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The map label for this gene is ywrD [H]

Identifier: 37520249

GI number: 37520249

Start: 724903

End: 726639

Strand: Reverse

Name: ywrD [H]

Synonym: gll0680

Alternate gene names: 37520249

Gene position: 726639-724903 (Counterclockwise)

Preceding gene: 37520250

Following gene: 37520246

Centisome position: 15.6

GC content: 64.36

Gene sequence:

>1737_bases
ATGAAATTGCACTCGGCCCTGCTGCTCGCTTCGCTGCTGGTGCTCAGTTGTGCCGCTACGGCGGCAGCCCTGCCCGGTGG
AGATCGAGGCGGAACCTATTTTTCGACGCGCAGCCCGGTGATTGCCAAAAACGGCATGGCTGCCACCAGCCACCCGCTGG
CCACCCAGATCGCCGTCGACGTGCTTAAAAAAGGCGGCAGCGCTGTCGACGCCGCCATCGCCGCCAACGCCGCCCTGGGA
TTGATGGAACCTACCGGCAACGGCATCGGTGGGGATCTATTCGCCATCGTCTGGGATCCGAGAGCGCGCAAACTCGCGGG
CCTCAACGCCAGTGGCCGCTCGCCGCTGGGACTCGACTACGAACGACTCAAAAGCGCGGTTGGGGGGAGCCCGACGATCC
CGATTTTTGGGCCGCTGCCCGTCACGGTGCCGGGGGCGGTGGACGGTTGGTTTATGCTGCACGGCCGCTACGGCCGATTG
CCCATAGCCGAACTGCTTGCTCCTGCTGTCCGTTACGCCCGCGAGGGGGTGCCGGTGCCGCAGATGATCGCCGGTTACTG
GCAGTCCAACCTCCGCCGCTTCGAGCGCGACAAAGACCAGATTCCCGAACTGGCCAATTTTCGCAAGACCTACTTGATAG
CCGGCAACCCCCCCGCCGAGGGGGAAATCTTCCGCAACCCGGATCTGGCGCTCACACTCGAAAAAATCGGCAAAGGCGGC
CGGGACGTATTCTACAAAGGCGAGATCGCCGACACCATCGACGCTTACATGCAGCGGGTAGGGGGGTATTTGCGCCGGAC
CGACTTCGAGCGGCACACCGGCACCTGGGTCGAGCCGGTGCGGGTCAATTACCGAGGCTATGACGTCTACGAACTGCCGC
CCAACGGCCAGGGGATCGCGGCCCTACAGATGCTTAACATCCTCGAAGGCTTCGATCTCAAAAAAATGGGCCACAACAGC
GCCGACTACCTGCACGCGCAGGTGGAAGCCAAAAAACTCGCCTTCGCCGACCGGGCGCGCTACTACGCCGACCCGGACTT
CAGCAAGATGCCGGTGGCCGGGTTGCTCGACAAGACCTACGCAAGCGACCGGCGGCGGCTCATCGCCATGGACCGCGCCC
AGTCGCGCCAGGCGGCGGGTCTGCCCCCCGCCGCCGATACGATCTACCTCACCACCGCCGACAAAGACGGCATGATGGTC
TCGCTCATCCAGAGCAACTACGTGGGCATGGGCAGCGGCCTGGTTCCGGACGGCCTCGGCTTTATGCTCCAGGACCGCGG
TGCACAATTTAGCCTCACCCCCGGCCACCCGAACGTCTATGCCCCCGGCAAGCGGCCCTTCCACACGATCATCCCGGCCT
TTGTGAGCAAAGACGGTGAGCCGTTTATGAGTTTTGGGGTGATGGGGGGTGACATGCAGCCGCAGGGCCACGTCCAGATT
CTATGCAACATCATCGACTTTGGTATGGACGTGCAGCAGGCCGGGGACGCGGCGCGCTACTACCACACTGGCGACAACGA
CCCGGACGGGCGGGTGATGGTCGATGGCGGCACCCTTAACCTCGAAAGCGGCGTGGGGGAGGATAGCCGTACCGAGCTTG
CCCGCCGGGGCCACCGGCTTGCCGCCACCTCCCCGGGAGCCTACGGCGGCTACCAGGTCATCCAGTGGGACCAGGTCAAC
CGCGTGTACCGCGGTGCTTCCGAGATGCGCAAGGACGGCCAGGTGAGCGGATTTTAG

Upstream 100 bases:

>100_bases
GAACTGCTGCAGGCGCATGGGCGATGTCTGTAACGCCCGGTGCAGTTACGCCACACCGACGGTGATATCTTTTTTAACTG
CCGTTTCGGATGATTAGGCG

Downstream 100 bases:

