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The map label for this gene is pdxA

Identifier: 34499686

GI number: 34499686

Start: 4566004

End: 4566990

Strand: Direct

Name: pdxA

Synonym: CV_4231

Alternate gene names: 34499686

Gene position: 4566004-4566990 (Clockwise)

Preceding gene: 34499685

Following gene: 34499690

Centisome position: 96.1

GC content: 72.75

Gene sequence:

>987_bases
ATGCCCAAGCGGCCCGTCCTGGCCGTCACCGCCGGCGAGCCGGCCGGCATCGGCCCCGACCTGGTGCTGCGGCTACCCGA
GCTGGCGCCGGAGGCCCGTTGCGTGGCGATCGCCGATCACGCCTTGCTGGCGGATCGCGCCGCGGCGCTGGGCCTGAACC
TGGAGCTGGCCGATTACCGCCGGGACCGGCCGGCGCCGGCCGGCGCGCTGGAGGTGCTGCACGTGCCGCTGGCCGCCCCG
GCGCAAGCCGGCAGGCTGGATCCGGCCAATGGCCGCTACGTGCTCGCCACGCTGGACGCGGCGATAGACGGCTGCGTGTC
CGGCGAGTTCGCCGCCATGGTGACCGCCCCGGTGCACAAAGGCGTGATCAACGACGCCGGCGTGCCGTTCACCGGCCACA
CCGAATACCTGGCGGAACGCACCGGCACGGGAAAAGTGGTGATGATGCTGGCCGGCGGCGGCATGCGCGTCGCGCTCGCC
ACCACCCACCTGCCCTTGCGCGAGGTCGCCGACGCGATCACCGCGCCGCTGCTGAATGAGGTGATCCGCATCCTGCACGC
CGACCTGGAAAACAAGTTCGGCATAGACGCGCCGCGCATCCTGGTGGCCGGCCTGAATCCGCACGCCGGCGAAGGCGGCC
ACATGGGCCGCGAGGAAATCGACGTCATCGAACCCGCGCTGGACGCGCTGCGCGCCGAAGGCATCAATCTGATCGGCCCG
CTGCCGGCCGACACGCTGTTCAATCCCGACAAGCTGGCCGCCGCCGACGCGGTGCTGGCGATGTACCACGACCAGGGCCT
GCCGGTGCTCAAGCACGCCAGCTTCGGCGCCGGCATCAACGTCACGCTGGGCCTGCCCATCGTCCGCACCTCGGTCGACC
ACGGCACCGCGCTGGACTTGGCCGGCAGCGGCCGCGCCGACCCGGGCAGCCTGCTGGAGGCGGTGCGGCTGGCGGAACAG
CTGGCCGGCCACGCGGGCAGGCGCTGA

Upstream 100 bases:

>100_bases
AGCAACAGATCCGCGCGCGCAAGATGGAGCAGGCTTACACCGACTGGGTGCGCCAGCTGCGCGACTCCGCCTTCGTCGAA
GAACACCTGGACGAGAAATG

Downstream 100 bases:

>100_bases
AGCCCTGCGAAACGGCTCAGCGCACCACCACCTGGTCCGGCAGCTCGTTGACGAAGGGCTCGCCGTTGCGCGGCGCGTGC
GCCAGCAACAAGGCGTGGAT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPKRPVLAVTAGEPAGIGPDLVLRLPELAPEARCVAIADHALLADRAAALGLNLELADYRRDRPAPAGALEVLHVPLAAP
AQAGRLDPANGRYVLATLDAAIDGCVSGEFAAMVTAPVHKGVINDAGVPFTGHTEYLAERTGTGKVVMMLAGGGMRVALA
TTHLPLREVADAITAPLLNEVIRILHADLENKFGIDAPRILVAGLNPHAGEGGHMGREEIDVIEPALDALRAEGINLIGP
LPADTLFNPDKLAAADAVLAMYHDQGLPVLKHASFGAGINVTLGLPIVRTSVDHGTALDLAGSGRADPGSLLEAVRLAEQ
LAGHAGRR

Sequences:

