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The map label for this gene is ptrB [C]

Identifier: 37520250

GI number: 37520250

Start: 727412

End: 729556

Strand: Reverse

Name: ptrB [C]

Synonym: gll0681

Alternate gene names: 37520250

Gene position: 729556-727412 (Counterclockwise)

Preceding gene: 37520251

Following gene: 37520249

Centisome position: 15.66

GC content: 59.72

Gene sequence:

>2145_bases
ATGAACGCCCTGTTCGGATTGTGTGCTGTCGCTCTTGCGATATCGCTGGATGCTTCTTGTGCCCTTGCCCAGAATCTGGC
GGCGAGCGCTCCGAGACTGACTTATCCGCCTACCGAGCGGGTCGAGCAATTTGACGACTACCACGGCACCCGCGTAGCCG
ACCCGTACCGCTGGCTTGAAGATCCCAATTCTCCCAAAACCAGAGCCTGGGTGGAGGCGCAAAACAAAGTCACCTTCGCT
TACCTGGAAGGCATTCCCTACCGCGAACCCCTCAAAGAACGGCTCACCAAGATCTGGAACTACGAGAAGTACGGCATCCC
CAACCGCGAAGGGGACCGGTTCTTCTTCACCCGCAACAGCGGCCTGCAAAATCAGAGCGTCCTGTACAATGCGGCGAAGT
TGGGTGATGCGCCCCGGGTACTGCTTGATCCCAATACACTCTCCAAAGACGGCACGGTGGCGCTCACCGGCATCGACATC
ACCGACGACGGCAGGTACCTAGCCTATGGCACCGCTGCTTCCGGCTCCGATTGGCAGCAGTGGCACGTGCGCGAAGTGGC
GACCGGCCGCGATCTGCCCGATGTAATTAAGTGGGTCAAATTCTCTGAGGCGTCCTGGCTTAAGGACGGCAAGGGCTTTT
TCTACAGCCGCTACGACGAGCCGAACGCCGCCACCCAGTTTCAGGATGTCAATTATTTTCAGAAGCTCTACTTCCACCGC
CTCAGCACCCCCCAGGCTCAAGACGTGCTGGTCTATGAGCGCAAAGATCAAAAAGAGTGGGGCTTCGGCGGCGAAGTCAG
CGAAGACGGACGCTACCTCGTCATCAACGTCAGCCAGGGCACCGACCCCAAAAACCGGGTCTTCTACAAAGACCTGCAAA
ACAACTCAGGCAGGGTGATGGAGCTATTGCCCGACGCCGACGCCGCTTATACGTTTATCGGCAACGACGGGCCGCGCTTT
TGGTTTGTTACCGACAAAGAGGCGCCCCGCGGTCGCCTGGTGCTTATCGACACGACGCGACCTTTGCAGTTGCAGGAGGT
GGTTCCCCAGACCGACGCCACTTTGCAGAGCGCCGATATTGTGGGGGAACGGTTGTTCTTGCGTTACCTCAAAGACGCCC
GCAGCCAGGTAAAAGTCTTCGATCTCAAAGGCAAGTTCCTGAGCGAAGTGGCCTTCCCCGGCCTTGGCACCGTCACGGGT
TTTGGCGGCAAGCGCACGGACACCGAGACGTTTTACGCCTTTACCAGCTTCACCACCCCCACCACCATCTACCGCTACGA
CATCCCCACTGCCAAAAGCACCGTGCTCTTCCAGCCTAAAGTCGACTTCGACCCCACCGCCTACACCACCGAGCAGGTCT
TCTTCAACAGCAAGGACGGCACCCGCATCCCGATGTTCATCACCTATAAAAAAGGCACCCCCCGCAACGCCCTCAACCCT
ACCTACCTCTATGGCTACGGCGGCTTCAACGTTTCTATTACCCCCACTTTTTCACCCGCCAACCTGCTGTGGTTGGAAAT
GGGCGGCCTCTACGCCGTCCCCAACCTGCGCGGCGGCGGCGAGTACGGCGAGGATTGGCATCAGGCGGGCACCAGGCTCA
ACAAGCAAAACGTCTTCGATGACTTTCTCGCCGCGGCCGAATACCTGATCGCCAATAAATACACCTCGCCGGAGAAATTG
GCGATCGGCGGCGGCAGCAACGGTGGTTTGCTGGTGGGAGCTGCCATGACCCAGCGCCCGGAGTTGTTTGCTGCTGCGCT
GCCCGCGGTCGGGGTGATGGACATGCTGCGCTTTGAGCAGTTCACGATTGGCTGGGCGTGGGTGTCCGATTACGGCTCTT
CGCAAGACCCCGAGCAATTCCAGGCGTTGTATGCCTACTCGCCTTTGCACAACTTGAAGGCAGGGACACGCTACCCGGCG
ACGCTGGTGACGACGGCGGACACCGACGACCGGGTGGTGCCGGGACACAGTTACAAGTTCACAGCGGCGCTACAGGCGGC
GCAGGCGGGCGAAGGACCGGTGTTGATCCGCATCGAGACGAAGGCGGGCCACGGAGCGGGCAAGCCGACCACCAAGCTGA
TCGAAGAAGCGGCGGACCGCTGGGCGTTTCTGGTGGCCAACCTCCGCATGCAACTGAAGTTTTGA