>100_bases
GCGGTCGTGCGCAGCATACGGGCGGCTTTGACCAGGGCGTAGGCGAGTTTGTCGAGGCGATCTTTGAGCTTGGGATCGGT
GAGGTTGCCCTCGGCGTCGA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MKLHSALLLASLLVLSCAATAAALPGGDRGGTYFSTRSPVIAKNGMAATSHPLATQIAVDVLKKGGSAVDAAIAANAALG
LMEPTGNGIGGDLFAIVWDPRARKLAGLNASGRSPLGLDYERLKSAVGGSPTIPIFGPLPVTVPGAVDGWFMLHGRYGRL
PIAELLAPAVRYAREGVPVPQMIAGYWQSNLRRFERDKDQIPELANFRKTYLIAGNPPAEGEIFRNPDLALTLEKIGKGG
RDVFYKGEIADTIDAYMQRVGGYLRRTDFERHTGTWVEPVRVNYRGYDVYELPPNGQGIAALQMLNILEGFDLKKMGHNS
ADYLHAQVEAKKLAFADRARYYADPDFSKMPVAGLLDKTYASDRRRLIAMDRAQSRQAAGLPPAADTIYLTTADKDGMMV
SLIQSNYVGMGSGLVPDGLGFMLQDRGAQFSLTPGHPNVYAPGKRPFHTIIPAFVSKDGEPFMSFGVMGGDMQPQGHVQI
LCNIIDFGMDVQQAGDAARYYHTGDNDPDGRVMVDGGTLNLESGVGEDSRTELARRGHRLAATSPGAYGGYQVIQWDQVN
RVYRGASEMRKDGQVSGF

Sequences:

>Translated_578_residues
MKLHSALLLASLLVLSCAATAAALPGGDRGGTYFSTRSPVIAKNGMAATSHPLATQIAVDVLKKGGSAVDAAIAANAALG
LMEPTGNGIGGDLFAIVWDPRARKLAGLNASGRSPLGLDYERLKSAVGGSPTIPIFGPLPVTVPGAVDGWFMLHGRYGRL
PIAELLAPAVRYAREGVPVPQMIAGYWQSNLRRFERDKDQIPELANFRKTYLIAGNPPAEGEIFRNPDLALTLEKIGKGG
RDVFYKGEIADTIDAYMQRVGGYLRRTDFERHTGTWVEPVRVNYRGYDVYELPPNGQGIAALQMLNILEGFDLKKMGHNS
ADYLHAQVEAKKLAFADRARYYADPDFSKMPVAGLLDKTYASDRRRLIAMDRAQSRQAAGLPPAADTIYLTTADKDGMMV
SLIQSNYVGMGSGLVPDGLGFMLQDRGAQFSLTPGHPNVYAPGKRPFHTIIPAFVSKDGEPFMSFGVMGGDMQPQGHVQI
LCNIIDFGMDVQQAGDAARYYHTGDNDPDGRVMVDGGTLNLESGVGEDSRTELARRGHRLAATSPGAYGGYQVIQWDQVN
RVYRGASEMRKDGQVSGF
>Mature_578_residues
MKLHSALLLASLLVLSCAATAAALPGGDRGGTYFSTRSPVIAKNGMAATSHPLATQIAVDVLKKGGSAVDAAIAANAALG
LMEPTGNGIGGDLFAIVWDPRARKLAGLNASGRSPLGLDYERLKSAVGGSPTIPIFGPLPVTVPGAVDGWFMLHGRYGRL
PIAELLAPAVRYAREGVPVPQMIAGYWQSNLRRFERDKDQIPELANFRKTYLIAGNPPAEGEIFRNPDLALTLEKIGKGG
RDVFYKGEIADTIDAYMQRVGGYLRRTDFERHTGTWVEPVRVNYRGYDVYELPPNGQGIAALQMLNILEGFDLKKMGHNS
ADYLHAQVEAKKLAFADRARYYADPDFSKMPVAGLLDKTYASDRRRLIAMDRAQSRQAAGLPPAADTIYLTTADKDGMMV
SLIQSNYVGMGSGLVPDGLGFMLQDRGAQFSLTPGHPNVYAPGKRPFHTIIPAFVSKDGEPFMSFGVMGGDMQPQGHVQI
LCNIIDFGMDVQQAGDAARYYHTGDNDPDGRVMVDGGTLNLESGVGEDSRTELARRGHRLAATSPGAYGGYQVIQWDQVN
RVYRGASEMRKDGQVSGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI109148539, Length=552, Percent_Identity=28.4420289855072, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI73915092, Length=500, Percent_Identity=27.4, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI73915090, Length=500, Percent_Identity=27.4, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI73915096, Length=500, Percent_Identity=27.4, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI73915094, Length=500, Percent_Identity=27.4, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI113429324, Length=485, Percent_Identity=26.5979381443299, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI113429326, Length=485, Percent_Identity=26.1855670103093, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI153266885, Length=560, Percent_Identity=21.9642857142857, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI153266901, Length=561, Percent_Identity=22.6381461675579, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI153266907, Length=559, Percent_Identity=21.1091234347048, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1789856, Length=559, Percent_Identity=31.8425760286225, Blast_Score=255, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17506189, Length=482, Percent_Identity=24.896265560166, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17542894, Length=442, Percent_Identity=28.0542986425339, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=437, Percent_Identity=26.0869565217391, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI212646519, Length=437, Percent_Identity=26.0869565217391, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=498, Percent_Identity=24.4979919678715, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193208245, Length=498, Percent_Identity=24.0963855421687, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI161077880, Length=567, Percent_Identity=26.4550264550265, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24642670, Length=567, Percent_Identity=26.4550264550265, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24642666, Length=567, Percent_Identity=26.4550264550265, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI161077878, Length=567, Percent_Identity=26.4550264550265, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45551474, Length=567, Percent_Identity=26.4550264550265, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI161077496, Length=517, Percent_Identity=25.1450676982592, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18859893, Length=439, Percent_Identity=30.0683371298405, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18859741, Length=554, Percent_Identity=24.9097472924188, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62372; Mature: 62372

