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The map label for this gene is mscS [H]

Identifier: 37520506

GI number: 37520506

Start: 992600

End: 993409

Strand: Reverse

Name: mscS [H]

Synonym: gll0937

Alternate gene names: 37520506

Gene position: 993409-992600 (Counterclockwise)

Preceding gene: 37520507

Following gene: 37520503

Centisome position: 21.32

GC content: 59.26

Gene sequence:

>810_bases
ATGGACCTCAATGCAATCGGTCAAACGATTCTTGTTACTGTCACCGACGTTGGCTTGAAGATTGTCGGCGCGATTCTTCT
TTATATCTTCGGTCGCTGGCTGATCGGCGTGGTCATCGGATTGGTGCAAAACGCCCTTTATAAACAAAAAATTGATCCGA
CGGTCGTCCGCTACGTGGGTTCGATTGTCGGCGTGCTCGCCAACATCGCGCTGGTAGTCTCCATTCTTGGTTACTTCGGC
GTCGAGACCACCACCTTCGCCGCCCTGGTGGCAGCGGCCGGCGTAGCCATCGGTGCCGCCTGGGGCGGGCTGCTCTCGAA
CTTCGCCGCCGGGGTTTTTCTGATCATTTTGCGGCCCTTCAAAGTCGGCGACTTCATCACCGTCGGAGGCGTCACAGGCA
CCGTCAAGGAGATCGGTTTGTTCGTGACGGCGATCGACACCCCGGACAACGTCCACACCTTCGTAGGCAACACCAAGGTC
TTCGGCGACAATATCCAGAACTACTCGACCAATCCCTACCGCCGCGTCGAGTTGACCGCTCAGCTCAACGCTGGCGTCGA
TCACGCCGACGCCATCGCCCGCCTCAAACAAAAGCTCGCTTCGATCCCGAATGTGCTGATCGACCCGGCCCCGGACGTCG
AGATTCTCGAATTCAGCGCCGCCGGTCCGGTGCTCGCCGTGCGGCCCTTCTGCAACAACGCCCATTACTGGCAGGTCTAC
TTCGACACCAACCGCCTGATTCGCGAAACCTTCGGCGAAGCGGGCTACCCGGTGCCGCAGCAGTACGTGACGATGCGCAA
CGTAGCGTAG

Upstream 100 bases:

>100_bases
GGTGATAGCCGCCTCCGGTTCTCTCAAACTCCGGGCCGGTCTAACTCAGTATCTGATGCACACTGTGCTGCACATTTCGC
TCACTAGAGAAGGGTAAAAC

Downstream 100 bases:

>100_bases
GAAGCCCTCATCCCCCTGGCCCCTTCTGCTCAGGGGGATAAACCTTTTGCACAACAAACTTTGCCGCTCGCGCTTAGAGT
TGAAGTTGTTCCTTTACCCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDLNAIGQTILVTVTDVGLKIVGAILLYIFGRWLIGVVIGLVQNALYKQKIDPTVVRYVGSIVGVLANIALVVSILGYFG
VETTTFAALVAAAGVAIGAAWGGLLSNFAAGVFLIILRPFKVGDFITVGGVTGTVKEIGLFVTAIDTPDNVHTFVGNTKV
FGDNIQNYSTNPYRRVELTAQLNAGVDHADAIARLKQKLASIPNVLIDPAPDVEILEFSAAGPVLAVRPFCNNAHYWQVY
FDTNRLIRETFGEAGYPVPQQYVTMRNVA

Sequences:

>Translated_269_residues
MDLNAIGQTILVTVTDVGLKIVGAILLYIFGRWLIGVVIGLVQNALYKQKIDPTVVRYVGSIVGVLANIALVVSILGYFG
VETTTFAALVAAAGVAIGAAWGGLLSNFAAGVFLIILRPFKVGDFITVGGVTGTVKEIGLFVTAIDTPDNVHTFVGNTKV
FGDNIQNYSTNPYRRVELTAQLNAGVDHADAIARLKQKLASIPNVLIDPAPDVEILEFSAAGPVLAVRPFCNNAHYWQVY
FDTNRLIRETFGEAGYPVPQQYVTMRNVA
>Mature_269_residues
MDLNAIGQTILVTVTDVGLKIVGAILLYIFGRWLIGVVIGLVQNALYKQKIDPTVVRYVGSIVGVLANIALVVSILGYFG
VETTTFAALVAAAGVAIGAAWGGLLSNFAAGVFLIILRPFKVGDFITVGGVTGTVKEIGLFVTAIDTPDNVHTFVGNTKV
FGDNIQNYSTNPYRRVELTAQLNAGVDHADAIARLKQKLASIPNVLIDPAPDVEILEFSAAGPVLAVRPFCNNAHYWQVY
FDTNRLIRETFGEAGYPVPQQYVTMRNVA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=259, Percent_Identity=33.2046332046332, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI2367355, Length=254, Percent_Identity=23.6220472440945, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787591, Length=199, Percent_Identity=28.643216080402, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786670, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 28840; Mature: 28840

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNAIGQTILVTVTDVGLKIVGAILLYIFGRWLIGVVIGLVQNALYKQKIDPTVVRYVG
CCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SIVGVLANIALVVSILGYFGVETTTFAALVAAAGVAIGAAWGGLLSNFAAGVFLIILRPF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KVGDFITVGGVTGTVKEIGLFVTAIDTPDNVHTFVGNTKVFGDNIQNYSTNPYRRVELTA
CCCCEEEECCCCHHHHHHEEEEEEECCCCCCEECCCCCEEECCCCCCCCCCCEEEEEEEE
QLNAGVDHADAIARLKQKLASIPNVLIDPAPDVEILEFSAAGPVLAVRPFCNNAHYWQVY
ECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCEEEEEECCCCCEEEEEE
FDTNRLIRETFGEAGYPVPQQYVTMRNVA
ECCHHHHHHHHCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MDLNAIGQTILVTVTDVGLKIVGAILLYIFGRWLIGVVIGLVQNALYKQKIDPTVVRYVG
CCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SIVGVLANIALVVSILGYFGVETTTFAALVAAAGVAIGAAWGGLLSNFAAGVFLIILRPF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KVGDFITVGGVTGTVKEIGLFVTAIDTPDNVHTFVGNTKVFGDNIQNYSTNPYRRVELTA
CCCCEEEECCCCHHHHHHEEEEEEECCCCCCEECCCCCEEECCCCCCCCCCCEEEEEEEE
QLNAGVDHADAIARLKQKLASIPNVLIDPAPDVEILEFSAAGPVLAVRPFCNNAHYWQVY
ECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCEEEEEECCCCCEEEEEE
FDTNRLIRETFGEAGYPVPQQYVTMRNVA
ECCHHHHHHHHCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]