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The map label for this gene is ispA [H]

Identifier: 34499413

GI number: 34499413

Start: 4278258

End: 4279397

Strand: Reverse

Name: ispA [H]

Synonym: CV_3958

Alternate gene names: 34499413

Gene position: 4279397-4278258 (Counterclockwise)

Preceding gene: 34499414

Following gene: 34499412

Centisome position: 90.07

GC content: 72.19

Gene sequence:

>1140_bases
ATGCCGGCCGAACTGGAGCGGCTGCGGGGCAGGATAGACGAATGCATCGCGGCGGCGATCGAATCGCTGCGCGAGGACGG
GCCGGAGCGCGGCCATCCGCTGATAGGCCGCGTGTACGGCTGGCTGCGGCATTACCTGGACTGCGACGGCAAGCGGATGC
ACGGCATCGCCGCGGCGCTGGCCCATCTGGCCTGCGGCGGCGGCGAGGACGCCATCCTGCCGGTGGCCGCGGCGATGCAG
CTGTACCACCACCATACCCTGGTGCACGACGACATCTACGACGAGGATGCGGCGCGGCGAGGCTGGCCGACCGTGCACCA
GGCCTTCGCCGGCTGGTTCGCCGATCGGCGCGGGTCGGAGGAGGGCGTCGGCAGGGTGTTTTCCGGCGGCGCGATGCGGC
GCGGCGCGATCACCGCCTTCGCCTACGGCAAGATCTGCCGCGCGCTGGCCGGCAGGCTGCTGCTGGAGAGCGGATTCGAC
CAGGCCGCGGTGCTGGACGTCGCCCGCGCGCTGGAGAGGCACGAATTCTTCGACAACGCGGCCCAGCTCAAGGACGTGTT
CCACGAGGGCGACGAGATGCCATCGCCGCAGGCCTGCCTGGATAACGCCTGGCTGAAGACCGGCAGGCTATTCGAGCTGT
GCGCGTACGCCGGCGCGCGGCTGGCCGGCGCGGAAGCGGGCCGGACCAAGGCGCTGGAGCGCTGGGCGGGGCAATCGGCG
CTGGCCTACCAGCTGCAGGATGATCTGGAGGACTTGAACGCTGCCAGCGAGAAGGGACAGGGGCGCGGCGTCGCCACCGA
CCTGCTGCACTGCAAGCCCACCTATCTCTACGCGCTGGCCAAGACCATGGCCGAGGGCCGCGACCGCGACGCGCTGCTGG
CGTGGCAATCGGGCGCGCAGGCCGGCCTGGACAGCGGCGACATCATCGCCATCCTGGCGCGCAGCGGCGCGCTGGACGCC
TGCGGGGGCGAAGTGGCGCGCTGCATCGCCCGCGCCGGCGCGGCGCTGGACGGCGCGGTGCCGGCATTGGCGGCGGACAG
GCTGCCGCTGCTGCGGCAATTTTCCGACTACTTCGTGTCGCCGGCCTACTGGCATCGTCCGCTGGCGGCTTCGCGCCCGG
CGGCGGCGCTGCTGGCCTGA

Upstream 100 bases:

>100_bases
GATCGGCCGTGTCCGGAGAGGCGGCGCGGCGCTCCGCGCCGGCGACCATCGCATGAGCAAGGAGCCGTTGATGAACGCAA
CAGCGCACGATGCGCAGCGC

Downstream 100 bases:

>100_bases
GGAGGACGCCATGGCTTACGCGCCCCTGATCTTCGATCTGCACGGCGTGCTGCTGGGCCGGCGGGAGCCCGATGGCCATC
TGCCGGCCGGAGAAGTGCTG

Product: octaprenyl-diphosphate synthase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPAELERLRGRIDECIAAAIESLREDGPERGHPLIGRVYGWLRHYLDCDGKRMHGIAAALAHLACGGGEDAILPVAAAMQ
LYHHHTLVHDDIYDEDAARRGWPTVHQAFAGWFADRRGSEEGVGRVFSGGAMRRGAITAFAYGKICRALAGRLLLESGFD
QAAVLDVARALERHEFFDNAAQLKDVFHEGDEMPSPQACLDNAWLKTGRLFELCAYAGARLAGAEAGRTKALERWAGQSA
LAYQLQDDLEDLNAASEKGQGRGVATDLLHCKPTYLYALAKTMAEGRDRDALLAWQSGAQAGLDSGDIIAILARSGALDA
CGGEVARCIARAGAALDGAVPALAADRLPLLRQFSDYFVSPAYWHRPLAASRPAAALLA

