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The map label for this gene is nadB [H]

Identifier: 37520415

GI number: 37520415

Start: 897845

End: 899437

Strand: Direct

Name: nadB [H]

Synonym: gvip103

Alternate gene names: 37520415

Gene position: 897845-899437 (Clockwise)

Preceding gene: 37520412

Following gene: 37520416

Centisome position: 19.27

GC content: 66.16

Gene sequence:

>1593_bases
ATGAAAGCTTACGATGCGATCGTGATCGGCAGCGGCGCGGCGGGACTGTATACGGCCCTGAAGCTGCCGCGCGAGTGGCG
TATCGCCCTACTCACCAAAGAAAATTTGACCCTTTCTTCGAGCCAATGGGCCCAGGGGGGGATCGCTGCGGTAGTCGAGC
CGGATGACTCCTTTCGGCTCCATTACGAGGACACCCTGGCGGCTGGGGCAGGCTTGTGCGAGCCGGAGGCGGTGCGGGTG
CTGGTGGAGGAAGCGCCCGAGCGCATTCGCGAACTGATCGCACTGGGGGTCGAGTTCGATCGCTACCAGGGGCGGCTCGC
AGTCACCCTCGAAGCGGCCCACTCCCGCAGGCGCATCTTGCACGCCGCCGACGCCACCGGCCGCGAACTGGTGCGCGCCC
TGGTCGAGGAGGTGCGCGACCTTGGCAACATCCGCGTCGTCGAGGAGGCCCTTGCCATCGACCTGGCCCTCGACGGCGGG
CGCTGTCGCGGGGTGCTGGTGGACGCGCTCGGGGTGCGCGAATGGTACATGTCGCCGGTGACAGTGCTTGCCACCGGCGG
GGCCGGGCAGGTGTTCGCCTACACCACCAACCCCGCAGTCGCTACAGGCGACGGGATCGCCATGGCGGCCCGGGCGGGGG
TGGCGCTGCGGGATCTCGAATTCGTCCAGTTTCATCCGACGGCGCTTGCCATCGACGGGGCGCCGCGCTTTTTGATCTCA
GAAGCGGTGCGCGGCGAAGGGGGACAACTGGTCAACCTGGCCGGCGAGCGCTTCATGGGCCGCTACCACCCTCAGGGGGA
ACTGGCTCCGCGCGACGTGGTCGCCCGGGCCATCTTCGATCAGATGCAATCGAGCGGCGCCACCCACGTGCTTATCGACC
TGCGGCCCATCGGCGAAGCGACGATTGAGCAGCGCTTTCCCAACATCGCCCACGTCTGCCGCAAGTTCGGCGTCGATGTC
TTCAGTGAAGCGGTCCCCGTCGCCCCCGCCGCCCACTACTGGATGGGCGGCGTTCTCACCGATCTCGATGGCCGCACAAG
CTTGCCGGGGCTGTTTGCCGTGGGTGAAGTCGCTTCCACCGGCGTGCACGGCGCCAATCGCCTCGCGAGCAATTCGCTGC
TGGAATGTCTGGTTTTTGCCCACCGCATCGCCGAGGCCGTGCGCAGTAGCGGCATCAGCCGTACCGCCGCAGGCATCATT
CACTTTCCGCCCGCCGCCGCCCAGAGCCCGGTCAACTTTGAACTGGTTCAACGCATCCGCAACGAAATGCCGTGGTTGGT
TTGGCGCACCTGCGGGATCATCCGCGAGGCAGACGGCCTCAGGCGCGGCTTGGAGCAGTTGCAAATGTGGAAACAGCAAC
TGAGCGGCGTCGATGCCACCACCGAGCGAGCCACCCTGGAGGTGCGCAATCTGGTGATTGCTGCGGAACTGTTGCTCAAA
AGCGCCCTCTTGCGCACCGAGTCGCGGGGGGGGCACTACCGCAGCGACCACCCGGCCCCGGATCCCGCCTGGCAGGTACA
CACTGAGATTGCCGAGGGCCGCTTGTTTCAAACCCCGCTCGCGGTCGCTAAAATAAGACCAACTTCAGGCTAG

Upstream 100 bases:

>100_bases
ACCCTCGGATATTTTTATCACATATTGATATGTTATACGTGCCCGGAGCACAAACACCATGGGCAGCCACGCCCGCGCGG
ATCGCCGATAATAGCGGATT

Downstream 100 bases:

