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The map label for this gene is gyrA [H]

Identifier: 37521619

GI number: 37521619

Start: 2198917

End: 2201394

Strand: Reverse

Name: gyrA [H]

Synonym: gvip274

Alternate gene names: 37521619

Gene position: 2201394-2198917 (Counterclockwise)

Preceding gene: 37521625

Following gene: 37521617

Centisome position: 47.25

GC content: 66.1

Gene sequence:

>2478_bases
ATGCCCAGACAACTCGAACTGACCGGCCCCGAACCCAAAGCCCGGGTCGTGCCCACCGCCCTGCACTCGGAGATGCAGCG
CTCGTATCTTGAGTACGCGATGAGCGTGATTGTCGGGCGGGCGCTGCCGGATGTGCGCGACGGCCTCAAACCGGTGCACC
GGCGGATTCTCTTTGCGATGCACGAACTGGGACTGGCCCCCGACCGGCCTTTTCGCAAGTGCGCCCGCGTCGTGGGCGAC
GTGCTGGGCAAGTACCATCCCCACGGCGACACGGCGGTCTACGACGCCCTGGTGCGGCTGGTGCAAGATTTTTCTTCGCG
CTACCCGCTGCTGTCGGGCCACGGCAACTTCGGCTCGATCGACAACGACCCGCCCGCGGCGATGCGCTACACCGAGTGCC
GGCTGGCTGCGGTGGGGGTCGATGCGCTGCTGGCGGAGATCGACGATCAGACAGTCGAATTTACCGACAACTTCGACGGC
TCCCAGCGCGAACCGGAAGTGCTGCCGGCGCGTTTGCCGGTGTTGCTGCTCAACGGCAGCGCCGGGATCGCCGTCGGCAT
GGCCACGAATATTCCGCCCCACAACCTGGGGGAGCTGGTGGATGGGCTGGTGGCCCTGATCGACAATCCCGAATTGGCCG
ACGAGCAGTTGCTGCGGATCATTCCCGGGCCGGACTTTCCGACCGGCGGCCAAATTATCGGCACCGAGGGCATCCGCGAG
GCGTACCTCACTGGCCGCGGCTCGATCACCATGCGCGGGATCACCCACTGCGAGGAGGTGGGCAGCGGCCGACGGCGCAA
ACCGGCGATCATCGTCACCGCCCTGCCCTACCAGGTCAACAAAGCCGCCTGGATCGAAAAAGTGGCCGAGCTGGTCAACC
TGGGCAAGGTCAACGGCATCAGCGACCTGCGCGACGAATCGAACCGCGAAGGGGTGCGCGTCGTGCTCGAAATGAAGCGC
GAGGCGCGCCCCGAGGCGATTCTGGCGGGCCTCTACCGCCTCACGCCGCTGCAGGCCAACTTCGGGACGATCTTGCTGAC
GCTGGTGGGGGGCCAGCCCCGCCTGCTCAAGCTGCGCGAACTGCTCGAGCAGTTTCTCGAATTTCGGGTGGCTACCCTTA
CCCGCCGCATTCAGTACAACCTCCGGCGCGCGAGTGAGCGCGCCCACCAGCTCGAAGGACAACTTGTCGCCCTGGCCAAT
TTGCAGCCCATCGTCCAGATGCTGAGTGCGGCGCGCGACGCCGCCCAGGCCCGAGCCGAACTGGAGGCGAGCTACGGCCT
GAGCGAACGGCAATCCGAAGAAATTTTGCAGATGCCCCTCAGGCGGCTCACCCAGCTCGACCGCGAGCGCCTTGCCTCCG
AGCACCGCGAACTGCGCGAGAAGGTGATCGAGCTGCAGTCGCAGCTCGATAGCCGCCGCAAATTGCTCGGTCTGCTCAAG
CGCGAACTGCGCGATCTCAAGAAAAAACACGCCGACCCCCGCCGCACCTGCATCGAGGCGCGCACCGCGCCGCTGCCGAC
CCTCGCCGAGATCACCAGCGACGACGAAGTTGTGGTGCAACTGACCCACCGCGGCTACGTGCGCCGGATCCCCGCCGCCG
CCTTTGAGCGGCGCAGCCGCTCGCGCAGGGCCGTCTCGCGCACGGAGGACAACGACTTTGTCGTCGAGAGCTACCCGACG
CGCACCCGCAACGAATTGCTGGTCATCACCCGCTCCGGACGCGCCTACTCGCTGAAAGTCAGCGAAATCCCCGAGACGGG
ACCCCGCAGCCGGGGTACGCCCCTGGTCACTTTGCTGTCGATCCAGGGGGAGCAGATAGCCGCCACCTTCGTGCGCGAAA
ATTATCCACCGGATTTGTTTTTGGTGCTGCTCACCCGCGAGGGCCGCATTAAGAAGCTGCTCTTGAGCGAGTGTGCCAAC
CTTACCGGTCGCGGCCTGATGATGCTCAAACTGAGCGAGGAGGACCAGCTCATCCAGGTGGGGCTTGCCACAGCCCACAG
CCAGATCGTCGTGGGTACCAGCGCCGGGCGGCTGTTGCGCTTTGTGGCCGACGAGGCGCAGCTGCCGGCCATGGGCCGCT
CCGCCCTCGGTTTGCAGGCCATCAAGCTGCGCCGCGGCGAGTCGCTCGCGGCCATGACCGTAGTGGGCAACGGCGAAGAT
CTGCTGATGGTAAGCCGCCTGGGCCTCGGCAAGCGCCTGAAGACAGGCGAGATACGCCTGCAGGAGCGCGCGGGCTTGGG
TACACCCGTGGGTCTATTGCGCGAGCGCAACGGCGACAGTTTGCTGGCGGTGCTGGCGGTCGGAGCCGAAGGGGAGGTGG
CTATGGCCACCGATCAAGAGCGCTTGGTGCAGGTCGATCTGGGCGAACTGGCGGCAACCGACCGCTCAAGCCCCGGCAAG
CCCCTCGCAGTGCTCAATCCGGCTGAGCAGATCATCGCGGTCACCCGTCTGTCGGCGGAGCCGGAGGAAACGGATTGA