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHSALLLASLLVLSCAATAAALPGGDRGGTYFSTRSPVIAKNGMAATSHPLATQIAVD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHHHHHHH
VLKKGGSAVDAAIAANAALGLMEPTGNGIGGDLFAIVWDPRARKLAGLNASGRSPLGLDY
HHHCCCCHHHHHHHHHHHEEEECCCCCCCCCCEEEEEECCCCHHEECCCCCCCCCCCCCH
ERLKSAVGGSPTIPIFGPLPVTVPGAVDGWFMLHGRYGRLPIAELLAPAVRYAREGVPVP
HHHHHHHCCCCCCEEECCCCEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHH
QMIAGYWQSNLRRFERDKDQIPELANFRKTYLIAGNPPAEGEIFRNPDLALTLEKIGKGG
HHHHHHHHHHHHHHHCCHHHCHHHHCCCEEEEEECCCCCCCCEEECCCCEEEHHHHCCCC
RDVFYKGEIADTIDAYMQRVGGYLRRTDFERHTGTWVEPVRVNYRGYDVYELPPNGQGIA
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEECCCCCCCHH
ALQMLNILEGFDLKKMGHNSADYLHAQVEAKKLAFADRARYYADPDFSKMPVAGLLDKTY
HHHHHHHHCCCCHHHCCCCCHHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ASDRRRLIAMDRAQSRQAAGLPPAADTIYLTTADKDGMMVSLIQSNYVGMGSGLVPDGLG
HHHCCEEEEEHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
FMLQDRGAQFSLTPGHPNVYAPGKRPFHTIIPAFVSKDGEPFMSFGVMGGDMQPQGHVQI
HHEECCCCEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCCHHEEECCCCCCCCCCHHHH
LCNIIDFGMDVQQAGDAARYYHTGDNDPDGRVMVDGGTLNLESGVGEDSRTELARRGHRL
HEEHHHCCCCHHHCCCCEEEEECCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHCCCEE
AATSPGAYGGYQVIQWDQVNRVYRGASEMRKDGQVSGF
EECCCCCCCCEEEEEEHHHHHHHHCHHHHHHCCCCCCC
>Mature Secondary Structure
MKLHSALLLASLLVLSCAATAAALPGGDRGGTYFSTRSPVIAKNGMAATSHPLATQIAVD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHHHHHHH
VLKKGGSAVDAAIAANAALGLMEPTGNGIGGDLFAIVWDPRARKLAGLNASGRSPLGLDY
HHHCCCCHHHHHHHHHHHEEEECCCCCCCCCCEEEEEECCCCHHEECCCCCCCCCCCCCH
ERLKSAVGGSPTIPIFGPLPVTVPGAVDGWFMLHGRYGRLPIAELLAPAVRYAREGVPVP
HHHHHHHCCCCCCEEECCCCEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHH
QMIAGYWQSNLRRFERDKDQIPELANFRKTYLIAGNPPAEGEIFRNPDLALTLEKIGKGG
HHHHHHHHHHHHHHHCCHHHCHHHHCCCEEEEEECCCCCCCCEEECCCCEEEHHHHCCCC
RDVFYKGEIADTIDAYMQRVGGYLRRTDFERHTGTWVEPVRVNYRGYDVYELPPNGQGIA
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEECCCCCCCHH
ALQMLNILEGFDLKKMGHNSADYLHAQVEAKKLAFADRARYYADPDFSKMPVAGLLDKTY
HHHHHHHHCCCCHHHCCCCCHHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ASDRRRLIAMDRAQSRQAAGLPPAADTIYLTTADKDGMMVSLIQSNYVGMGSGLVPDGLG
HHHCCEEEEEHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
FMLQDRGAQFSLTPGHPNVYAPGKRPFHTIIPAFVSKDGEPFMSFGVMGGDMQPQGHVQI
HHEECCCCEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCCHHEEECCCCCCCCCCHHHH
LCNIIDFGMDVQQAGDAARYYHTGDNDPDGRVMVDGGTLNLESGVGEDSRTELARRGHRL
HEEHHHCCCCHHHCCCCEEEEECCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHCCCEE
AATSPGAYGGYQVIQWDQVNRVYRGASEMRKDGQVSGF
EECCCCCCCCEEEEEEHHHHHHHHCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]