>100_bases
CCACTTGATCGCACTGTATCCGGGGAGCTTTGATCCCCTGACCTACGGCCATCTGGATATTATCGAGCGCGCCGCCCGTC
TGTTCGACCGGGTGGTCGTC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MKAYDAIVIGSGAAGLYTALKLPREWRIALLTKENLTLSSSQWAQGGIAAVVEPDDSFRLHYEDTLAAGAGLCEPEAVRV
LVEEAPERIRELIALGVEFDRYQGRLAVTLEAAHSRRRILHAADATGRELVRALVEEVRDLGNIRVVEEALAIDLALDGG
RCRGVLVDALGVREWYMSPVTVLATGGAGQVFAYTTNPAVATGDGIAMAARAGVALRDLEFVQFHPTALAIDGAPRFLIS
EAVRGEGGQLVNLAGERFMGRYHPQGELAPRDVVARAIFDQMQSSGATHVLIDLRPIGEATIEQRFPNIAHVCRKFGVDV
FSEAVPVAPAAHYWMGGVLTDLDGRTSLPGLFAVGEVASTGVHGANRLASNSLLECLVFAHRIAEAVRSSGISRTAAGII
HFPPAAAQSPVNFELVQRIRNEMPWLVWRTCGIIREADGLRRGLEQLQMWKQQLSGVDATTERATLEVRNLVIAAELLLK
SALLRTESRGGHYRSDHPAPDPAWQVHTEIAEGRLFQTPLAVAKIRPTSG

Sequences:

>Translated_530_residues
MKAYDAIVIGSGAAGLYTALKLPREWRIALLTKENLTLSSSQWAQGGIAAVVEPDDSFRLHYEDTLAAGAGLCEPEAVRV
LVEEAPERIRELIALGVEFDRYQGRLAVTLEAAHSRRRILHAADATGRELVRALVEEVRDLGNIRVVEEALAIDLALDGG
RCRGVLVDALGVREWYMSPVTVLATGGAGQVFAYTTNPAVATGDGIAMAARAGVALRDLEFVQFHPTALAIDGAPRFLIS
EAVRGEGGQLVNLAGERFMGRYHPQGELAPRDVVARAIFDQMQSSGATHVLIDLRPIGEATIEQRFPNIAHVCRKFGVDV
FSEAVPVAPAAHYWMGGVLTDLDGRTSLPGLFAVGEVASTGVHGANRLASNSLLECLVFAHRIAEAVRSSGISRTAAGII
HFPPAAAQSPVNFELVQRIRNEMPWLVWRTCGIIREADGLRRGLEQLQMWKQQLSGVDATTERATLEVRNLVIAAELLLK
SALLRTESRGGHYRSDHPAPDPAWQVHTEIAEGRLFQTPLAVAKIRPTSG
>Mature_530_residues
MKAYDAIVIGSGAAGLYTALKLPREWRIALLTKENLTLSSSQWAQGGIAAVVEPDDSFRLHYEDTLAAGAGLCEPEAVRV
LVEEAPERIRELIALGVEFDRYQGRLAVTLEAAHSRRRILHAADATGRELVRALVEEVRDLGNIRVVEEALAIDLALDGG
RCRGVLVDALGVREWYMSPVTVLATGGAGQVFAYTTNPAVATGDGIAMAARAGVALRDLEFVQFHPTALAIDGAPRFLIS
EAVRGEGGQLVNLAGERFMGRYHPQGELAPRDVVARAIFDQMQSSGATHVLIDLRPIGEATIEQRFPNIAHVCRKFGVDV
FSEAVPVAPAAHYWMGGVLTDLDGRTSLPGLFAVGEVASTGVHGANRLASNSLLECLVFAHRIAEAVRSSGISRTAAGII
HFPPAAAQSPVNFELVQRIRNEMPWLVWRTCGIIREADGLRRGLEQLQMWKQQLSGVDATTERATLEVRNLVIAAELLLK
SALLRTESRGGHYRSDHPAPDPAWQVHTEIAEGRLFQTPLAVAKIRPTSG