Upstream 100 bases:

>100_bases
GGCCACCGGGACAAGCGCTGTGTACAATCGTGCACAACTCGTCCCTTGTCGCGTCCGCCTATTTGTCCGGCCACCTTCTT
ACCCGAGTGCCGCCATCGCC

Downstream 100 bases:

>100_bases
TCGGCTTCAGGTGGCCTATTCCGCCAAAATCCCCGCCAGGGTGTTGAAGGGCGTGCTCAGCCCGAAGGTGGCCGGATTGA
CCACCTGCTTGTAATTGAAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 825; Mature: 824

Protein sequence:

>825_residues
MPRQLELTGPEPKARVVPTALHSEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILFAMHELGLAPDRPFRKCARVVGD
VLGKYHPHGDTAVYDALVRLVQDFSSRYPLLSGHGNFGSIDNDPPAAMRYTECRLAAVGVDALLAEIDDQTVEFTDNFDG
SQREPEVLPARLPVLLLNGSAGIAVGMATNIPPHNLGELVDGLVALIDNPELADEQLLRIIPGPDFPTGGQIIGTEGIRE
AYLTGRGSITMRGITHCEEVGSGRRRKPAIIVTALPYQVNKAAWIEKVAELVNLGKVNGISDLRDESNREGVRVVLEMKR
EARPEAILAGLYRLTPLQANFGTILLTLVGGQPRLLKLRELLEQFLEFRVATLTRRIQYNLRRASERAHQLEGQLVALAN
LQPIVQMLSAARDAAQARAELEASYGLSERQSEEILQMPLRRLTQLDRERLASEHRELREKVIELQSQLDSRRKLLGLLK
RELRDLKKKHADPRRTCIEARTAPLPTLAEITSDDEVVVQLTHRGYVRRIPAAAFERRSRSRRAVSRTEDNDFVVESYPT
RTRNELLVITRSGRAYSLKVSEIPETGPRSRGTPLVTLLSIQGEQIAATFVRENYPPDLFLVLLTREGRIKKLLLSECAN
LTGRGLMMLKLSEEDQLIQVGLATAHSQIVVGTSAGRLLRFVADEAQLPAMGRSALGLQAIKLRRGESLAAMTVVGNGED
LLMVSRLGLGKRLKTGEIRLQERAGLGTPVGLLRERNGDSLLAVLAVGAEGEVAMATDQERLVQVDLGELAATDRSSPGK
PLAVLNPAEQIIAVTRLSAEPEETD

Sequences:

