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The map label for this gene is apaH

Identifier: 34499522

GI number: 34499522

Start: 4397963

End: 4398796

Strand: Reverse

Name: apaH

Synonym: CV_4067

Alternate gene names: 34499522

Gene position: 4398796-4397963 (Counterclockwise)

Preceding gene: 34499524

Following gene: 34499521

Centisome position: 92.59

GC content: 64.15

Gene sequence:

>834_bases
ATGGCCATTTACGCAATCGGCGACATCCAGGGCTGCTTCGAGCCGTTCCAGCAGCTGCTGAGGCTGATCGATTTCAATCC
CGGCAAGGACACGCTGTGGCTGACCGGCGACCTGGTCAACCGCGGACCGCAATCGCTGGAGGTGTTGCGCTGGGTGTTCC
AGCATCAGGACCAGGTGGAGATGGTGCTGGGCAATCATGATCTGCACCTGCTGGCGGTGTCGGAAGGCTTCGGCAAGATC
CACCGCGACGACACCATAGACGATGTGCTCAACGCGGCCGACGGCAAGGTGCTGCTGGACTGGCTGCGTTGCCAGCCGAT
GATGCTGGAGGGGCACGGCTACGCGATGGTGCACGCCGGGCTGCTGCCGGAATGGACGATATCCAAGGCGCTCAGGCTGG
CGGAGGAGGTCGAGTTCGGCCTGTCCGGCACCCGCTACCGGGAATTCCTCGGCCGTTTGTACGGCAACAAGCCGACGCGC
TGGACCGACGATCTGAAAGGCGTGGACCGGCTGCGGCTGATCGTCAACGTGATGACGCGGATGCGCTTCCTGACCCGCGA
CGGCGAGCTGGATCTCAGCTACAAGGGCGAGCTGGAAGGCGCGCCGGCCAATCTGGTGCCCTGGTTCGAGGCGCCGAACC
GCCGCCATGGCGGCACGCCCATCGTCTGCGGGCACTGGTCGGCGCTGGGCGTGCATCTGGACGAAGACATCCTGGCGATC
GATTCCGGCTGTTTATGGGGCGGCAGCCTGTCGGCGCTCCGGCTGGATGACAAACAGCTTTTCTCGCTGCCTTGCCAGGC
TTACCGCGAAATCGCGCTTGCAACAGGCAGATAA

Upstream 100 bases:

>100_bases
CGGGCGCAGCAAATCGGTAATCAAGGCCATGCATTGTAGCATGGGGTATCATGGCTTATCGCGGATGAGGCGCGCTCGAT
CCGCCTGACAAGGGAACAAT

Downstream 100 bases:

>100_bases
ATAAATTTTTACCGGAGCTGGCATGCGGCGGGGCTTGTTGTCATAATTGCCGCCTCCGCCAGCTTGTTACCTTAGCATGA
GCTATCTGTCGATTGAATTC

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MAIYAIGDIQGCFEPFQQLLRLIDFNPGKDTLWLTGDLVNRGPQSLEVLRWVFQHQDQVEMVLGNHDLHLLAVSEGFGKI
HRDDTIDDVLNAADGKVLLDWLRCQPMMLEGHGYAMVHAGLLPEWTISKALRLAEEVEFGLSGTRYREFLGRLYGNKPTR
WTDDLKGVDRLRLIVNVMTRMRFLTRDGELDLSYKGELEGAPANLVPWFEAPNRRHGGTPIVCGHWSALGVHLDEDILAI
DSGCLWGGSLSALRLDDKQLFSLPCQAYREIALATGR

Sequences:

>Translated_277_residues
MAIYAIGDIQGCFEPFQQLLRLIDFNPGKDTLWLTGDLVNRGPQSLEVLRWVFQHQDQVEMVLGNHDLHLLAVSEGFGKI
HRDDTIDDVLNAADGKVLLDWLRCQPMMLEGHGYAMVHAGLLPEWTISKALRLAEEVEFGLSGTRYREFLGRLYGNKPTR
WTDDLKGVDRLRLIVNVMTRMRFLTRDGELDLSYKGELEGAPANLVPWFEAPNRRHGGTPIVCGHWSALGVHLDEDILAI
DSGCLWGGSLSALRLDDKQLFSLPCQAYREIALATGR
>Mature_276_residues
AIYAIGDIQGCFEPFQQLLRLIDFNPGKDTLWLTGDLVNRGPQSLEVLRWVFQHQDQVEMVLGNHDLHLLAVSEGFGKIH
RDDTIDDVLNAADGKVLLDWLRCQPMMLEGHGYAMVHAGLLPEWTISKALRLAEEVEFGLSGTRYREFLGRLYGNKPTRW
TDDLKGVDRLRLIVNVMTRMRFLTRDGELDLSYKGELEGAPANLVPWFEAPNRRHGGTPIVCGHWSALGVHLDEDILAID
SGCLWGGSLSALRLDDKQLFSLPCQAYREIALATGR

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=279, Percent_Identity=45.8781362007168, Blast_Score=244, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_CHRVO (Q7NQS0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903737.1
- ProteinModelPortal:   Q7NQS0
- SMR:   Q7NQS0
- GeneID:   2550938
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4067
- NMPDR:   fig|243365.1.peg.4067
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- PhylomeDB:   Q7NQS0
- ProtClustDB:   PRK00166
- BioCyc:   CVIO243365:CV_4067-MONOMER
- BRENDA:   3.6.1.41
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 31193; Mature: 31062

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYAIGDIQGCFEPFQQLLRLIDFNPGKDTLWLTGDLVNRGPQSLEVLRWVFQHQDQVE
CEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHCCHHHHHHHHHHHCCCCCEE
MVLGNHDLHLLAVSEGFGKIHRDDTIDDVLNAADGKVLLDWLRCQPMMLEGHGYAMVHAG
EEECCCCEEEEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCEEEECCCEEEEECC
LLPEWTISKALRLAEEVEFGLSGTRYREFLGRLYGNKPTRWTDDLKGVDRLRLIVNVMTR
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
MRFLTRDGELDLSYKGELEGAPANLVPWFEAPNRRHGGTPIVCGHWSALGVHLDEDILAI
HHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCEEEE
DSGCLWGGSLSALRLDDKQLFSLPCQAYREIALATGR
CCCCCCCCCCCEEEECCHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AIYAIGDIQGCFEPFQQLLRLIDFNPGKDTLWLTGDLVNRGPQSLEVLRWVFQHQDQVE
EEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHCCHHHHHHHHHHHCCCCCEE
MVLGNHDLHLLAVSEGFGKIHRDDTIDDVLNAADGKVLLDWLRCQPMMLEGHGYAMVHAG
EEECCCCEEEEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCEEEECCCEEEEECC
LLPEWTISKALRLAEEVEFGLSGTRYREFLGRLYGNKPTRWTDDLKGVDRLRLIVNVMTR
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
MRFLTRDGELDLSYKGELEGAPANLVPWFEAPNRRHGGTPIVCGHWSALGVHLDEDILAI
HHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCEEEE
DSGCLWGGSLSALRLDDKQLFSLPCQAYREIALATGR
CCCCCCCCCCCEEEECCHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782