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The map label for this gene is hisC

Identifier: 37520892

GI number: 37520892

Start: 1415082

End: 1416143

Strand: Reverse

Name: hisC

Synonym: gvip193

Alternate gene names: 37520892

Gene position: 1416143-1415082 (Counterclockwise)

Preceding gene: 37520893

Following gene: 37520890

Centisome position: 30.4

GC content: 64.69

Gene sequence:

>1062_bases
GTGATGCAACCCTATCTACGCCCCGATCTGGACCGCTTGCAGGCTTACCACGCGCCGCACTTTCCAGAGGCCGACAAGCT
CGACGCCAACGAACTGCCCCACGATCTGCCCGAGTGGCTCAAGAACAAGCTCGCCTTTTTGCTGGAGCAGGGCGTGCGAA
CGAACCGCTACCCCGAGGGCGATCCGTTGGCCCTGAAGGCGGCAATCGCCGAGTACTGCGGGGTCACCTCGGAGATGGTC
TGTGTGGGCAACGGCTCAGACGAGTTGATTCGCTCGCTGATCACGGCGACTTGCCTGGGTGGGCGGGGGACGGTGGCAAG
CGCCGAACCCACCTTCTCGATGTACCGCATCCTGGCTGAGACCCTGGCGGTGCCCTACATCGGCGTCGCGCGTACGGCCA
ATTACGGCGTCGATGCGGACGTCCTGGAGGCCGCCGTCGGGGCGAACGGCGTGCGGGTGCTGTTTCTGGCCAATCCCAAC
AGCCCGACCGGCAACCTGCTTTCTGACGAGATCATCGAGCGCCTCGGATCCCTGCCGGTGTTGGTGGTTCTCGACGAGGC
CTACTACGAATTCAGCCGCTTCAGCGCCGTACCTTTGCTGTGGGAGCGGCCGAACCTGGTCATCCTGCGCACGTTTTCCA
AAGCCTTTCGCCTCGCCAATTTCCGGGTGGGCTACGCCCTCGCCAACCCCGAGATTGCCGCAGTACTCGAAAAGGTGCGC
CTGCCCTACAATCTGCCGGGTCTGTCGCAGCTGGCCGCTTTTGCTGCCCTCGAACATCGCGATGTCCTCCTTGCGGCCAT
CCCCGAGATCCTGGCGGAGCGACGGCGCATCGAGCGCTTTCTGGCGGATTTCGAGCAGCTCGAGCTATTTCCGAGTGACG
CCAATTTTTTGTTTGTCCGGCCCCGCATCGCCGATCCCGAGGCGGTGCGGGTTGCCCTGGCCGGGCGCGGCTCGCTGGTG
CGCGGCGCGGCCGGTGGTCTGCGCGTCACCGTGGGTACCCCCGAGCAGAACGACCGACTCATCGCCAACGTCGCGGCGCT
CTTTACACCGGAAATGCGGTAG

Upstream 100 bases:

>100_bases
TGACTGCCGCCGAGGGACTGCCTTCCCACGGCGATTCGGTGCGCCTGCGGTTGCAGCAGTACGAAAACCCCCACTCCCCG
ACTCAACAGCAGCAGGAGGA

Downstream 100 bases:

>100_bases
TCAGCGGTTGGACCCGGCCGAGTTGCTCGACCATCGCCGCGTGCACAGCGCCGTTGGTGGCGAGCACCCGGCCCGAGCGC
AGATCCAGCGGCGAGCCGTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MMQPYLRPDLDRLQAYHAPHFPEADKLDANELPHDLPEWLKNKLAFLLEQGVRTNRYPEGDPLALKAAIAEYCGVTSEMV
CVGNGSDELIRSLITATCLGGRGTVASAEPTFSMYRILAETLAVPYIGVARTANYGVDADVLEAAVGANGVRVLFLANPN
SPTGNLLSDEIIERLGSLPVLVVLDEAYYEFSRFSAVPLLWERPNLVILRTFSKAFRLANFRVGYALANPEIAAVLEKVR
LPYNLPGLSQLAAFAALEHRDVLLAAIPEILAERRRIERFLADFEQLELFPSDANFLFVRPRIADPEAVRVALAGRGSLV
RGAAGGLRVTVGTPEQNDRLIANVAALFTPEMR