>Translated_825_residues
MPRQLELTGPEPKARVVPTALHSEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILFAMHELGLAPDRPFRKCARVVGD
VLGKYHPHGDTAVYDALVRLVQDFSSRYPLLSGHGNFGSIDNDPPAAMRYTECRLAAVGVDALLAEIDDQTVEFTDNFDG
SQREPEVLPARLPVLLLNGSAGIAVGMATNIPPHNLGELVDGLVALIDNPELADEQLLRIIPGPDFPTGGQIIGTEGIRE
AYLTGRGSITMRGITHCEEVGSGRRRKPAIIVTALPYQVNKAAWIEKVAELVNLGKVNGISDLRDESNREGVRVVLEMKR
EARPEAILAGLYRLTPLQANFGTILLTLVGGQPRLLKLRELLEQFLEFRVATLTRRIQYNLRRASERAHQLEGQLVALAN
LQPIVQMLSAARDAAQARAELEASYGLSERQSEEILQMPLRRLTQLDRERLASEHRELREKVIELQSQLDSRRKLLGLLK
RELRDLKKKHADPRRTCIEARTAPLPTLAEITSDDEVVVQLTHRGYVRRIPAAAFERRSRSRRAVSRTEDNDFVVESYPT
RTRNELLVITRSGRAYSLKVSEIPETGPRSRGTPLVTLLSIQGEQIAATFVRENYPPDLFLVLLTREGRIKKLLLSECAN
LTGRGLMMLKLSEEDQLIQVGLATAHSQIVVGTSAGRLLRFVADEAQLPAMGRSALGLQAIKLRRGESLAAMTVVGNGED
LLMVSRLGLGKRLKTGEIRLQERAGLGTPVGLLRERNGDSLLAVLAVGAEGEVAMATDQERLVQVDLGELAATDRSSPGK
PLAVLNPAEQIIAVTRLSAEPEETD
>Mature_824_residues
PRQLELTGPEPKARVVPTALHSEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILFAMHELGLAPDRPFRKCARVVGDV
LGKYHPHGDTAVYDALVRLVQDFSSRYPLLSGHGNFGSIDNDPPAAMRYTECRLAAVGVDALLAEIDDQTVEFTDNFDGS
QREPEVLPARLPVLLLNGSAGIAVGMATNIPPHNLGELVDGLVALIDNPELADEQLLRIIPGPDFPTGGQIIGTEGIREA
YLTGRGSITMRGITHCEEVGSGRRRKPAIIVTALPYQVNKAAWIEKVAELVNLGKVNGISDLRDESNREGVRVVLEMKRE
ARPEAILAGLYRLTPLQANFGTILLTLVGGQPRLLKLRELLEQFLEFRVATLTRRIQYNLRRASERAHQLEGQLVALANL
QPIVQMLSAARDAAQARAELEASYGLSERQSEEILQMPLRRLTQLDRERLASEHRELREKVIELQSQLDSRRKLLGLLKR
ELRDLKKKHADPRRTCIEARTAPLPTLAEITSDDEVVVQLTHRGYVRRIPAAAFERRSRSRRAVSRTEDNDFVVESYPTR
TRNELLVITRSGRAYSLKVSEIPETGPRSRGTPLVTLLSIQGEQIAATFVRENYPPDLFLVLLTREGRIKKLLLSECANL
TGRGLMMLKLSEEDQLIQVGLATAHSQIVVGTSAGRLLRFVADEAQLPAMGRSALGLQAIKLRRGESLAAMTVVGNGEDL
LMVSRLGLGKRLKTGEIRLQERAGLGTPVGLLRERNGDSLLAVLAVGAEGEVAMATDQERLVQVDLGELAATDRSSPGKP
LAVLNPAEQIIAVTRLSAEPEETD

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=453, Percent_Identity=25.60706401766, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI19913406, Length=373, Percent_Identity=26.0053619302949, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1788562, Length=848, Percent_Identity=39.5047169811321, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1789396, Length=720, Percent_Identity=36.25, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=34.2857142857143, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=462, Percent_Identity=24.8917748917749, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=385, Percent_Identity=23.3766233766234, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90975; Mature: 90844

