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The map label for this gene is gsk [C]

Identifier: 37520360

GI number: 37520360

Start: 842920

End: 843909

Strand: Direct

Name: gsk [C]

Synonym: glr0791

Alternate gene names: 37520360

Gene position: 842920-843909 (Clockwise)

Preceding gene: 37520359

Following gene: 37520362

Centisome position: 18.09

GC content: 64.24

Gene sequence:

>990_bases
ATGAGCACCTTCGACGTTTTTGCCCTGTGCAATCCGCTTTACGACCTGCAGGTGCAGGTCTCCGACGCCCTGCTGGTGAG
CTTCGGCTTTCCCAAAGGCGGGGTCTGCCTGATCGACCGCGAGCAGTACGACGAGCTGATCCCCAAACTGGCGGGTCTGC
CTATTCACGCCACCCCGGGCGGTTCGGCCGCCAACACGGTGATCGGCATCCAGCAGCTGGGGGGGACCACCTGCTACACC
GGCAAAGTCGGCGCCGACAGCTACGGCGCCGCCTACCGCAACGGCATGATTTCCCGGGGGGTGCAGGCCAACCTGGGGGT
CGGCTCCCAACCTACCGGGCTGAGTGTGATCTTGATCACCCCCGACGCCCAGCGCACGATGTTCACTTATTTGGGCGCCT
GCCGCGAACTGGGGCTGTTTGACATCGACCCCGATGCGATTGCCCAGAGCCGCTATCTCTACATCACGGGCTACTGCTGG
GATACCCAAAATCAAAAAGACGCGGTGCTCTTTGCCATGGAGCAGGCCCGCGCCGCCGGGGTGCCCATCGCTTTGAGTCT
TTCCGACCCGTTCGTGGTGCGCCGCCACAAAGAAGAACTGCGGCGCGTGGTCAATGACCATGTCGATGTGCTCTTCGGCA
ACCAGGAGGAGGCGGAGGTCTTCACCGAGACCAGTTCCCCGGAAGCGGCGGTCGATGTTCTGCGTTCTTACTGCAACACG
GCGGTAGTCACCATGAGTGCCGCCGGTTCCTACATCGCCCACGGCAGCCATGTGTACCGCATCGAACCGTTTGCGGTGGC
GGCCGTCGACGCGACGGGCGCGGGCGACATGTACGCAGCGGGGTTGCTCTACGGCCTCACCCACGATCTGGCCGTCCCGG
CCACCGGCCGGTTGGCTTCGTATCTGGCGGCCAGGGTGGTGGCCCAACTTGGCCCGCGCCTCGATGCCATTGATCCCCAG
GTGGTCGCAGAACTGCTCGCCGAAGCCTGA

Upstream 100 bases:

>100_bases
TCGCCGCGGTCGGCTCCACCGGCTTTTCGACCGGACCGCATCTGCACTTTGAAGTGCGCGTCAACGGTTCACCCGTCAAT
CCCCTCGATTACCTGCGCTG

Downstream 100 bases:

>100_bases
AAACCCACAACATAAGGGGCAGCCCTGGAGGGCTGCCCCGAGCGGAGAGTCGATTGTCGGAGGTCGTCGTCGACTACTCT
TCTGCTTGCTCTTCTTCCTC

Product: sugar kinase

Products: ADP; H+; IMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSTFDVFALCNPLYDLQVQVSDALLVSFGFPKGGVCLIDREQYDELIPKLAGLPIHATPGGSAANTVIGIQQLGGTTCYT
GKVGADSYGAAYRNGMISRGVQANLGVGSQPTGLSVILITPDAQRTMFTYLGACRELGLFDIDPDAIAQSRYLYITGYCW
DTQNQKDAVLFAMEQARAAGVPIALSLSDPFVVRRHKEELRRVVNDHVDVLFGNQEEAEVFTETSSPEAAVDVLRSYCNT
AVVTMSAAGSYIAHGSHVYRIEPFAVAAVDATGAGDMYAAGLLYGLTHDLAVPATGRLASYLAARVVAQLGPRLDAIDPQ
VVAELLAEA

Sequences:

>Translated_329_residues
MSTFDVFALCNPLYDLQVQVSDALLVSFGFPKGGVCLIDREQYDELIPKLAGLPIHATPGGSAANTVIGIQQLGGTTCYT
GKVGADSYGAAYRNGMISRGVQANLGVGSQPTGLSVILITPDAQRTMFTYLGACRELGLFDIDPDAIAQSRYLYITGYCW
DTQNQKDAVLFAMEQARAAGVPIALSLSDPFVVRRHKEELRRVVNDHVDVLFGNQEEAEVFTETSSPEAAVDVLRSYCNT
AVVTMSAAGSYIAHGSHVYRIEPFAVAAVDATGAGDMYAAGLLYGLTHDLAVPATGRLASYLAARVVAQLGPRLDAIDPQ
VVAELLAEA
>Mature_328_residues
STFDVFALCNPLYDLQVQVSDALLVSFGFPKGGVCLIDREQYDELIPKLAGLPIHATPGGSAANTVIGIQQLGGTTCYTG
KVGADSYGAAYRNGMISRGVQANLGVGSQPTGLSVILITPDAQRTMFTYLGACRELGLFDIDPDAIAQSRYLYITGYCWD
TQNQKDAVLFAMEQARAAGVPIALSLSDPFVVRRHKEELRRVVNDHVDVLFGNQEEAEVFTETSSPEAAVDVLRSYCNTA
VVTMSAAGSYIAHGSHVYRIEPFAVAAVDATGAGDMYAAGLLYGLTHDLAVPATGRLASYLAARVVAQLGPRLDAIDPQV
VAELLAEA

Specific function: Unknown

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI32484975, Length=337, Percent_Identity=26.1127596439169, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32484973, Length=337, Percent_Identity=26.1127596439169, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786684, Length=255, Percent_Identity=27.4509803921569, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87081971, Length=285, Percent_Identity=25.6140350877193, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541820, Length=332, Percent_Identity=24.6987951807229, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322565, Length=326, Percent_Identity=26.0736196319018, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355521, Length=340, Percent_Identity=27.3529411764706, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.73 [C]

Molecular weight: Translated: 34988; Mature: 34857

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFDVFALCNPLYDLQVQVSDALLVSFGFPKGGVCLIDREQYDELIPKLAGLPIHATPG
CCCCHHHHHHCCCEEEEEEECCEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCEEECCC
GSAANTVIGIQQLGGTTCYTGKVGADSYGAAYRNGMISRGVQANLGVGSQPTGLSVILIT
CCCHHHEEEHHHCCCCEEEECCCCCCCCCHHHHCCHHHCCCEECCCCCCCCCCCEEEEEC
PDAQRTMFTYLGACRELGLFDIDPDAIAQSRYLYITGYCWDTQNQKDAVLFAMEQARAAG
CCCHHHHHHHHHHHHHCCCEECCHHHHHCCCEEEEEEEEECCCCCCCCEEEEEHHHHHCC
VPIALSLSDPFVVRRHKEELRRVVNDHVDVLFGNQEEAEVFTETSSPEAAVDVLRSYCNT
CCEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHEEECCCCCHHHHHHHHHHHCC
AVVTMSAAGSYIAHGSHVYRIEPFAVAAVDATGAGDMYAAGLLYGLTHDLAVPATGRLAS
EEEEEECCCCEEECCCEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
YLAARVVAQLGPRLDAIDPQVVAELLAEA
HHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STFDVFALCNPLYDLQVQVSDALLVSFGFPKGGVCLIDREQYDELIPKLAGLPIHATPG
CCCHHHHHHCCCEEEEEEECCEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCEEECCC
GSAANTVIGIQQLGGTTCYTGKVGADSYGAAYRNGMISRGVQANLGVGSQPTGLSVILIT
CCCHHHEEEHHHCCCCEEEECCCCCCCCCHHHHCCHHHCCCEECCCCCCCCCCCEEEEEC
PDAQRTMFTYLGACRELGLFDIDPDAIAQSRYLYITGYCWDTQNQKDAVLFAMEQARAAG
CCCHHHHHHHHHHHHHCCCEECCHHHHHCCCEEEEEEEEECCCCCCCCEEEEEHHHHHCC
VPIALSLSDPFVVRRHKEELRRVVNDHVDVLFGNQEEAEVFTETSSPEAAVDVLRSYCNT
CCEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHEEECCCCCHHHHHHHHHHHCC
AVVTMSAAGSYIAHGSHVYRIEPFAVAAVDATGAGDMYAAGLLYGLTHDLAVPATGRLAS
EEEEEECCCCEEECCCEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
YLAARVVAQLGPRLDAIDPQVVAELLAEA
HHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; Inosine [C]

Specific reaction: ATP + Inosine --> ADP + H+ + IMP [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]