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The map label for this gene is hrcA

Identifier: 37521840

GI number: 37521840

Start: 2436258

End: 2437340

Strand: Reverse

Name: hrcA

Synonym: gll2271

Alternate gene names: 37521840

Gene position: 2437340-2436258 (Counterclockwise)

Preceding gene: 37521851

Following gene: 37521839

Centisome position: 52.31

GC content: 63.8

Gene sequence:

>1083_bases
GTGAGCAGTTTTTCGTTCGAATCCTCCGCAAGATTGCCCTTGAACCCGCGCTTCAAGCAGATTTTGCACGCGACGGTCAA
AAGCTACATCGATACCGCCGAGCCGGTCGGCTCGAAGATGCTCACCCAGCAATACAACTTCGGCCTCAGCTCGGCCACGA
TCCGCAACGCCATGGCGGTGCTCGAGAGCTGGGGATTGTTGTTCCAGCCCCACACCAGCGCCGGTCGCATCCCGTCGGAT
TCGGGCTACCGGGTCTACGTCGATGAGTTGATTTCGCCGCCGACCGAACTCATCCAGCAGATGCGCGCCGCCCTCGCTGA
GAACCTGGGGGAGCGACAGGACTTAGAAAGCCTTCTGCAGGGGGCGACCCGGCTTCTAGCCACCCTGAGCGGCTGTGTAG
CGCTGATCACCGCCCCCCAGAGCGTCTTTGTGAGTGTCCGTCATCTGCAGATCGTGCACATCGGCGAGGGGCGGGCGCTG
GTGATCGTGGTCACCGACGCGCTGCAGACGCGCTCGTTTTTGCTCGATCTGCCCCAGCCGGAGATGGCCGAGCAACTCGA
GACGCTCAACAACTTCCTGAACCTCCAGCTCCAGAATCGGCGGCTGGACGATCTCAATGCGGCGGCCGTGGAGGCGATGG
GCGGCGAGTTTCACTGGTACACCGACTTTTTGCGCGGCCTGATTGCGCTGTTGCAGCGGGTTCTGCAGCCGCCCACGGGC
CAGCTTTACGTGAGCGGCGTGGGTGAAATCCTCAAGCAGCCCGAATTTGCCGAACCCGAGCGCATCCAGGCCATCGTGCA
GCTGCTCGAAGTCGAGCGCGAACGGCTCGGGCCGCTCATCTCCCCGACCCAGCGCCACAGCCGGCAGATCGTCGTGCGCA
TCGGCGCTGAAAACCCGCTGGGGCCGATGCAGTTCTGCTCGCTGGTCAGCAGCACCTATTACCTCAACGAGGTGCCGGTG
GGTTCGGTGGGCGTTCTCGGCCCCACCCGGCTACCCTACGACCGGGCCATCGCTTCGGTACAGGCCGCAAGCGACCACCT
CTGCCAGGTGATGCAGGCCGAGGACGAACCGCACCGCTGGTAG

Upstream 100 bases:

>100_bases
CAAGATGTATCACAGTGCGGGCGGGCCCGGCCCGGCGACCCCGGGCCGTGTCCCCGTTAGAATGCTGGTGTTGATCCCAG
AAGCGAGATAGGCAGTCGTC

Downstream 100 bases:

>100_bases
GTTGGTTTTCTCGACGCCCTGACTTGCTAGCATGGAGAAAAAGTTGGCAAAACGTTTTGCCTGGATCTTTTGTGGTCGAT
GGAGGACAGTTCTGTGCATA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSSFSFESSARLPLNPRFKQILHATVKSYIDTAEPVGSKMLTQQYNFGLSSATIRNAMAVLESWGLLFQPHTSAGRIPSD
SGYRVYVDELISPPTELIQQMRAALAENLGERQDLESLLQGATRLLATLSGCVALITAPQSVFVSVRHLQIVHIGEGRAL
VIVVTDALQTRSFLLDLPQPEMAEQLETLNNFLNLQLQNRRLDDLNAAAVEAMGGEFHWYTDFLRGLIALLQRVLQPPTG
QLYVSGVGEILKQPEFAEPERIQAIVQLLEVERERLGPLISPTQRHSRQIVVRIGAENPLGPMQFCSLVSSTYYLNEVPV
GSVGVLGPTRLPYDRAIASVQAASDHLCQVMQAEDEPHRW

