEAEADWN
ARFAAYKAEFPELAAELESLIEGRLPEGWESSLPSFSPADKPLATRAASGKVLNAVTAALPGLIGGSADLAPSNNTYVKA
FVDFQKATPEGRNFHFGVREHGMGAVMNGMAMHGGLKVYGGTFLIFMDYMKGAVRVAALSHSPVVYVFTHDSIGLGEDGP
THQPVEQILTLRATPQLTVIRPGDAVETVGAWKVAIESNRDPVALILTRQNLPIQPGSTVEAVAKGAYTLVEADNPEIIL
IGTGSEVQLVVEAQKQLAEQGIAARVVSFPSWELFEAQPQEYKDSVLTPGVKRLAVEAGTSLGWHKYVGLEGAVIGVDRY
GASAPIKAVMPEYGFTIDNVVAHALKVLGR
>Mature_669_residues
TGTLLDKTAAQLDELSVNTIRFLAVDAVQKANSGHPGLPMGAAPMAYVIWTKFLKHNPTNPKWFDRDRFILSAGHGSMLL
YALLHLTGYDLAIDDLKQFRQLHSRTPGHPENFMTPGVEVTTGPLGQGLGNGIGIAVAEAHLAARYNRPGHEIIDHTTYA
IVSDGDLMEGVASEAASLGGHLGLGKVIYLYDDNHISIDGETELSFTEDRMQRFDAYGWHTQAVADGNDIAAIEQAIHNA
RAVTDKPSIIAVRTIIGYGSPNKANSHDVHGSPLGGDEVKATKENLKWPLEPEFYIPEETLAQFRKAVEAGKEAEADWNA
RFAAYKAEFPELAAELESLIEGRLPEGWESSLPSFSPADKPLATRAASGKVLNAVTAALPGLIGGSADLAPSNNTYVKAF
VDFQKATPEGRNFHFGVREHGMGAVMNGMAMHGGLKVYGGTFLIFMDYMKGAVRVAALSHSPVVYVFTHDSIGLGEDGPT
HQPVEQILTLRATPQLTVIRPGDAVETVGAWKVAIESNRDPVALILTRQNLPIQPGSTVEAVAKGAYTLVEADNPEIILI
GTGSEVQLVVEAQKQLAEQGIAARVVSFPSWELFEAQPQEYKDSVLTPGVKRLAVEAGTSLGWHKYVGLEGAVIGVDRYG
ASAPIKAVMPEYGFTIDNVVAHALKVLGR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=588, Percent_Identity=27.2108843537415, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI205277463, Length=593, Percent_Identity=25.8010118043845, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI4507521, Length=593, Percent_Identity=25.8010118043845, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI225637459, Length=595, Percent_Identity=22.6890756302521, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI225637463, Length=483, Percent_Identity=24.6376811594203, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI225637461, Length=483, Percent_Identity=24.6376811594203, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=53.5552193645991, Blast_Score=687, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=52.9411764705882, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=578, Percent_Identity=25.4325259515571, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=50.9036144578313, Blast_Score=658, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=48.4304932735426, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI45551847, Length=601, Percent_Identity=26.955074875208, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45550715, Length=601, Percent_Identity=26.955074875208, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24666278, Length=594, Percent_Identity=27.1043771043771, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24645119, Length=555, Percent_Identity=27.027027027027, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72026; Mature: 71895

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTLLDKTAAQLDELSVNTIRFLAVDAVQKANSGHPGLPMGAAPMAYVIWTKFLKHNPT
CCCCHHHHHHHHHHHCCCHHEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
