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The map label for this gene is cysK [H]

Identifier: 37520367

GI number: 37520367

Start: 850269

End: 851231

Strand: Direct

Name: cysK [H]

Synonym: gvip092

Alternate gene names: 37520367

Gene position: 850269-851231 (Clockwise)

Preceding gene: 37520366

Following gene: 37520368

Centisome position: 18.25

GC content: 64.49

Gene sequence:

>963_bases
ATGCATATCGCTCACGACATCACCGAACTGATCGGCCGCACTCCGCTGGTGCAGCTCAACCGTATTCCGGCCGCCGAGGG
TGCCCTTGCCCGCATCGTGGTCAAACTCGAAAGTTTCAACCCGGCCGCCTCCGTCAAAGACCGCATCGGCGTCTCGATGA
TCAACGAAGCCGAAAAGTCGGGCTTTATCCTGCCGGGCAAAACGACCCTGGTCGAACCCACCTCCGGCAACACCGGCATC
GCCCTGGCCATGGTGGCGGCGGCGCGCGGCTACCGGCTCATCCTCACGATGCCCGAGACGATGAGCAGCGAGCGGCGGGC
GCTCCTGCGGGCCTACGGCGCCCAACTCGAATTGACCCCCGGTTCAGAAGGGATGCGCGGGGCCATCCGCCGCGCTGAGG
AGATTACCCGCGAAGTGCCCGACGCGTTTATACTCCAGCAGTTTCGCAACCCCGCCAATCCCAAGATCCACCGCGAGACG
ACCGCCGAAGAACTCTGGCGCGACACCGACGGGCAGATGGATATTTTTGTCTCCGGGGTGGGTACCGGCGGCACCGTGAC
CGGGGTGGGCGAAGTCTGGAAGGTGCGCAAGCCCGGCGTGCAGATCGTGGCAGTGGAACCGGCGGCAAGCCCGGTGCTCT
CCGGCGGTAAACCCGGCTCGCACCTCATCCAGGGCATTGGCGCGGGCTTTGTACCGGATGTACTGCGGCGCGACGTGATC
GACGAAGTGATCGCCGTAGCCGATGAGAAAGCGATCGAATACAGCCGCAGGCTTGCCAAAGAAGAAGGGCTTCTCTCGGG
CATCTCCACCGGGGCGGCTCTGTGGGCGGCTCTGCAGCTGGCCAAGCGCCCCGAGAACACCGGCAAGCTCATTGTCTTTA
TCCAACCCAGCTTCGGCGAGCGCTACTTGAGCACGGCCCTTTTCCAGAACGAAGGGCAATCGCCCACCGCCGTCGCCCGC
TAG

Upstream 100 bases:

>100_bases
CGAGCAAGTGCTCAAAGGCCATACGCTCCAAAAGCTCTGCGAACTGCACGATCGCCGCCAGAGCACCGTCATGTACTACA
TCTAAGCGAACCTGCCACCC

Downstream 100 bases:

>100_bases
GAGCGGGCGGTAAGCCGCCGGTTGCGTTGCAAAAAATAGCGGCTATCCCTACTGGAAAATGCAGGCAATAGTCGATGCGT
AATCCTGCGGTAGTAAGGTT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MHIAHDITELIGRTPLVQLNRIPAAEGALARIVVKLESFNPAASVKDRIGVSMINEAEKSGFILPGKTTLVEPTSGNTGI
ALAMVAAARGYRLILTMPETMSSERRALLRAYGAQLELTPGSEGMRGAIRRAEEITREVPDAFILQQFRNPANPKIHRET
TAEELWRDTDGQMDIFVSGVGTGGTVTGVGEVWKVRKPGVQIVAVEPAASPVLSGGKPGSHLIQGIGAGFVPDVLRRDVI
DEVIAVADEKAIEYSRRLAKEEGLLSGISTGAALWAALQLAKRPENTGKLIVFIQPSFGERYLSTALFQNEGQSPTAVAR

Sequences:

>Translated_320_residues
MHIAHDITELIGRTPLVQLNRIPAAEGALARIVVKLESFNPAASVKDRIGVSMINEAEKSGFILPGKTTLVEPTSGNTGI
ALAMVAAARGYRLILTMPETMSSERRALLRAYGAQLELTPGSEGMRGAIRRAEEITREVPDAFILQQFRNPANPKIHRET
TAEELWRDTDGQMDIFVSGVGTGGTVTGVGEVWKVRKPGVQIVAVEPAASPVLSGGKPGSHLIQGIGAGFVPDVLRRDVI
DEVIAVADEKAIEYSRRLAKEEGLLSGISTGAALWAALQLAKRPENTGKLIVFIQPSFGERYLSTALFQNEGQSPTAVAR
>Mature_320_residues
MHIAHDITELIGRTPLVQLNRIPAAEGALARIVVKLESFNPAASVKDRIGVSMINEAEKSGFILPGKTTLVEPTSGNTGI
ALAMVAAARGYRLILTMPETMSSERRALLRAYGAQLELTPGSEGMRGAIRRAEEITREVPDAFILQQFRNPANPKIHRET
TAEELWRDTDGQMDIFVSGVGTGGTVTGVGEVWKVRKPGVQIVAVEPAASPVLSGGKPGSHLIQGIGAGFVPDVLRRDVI
DEVIAVADEKAIEYSRRLAKEEGLLSGISTGAALWAALQLAKRPENTGKLIVFIQPSFGERYLSTALFQNEGQSPTAVAR

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=40.2555910543131, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=40.2555910543131, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=40.2555910543131, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=57.0977917981073, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=42.6229508196721, Blast_Score=214, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=55, Blast_Score=330, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=51.9480519480519, Blast_Score=311, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=52.8239202657807, Blast_Score=307, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI115535073, Length=317, Percent_Identity=52.6813880126183, Blast_Score=302, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=50.6535947712418, Blast_Score=276, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=50, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17534315, Length=314, Percent_Identity=38.2165605095541, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=287, Percent_Identity=39.3728222996516, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=48.2758620689655, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=38.9240506329114, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=34.5565749235474, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24643623, Length=317, Percent_Identity=40.0630914826498, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI20129101, Length=317, Percent_Identity=40.0630914826498, Blast_Score=212, Evalue=2e-55,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34294; Mature: 34294

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIAHDITELIGRTPLVQLNRIPAAEGALARIVVKLESFNPAASVKDRIGVSMINEAEKS
CCCHHHHHHHHCCCCEEEECCCCCCCCHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
GFILPGKTTLVEPTSGNTGIALAMVAAARGYRLILTMPETMSSERRALLRAYGAQLELTP
CEEECCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCEEEECC
GSEGMRGAIRRAEEITREVPDAFILQQFRNPANPKIHRETTAEELWRDTDGQMDIFVSGV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEECHHHHHHHHCCCCCCEEEEEEEC
GTGGTVTGVGEVWKVRKPGVQIVAVEPAASPVLSGGKPGSHLIQGIGAGFVPDVLRRDVI
CCCCCCCCCHHHHEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
DEVIAVADEKAIEYSRRLAKEEGLLSGISTGAALWAALQLAKRPENTGKLIVFIQPSFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCH
RYLSTALFQNEGQSPTAVAR
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MHIAHDITELIGRTPLVQLNRIPAAEGALARIVVKLESFNPAASVKDRIGVSMINEAEKS
CCCHHHHHHHHCCCCEEEECCCCCCCCHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
GFILPGKTTLVEPTSGNTGIALAMVAAARGYRLILTMPETMSSERRALLRAYGAQLELTP
CEEECCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCEEEECC
GSEGMRGAIRRAEEITREVPDAFILQQFRNPANPKIHRETTAEELWRDTDGQMDIFVSGV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEECHHHHHHHHCCCCCCEEEEEEEC
GTGGTVTGVGEVWKVRKPGVQIVAVEPAASPVLSGGKPGSHLIQGIGAGFVPDVLRRDVI
CCCCCCCCCHHHHEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
DEVIAVADEKAIEYSRRLAKEEGLLSGISTGAALWAALQLAKRPENTGKLIVFIQPSFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCH
RYLSTALFQNEGQSPTAVAR
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]