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The map label for this gene is surA

Identifier: 34499685

GI number: 34499685

Start: 4564715

End: 4566004

Strand: Direct

Name: surA

Synonym: CV_4230

Alternate gene names: 34499685

Gene position: 4564715-4566004 (Clockwise)

Preceding gene: 34499684

Following gene: 34499686

Centisome position: 96.08

GC content: 65.58

Gene sequence:

>1290_bases
ATGAAAAAGACCCTGCTTGCCCTGTTGATCGCCAGCGTGATGCAAAGCGCCCTGGCGGCCCCCGCCACCCCGGTACGCGA
AGTGGATCGCATCGTCGCCGTGGTCAACAAGAACGTGATCACCTGGCAAGAGCTGCAGGCGCGCGTCAACGAAGCGATCA
AGCAGCTGGAAGCGCAAAAGGTGGCGCCGCCGCCGCGCGAAGTGCTGGAACGCCAGGTGCTGGAGCAGATGATCACCGAG
GAAGTCCAGCTGCAGTACGCGGCCAGCGGCGGCTTGCGCATCGAGGACGCCGCGGTCGACCAGGCGGTGGCCAACCTCGC
CAAGCAGAACAAGTTGAGCGAAGCGGGCCTGAAGGCCCAGCTGGCCAAAGACGGCATCACCCTGGATCGCCTGCGCGCAG
ACATCCGCCGCGAACTGACCATCTCCCGCCTGCGGGACAGCGAAGTGGCGTCCCGCGTCAACGTCAGCGACAGCGAAGTG
GATCAGGCGATGAAGAGCGCCCAGAGCGCCAACCGCACCGAATACCACCTGGCCAGCATCCTGGTCGCCGTGCCGGAGCG
GGCCGACGCCAAGCAAATCGACCAGCTGTCGCAGAAAGTCCACAAGGCCCAGGCCGACCTGGCCGCCGGCCAGCCGTTCG
CCAAAGTGTCCGCCGCTTACTCCGACGCGCCCAACGCGCTGAAGGGCGGCGACATGGGCTGGCGCAGCGCCACCTCGCTG
CCGCAGGAATTCGTCCAGTTGCTGGAGCAGATGAAGGTCGGCGCCGACACCGACGTGATCCGCACCCAGCAGGGCTTCTT
CATCTTCAAGCTGGTGGACAAACGCAGCGGCGGCGCGCCGATGATGGTGGAGCAGTACCACCCGCGCCACATCCTGATCC
GCACCAACGAGGCGGTGTCCGAAGCCGACGCCAAGGCCCGCATCGACCAGGTGCGCGACCGCATCATGCGCGGCGCTAAG
TTCGCCGACATGGCCAAGCTGTACTCTGAAGACGGCAGCAACGCCAAGGGCGGCGACCTGGGCTGGGTGAACATGGGCGA
CCTGGTGCCGGAATTCGAGAAGGCGATGGTGTCGCTGCCCATCGGCCAGGTGTCGCAGCCGGTGCGCACGCCGTTCGGCT
GGCACCTTATTCTGGTCGAGGGCAAGCGCAACCAGGACGTCTCCAGCGACCACGAGAAAATGGCGGTCAAGCAACAGATC
CGCGCGCGCAAGATGGAGCAGGCTTACACCGACTGGGTGCGCCAGCTGCGCGACTCCGCCTTCGTCGAAGAACACCTGGA
CGAGAAATGA

Upstream 100 bases:

>100_bases
ACTCAAGGGCCTCGGCGCCCTGGGCAACAACGGCGTGCAGGACACGCTGCGTCTGGCCGTACCCGGCTACACCAAGATTA
ACGAGTAACAAAGCCTGACC

Downstream 100 bases:

>100_bases
TGCCCAAGCGGCCCGTCCTGGCCGTCACCGCCGGCGAGCCGGCCGGCATCGGCCCCGACCTGGTGCTGCGGCTACCCGAG
CTGGCGCCGGAGGCCCGTTG

Product: survival protein surA

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKKTLLALLIASVMQSALAAPATPVREVDRIVAVVNKNVITWQELQARVNEAIKQLEAQKVAPPPREVLERQVLEQMITE
EVQLQYAASGGLRIEDAAVDQAVANLAKQNKLSEAGLKAQLAKDGITLDRLRADIRRELTISRLRDSEVASRVNVSDSEV
DQAMKSAQSANRTEYHLASILVAVPERADAKQIDQLSQKVHKAQADLAAGQPFAKVSAAYSDAPNALKGGDMGWRSATSL
PQEFVQLLEQMKVGADTDVIRTQQGFFIFKLVDKRSGGAPMMVEQYHPRHILIRTNEAVSEADAKARIDQVRDRIMRGAK
FADMAKLYSEDGSNAKGGDLGWVNMGDLVPEFEKAMVSLPIGQVSQPVRTPFGWHLILVEGKRNQDVSSDHEKMAVKQQI
RARKMEQAYTDWVRQLRDSAFVEEHLDEK

Sequences:

>Translated_429_residues
MKKTLLALLIASVMQSALAAPATPVREVDRIVAVVNKNVITWQELQARVNEAIKQLEAQKVAPPPREVLERQVLEQMITE
EVQLQYAASGGLRIEDAAVDQAVANLAKQNKLSEAGLKAQLAKDGITLDRLRADIRRELTISRLRDSEVASRVNVSDSEV
DQAMKSAQSANRTEYHLASILVAVPERADAKQIDQLSQKVHKAQADLAAGQPFAKVSAAYSDAPNALKGGDMGWRSATSL
PQEFVQLLEQMKVGADTDVIRTQQGFFIFKLVDKRSGGAPMMVEQYHPRHILIRTNEAVSEADAKARIDQVRDRIMRGAK
FADMAKLYSEDGSNAKGGDLGWVNMGDLVPEFEKAMVSLPIGQVSQPVRTPFGWHLILVEGKRNQDVSSDHEKMAVKQQI
RARKMEQAYTDWVRQLRDSAFVEEHLDEK
>Mature_429_residues
MKKTLLALLIASVMQSALAAPATPVREVDRIVAVVNKNVITWQELQARVNEAIKQLEAQKVAPPPREVLERQVLEQMITE
EVQLQYAASGGLRIEDAAVDQAVANLAKQNKLSEAGLKAQLAKDGITLDRLRADIRRELTISRLRDSEVASRVNVSDSEV
DQAMKSAQSANRTEYHLASILVAVPERADAKQIDQLSQKVHKAQADLAAGQPFAKVSAAYSDAPNALKGGDMGWRSATSL
PQEFVQLLEQMKVGADTDVIRTQQGFFIFKLVDKRSGGAPMMVEQYHPRHILIRTNEAVSEADAKARIDQVRDRIMRGAK
FADMAKLYSEDGSNAKGGDLGWVNMGDLVPEFEKAMVSLPIGQVSQPVRTPFGWHLILVEGKRNQDVSSDHEKMAVKQQI
RARKMEQAYTDWVRQLRDSAFVEEHLDEK

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains

Homologues:

Organism=Homo sapiens, GI38679892, Length=101, Percent_Identity=34.6534653465347, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786238, Length=364, Percent_Identity=33.2417582417582, Blast_Score=207, Evalue=7e-55,
Organism=Drosophila melanogaster, GI21356303, Length=101, Percent_Identity=38.6138613861386, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): SURA_CHRVO (Q7NQB0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903900.1
- HSSP:   P24327
- ProteinModelPortal:   Q7NQB0
- SMR:   Q7NQB0
- GeneID:   2549782
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4230
- NMPDR:   fig|243365.1.peg.4230
- HOGENOM:   HBG391483
- OMA:   RHILIKT
- PhylomeDB:   Q7NQB0
- ProtClustDB:   CLSK2485718
- BioCyc:   CVIO243365:CV_4230-MONOMER
- BRENDA:   5.2.1.8
- HAMAP:   MF_01183
- InterPro:   IPR000297
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 47592; Mature: 47592

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTLLALLIASVMQSALAAPATPVREVDRIVAVVNKNVITWQELQARVNEAIKQLEAQK
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
VAPPPREVLERQVLEQMITEEVQLQYAASGGLRIEDAAVDQAVANLAKQNKLSEAGLKAQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKDGITLDRLRADIRRELTISRLRDSEVASRVNVSDSEVDQAMKSAQSANRTEYHLASI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
LVAVPERADAKQIDQLSQKVHKAQADLAAGQPFAKVSAAYSDAPNALKGGDMGWRSATSL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHH
PQEFVQLLEQMKVGADTDVIRTQQGFFIFKLVDKRSGGAPMMVEQYHPRHILIRTNEAVS
HHHHHHHHHHHHCCCCCHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCEEEEECCHHHH
EADAKARIDQVRDRIMRGAKFADMAKLYSEDGSNAKGGDLGWVNMGDLVPEFEKAMVSLP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
IGQVSQPVRTPFGWHLILVEGKRNQDVSSDHEKMAVKQQIRARKMEQAYTDWVRQLRDSA
HHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVEEHLDEK
HHHHHCCCC
>Mature Secondary Structure
MKKTLLALLIASVMQSALAAPATPVREVDRIVAVVNKNVITWQELQARVNEAIKQLEAQK
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
VAPPPREVLERQVLEQMITEEVQLQYAASGGLRIEDAAVDQAVANLAKQNKLSEAGLKAQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKDGITLDRLRADIRRELTISRLRDSEVASRVNVSDSEVDQAMKSAQSANRTEYHLASI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
LVAVPERADAKQIDQLSQKVHKAQADLAAGQPFAKVSAAYSDAPNALKGGDMGWRSATSL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHH
PQEFVQLLEQMKVGADTDVIRTQQGFFIFKLVDKRSGGAPMMVEQYHPRHILIRTNEAVS
HHHHHHHHHHHHCCCCCHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCEEEEECCHHHH
EADAKARIDQVRDRIMRGAKFADMAKLYSEDGSNAKGGDLGWVNMGDLVPEFEKAMVSLP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
IGQVSQPVRTPFGWHLILVEGKRNQDVSSDHEKMAVKQQIRARKMEQAYTDWVRQLRDSA
HHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVEEHLDEK
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782