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=522, Percent_Identity=33.9080459770115, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1788928, Length=513, Percent_Identity=42.8849902534113, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1790597, Length=513, Percent_Identity=34.8927875243665, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1786942, Length=565, Percent_Identity=34.6902654867257, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17550100, Length=521, Percent_Identity=34.7408829174664, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17505833, Length=520, Percent_Identity=33.0769230769231, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71986328, Length=476, Percent_Identity=27.5210084033613, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322416, Length=559, Percent_Identity=33.6314847942755, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6322701, Length=560, Percent_Identity=33.3928571428571, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6322511, Length=475, Percent_Identity=28, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320788, Length=478, Percent_Identity=28.4518828451883, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137288, Length=543, Percent_Identity=35.1749539594843, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24655642, Length=543, Percent_Identity=35.1749539594843, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24655647, Length=543, Percent_Identity=35.1749539594843, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24663005, Length=548, Percent_Identity=32.8467153284672, Blast_Score=221, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 57298; Mature: 57298

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYDAIVIGSGAAGLYTALKLPREWRIALLTKENLTLSSSQWAQGGIAAVVEPDDSFRL
CCCCEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCEECCCCCCCCCEEEEECCCCCEEE
HYEDTLAAGAGLCEPEAVRVLVEEAPERIRELIALGVEFDRYQGRLAVTLEAAHSRRRIL
EEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEEEHHHHHHHHH
HAADATGRELVRALVEEVRDLGNIRVVEEALAIDLALDGGRCRGVLVDALGVREWYMSPV
HHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHEEEEEECCCCCCEEEEHHHHHHHHHCCCE
TVLATGGAGQVFAYTTNPAVATGDGIAMAARAGVALRDLEFVQFHPTALAIDGAPRFLIS
EEEEECCCCEEEEEECCCCEECCCCHHHHHHCCCEEECCEEEEECCCEEEECCCCHHHHH
EAVRGEGGQLVNLAGERFMGRYHPQGELAPRDVVARAIFDQMQSSGATHVLIDLRPIGEA
HHHCCCCCCEEEECHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHH
TIEQRFPNIAHVCRKFGVDVFSEAVPVAPAAHYWMGGVLTDLDGRTSLPGLFAVGEVAST
HHHHHCCHHHHHHHHHCHHHHHHCCCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHHC
GVHGANRLASNSLLECLVFAHRIAEAVRSSGISRTAAGIIHFPPAAAQSPVNFELVQRIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEECCCCCCCCCCCHHHHHHHH
NEMPWLVWRTCGIIREADGLRRGLEQLQMWKQQLSGVDATTERATLEVRNLVIAAELLLK
HCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SALLRTESRGGHYRSDHPAPDPAWQVHTEIAEGRLFQTPLAVAKIRPTSG
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEECCCCC
>Mature Secondary Structure
MKAYDAIVIGSGAAGLYTALKLPREWRIALLTKENLTLSSSQWAQGGIAAVVEPDDSFRL
CCCCEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCEECCCCCCCCCEEEEECCCCCEEE
HYEDTLAAGAGLCEPEAVRVLVEEAPERIRELIALGVEFDRYQGRLAVTLEAAHSRRRIL
EEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEEEHHHHHHHHH
HAADATGRELVRALVEEVRDLGNIRVVEEALAIDLALDGGRCRGVLVDALGVREWYMSPV
HHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHEEEEEECCCCCCEEEEHHHHHHHHHCCCE
TVLATGGAGQVFAYTTNPAVATGDGIAMAARAGVALRDLEFVQFHPTALAIDGAPRFLIS
EEEEECCCCEEEEEECCCCEECCCCHHHHHHCCCEEECCEEEEECCCEEEECCCCHHHHH
EAVRGEGGQLVNLAGERFMGRYHPQGELAPRDVVARAIFDQMQSSGATHVLIDLRPIGEA
HHHCCCCCCEEEECHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHH
TIEQRFPNIAHVCRKFGVDVFSEAVPVAPAAHYWMGGVLTDLDGRTSLPGLFAVGEVAST
HHHHHCCHHHHHHHHHCHHHHHHCCCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHHC
GVHGANRLASNSLLECLVFAHRIAEAVRSSGISRTAAGIIHFPPAAAQSPVNFELVQRIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEECCCCCCCCCCCHHHHHHHH
NEMPWLVWRTCGIIREADGLRRGLEQLQMWKQQLSGVDATTERATLEVRNLVIAAELLLK
HCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SALLRTESRGGHYRSDHPAPDPAWQVHTEIAEGRLFQTPLAVAKIRPTSG
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]