Upstream 100 bases:

>100_bases
GTTTCCAGAAAGCCTCCACCGGGTTGTAGGGCGGTTTTGCCGCCTGGCGGGGCGTTCGGTTAGCCTGGAGCGTAATCTTT
ACCGCGCTGGGGATCTGACC

Downstream 100 bases:

>100_bases
CCTCTCTCCCGCTTCTTTATCTTGGTGGGAAGCAGACCGGGAATCGGTACGTACTGCGGTACGATTCTGAATACCTGTTA
CAGAGTTTGCCGATAACATT

Product: prolyl endopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MNALFGLCAVALAISLDASCALAQNLAASAPRLTYPPTERVEQFDDYHGTRVADPYRWLEDPNSPKTRAWVEAQNKVTFA
YLEGIPYREPLKERLTKIWNYEKYGIPNREGDRFFFTRNSGLQNQSVLYNAAKLGDAPRVLLDPNTLSKDGTVALTGIDI
TDDGRYLAYGTAASGSDWQQWHVREVATGRDLPDVIKWVKFSEASWLKDGKGFFYSRYDEPNAATQFQDVNYFQKLYFHR
LSTPQAQDVLVYERKDQKEWGFGGEVSEDGRYLVINVSQGTDPKNRVFYKDLQNNSGRVMELLPDADAAYTFIGNDGPRF
WFVTDKEAPRGRLVLIDTTRPLQLQEVVPQTDATLQSADIVGERLFLRYLKDARSQVKVFDLKGKFLSEVAFPGLGTVTG
FGGKRTDTETFYAFTSFTTPTTIYRYDIPTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNP
TYLYGYGGFNVSITPTFSPANLLWLEMGGLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKL
AIGGGSNGGLLVGAAMTQRPELFAAALPAVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPA
TLVTTADTDDRVVPGHSYKFTAALQAAQAGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF

Sequences:

>Translated_714_residues
MNALFGLCAVALAISLDASCALAQNLAASAPRLTYPPTERVEQFDDYHGTRVADPYRWLEDPNSPKTRAWVEAQNKVTFA
YLEGIPYREPLKERLTKIWNYEKYGIPNREGDRFFFTRNSGLQNQSVLYNAAKLGDAPRVLLDPNTLSKDGTVALTGIDI
TDDGRYLAYGTAASGSDWQQWHVREVATGRDLPDVIKWVKFSEASWLKDGKGFFYSRYDEPNAATQFQDVNYFQKLYFHR
LSTPQAQDVLVYERKDQKEWGFGGEVSEDGRYLVINVSQGTDPKNRVFYKDLQNNSGRVMELLPDADAAYTFIGNDGPRF
WFVTDKEAPRGRLVLIDTTRPLQLQEVVPQTDATLQSADIVGERLFLRYLKDARSQVKVFDLKGKFLSEVAFPGLGTVTG
FGGKRTDTETFYAFTSFTTPTTIYRYDIPTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNP
TYLYGYGGFNVSITPTFSPANLLWLEMGGLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKL
AIGGGSNGGLLVGAAMTQRPELFAAALPAVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPA
TLVTTADTDDRVVPGHSYKFTAALQAAQAGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF
>Mature_714_residues
MNALFGLCAVALAISLDASCALAQNLAASAPRLTYPPTERVEQFDDYHGTRVADPYRWLEDPNSPKTRAWVEAQNKVTFA
YLEGIPYREPLKERLTKIWNYEKYGIPNREGDRFFFTRNSGLQNQSVLYNAAKLGDAPRVLLDPNTLSKDGTVALTGIDI
TDDGRYLAYGTAASGSDWQQWHVREVATGRDLPDVIKWVKFSEASWLKDGKGFFYSRYDEPNAATQFQDVNYFQKLYFHR
LSTPQAQDVLVYERKDQKEWGFGGEVSEDGRYLVINVSQGTDPKNRVFYKDLQNNSGRVMELLPDADAAYTFIGNDGPRF
WFVTDKEAPRGRLVLIDTTRPLQLQEVVPQTDATLQSADIVGERLFLRYLKDARSQVKVFDLKGKFLSEVAFPGLGTVTG
FGGKRTDTETFYAFTSFTTPTTIYRYDIPTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNP
TYLYGYGGFNVSITPTFSPANLLWLEMGGLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKL
AIGGGSNGGLLVGAAMTQRPELFAAALPAVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPA
TLVTTADTDDRVVPGHSYKFTAALQAAQAGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=707, Percent_Identity=45.1202263083451, Blast_Score=620, Evalue=1e-178,
Organism=Homo sapiens, GI108860686, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172438, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172431, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172420, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172413, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI70778815, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI108860692, Length=225, Percent_Identity=26.2222222222222, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788150, Length=689, Percent_Identity=26.5602322206096, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24583414, Length=727, Percent_Identity=45.3920220082531, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI221510989, Length=721, Percent_Identity=42.1636615811373, Blast_Score=573, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 79785; Mature: 79785