>Translated_328_residues
MPKRPVLAVTAGEPAGIGPDLVLRLPELAPEARCVAIADHALLADRAAALGLNLELADYRRDRPAPAGALEVLHVPLAAP
AQAGRLDPANGRYVLATLDAAIDGCVSGEFAAMVTAPVHKGVINDAGVPFTGHTEYLAERTGTGKVVMMLAGGGMRVALA
TTHLPLREVADAITAPLLNEVIRILHADLENKFGIDAPRILVAGLNPHAGEGGHMGREEIDVIEPALDALRAEGINLIGP
LPADTLFNPDKLAAADAVLAMYHDQGLPVLKHASFGAGINVTLGLPIVRTSVDHGTALDLAGSGRADPGSLLEAVRLAEQ
LAGHAGRR
>Mature_327_residues
PKRPVLAVTAGEPAGIGPDLVLRLPELAPEARCVAIADHALLADRAAALGLNLELADYRRDRPAPAGALEVLHVPLAAPA
QAGRLDPANGRYVLATLDAAIDGCVSGEFAAMVTAPVHKGVINDAGVPFTGHTEYLAERTGTGKVVMMLAGGGMRVALAT
THLPLREVADAITAPLLNEVIRILHADLENKFGIDAPRILVAGLNPHAGEGGHMGREEIDVIEPALDALRAEGINLIGPL
PADTLFNPDKLAAADAVLAMYHDQGLPVLKHASFGAGINVTLGLPIVRTSVDHGTALDLAGSGRADPGSLLEAVRLAEQL
AGHAGRR

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=324, Percent_Identity=62.962962962963, Blast_Score=386, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_CHRVO (Q7NQA9)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903901.1
- HSSP:   Q9I5U4
- ProteinModelPortal:   Q7NQA9
- SMR:   Q7NQA9
- GeneID:   2549783
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4231
- NMPDR:   fig|243365.1.peg.4231
- HOGENOM:   HBG451136
- OMA:   NPANAAY
- PhylomeDB:   Q7NQA9
- ProtClustDB:   PRK00232
- BioCyc:   CVIO243365:CV_4231-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 33876; Mature: 33745

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: BINDING 133-133 BINDING 134-134 BINDING 271-271 BINDING 280-280 BINDING 289-289

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRPVLAVTAGEPAGIGPDLVLRLPELAPEARCVAIADHALLADRAAALGLNLELADYR
CCCCCEEEEECCCCCCCCHHHEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEHHHC
RDRPAPAGALEVLHVPLAAPAQAGRLDPANGRYVLATLDAAIDGCVSGEFAAMVTAPVHK
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECHHHHHHCCCCCCEEEECHHHC
GVINDAGVPFTGHTEYLAERTGTGKVVMMLAGGGMRVALATTHLPLREVADAITAPLLNE
CCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH
VIRILHADLENKFGIDAPRILVAGLNPHAGEGGHMGREEIDVIEPALDALRAEGINLIGP
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECC
LPADTLFNPDKLAAADAVLAMYHDQGLPVLKHASFGAGINVTLGLPIVRTSVDHGTALDL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCEEEEECCCCCCEEEE
AGSGRADPGSLLEAVRLAEQLAGHAGRR
CCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKRPVLAVTAGEPAGIGPDLVLRLPELAPEARCVAIADHALLADRAAALGLNLELADYR
CCCCEEEEECCCCCCCCHHHEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEHHHC
RDRPAPAGALEVLHVPLAAPAQAGRLDPANGRYVLATLDAAIDGCVSGEFAAMVTAPVHK
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECHHHHHHCCCCCCEEEECHHHC
GVINDAGVPFTGHTEYLAERTGTGKVVMMLAGGGMRVALATTHLPLREVADAITAPLLNE
CCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH
VIRILHADLENKFGIDAPRILVAGLNPHAGEGGHMGREEIDVIEPALDALRAEGINLIGP
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECC
LPADTLFNPDKLAAADAVLAMYHDQGLPVLKHASFGAGINVTLGLPIVRTSVDHGTALDL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCEEEEECCCCCCEEEE
AGSGRADPGSLLEAVRLAEQLAGHAGRR
CCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782