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRQLELTGPEPKARVVPTALHSEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILFAM
CCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HELGLAPDRPFRKCARVVGDVLGKYHPHGDTAVYDALVRLVQDFSSRYPLLSGHGNFGSI
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCC
DNDPPAAMRYTECRLAAVGVDALLAEIDDQTVEFTDNFDGSQREPEVLPARLPVLLLNGS
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECC
AGIAVGMATNIPPHNLGELVDGLVALIDNPELADEQLLRIIPGPDFPTGGQIIGTEGIRE
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEECCCHHHH
AYLTGRGSITMRGITHCEEVGSGRRRKPAIIVTALPYQVNKAAWIEKVAELVNLGKVNGI
HHHCCCCCEEECCHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
SDLRDESNREGVRVVLEMKREARPEAILAGLYRLTPLQANFGTILLTLVGGQPRLLKLRE
HHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHH
LLEQFLEFRVATLTRRIQYNLRRASERAHQLEGQLVALANLQPIVQMLSAARDAAQARAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LEASYGLSERQSEEILQMPLRRLTQLDRERLASEHRELREKVIELQSQLDSRRKLLGLLK
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELRDLKKKHADPRRTCIEARTAPLPTLAEITSDDEVVVQLTHRGYVRRIPAAAFERRSR
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCEEEEEECCCHHHHCCHHHHHHHHH
SRRAVSRTEDNDFVVESYPTRTRNELLVITRSGRAYSLKVSEIPETGPRSRGTPLVTLLS
HHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEE
IQGEQIAATFVRENYPPDLFLVLLTREGRIKKLLLSECANLTGRGLMMLKLSEEDQLIQV
ECCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEH
GLATAHSQIVVGTSAGRLLRFVADEAQLPAMGRSALGLQAIKLRRGESLAAMTVVGNGED
HHHHCCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHCCCCEEEEEEEECCCC
LLMVSRLGLGKRLKTGEIRLQERAGLGTPVGLLRERNGDSLLAVLAVGAEGEVAMATDQE
EEEEECCCCCCCCCCCCEEEHHHCCCCCCHHHHHCCCCCCEEEEEEECCCCCEEEECCHH
RLVQVDLGELAATDRSSPGKPLAVLNPAEQIIAVTRLSAEPEETD
HHEEEEHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PRQLELTGPEPKARVVPTALHSEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILFAM
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HELGLAPDRPFRKCARVVGDVLGKYHPHGDTAVYDALVRLVQDFSSRYPLLSGHGNFGSI
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCC
DNDPPAAMRYTECRLAAVGVDALLAEIDDQTVEFTDNFDGSQREPEVLPARLPVLLLNGS
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECC
AGIAVGMATNIPPHNLGELVDGLVALIDNPELADEQLLRIIPGPDFPTGGQIIGTEGIRE
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEECCCHHHH
AYLTGRGSITMRGITHCEEVGSGRRRKPAIIVTALPYQVNKAAWIEKVAELVNLGKVNGI
HHHCCCCCEEECCHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
SDLRDESNREGVRVVLEMKREARPEAILAGLYRLTPLQANFGTILLTLVGGQPRLLKLRE
HHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHH
LLEQFLEFRVATLTRRIQYNLRRASERAHQLEGQLVALANLQPIVQMLSAARDAAQARAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LEASYGLSERQSEEILQMPLRRLTQLDRERLASEHRELREKVIELQSQLDSRRKLLGLLK
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELRDLKKKHADPRRTCIEARTAPLPTLAEITSDDEVVVQLTHRGYVRRIPAAAFERRSR
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCEEEEEECCCHHHHCCHHHHHHHHH
SRRAVSRTEDNDFVVESYPTRTRNELLVITRSGRAYSLKVSEIPETGPRSRGTPLVTLLS
HHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEE
IQGEQIAATFVRENYPPDLFLVLLTREGRIKKLLLSECANLTGRGLMMLKLSEEDQLIQV
ECCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEH
GLATAHSQIVVGTSAGRLLRFVADEAQLPAMGRSALGLQAIKLRRGESLAAMTVVGNGED
HHHHCCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHCCCCEEEEEEEECCCC
LLMVSRLGLGKRLKTGEIRLQERAGLGTPVGLLRERNGDSLLAVLAVGAEGEVAMATDQE
EEEEECCCCCCCCCCCCEEEHHHCCCCCCHHHHHCCCCCCEEEEEEECCCCCEEEECCHH
RLVQVDLGELAATDRSSPGKPLAVLNPAEQIIAVTRLSAEPEETD
HHEEEEHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]