Click here to switch to the map view.

The map label for this gene is hisD

Identifier: 37520893

GI number: 37520893

Start: 1416140

End: 1417477

Strand: Reverse

Name: hisD

Synonym: gvip194

Alternate gene names: 37520893

Gene position: 1417477-1416140 (Counterclockwise)

Preceding gene: 37520895

Following gene: 37520892

Centisome position: 30.42

GC content: 64.8

Gene sequence:

>1338_bases
ATGTTGCGACTGATCACCCAGTTGTCCGAAGCGCAAACCGAAATCAAGCGGATTGCCGCGCGAACGCACTCCGAGCAGGT
GCAACACCAAGAAGCGACCGTCCGCGAAATCCTGCAGAACGTTCGCCGCCAGGGGGACGAAGCGCTGTTGCGCTACACCC
TCGAATTTGATCAGGTGCGCCTTGCCCCAGGGGATCTGGTGGTGGGCGCCGCCGAACTGGACGCCGCCTATCAGCGGGTC
TCCACCAGTCTGCTCAAGGCGATTCGCCTCGCCAAGCAGCGCATCGAGCAATTTCACCGCGAGCGCATCTGCAAATCCTG
GGTGCAGTTTCAAGATCGCGGGATTGTGCTGGGTCGGCGCTACACGCCCGTCGATGCGGCCGGGCTCTACATTCCGGGCG
GGCGGGCAAGTTACCCCAGTTCGGTGCTGATGAGTGCTATCCCGGCTGTGGTGGCGGGAGTTCCCCGCATCGTGCTGGTC
ACCCCGCCCAATCCCGAGGGCAAGATCAACCCGGCGGTGCTGGTGGCCGCCCAAGAATCGGGAGTGCACGAGATTTACCG
CATCGGCGGCGCCCAGGCGATCGGAGCCCTCACCTACGGTACACGCACGATCGCCCCGGTGAGCGTCATCGCCGGCCCCG
GCAATATCTACGTCACCCTGGCCAAAAAACTGGTTTACGGCGAGGTGGGCATCGACTCGCTGGCCGGTCCGTCCGAGGTG
CTCATCATCGCCGACAGCACCGCCAATCCGGTGTTCCTGGCGGCGGATATGCTCGCCCAGGCCGAGCACGACTCGCTTGC
CTCGGCCATCTTGATCACCCCTGACGGCCGCCTTGCCGAGCGCACCATCGAAGCGGTCGACCGCCAACTCGAAAACCACC
CACGCCGCACGCTCACCGAAAAATCCCTCGCCAACTACGGACTGGTGATCGTCACCGCCGATCTGGCCGAGGCGGCGGCC
CTATCGAACCTGTTCGCCCCCGAACACCTCGAACTGGAGGTCGAAGATCCCTGGGAGTTGCTCGAGAAGGTACGTCACGC
CGGGGCAATCTTCTTGGGCCACGCCACCCCGGAAGCGGTGGGCGACTATCTGGCCGGACCCAGCCACATTCTGCCCACCT
CCGGCACGGCGCGCTACGCCTCGGGGGTCGGGGTCGAGACATTCCAGAAGTGCTCCAGCCTGGTGCAGTACACCCCCCAG
GCCCTGGCCGAGGTGGGAGAAGCGATCGATGCGTTGACTGCCGCCGAGGGACTGCCTTCCCACGGCGATTCGGTGCGCCT
GCGGTTGCAGCAGTACGAAAACCCCCACTCCCCGACTCAACAGCAGCAGGAGGAGTGA

Upstream 100 bases:

>100_bases
CTGGAGCAGGCGCGGCAACCGGGACCTGCCGGTATCTGGCCTTGATGATGCCGGACAGATCAGCGAGACTGGTTGGCAGC
GCACCCCTGAAGCAAAGCGT

Downstream 100 bases:

>100_bases
TGCAACCCTATCTACGCCCCGATCTGGACCGCTTGCAGGCTTACCACGCGCCGCACTTTCCAGAGGCCGACAAGCTCGAC
GCCAACGAACTGCCCCACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLRLITQLSEAQTEIKRIAARTHSEQVQHQEATVREILQNVRRQGDEALLRYTLEFDQVRLAPGDLVVGAAELDAAYQRV
STSLLKAIRLAKQRIEQFHRERICKSWVQFQDRGIVLGRRYTPVDAAGLYIPGGRASYPSSVLMSAIPAVVAGVPRIVLV
TPPNPEGKINPAVLVAAQESGVHEIYRIGGAQAIGALTYGTRTIAPVSVIAGPGNIYVTLAKKLVYGEVGIDSLAGPSEV
LIIADSTANPVFLAADMLAQAEHDSLASAILITPDGRLAERTIEAVDRQLENHPRRTLTEKSLANYGLVIVTADLAEAAA
LSNLFAPEHLELEVEDPWELLEKVRHAGAIFLGHATPEAVGDYLAGPSHILPTSGTARYASGVGVETFQKCSSLVQYTPQ
ALAEVGEAIDALTAAEGLPSHGDSVRLRLQQYENPHSPTQQQQEE

Sequences:

>Translated_445_residues
MLRLITQLSEAQTEIKRIAARTHSEQVQHQEATVREILQNVRRQGDEALLRYTLEFDQVRLAPGDLVVGAAELDAAYQRV
STSLLKAIRLAKQRIEQFHRERICKSWVQFQDRGIVLGRRYTPVDAAGLYIPGGRASYPSSVLMSAIPAVVAGVPRIVLV
TPPNPEGKINPAVLVAAQESGVHEIYRIGGAQAIGALTYGTRTIAPVSVIAGPGNIYVTLAKKLVYGEVGIDSLAGPSEV
LIIADSTANPVFLAADMLAQAEHDSLASAILITPDGRLAERTIEAVDRQLENHPRRTLTEKSLANYGLVIVTADLAEAAA
LSNLFAPEHLELEVEDPWELLEKVRHAGAIFLGHATPEAVGDYLAGPSHILPTSGTARYASGVGVETFQKCSSLVQYTPQ
ALAEVGEAIDALTAAEGLPSHGDSVRLRLQQYENPHSPTQQQQEE
>Mature_445_residues
MLRLITQLSEAQTEIKRIAARTHSEQVQHQEATVREILQNVRRQGDEALLRYTLEFDQVRLAPGDLVVGAAELDAAYQRV
STSLLKAIRLAKQRIEQFHRERICKSWVQFQDRGIVLGRRYTPVDAAGLYIPGGRASYPSSVLMSAIPAVVAGVPRIVLV
TPPNPEGKINPAVLVAAQESGVHEIYRIGGAQAIGALTYGTRTIAPVSVIAGPGNIYVTLAKKLVYGEVGIDSLAGPSEV
LIIADSTANPVFLAADMLAQAEHDSLASAILITPDGRLAERTIEAVDRQLENHPRRTLTEKSLANYGLVIVTADLAEAAA
LSNLFAPEHLELEVEDPWELLEKVRHAGAIFLGHATPEAVGDYLAGPSHILPTSGTARYASGVGVETFQKCSSLVQYTPQ
ALAEVGEAIDALTAAEGLPSHGDSVRLRLQQYENPHSPTQQQQEE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=402, Percent_Identity=41.5422885572139, Blast_Score=290, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=37.0098039215686, Blast_Score=263, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_GLOVI (Q7NL02)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924270.1
- ProteinModelPortal:   Q7NL02
- SMR:   Q7NL02
- GeneID:   2598786
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1324
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   GVIO251221:GLL1324-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 48032; Mature: 48032

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 328-328 ACT_SITE 329-329 BINDING 130-130 BINDING 192-192 BINDING 215-215 BINDING 238-238 BINDING 260-260 BINDING 263-263 BINDING 329-329 BINDING 362-362 BINDING 416-416 BINDING 421-421

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLITQLSEAQTEIKRIAARTHSEQVQHQEATVREILQNVRRQGDEALLRYTLEFDQVR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCEE
LAPGDLVVGAAELDAAYQRVSTSLLKAIRLAKQRIEQFHRERICKSWVQFQDRGIVLGRR
ECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
YTPVDAAGLYIPGGRASYPSSVLMSAIPAVVAGVPRIVLVTPPNPEGKINPAVLVAAQES
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCC
GVHEIYRIGGAQAIGALTYGTRTIAPVSVIAGPGNIYVTLAKKLVYGEVGIDSLAGPSEV
CHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCEE
LIIADSTANPVFLAADMLAQAEHDSLASAILITPDGRLAERTIEAVDRQLENHPRRTLTE
EEEECCCCCCEEEHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHH
KSLANYGLVIVTADLAEAAALSNLFAPEHLELEVEDPWELLEKVRHAGAIFLGHATPEAV
HHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCEEEEECCCHHHH
GDYLAGPSHILPTSGTARYASGVGVETFQKCSSLVQYTPQALAEVGEAIDALTAAEGLPS
HHHHCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
HGDSVRLRLQQYENPHSPTQQQQEE
CCCHHEEEHHHCCCCCCCCHHHCCC
>Mature Secondary Structure
MLRLITQLSEAQTEIKRIAARTHSEQVQHQEATVREILQNVRRQGDEALLRYTLEFDQVR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCEE
LAPGDLVVGAAELDAAYQRVSTSLLKAIRLAKQRIEQFHRERICKSWVQFQDRGIVLGRR
ECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
YTPVDAAGLYIPGGRASYPSSVLMSAIPAVVAGVPRIVLVTPPNPEGKINPAVLVAAQES
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCC
GVHEIYRIGGAQAIGALTYGTRTIAPVSVIAGPGNIYVTLAKKLVYGEVGIDSLAGPSEV
CHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCEE
LIIADSTANPVFLAADMLAQAEHDSLASAILITPDGRLAERTIEAVDRQLENHPRRTLTE
EEEECCCCCCEEEHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHH
KSLANYGLVIVTADLAEAAALSNLFAPEHLELEVEDPWELLEKVRHAGAIFLGHATPEAV
HHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCEEEEECCCHHHH
GDYLAGPSHILPTSGTARYASGVGVETFQKCSSLVQYTPQALAEVGEAIDALTAAEGLPS
HHHHCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
HGDSVRLRLQQYENPHSPTQQQQEE
CCCHHEEEHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292