NPKWFDRDRFILSAGHGSMLLYALLHLTGYDLAIDDLKQFRQLHSRTPGHPENFMTPGVE
CCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCHHHCCCCCE
VTTGPLGQGLGNGIGIAVAEAHLAARYNRPGHEIIDHTTYAIVSDGDLMEGVASEAASLG
EECCCCCCCCCCCCEEEEHHHHHHHHCCCCCHHHHCCCEEEEEECCHHHHHHHHHHHHCC
GHLGLGKVIYLYDDNHISIDGETELSFTEDRMQRFDAYGWHTQAVADGNDIAAIEQAIHN
CCCCCCCEEEEEECCEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
ARAVTDKPSIIAVRTIIGYGSPNKANSHDVHGSPLGGDEVKATKENLKWPLEPEFYIPEE
HHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCHH
TLAQFRKAVEAGKEAEADWNARFAAYKAEFPELAAELESLIEGRLPEGWESSLPSFSPAD
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
KPLATRAASGKVLNAVTAALPGLIGGSADLAPSNNTYVKAFVDFQKATPEGRNFHFGVRE
CCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCEEECHHH
HGMGAVMNGMAMHGGLKVYGGTFLIFMDYMKGAVRVAALSHSPVVYVFTHDSIGLGEDGP
CCCHHHHHCHHHCCCEEEECCEEEEHHHHHHCCEEEEEECCCCEEEEEECCCCCCCCCCC
THQPVEQILTLRATPQLTVIRPGDAVETVGAWKVAIESNRDPVALILTRQNLPIQPGSTV
CHHHHHHHHHHCCCCCEEEECCCCCHHHCCEEEEEEECCCCCEEEEEECCCCCCCCCCHH
EAVAKGAYTLVEADNPEIILIGTGSEVQLVVEAQKQLAEQGIAARVVSFPSWELFEAQPQ
HHHHCCCEEEEECCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEECCCCCHHCCCCCH
EYKDSVLTPGVKRLAVEAGTSLGWHKYVGLEGAVIGVDRYGASAPIKAVMPEYGFTIDNV
HHHHHHCCCCHHHHHHHCCCCCCCCEEECCCCEEEEEECCCCCCCHHHHCCCCCCCHHHH
VAHALKVLGR
HHHHHHHHCC
>Mature Secondary Structure 
TGTLLDKTAAQLDELSVNTIRFLAVDAVQKANSGHPGLPMGAAPMAYVIWTKFLKHNPT
CCCHHHHHHHHHHHCCCHHEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
NPKWFDRDRFILSAGHGSMLLYALLHLTGYDLAIDDLKQFRQLHSRTPGHPENFMTPGVE
CCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCHHHCCCCCE
VTTGPLGQGLGNGIGIAVAEAHLAARYNRPGHEIIDHTTYAIVSDGDLMEGVASEAASLG
EECCCCCCCCCCCCEEEEHHHHHHHHCCCCCHHHHCCCEEEEEECCHHHHHHHHHHHHCC
GHLGLGKVIYLYDDNHISIDGETELSFTEDRMQRFDAYGWHTQAVADGNDIAAIEQAIHN
CCCCCCCEEEEEECCEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
ARAVTDKPSIIAVRTIIGYGSPNKANSHDVHGSPLGGDEVKATKENLKWPLEPEFYIPEE
HHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEECCHH
TLAQFRKAVEAGKEAEADWNARFAAYKAEFPELAAELESLIEGRLPEGWESSLPSFSPAD
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
KPLATRAASGKVLNAVTAALPGLIGGSADLAPSNNTYVKAFVDFQKATPEGRNFHFGVRE
CCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCEEECHHH
HGMGAVMNGMAMHGGLKVYGGTFLIFMDYMKGAVRVAALSHSPVVYVFTHDSIGLGEDGP
CCCHHHHHCHHHCCCEEEECCEEEEHHHHHHCCEEEEEECCCCEEEEEECCCCCCCCCCC
THQPVEQILTLRATPQLTVIRPGDAVETVGAWKVAIESNRDPVALILTRQNLPIQPGSTV
CHHHHHHHHHHCCCCCEEEECCCCCHHHCCEEEEEEECCCCCEEEEEECCCCCCCCCCHH
EAVAKGAYTLVEADNPEIILIGTGSEVQLVVEAQKQLAEQGIAARVVSFPSWELFEAQPQ
HHHHCCCEEEEECCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEECCCCCHHCCCCCH
EYKDSVLTPGVKRLAVEAGTSLGWHKYVGLEGAVIGVDRYGASAPIKAVMPEYGFTIDNV
HHHHHHCCCCHHHHHHHCCCCCCCCEEECCCCEEEEEECCCCCCCHHHHCCCCCCCHHHH
VAHALKVLGR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]