Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 37520279

GI number: 37520279

Start: 754448

End: 754897

Strand: Direct

Name: ndk

Synonym: glr0710

Alternate gene names: 37520279

Gene position: 754448-754897 (Clockwise)

Preceding gene: 37520277

Following gene: 37520281

Centisome position: 16.19

GC content: 60.22

Gene sequence:

>450_bases
GTGGAACGGACATTCATTGCCATCAAACCCGACGGTGTCCAGCGCGGTCTGGTGGGAGAAATTTTGCAGCGCTTCGAGCG
GCGCGGTTTTAAACTGGTCGGCCTCAAATTGATGCAGGTGAGCGAAGCCTTGGCCCAAAAACACTACGCCGAACACAAAG
AACGCCCCTTTTTTGGGGGGCTGGTGGCGTTTATCACGTCCTCGCCGGTGGTGGCGGTGGTGCTCGAAGGCAAAGGGGTG
GTGGCGACGGCCCGGGCGATGATGGGTGTCACCAACCCGCTCAATTCTCCCCTGGGCACTATCCGGGGCGACTACGGCAT
CGACATCGGCCGCAATATCATCCATGGCTCCGACAGCCTCGAATCGGCCGAGCGCGAAATCGCCCTCTGGTTTGCCCCCG
CAGAATTGCTCGAATGGCAGGCCACCCTCGGAAGCTGGGTCTACGAATAG

Upstream 100 bases:

>100_bases
CTTCAGCTCTATACCCGTTCTTCGAGTCAGGATCGCCGCCTCGACAGACCGGTCAAACCCCTAAAATGGCCCTTGGCCTA
TTACACATCGGAGAGCCCAA

Downstream 100 bases:

>100_bases
CGCCTCTACGAGTCCTTGCCCGAGGGCAGGCTCTGGGGAGGATTGGGGGCGGTTTCTTTGGAGGCGCTCTGCTGTGGGGC
CGGTTCGTCGCTCACGCCGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTFIAIKPDGVQRGLVGEILQRFERRGFKLVGLKLMQVSEALAQKHYAEHKERPFFGGLVAFITSSPVVAVVLEGKGV
VATARAMMGVTNPLNSPLGTIRGDYGIDIGRNIIHGSDSLESAEREIALWFAPAELLEWQATLGSWVYE

Sequences:

>Translated_149_residues
MERTFIAIKPDGVQRGLVGEILQRFERRGFKLVGLKLMQVSEALAQKHYAEHKERPFFGGLVAFITSSPVVAVVLEGKGV
VATARAMMGVTNPLNSPLGTIRGDYGIDIGRNIIHGSDSLESAEREIALWFAPAELLEWQATLGSWVYE
>Mature_149_residues
MERTFIAIKPDGVQRGLVGEILQRFERRGFKLVGLKLMQVSEALAQKHYAEHKERPFFGGLVAFITSSPVVAVVLEGKGV
VATARAMMGVTNPLNSPLGTIRGDYGIDIGRNIIHGSDSLESAEREIALWFAPAELLEWQATLGSWVYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=63.758389261745, Blast_Score=206, Evalue=8e-54,
Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=63.758389261745, Blast_Score=205, Evalue=1e-53,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=63.5135135135135, Blast_Score=203, Evalue=4e-53,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=60.4026845637584, Blast_Score=198, Evalue=1e-51,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=60.4026845637584, Blast_Score=198, Evalue=1e-51,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=60.4026845637584, Blast_Score=198, Evalue=1e-51,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=60.4026845637584, Blast_Score=198, Evalue=1e-51,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=60.4026845637584, Blast_Score=198, Evalue=2e-51,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=52.8985507246377, Blast_Score=164, Evalue=2e-41,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=34.5588235294118, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=34.5588235294118, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI5031951, Length=143, Percent_Identity=33.5664335664336, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=32.089552238806, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=48.1751824817518, Blast_Score=138, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=56.3758389261745, Blast_Score=175, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=58.1081081081081, Blast_Score=197, Evalue=7e-52,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=60.1351351351351, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18860097, Length=148, Percent_Identity=31.7567567567568, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_GLOVI (Q7NMQ5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923656.1
- ProteinModelPortal:   Q7NMQ5
- SMR:   Q7NMQ5
- GeneID:   2599429
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr0710
- NMPDR:   fig|251221.1.peg.710
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- BioCyc:   GVIO251221:GLR0710-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16397; Mature: 16397

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFIAIKPDGVQRGLVGEILQRFERRGFKLVGLKLMQVSEALAQKHYAEHKERPFFGG
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHH
LVAFITSSPVVAVVLEGKGVVATARAMMGVTNPLNSPLGTIRGDYGIDIGRNIIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEEECCCCCH
ESAEREIALWFAPAELLEWQATLGSWVYE
HHHHHEEEEEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERTFIAIKPDGVQRGLVGEILQRFERRGFKLVGLKLMQVSEALAQKHYAEHKERPFFGG
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHH
LVAFITSSPVVAVVLEGKGVVATARAMMGVTNPLNSPLGTIRGDYGIDIGRNIIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEEECCCCCH
ESAEREIALWFAPAELLEWQATLGSWVYE
HHHHHEEEEEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292