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The map label for this gene is lpxD3

Identifier: 37521433

GI number: 37521433

Start: 1986073

End: 1987122

Strand: Direct

Name: lpxD3

Synonym: glr1864

Alternate gene names: 37521433

Gene position: 1986073-1987122 (Clockwise)

Preceding gene: 37521432

Following gene: 37521434

Centisome position: 42.63

GC content: 67.24

Gene sequence:

>1050_bases
ATGGGAGTCCAATTCAGCGCTGCTGAATTGACCGACCTGGTCGGCGGCGAGCTGTCGGGCGATCCCGGGCGGCTGGTCGT
GGGTGCCCGGCCTCCGGAGGAAGCCGAAGGGGGCGATCTGACCTTTGCCCTCGACCTGCACGCGCGCAAGCTCATCGAGA
CGACCCGCGCCGGGGTGGCGATCACCCCGGTGCGCTGGCCCTTCGAGCATCTCACCCAGATCGTGGTGGCCAACCCGCGC
CTGGCCATGGCGCAGGTGCTCGCCCACATGTTTCCGCAGCCGATTGCGATGCCGCCCGCGGGCATCCATCCGAGTGCGGT
CGTCCATCCGAGTGCGGTGGTCCATCCGAGTGCCTCGGTGGCGGCCCTGGTCTACGTCGGTCCGCGCGCCGCGGTCGGGG
CCAACACGCACCTGTTTCCGGGGGTGTACGTCGGGGCGGAGGCGGTGGTGGGCAGCGAGTGTCTGATCTATCCGAACGTG
GTGCTCATGGACGGCATCCGCCTGGGCGACCGGGTGGTCATCCACGCGGGCAGCGTGCTCGGCTCCGACGGCTACGGCTT
TGTGCCGACCGGCGAAAGGCACCTCAAAGTGCCGCAGGTGGGCACGGTGGTTATCGGCGACGACGTCGAGGTGGGCGCCA
ACGTCGCGGTGGACCGCGCCACCATGGGCCAGACCGAAATCCAGGCGGGCACCAAGATCGATAATCTGGTCCACATCGGC
CACAACGACCGCATCGGCCGCCACTGCCTGATCGTCTCCCAGGTTGGTCTTGCAGGCTCGGTCAAAGTCGGCGACCGCAC
CGTGATCGCTGGGCAGGCGGGGGTGGCCAACCAGACTACCGTGGGCGCCGATTGTTTGGTGCTTGCCCGTTCCGGGGTGA
CCAAAGATTTGCCCGATCACTCCAAGGTCTCCGGTTTTCCGGCCCAAGATCACCTGCTCGAACTCAAGCAGCAGGCGGCC
CGCTCGCGCCTGCCGCAGATCGTCGAGCAGATGCGCCAGATGCAGCGGCGCATCGAGCAATTGGAAGTGCAGCTTTTGGG
GAGGCTCTGA

Upstream 100 bases:

>100_bases
GCGCGTCCAGTCGCCCCTCGGTCCCCTGCGCATCGACTTTGCCGCCAACACCGCCGGGCTACCCAGCCAGGTGCACTTTG
GCCTTGGAGAAAAGTTTTAG

Downstream 100 bases:

>100_bases
TCGGTGCAGCAGCAGACCCTAGCCGCCACCGTCCAGCTTTCGGGCATCTCGTTGCACAAGGGGGCGTCCGTCGCCGTGCG
GCTGTGCCCGGCTCCTCCGG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MGVQFSAAELTDLVGGELSGDPGRLVVGARPPEEAEGGDLTFALDLHARKLIETTRAGVAITPVRWPFEHLTQIVVANPR
LAMAQVLAHMFPQPIAMPPAGIHPSAVVHPSAVVHPSASVAALVYVGPRAAVGANTHLFPGVYVGAEAVVGSECLIYPNV
VLMDGIRLGDRVVIHAGSVLGSDGYGFVPTGERHLKVPQVGTVVIGDDVEVGANVAVDRATMGQTEIQAGTKIDNLVHIG
HNDRIGRHCLIVSQVGLAGSVKVGDRTVIAGQAGVANQTTVGADCLVLARSGVTKDLPDHSKVSGFPAQDHLLELKQQAA
RSRLPQIVEQMRQMQRRIEQLEVQLLGRL

Sequences:

>Translated_349_residues
MGVQFSAAELTDLVGGELSGDPGRLVVGARPPEEAEGGDLTFALDLHARKLIETTRAGVAITPVRWPFEHLTQIVVANPR
LAMAQVLAHMFPQPIAMPPAGIHPSAVVHPSAVVHPSASVAALVYVGPRAAVGANTHLFPGVYVGAEAVVGSECLIYPNV
VLMDGIRLGDRVVIHAGSVLGSDGYGFVPTGERHLKVPQVGTVVIGDDVEVGANVAVDRATMGQTEIQAGTKIDNLVHIG
HNDRIGRHCLIVSQVGLAGSVKVGDRTVIAGQAGVANQTTVGADCLVLARSGVTKDLPDHSKVSGFPAQDHLLELKQQAA
RSRLPQIVEQMRQMQRRIEQLEVQLLGRL
>Mature_348_residues
GVQFSAAELTDLVGGELSGDPGRLVVGARPPEEAEGGDLTFALDLHARKLIETTRAGVAITPVRWPFEHLTQIVVANPRL
AMAQVLAHMFPQPIAMPPAGIHPSAVVHPSAVVHPSASVAALVYVGPRAAVGANTHLFPGVYVGAEAVVGSECLIYPNVV
LMDGIRLGDRVVIHAGSVLGSDGYGFVPTGERHLKVPQVGTVVIGDDVEVGANVAVDRATMGQTEIQAGTKIDNLVHIGH
NDRIGRHCLIVSQVGLAGSVKVGDRTVIAGQAGVANQTTVGADCLVLARSGVTKDLPDHSKVSGFPAQDHLLELKQQAAR
SRLPQIVEQMRQMQRRIEQLEVQLLGRL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=338, Percent_Identity=28.698224852071, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1786378, Length=210, Percent_Identity=30, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD3_GLOVI (Q7NJG8)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924810.1
- ProteinModelPortal:   Q7NJG8
- SMR:   Q7NJG8
- GeneID:   2600266
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr1864
- NMPDR:   fig|251221.1.peg.1864
- HOGENOM:   HBG469615
- OMA:   RINICLH
- BioCyc:   GVIO251221:GLR1864-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36735; Mature: 36604

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVQFSAAELTDLVGGELSGDPGRLVVGARPPEEAEGGDLTFALDLHARKLIETTRAGVA
CCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCEE
ITPVRWPFEHLTQIVVANPRLAMAQVLAHMFPQPIAMPPAGIHPSAVVHPSAVVHPSASV
EECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCEEECCCCCE
AALVYVGPRAAVGANTHLFPGVYVGAEAVVGSECLIYPNVVLMDGIRLGDRVVIHAGSVL
EEEEEECCCCCCCCCCCCCCCEEECCHHHCCCCEEEECCEEEECCCCCCCEEEEEECCEE
GSDGYGFVPTGERHLKVPQVGTVVIGDDVEVGANVAVDRATMGQTEIQAGTKIDNLVHIG
CCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEC
HNDRIGRHCLIVSQVGLAGSVKVGDRTVIAGQAGVANQTTVGADCLVLARSGVTKDLPDH
CCCCCCCEEEEEEECCCCCEEEECCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCC
SKVSGFPAQDHLLELKQQAARSRLPQIVEQMRQMQRRIEQLEVQLLGRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVQFSAAELTDLVGGELSGDPGRLVVGARPPEEAEGGDLTFALDLHARKLIETTRAGVA
CCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCEE
ITPVRWPFEHLTQIVVANPRLAMAQVLAHMFPQPIAMPPAGIHPSAVVHPSAVVHPSASV
EECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCEEECCCCCE
AALVYVGPRAAVGANTHLFPGVYVGAEAVVGSECLIYPNVVLMDGIRLGDRVVIHAGSVL
EEEEEECCCCCCCCCCCCCCCEEECCHHHCCCCEEEECCEEEECCCCCCCEEEEEECCEE
GSDGYGFVPTGERHLKVPQVGTVVIGDDVEVGANVAVDRATMGQTEIQAGTKIDNLVHIG
CCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEC
HNDRIGRHCLIVSQVGLAGSVKVGDRTVIAGQAGVANQTTVGADCLVLARSGVTKDLPDH
CCCCCCCEEEEEEECCCCCEEEECCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCC
SKVSGFPAQDHLLELKQQAARSRLPQIVEQMRQMQRRIEQLEVQLLGRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292