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The map label for this gene is lpxC [H]

Identifier: 37521434

GI number: 37521434

Start: 1987126

End: 1987986

Strand: Direct

Name: lpxC [H]

Synonym: gvip256

Alternate gene names: 37521434

Gene position: 1987126-1987986 (Clockwise)

Preceding gene: 37521433

Following gene: 37521435

Centisome position: 42.65

GC content: 67.83

Gene sequence:

>861_bases
GTGCAGCAGCAGACCCTAGCCGCCACCGTCCAGCTTTCGGGCATCTCGTTGCACAAGGGGGCGTCCGTCGCCGTGCGGCT
GTGCCCGGCTCCTCCGGATAGCGGCCGGTGCTTCGTGCGCGCCGATCTTGCCGGCACCCCGGCGATCCCGGCCCTGGCCC
GCGGCTTTCGTCCCAGTCCCCTGTGCACCACCCTCAGCGAGAACGGCGCGGCGATCCAGACCGTCGAGCACGTGCTCGCG
GCCCTCTACGGTCTGGGGATCGACAACTGCCGCATCGAGGTGGAAGGTCCCGAACTGCCCATCCTCGACGGCTCCGCCCG
CCCCTACGTCGAGGCGGTGGTCCGCTCGGGAACCGTCCGGCAAAACGCTCCCCGGCGCTTCTATCAGATTGCCGAGCCGG
TAGCCGTCTACGAGCGCGACGCCTTCGTAGTCGCCATGCCCACCGACACCCCGGCTTTGCAGGTCAGTTACGGCATCGAC
TTTCCCCACCCGATCGGCCGGCACTGGTTCAGCCTGGAGCTGACCCCTGAGAATTTTGCCCGCGAGGTGGCTCCGGCGCG
CACCTTCACCCTCCAGTCCCAGGTCGAACAACTGCTTGCCTGTGGCCTGATTCAGGGAGGCAGCCTCGATTGCGCCCTGG
TGGCCGGTGCCGACGACTGGCTCACACCGCCCACCTGGCCCGACGAGCCCGCCCGCCACAAGCTGCTCGATCTGTTGGGG
GATTTGAGTCTGGCAGGAGTCGCCCTCAGTGGGCACATCGTCGCCTACAAAGCGGGCCACGCCCTGCACGGCAGGCTCGC
CCGCGCCCTTGCCGAAAAGGTTCCCGTTCCATCCGTATGCTCCCAAAAGCCGTCCCAATGA

Upstream 100 bases:

>100_bases
GGCGGCCCGCTCGCGCCTGCCGCAGATCGTCGAGCAGATGCGCCAGATGCAGCGGCGCATCGAGCAATTGGAAGTGCAGC
TTTTGGGGAGGCTCTGATCG

Downstream 100 bases:

>100_bases
TCGACAACATCGAAATTCAGAAGATCCTCGCCCACCGCTACCCGTTTTTACTCGTCGACCGCGTGCTCGTCTTCGAGCCG
GGGGTGCGGGCGGTCGGCAT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQQQTLAATVQLSGISLHKGASVAVRLCPAPPDSGRCFVRADLAGTPAIPALARGFRPSPLCTTLSENGAAIQTVEHVLA
ALYGLGIDNCRIEVEGPELPILDGSARPYVEAVVRSGTVRQNAPRRFYQIAEPVAVYERDAFVVAMPTDTPALQVSYGID
FPHPIGRHWFSLELTPENFAREVAPARTFTLQSQVEQLLACGLIQGGSLDCALVAGADDWLTPPTWPDEPARHKLLDLLG
DLSLAGVALSGHIVAYKAGHALHGRLARALAEKVPVPSVCSQKPSQ

Sequences:

>Translated_286_residues
MQQQTLAATVQLSGISLHKGASVAVRLCPAPPDSGRCFVRADLAGTPAIPALARGFRPSPLCTTLSENGAAIQTVEHVLA
ALYGLGIDNCRIEVEGPELPILDGSARPYVEAVVRSGTVRQNAPRRFYQIAEPVAVYERDAFVVAMPTDTPALQVSYGID
FPHPIGRHWFSLELTPENFAREVAPARTFTLQSQVEQLLACGLIQGGSLDCALVAGADDWLTPPTWPDEPARHKLLDLLG
DLSLAGVALSGHIVAYKAGHALHGRLARALAEKVPVPSVCSQKPSQ
>Mature_286_residues
MQQQTLAATVQLSGISLHKGASVAVRLCPAPPDSGRCFVRADLAGTPAIPALARGFRPSPLCTTLSENGAAIQTVEHVLA
ALYGLGIDNCRIEVEGPELPILDGSARPYVEAVVRSGTVRQNAPRRFYQIAEPVAVYERDAFVVAMPTDTPALQVSYGID
FPHPIGRHWFSLELTPENFAREVAPARTFTLQSQVEQLLACGLIQGGSLDCALVAGADDWLTPPTWPDEPARHKLLDLLG
DLSLAGVALSGHIVAYKAGHALHGRLARALAEKVPVPSVCSQKPSQ

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=281, Percent_Identity=38.7900355871886, Blast_Score=192, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30459; Mature: 30459

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQTLAATVQLSGISLHKGASVAVRLCPAPPDSGRCFVRADLAGTPAIPALARGFRPSP
CCCCCEEEEEEECCEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCCCCCC
LCTTLSENGAAIQTVEHVLAALYGLGIDNCRIEVEGPELPILDGSARPYVEAVVRSGTVR
CEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCCCC
QNAPRRFYQIAEPVAVYERDAFVVAMPTDTPALQVSYGIDFPHPIGRHWFSLELTPENFA
CCCCHHHHHHHCCHHEEECCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECHHHHH
REVAPARTFTLQSQVEQLLACGLIQGGSLDCALVAGADDWLTPPTWPDEPARHKLLDLLG
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
DLSLAGVALSGHIVAYKAGHALHGRLARALAEKVPVPSVCSQKPSQ
CHHHEEEEEECEEEEEECCCHHHHHHHHHHHHHCCCCHHHCCCCCC
>Mature Secondary Structure
MQQQTLAATVQLSGISLHKGASVAVRLCPAPPDSGRCFVRADLAGTPAIPALARGFRPSP
CCCCCEEEEEEECCEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCCCCCC
LCTTLSENGAAIQTVEHVLAALYGLGIDNCRIEVEGPELPILDGSARPYVEAVVRSGTVR
CEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCCCC
QNAPRRFYQIAEPVAVYERDAFVVAMPTDTPALQVSYGIDFPHPIGRHWFSLELTPENFA
CCCCHHHHHHHCCHHEEECCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECHHHHH
REVAPARTFTLQSQVEQLLACGLIQGGSLDCALVAGADDWLTPPTWPDEPARHKLLDLLG
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
DLSLAGVALSGHIVAYKAGHALHGRLARALAEKVPVPSVCSQKPSQ
CHHHEEEEEECEEEEEECCCHHHHHHHHHHHHHCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]