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The map label for this gene is fmt

Identifier: 37521400

GI number: 37521400

Start: 1949429

End: 1950361

Strand: Direct

Name: fmt

Synonym: gvip252

Alternate gene names: 37521400

Gene position: 1949429-1950361 (Clockwise)

Preceding gene: 37521397

Following gene: 37521401

Centisome position: 41.84

GC content: 64.52

Gene sequence:

>933_bases
ATGCGCGTCGTCTACTTCGGCACCGCCGAATTTGCCGTTCCGACTCTCGAAGCGCTCCTCGCCGCCCGCGAGATCGAGGT
GGTCGCCGCCGTCAGCCAACCCGACCGCCCCCAGGGCCGCGGCAACAGGCTCACCCCCCCGCCGGTCAAAGCGATTGCCC
AGAGCCGGGGCATCCCGGTATTTCAACCCGACCGTCTGCGCAAAGACCTTGAGGTCCTGGCCCACCTCGAAGCGCTCCAG
GCCGACTTTTTTGTGGTGGCCGCCTACGGCCAGATCCTGCCGCAGCGCGTACTCGATATGCCCGGGCGCGGTTGCATCAA
CGTGCACGGATCGCTGCTTCCCAAGTACCGGGGGGCCGCCCCCGTGCAGTGGGCCATCTACCACGGCGAACCCGAGACCG
GCATCACCACCATGCTCATGGAGGCGGGCCTCGACACCGGTCCGATGCTCAAAAAAATCGCCGTACCCATCGACGAGGAC
ATCACTGGCGAACAACTGCTCGCCCAACTGGCCCACCTCGGCGCCGGGCTGCTGCTGGAGACGCTGCGCGAATTCGACCG
CATCACCCCCGAACCCCAGGACGACAGCCTGAGTTCCTATGCTCCTCTCATCGACAAAGGCCAGTACCTCGTCGATTGGG
GCCAGTCCGCCCGCCAGATCCGCAACCAGATCCGGGCGTTCTATCCTTACACCCATACATTCCACCGCGGCAGCCGCCTG
CGGCTGCTCGCCGCTGAATTGACAAGCACTGGTTCAGAACAATTTCAGCCTTCCGCAATCATTCATGTCATCAAATCTAA
GGGATTCGAGGTCGTGACGGGCGATGGCGCACTCTTACTCACCAGGGTGCAGCCGGCCGGCGGCAAGGAGCAACCGGCCT
GGGACTACGCCAACGGCTGCCGCCTGATGCCTGGGGAGAGCCTGGGCCTCTAG

Upstream 100 bases:

>100_bases
CAGTGTAGTTGGCCAACCTAGTCTATCGGATAAGCGCCGCGCCCCGCCAGGGCGGCTCCCGCCGGGGCGATACTGGAAGG
CGTTGCTGCCGGGCCGTTCT

Downstream 100 bases:

>100_bases
AGGTATCCCCCGAGTCGGTGCATTCTCAAGAAAAGGTGCCATGTCTTTGGCGCCCGGTGGCGCGTGCAAACAAGCCTGCT
ACACTGCTGAATGTGTATCC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRVVYFGTAEFAVPTLEALLAAREIEVVAAVSQPDRPQGRGNRLTPPPVKAIAQSRGIPVFQPDRLRKDLEVLAHLEALQ
ADFFVVAAYGQILPQRVLDMPGRGCINVHGSLLPKYRGAAPVQWAIYHGEPETGITTMLMEAGLDTGPMLKKIAVPIDED
ITGEQLLAQLAHLGAGLLLETLREFDRITPEPQDDSLSSYAPLIDKGQYLVDWGQSARQIRNQIRAFYPYTHTFHRGSRL
RLLAAELTSTGSEQFQPSAIIHVIKSKGFEVVTGDGALLLTRVQPAGGKEQPAWDYANGCRLMPGESLGL

Sequences:

>Translated_310_residues
MRVVYFGTAEFAVPTLEALLAAREIEVVAAVSQPDRPQGRGNRLTPPPVKAIAQSRGIPVFQPDRLRKDLEVLAHLEALQ
ADFFVVAAYGQILPQRVLDMPGRGCINVHGSLLPKYRGAAPVQWAIYHGEPETGITTMLMEAGLDTGPMLKKIAVPIDED
ITGEQLLAQLAHLGAGLLLETLREFDRITPEPQDDSLSSYAPLIDKGQYLVDWGQSARQIRNQIRAFYPYTHTFHRGSRL
RLLAAELTSTGSEQFQPSAIIHVIKSKGFEVVTGDGALLLTRVQPAGGKEQPAWDYANGCRLMPGESLGL
>Mature_310_residues
MRVVYFGTAEFAVPTLEALLAAREIEVVAAVSQPDRPQGRGNRLTPPPVKAIAQSRGIPVFQPDRLRKDLEVLAHLEALQ
ADFFVVAAYGQILPQRVLDMPGRGCINVHGSLLPKYRGAAPVQWAIYHGEPETGITTMLMEAGLDTGPMLKKIAVPIDED
ITGEQLLAQLAHLGAGLLLETLREFDRITPEPQDDSLSSYAPLIDKGQYLVDWGQSARQIRNQIRAFYPYTHTFHRGSRL
RLLAAELTSTGSEQFQPSAIIHVIKSKGFEVVTGDGALLLTRVQPAGGKEQPAWDYANGCRLMPGESLGL

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=319, Percent_Identity=29.7805642633229, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI21614513, Length=235, Percent_Identity=28.0851063829787, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI238814322, Length=285, Percent_Identity=25.9649122807018, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1789683, Length=316, Percent_Identity=43.6708860759494, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1788589, Length=294, Percent_Identity=27.5510204081633, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI133930964, Length=241, Percent_Identity=27.8008298755187, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550868, Length=307, Percent_Identity=30.9446254071661, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=34.8017621145374, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585660, Length=154, Percent_Identity=31.1688311688312, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_GLOVI (Q7NJK1)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924777.1
- ProteinModelPortal:   Q7NJK1
- SMR:   Q7NJK1
- GeneID:   2600233
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1831
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- BioCyc:   GVIO251221:GLR1831-MONOMER
- BRENDA:   2.1.2.9
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33923; Mature: 33923

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVYFGTAEFAVPTLEALLAAREIEVVAAVSQPDRPQGRGNRLTPPPVKAIAQSRGIPV
CEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
FQPDRLRKDLEVLAHLEALQADFFVVAAYGQILPQRVLDMPGRGCINVHGSLLPKYRGAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCC
PVQWAIYHGEPETGITTMLMEAGLDTGPMLKKIAVPIDEDITGEQLLAQLAHLGAGLLLE
CEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHH
TLREFDRITPEPQDDSLSSYAPLIDKGQYLVDWGQSARQIRNQIRAFYPYTHTFHRGSRL
HHHHHHHCCCCCCCCCHHHHCCHHHCCCEEEHHHHHHHHHHHHHHHHCCCHHHHCCCCCE
RLLAAELTSTGSEQFQPSAIIHVIKSKGFEVVTGDGALLLTRVQPAGGKEQPAWDYANGC
EEEEEHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCC
RLMPGESLGL
EECCCCCCCC
>Mature Secondary Structure
MRVVYFGTAEFAVPTLEALLAAREIEVVAAVSQPDRPQGRGNRLTPPPVKAIAQSRGIPV
CEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
FQPDRLRKDLEVLAHLEALQADFFVVAAYGQILPQRVLDMPGRGCINVHGSLLPKYRGAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCC
PVQWAIYHGEPETGITTMLMEAGLDTGPMLKKIAVPIDEDITGEQLLAQLAHLGAGLLLE
CEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHH
TLREFDRITPEPQDDSLSSYAPLIDKGQYLVDWGQSARQIRNQIRAFYPYTHTFHRGSRL
HHHHHHHCCCCCCCCCHHHHCCHHHCCCEEEHHHHHHHHHHHHHHHHCCCHHHHCCCCCE
RLLAAELTSTGSEQFQPSAIIHVIKSKGFEVVTGDGALLLTRVQPAGGKEQPAWDYANGC
EEEEEHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCC
RLMPGESLGL
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292