Sequences:

>Translated_360_residues
MSSFSFESSARLPLNPRFKQILHATVKSYIDTAEPVGSKMLTQQYNFGLSSATIRNAMAVLESWGLLFQPHTSAGRIPSD
SGYRVYVDELISPPTELIQQMRAALAENLGERQDLESLLQGATRLLATLSGCVALITAPQSVFVSVRHLQIVHIGEGRAL
VIVVTDALQTRSFLLDLPQPEMAEQLETLNNFLNLQLQNRRLDDLNAAAVEAMGGEFHWYTDFLRGLIALLQRVLQPPTG
QLYVSGVGEILKQPEFAEPERIQAIVQLLEVERERLGPLISPTQRHSRQIVVRIGAENPLGPMQFCSLVSSTYYLNEVPV
GSVGVLGPTRLPYDRAIASVQAASDHLCQVMQAEDEPHRW
>Mature_359_residues
SSFSFESSARLPLNPRFKQILHATVKSYIDTAEPVGSKMLTQQYNFGLSSATIRNAMAVLESWGLLFQPHTSAGRIPSDS
GYRVYVDELISPPTELIQQMRAALAENLGERQDLESLLQGATRLLATLSGCVALITAPQSVFVSVRHLQIVHIGEGRALV
IVVTDALQTRSFLLDLPQPEMAEQLETLNNFLNLQLQNRRLDDLNAAAVEAMGGEFHWYTDFLRGLIALLQRVLQPPTGQ
LYVSGVGEILKQPEFAEPERIQAIVQLLEVERERLGPLISPTQRHSRQIVVRIGAENPLGPMQFCSLVSSTYYLNEVPVG
SVGVLGPTRLPYDRAIASVQAASDHLCQVMQAEDEPHRW

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_GLOVI (Q7NIB2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925217.1
- ProteinModelPortal:   Q7NIB2
- SMR:   Q7NIB2
- GeneID:   2600673
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll2271
- NMPDR:   fig|251221.1.peg.2271
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   GVIO251221:GLL2271-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39891; Mature: 39760

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFSFESSARLPLNPRFKQILHATVKSYIDTAEPVGSKMLTQQYNFGLSSATIRNAMAV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LESWGLLFQPHTSAGRIPSDSGYRVYVDELISPPTELIQQMRAALAENLGERQDLESLLQ
HHHCCCEECCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
GATRLLATLSGCVALITAPQSVFVSVRHLQIVHIGEGRALVIVVTDALQTRSFLLDLPQP
HHHHHHHHHHHHHHHHCCCHHHHHEEEEEEEEEECCCCEEEEEECCHHHHHHHHHCCCCH
EMAEQLETLNNFLNLQLQNRRLDDLNAAAVEAMGGEFHWYTDFLRGLIALLQRVLQPPTG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
QLYVSGVGEILKQPEFAEPERIQAIVQLLEVERERLGPLISPTQRHSRQIVVRIGAENPL
EEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCCCCC
GPMQFCSLVSSTYYLNEVPVGSVGVLGPTRLPYDRAIASVQAASDHLCQVMQAEDEPHRW
CHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSFSFESSARLPLNPRFKQILHATVKSYIDTAEPVGSKMLTQQYNFGLSSATIRNAMAV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LESWGLLFQPHTSAGRIPSDSGYRVYVDELISPPTELIQQMRAALAENLGERQDLESLLQ
HHHCCCEECCCCCCCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
GATRLLATLSGCVALITAPQSVFVSVRHLQIVHIGEGRALVIVVTDALQTRSFLLDLPQP
HHHHHHHHHHHHHHHHCCCHHHHHEEEEEEEEEECCCCEEEEEECCHHHHHHHHHCCCCH
EMAEQLETLNNFLNLQLQNRRLDDLNAAAVEAMGGEFHWYTDFLRGLIALLQRVLQPPTG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
QLYVSGVGEILKQPEFAEPERIQAIVQLLEVERERLGPLISPTQRHSRQIVVRIGAENPL
EEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCCCCC
GPMQFCSLVSSTYYLNEVPVGSVGVLGPTRLPYDRAIASVQAASDHLCQVMQAEDEPHRW
CHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292