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The map label for this gene is sglT [H]

Identifier: 37521242

GI number: 37521242

Start: 1786241

End: 1787812

Strand: Direct

Name: sglT [H]

Synonym: glr1673

Alternate gene names: 37521242

Gene position: 1786241-1787812 (Clockwise)

Preceding gene: 37521241

Following gene: 37521244

Centisome position: 38.34

GC content: 63.1

Gene sequence:

>1572_bases
ATGCAACTGAACGCGCTGGACTGGGCCGTCATCGGCATTTACATTGCCATGCTGCTGTCGATCGGTTGGTCGTTGCGCAA
ATTTGCCCAGCAGGGCCTTGAGAACTATTTTCTGGGCGGGCGCAACCTGCCGGGTTGGCTCAACGGCATTTCCTATGCCA
GCACCTGCCTGAACGCCGATGTGGCCCCGTTTTATTGCGGGCTGGCCGTCGCCACGGGCCTGTACATGGGCTGGTTTTAT
ATCGCCCGCTTCGGATGGGCGCTTTTGATTGGCGGGGTGCTTTTCGCCCTGTTCTGGCGGCGGCTGAAGATTTTTACCTC
GCCGGAGTTTTACGAACTGCGCTTTGCGGGCCGGGGAGCGAGCTGGATGCGCGGCTGGATCGCCTTTCGCTCGGCATTTA
TCGCAATTGTCGCCTGGACGGGGGCGGGGCTTCTGGGCATGACCAAGGTCGTGACCCCGATATTCGGCCTGGGCAAAATC
GAGACGATGCTGCTGGTTGTCCCGGTCATCCTGGTGTACCTCTACTTCAGCGGCTACCTGGGGGTGGTGATCACCGACGC
ACTCCAATCGCTGTTTATTTTTCTGGGCAGCCTGGTGCTGCTGGTGGCTGTCCTGGTCGATTTTGGCGGGCCGGTCGGTC
TGGGGGAGGCACTGGCGCAACTGCCCGATGGGGCCAGAGTACTGAGCAGTGTGCCGCCGCTGGAAGACAAGTACGTCTCG
CTCTTTGCGGTGATTGCCTTCACCCTCGGCACCTCGATCGGCTACGGCGGCGACGTTGCTCCCCTGGGCGGCGCCATGGA
GGGCCAGCGCATTCTCTCGTGCCGCAACGGCCGGGAGGCGGCGCGCATGTACGTCTGGACCGAGGTGGTGCTGTTTTTGT
TCTTGCTGGCCCTGTCGCTGCCGGCGCTGGGGGCGATGGTCGTCTGGCCGGGATTGCACACGGGGGCGGTGGACCCGGAA
CTGGCCTACGGCATGCTCATCGAAAAGTACATCCCAAGCGGCCTGCTGGGGATGGTGCTGGTGTCGATCATCGCTTCGCT
GATGTCGACGGTCAGTTCCAACCTCAACTTCGGCGCCCAGGTGGTCGTCAACGACATCTACCGCCGCTATTGGCGTCCCG
ACAAACCCGACGCCCACTACCTCAAAGTCGGCAAGGCGGTGACGCTGCTCATCCTGGCCATGTCCATGGGCGTCGTCTTC
GGCGTCAATTACCTGCTCGACATCGCCATATTTATGATCGGCCTGAGTGCCGCGGAACTGCCCGCCAACTGGGCGCAGTG
GTGGTGGTGGCGCTTCAACACCAAAGCCCGGCTCACCGCGTCAATCGGCGGTCCGCTCATCTACGTGCTGGTGCGCTTCG
TGCTGCTGCCAGAGCAGGATTTTGCCGTTTGGATTCTCGCTTCGATGGCGCTGACGACCGTGGCCTGGGTAGGCGTAGCG
CTGTTGACTCCGCCCGACGATGAAACCACCCTCGCGCGCTTCTACGAGCGCGCCCGGCCGCTAGGCTGGTGGGGACCGGT
GGCCCGGCGCGCCCGGCCCGCCACCAAAGCGGTGCTCACCCAGGAGGAGTAG

Upstream 100 bases:

>100_bases
GACGCTGATCGTGCTCAAAGCCCAGTAGCGCCTGCGGTTCTTCCTTTGCCGGTCGGATCGAGCTACGCTATCCAAGATCT
ACGCCCGCTTGGAAAAACCC

Downstream 100 bases:

>100_bases
ACGGCGGGGTTTTGGGGCCGTCTTTGAAGGTCGTTAGAACATTCTCGATTTCCCGGCGCAGCAGGGGGCCTCCGAGGCGG
GCCATCTCGGCGAGGGTGAA

Product: hypothetical protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Na(+)/glucose symporter [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MQLNALDWAVIGIYIAMLLSIGWSLRKFAQQGLENYFLGGRNLPGWLNGISYASTCLNADVAPFYCGLAVATGLYMGWFY
IARFGWALLIGGVLFALFWRRLKIFTSPEFYELRFAGRGASWMRGWIAFRSAFIAIVAWTGAGLLGMTKVVTPIFGLGKI
ETMLLVVPVILVYLYFSGYLGVVITDALQSLFIFLGSLVLLVAVLVDFGGPVGLGEALAQLPDGARVLSSVPPLEDKYVS
LFAVIAFTLGTSIGYGGDVAPLGGAMEGQRILSCRNGREAARMYVWTEVVLFLFLLALSLPALGAMVVWPGLHTGAVDPE
LAYGMLIEKYIPSGLLGMVLVSIIASLMSTVSSNLNFGAQVVVNDIYRRYWRPDKPDAHYLKVGKAVTLLILAMSMGVVF
GVNYLLDIAIFMIGLSAAELPANWAQWWWWRFNTKARLTASIGGPLIYVLVRFVLLPEQDFAVWILASMALTTVAWVGVA
LLTPPDDETTLARFYERARPLGWWGPVARRARPATKAVLTQEE

Sequences:

>Translated_523_residues
MQLNALDWAVIGIYIAMLLSIGWSLRKFAQQGLENYFLGGRNLPGWLNGISYASTCLNADVAPFYCGLAVATGLYMGWFY
IARFGWALLIGGVLFALFWRRLKIFTSPEFYELRFAGRGASWMRGWIAFRSAFIAIVAWTGAGLLGMTKVVTPIFGLGKI
ETMLLVVPVILVYLYFSGYLGVVITDALQSLFIFLGSLVLLVAVLVDFGGPVGLGEALAQLPDGARVLSSVPPLEDKYVS
LFAVIAFTLGTSIGYGGDVAPLGGAMEGQRILSCRNGREAARMYVWTEVVLFLFLLALSLPALGAMVVWPGLHTGAVDPE
LAYGMLIEKYIPSGLLGMVLVSIIASLMSTVSSNLNFGAQVVVNDIYRRYWRPDKPDAHYLKVGKAVTLLILAMSMGVVF
GVNYLLDIAIFMIGLSAAELPANWAQWWWWRFNTKARLTASIGGPLIYVLVRFVLLPEQDFAVWILASMALTTVAWVGVA
LLTPPDDETTLARFYERARPLGWWGPVARRARPATKAVLTQEE
>Mature_523_residues
MQLNALDWAVIGIYIAMLLSIGWSLRKFAQQGLENYFLGGRNLPGWLNGISYASTCLNADVAPFYCGLAVATGLYMGWFY
IARFGWALLIGGVLFALFWRRLKIFTSPEFYELRFAGRGASWMRGWIAFRSAFIAIVAWTGAGLLGMTKVVTPIFGLGKI
ETMLLVVPVILVYLYFSGYLGVVITDALQSLFIFLGSLVLLVAVLVDFGGPVGLGEALAQLPDGARVLSSVPPLEDKYVS
LFAVIAFTLGTSIGYGGDVAPLGGAMEGQRILSCRNGREAARMYVWTEVVLFLFLLALSLPALGAMVVWPGLHTGAVDPE
LAYGMLIEKYIPSGLLGMVLVSIIASLMSTVSSNLNFGAQVVVNDIYRRYWRPDKPDAHYLKVGKAVTLLILAMSMGVVF
GVNYLLDIAIFMIGLSAAELPANWAQWWWWRFNTKARLTASIGGPLIYVLVRFVLLPEQDFAVWILASMALTTVAWVGVA
LLTPPDDETTLARFYERARPLGWWGPVARRARPATKAVLTQEE

Specific function: Actively transports glucose into cells by Na(+) cotransport [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI14140236, Length=423, Percent_Identity=23.6406619385343, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4507033, Length=422, Percent_Identity=22.9857819905213, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI17941285, Length=401, Percent_Identity=22.1945137157107, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI109659836, Length=430, Percent_Identity=23.2558139534884, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI109659839, Length=445, Percent_Identity=23.1460674157303, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082237, Length=366, Percent_Identity=23.4972677595628, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 57348; Mature: 57348

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure
MQLNALDWAVIGIYIAMLLSIGWSLRKFAQQGLENYFLGGRNLPGWLNGISYASTCLNAD
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
VAPFYCGLAVATGLYMGWFYIARFGWALLIGGVLFALFWRRLKIFTSPEFYELRFAGRGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
SWMRGWIAFRSAFIAIVAWTGAGLLGMTKVVTPIFGLGKIETMLLVVPVILVYLYFSGYL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GVVITDALQSLFIFLGSLVLLVAVLVDFGGPVGLGEALAQLPDGARVLSSVPPLEDKYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHCCCCCHHHHHH
LFAVIAFTLGTSIGYGGDVAPLGGAMEGQRILSCRNGREAARMYVWTEVVLFLFLLALSL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
PALGAMVVWPGLHTGAVDPELAYGMLIEKYIPSGLLGMVLVSIIASLMSTVSSNLNFGAQ
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
VVVNDIYRRYWRPDKPDAHYLKVGKAVTLLILAMSMGVVFGVNYLLDIAIFMIGLSAAEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
PANWAQWWWWRFNTKARLTASIGGPLIYVLVRFVLLPEQDFAVWILASMALTTVAWVGVA
CCCHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LLTPPDDETTLARFYERARPLGWWGPVARRARPATKAVLTQEE
EECCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8652595; 10835424; 10757971 [H]