Sequences:

>Translated_353_residues
MMQPYLRPDLDRLQAYHAPHFPEADKLDANELPHDLPEWLKNKLAFLLEQGVRTNRYPEGDPLALKAAIAEYCGVTSEMV
CVGNGSDELIRSLITATCLGGRGTVASAEPTFSMYRILAETLAVPYIGVARTANYGVDADVLEAAVGANGVRVLFLANPN
SPTGNLLSDEIIERLGSLPVLVVLDEAYYEFSRFSAVPLLWERPNLVILRTFSKAFRLANFRVGYALANPEIAAVLEKVR
LPYNLPGLSQLAAFAALEHRDVLLAAIPEILAERRRIERFLADFEQLELFPSDANFLFVRPRIADPEAVRVALAGRGSLV
RGAAGGLRVTVGTPEQNDRLIANVAALFTPEMR
>Mature_353_residues
MMQPYLRPDLDRLQAYHAPHFPEADKLDANELPHDLPEWLKNKLAFLLEQGVRTNRYPEGDPLALKAAIAEYCGVTSEMV
CVGNGSDELIRSLITATCLGGRGTVASAEPTFSMYRILAETLAVPYIGVARTANYGVDADVLEAAVGANGVRVLFLANPN
SPTGNLLSDEIIERLGSLPVLVVLDEAYYEFSRFSAVPLLWERPNLVILRTFSKAFRLANFRVGYALANPEIAAVLEKVR
LPYNLPGLSQLAAFAALEHRDVLLAAIPEILAERRRIERFLADFEQLELFPSDANFLFVRPRIADPEAVRVALAGRGSLV
RGAAGGLRVTVGTPEQNDRLIANVAALFTPEMR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=35.3658536585366, Blast_Score=151, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322075, Length=376, Percent_Identity=31.1170212765957, Blast_Score=144, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_GLOVI (Q7NL03)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924269.1
- ProteinModelPortal:   Q7NL03
- SMR:   Q7NL03
- GeneID:   2598785
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1323
- HOGENOM:   HBG646350
- OMA:   QNPTYLE
- ProtClustDB:   PRK02610
- BioCyc:   GVIO251221:GLL1323-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38753; Mature: 38753

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQPYLRPDLDRLQAYHAPHFPEADKLDANELPHDLPEWLKNKLAFLLEQGVRTNRYPEG
CCCCCCCCCHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
DPLALKAAIAEYCGVTSEMVCVGNGSDELIRSLITATCLGGRGTVASAEPTFSMYRILAE
CCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
TLAVPYIGVARTANYGVDADVLEAAVGANGVRVLFLANPNSPTGNLLSDEIIERLGSLPV
HHHCCCHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCE
LVVLDEAYYEFSRFSAVPLLWERPNLVILRTFSKAFRLANFRVGYALANPEIAAVLEKVR
EEEECHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHCEEEEEEECCCHHHHHHHHHC
LPYNLPGLSQLAAFAALEHRDVLLAAIPEILAERRRIERFLADFEQLELFPSDANFLFVR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEE
PRIADPEAVRVALAGRGSLVRGAAGGLRVTVGTPEQNDRLIANVAALFTPEMR
CCCCCCHHEEEEEECCCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMQPYLRPDLDRLQAYHAPHFPEADKLDANELPHDLPEWLKNKLAFLLEQGVRTNRYPEG
CCCCCCCCCHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
DPLALKAAIAEYCGVTSEMVCVGNGSDELIRSLITATCLGGRGTVASAEPTFSMYRILAE
CCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
TLAVPYIGVARTANYGVDADVLEAAVGANGVRVLFLANPNSPTGNLLSDEIIERLGSLPV
HHHCCCHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCE
LVVLDEAYYEFSRFSAVPLLWERPNLVILRTFSKAFRLANFRVGYALANPEIAAVLEKVR
EEEECHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHCEEEEEEECCCHHHHHHHHHC
LPYNLPGLSQLAAFAALEHRDVLLAAIPEILAERRRIERFLADFEQLELFPSDANFLFVR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEE
PRIADPEAVRVALAGRGSLVRGAAGGLRVTVGTPEQNDRLIANVAALFTPEMR
CCCCCCHHEEEEEECCCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292