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALFGLCAVALAISLDASCALAQNLAASAPRLTYPPTERVEQFDDYHGTRVADPYRWLE
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHC
DPNSPKTRAWVEAQNKVTFAYLEGIPYREPLKERLTKIWNYEKYGIPNREGDRFFFTRNS
CCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCHHCCCCCCCCCEEEEEECC
GLQNQSVLYNAAKLGDAPRVLLDPNTLSKDGTVALTGIDITDDGRYLAYGTAASGSDWQQ
CCCCCHHEEEHHHCCCCCEEEECCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCHHH
WHVREVATGRDLPDVIKWVKFSEASWLKDGKGFFYSRYDEPNAATQFQDVNYFQKLYFHR
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
LSTPQAQDVLVYERKDQKEWGFGGEVSEDGRYLVINVSQGTDPKNRVFYKDLQNNSGRVM
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCEE
ELLPDADAAYTFIGNDGPRFWFVTDKEAPRGRLVLIDTTRPLQLQEVVPQTDATLQSADI
EEECCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHCCCCCCCHHHHHH
VGERLFLRYLKDARSQVKVFDLKGKFLSEVAFPGLGTVTGFGGKRTDTETFYAFTSFTTP
HHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCC
TTIYRYDIPTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNP
EEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCC
TYLYGYGGFNVSITPTFSPANLLWLEMGGLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFD
CEEEEECCEEEEEEECCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHHCCCCHHHHHH
DFLAAAEYLIANKYTSPEKLAIGGGSNGGLLVGAAMTQRPELFAAALPAVGVMDMLRFEQ
HHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
FTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPATLVTTADTDDRVVPGHSYKF
EEEEEEEEECCCCCCCHHHHHHHHHCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEE
TAALQAAQAGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEEECC
>Mature Secondary Structure
MNALFGLCAVALAISLDASCALAQNLAASAPRLTYPPTERVEQFDDYHGTRVADPYRWLE
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHC
DPNSPKTRAWVEAQNKVTFAYLEGIPYREPLKERLTKIWNYEKYGIPNREGDRFFFTRNS
CCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCHHCCCCCCCCCEEEEEECC
GLQNQSVLYNAAKLGDAPRVLLDPNTLSKDGTVALTGIDITDDGRYLAYGTAASGSDWQQ
CCCCCHHEEEHHHCCCCCEEEECCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCHHH
WHVREVATGRDLPDVIKWVKFSEASWLKDGKGFFYSRYDEPNAATQFQDVNYFQKLYFHR
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
LSTPQAQDVLVYERKDQKEWGFGGEVSEDGRYLVINVSQGTDPKNRVFYKDLQNNSGRVM
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCEE
ELLPDADAAYTFIGNDGPRFWFVTDKEAPRGRLVLIDTTRPLQLQEVVPQTDATLQSADI
EEECCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHCCCCCCCHHHHHH
VGERLFLRYLKDARSQVKVFDLKGKFLSEVAFPGLGTVTGFGGKRTDTETFYAFTSFTTP
HHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCC
TTIYRYDIPTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNP
EEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCC
TYLYGYGGFNVSITPTFSPANLLWLEMGGLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFD
CEEEEECCEEEEEEECCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHHCCCCHHHHHH
DFLAAAEYLIANKYTSPEKLAIGGGSNGGLLVGAAMTQRPELFAAALPAVGVMDMLRFEQ
HHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
FTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPATLVTTADTDDRVVPGHSYKF
EEEEEEEEECCCCCCCHHHHHHHHHCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEE
TAALQAAQAGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]