Sequences:

>Translated_379_residues
MPAELERLRGRIDECIAAAIESLREDGPERGHPLIGRVYGWLRHYLDCDGKRMHGIAAALAHLACGGGEDAILPVAAAMQ
LYHHHTLVHDDIYDEDAARRGWPTVHQAFAGWFADRRGSEEGVGRVFSGGAMRRGAITAFAYGKICRALAGRLLLESGFD
QAAVLDVARALERHEFFDNAAQLKDVFHEGDEMPSPQACLDNAWLKTGRLFELCAYAGARLAGAEAGRTKALERWAGQSA
LAYQLQDDLEDLNAASEKGQGRGVATDLLHCKPTYLYALAKTMAEGRDRDALLAWQSGAQAGLDSGDIIAILARSGALDA
CGGEVARCIARAGAALDGAVPALAADRLPLLRQFSDYFVSPAYWHRPLAASRPAAALLA
>Mature_378_residues
PAELERLRGRIDECIAAAIESLREDGPERGHPLIGRVYGWLRHYLDCDGKRMHGIAAALAHLACGGGEDAILPVAAAMQL
YHHHTLVHDDIYDEDAARRGWPTVHQAFAGWFADRRGSEEGVGRVFSGGAMRRGAITAFAYGKICRALAGRLLLESGFDQ
AAVLDVARALERHEFFDNAAQLKDVFHEGDEMPSPQACLDNAWLKTGRLFELCAYAGARLAGAEAGRTKALERWAGQSAL
AYQLQDDLEDLNAASEKGQGRGVATDLLHCKPTYLYALAKTMAEGRDRDALLAWQSGAQAGLDSGDIIAILARSGALDAC
GGEVARCIARAGAALDGAVPALAADRLPLLRQFSDYFVSPAYWHRPLAASRPAAALLA

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 40754; Mature: 40623

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAELERLRGRIDECIAAAIESLREDGPERGHPLIGRVYGWLRHYLDCDGKRMHGIAAAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
AHLACGGGEDAILPVAAAMQLYHHHTLVHDDIYDEDAARRGWPTVHQAFAGWFADRRGSE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCH
EGVGRVFSGGAMRRGAITAFAYGKICRALAGRLLLESGFDQAAVLDVARALERHEFFDNA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AQLKDVFHEGDEMPSPQACLDNAWLKTGRLFELCAYAGARLAGAEAGRTKALERWAGQSA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCHH
LAYQLQDDLEDLNAASEKGQGRGVATDLLHCKPTYLYALAKTMAEGRDRDALLAWQSGAQ
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCC
AGLDSGDIIAILARSGALDACGGEVARCIARAGAALDGAVPALAADRLPLLRQFSDYFVS
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCC
PAYWHRPLAASRPAAALLA
HHHHHCCCCCCCCHHHHCC
>Mature Secondary Structure 
PAELERLRGRIDECIAAAIESLREDGPERGHPLIGRVYGWLRHYLDCDGKRMHGIAAAL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
AHLACGGGEDAILPVAAAMQLYHHHTLVHDDIYDEDAARRGWPTVHQAFAGWFADRRGSE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCH
EGVGRVFSGGAMRRGAITAFAYGKICRALAGRLLLESGFDQAAVLDVARALERHEFFDNA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AQLKDVFHEGDEMPSPQACLDNAWLKTGRLFELCAYAGARLAGAEAGRTKALERWAGQSA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCHH
LAYQLQDDLEDLNAASEKGQGRGVATDLLHCKPTYLYALAKTMAEGRDRDALLAWQSGAQ
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCC
AGLDSGDIIAILARSGALDACGGEVARCIARAGAALDGAVPALAADRLPLLRQFSDYFVS
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCC
PAYWHRPLAASRPAAALLA
HHHHHCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8182085 [H]