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The map label for this gene is ffh [H]

Identifier: 34499288

GI number: 34499288

Start: 4130486

End: 4131841

Strand: Direct

Name: ffh [H]

Synonym: CV_3833

Alternate gene names: 34499288

Gene position: 4130486-4131841 (Clockwise)

Preceding gene: 34499277

Following gene: 34499289

Centisome position: 86.94

GC content: 64.6

Gene sequence:

>1356_bases
ATGCTAGACAACTTGACCAGCCGCCTGTCCGGCGTGATGAAAACCTTGCGCGGCAACGCGCGGCTGACGGAATCGAACAT
CCAGGACGCGATGCGCGAAGTGCGCATGGCGCTGTTGGAAGCCGACGTGGCGCTGCCCGTCGTCAAAACCTTCATCGCCC
AGGTGAAGGAGCGCGCGCTGGGCCAGGACGTGATGGGCAGCCTGACCCCGGGCCAAGCGCTGGTGGGCGTGGTCAACGAA
GAGCTCGTCAAGCTGATGGGCGACAAGAACGACGAGCTCAACCTGGCTGCCGTGCCGCCCGCCATCGTGCTGATGGCCGG
CCTGCAGGGCGCCGGCAAGACCACCACCGTCGGCAAGCTGGCCAAAAGGCTGAAGGAAACCCAGAAGAAGAAGGTGCTGG
TGGTTTCCGCCGACGTCTACCGCCCCGCCGCCATCGAGCAGCTGAAGCTGCTGGCCTCGCAGGTGGGCGTGGAATGGTTC
CCGTCCGACGAGAAGCAGAAACCGGTCGACATCGCCCGCGCCGCGATCGACCACGCGCGCCGCCACTTCTTCGACGTGCT
GCTGGTCGACACCGCCGGCCGCCTCGCCATCGACGAGGCGATGATGGAGGAGATCAAGGCGCTGCACGCGGCGATCAACC
CGGTGGAGACGCTGTTCGTGGTGGACGCGATGCAGGGCCAGGACGCGGTCAACACCGCCAAGGCCTTCAATGAAGCGCTG
CCGCTGACCGGCGTCATCCTCACCAAGATGGACGGCGATTCGCGCGGCGGCGCCGCGCTGTCGGTGCGCCACGTCACCGG
CAAGCCGATCAAGTTCATCGGCGTCGGCGAAAAGGTCGCCGCCATCGAACCGTTCCACCCCGACCGCATCGCCAGCCGCA
TCCTGGGCATGGGCGATGTGCTGTCGCTGATCGAAGAAGTCCAGAAGGGCATCGATCAGAAGGAAGCGGAGGCGATGGCC
AAGAAGCTGAAGTCCGGCAAGGGTTTCGACCTGGAGGACTTCAAGGCTCAGATGCAGCAAATGAAGAAGATGGGCGGCAT
GGCCAACCTGCTGGAAAAGATGCCGGGCCAGCTGGGCGAGATGGCCAAGGGCGTGCAGGGCGCGGAGGCCGAGAAGGCGA
TGCGCCGCGTCGAAGGCATCATCAACTCGATGACGCCGGAAGAGCGCCGCAAGCCGGAACTGCTGAAGGCCAGCCGCAAA
CGCCGCATCGCCGCCGGCTCCGGCGTGACGGTGCAAGAGGTGAACCGCCTGCTCAACCAGTTCGAACAGATGCAGAAGAT
GATGAAGCAGTTCTCGTCCAAGGGCGGGATGATGAAGATGATGCGCGGCATGAAGGGCATGATGCCCGGCATGTAA

Upstream 100 bases:

>100_bases
TCAAATCCGGGCGCGGCCCGGGCGGCTCGTGGTAAAATCGACGGATTTGAGAGTCTACACCAAGCTGCCGCTCGTTGGCA
GAGAGTAAGGACAGCACCCC

Downstream 100 bases:

>100_bases
GCAAAACCAACGGGCGCTAGTCGCCCGTTTCTTTTGAGATGAAGACAAGCTGCCGGCAAGATGGCAGCCAGCCGCTACAT
TGATAGGAAGGCGAGCCGGC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLDNLTSRLSGVMKTLRGNARLTESNIQDAMREVRMALLEADVALPVVKTFIAQVKERALGQDVMGSLTPGQALVGVVNE
ELVKLMGDKNDELNLAAVPPAIVLMAGLQGAGKTTTVGKLAKRLKETQKKKVLVVSADVYRPAAIEQLKLLASQVGVEWF
PSDEKQKPVDIARAAIDHARRHFFDVLLVDTAGRLAIDEAMMEEIKALHAAINPVETLFVVDAMQGQDAVNTAKAFNEAL
PLTGVILTKMDGDSRGGAALSVRHVTGKPIKFIGVGEKVAAIEPFHPDRIASRILGMGDVLSLIEEVQKGIDQKEAEAMA
KKLKSGKGFDLEDFKAQMQQMKKMGGMANLLEKMPGQLGEMAKGVQGAEAEKAMRRVEGIINSMTPEERRKPELLKASRK
RRIAAGSGVTVQEVNRLLNQFEQMQKMMKQFSSKGGMMKMMRGMKGMMPGM

Sequences:

>Translated_451_residues
MLDNLTSRLSGVMKTLRGNARLTESNIQDAMREVRMALLEADVALPVVKTFIAQVKERALGQDVMGSLTPGQALVGVVNE
ELVKLMGDKNDELNLAAVPPAIVLMAGLQGAGKTTTVGKLAKRLKETQKKKVLVVSADVYRPAAIEQLKLLASQVGVEWF
PSDEKQKPVDIARAAIDHARRHFFDVLLVDTAGRLAIDEAMMEEIKALHAAINPVETLFVVDAMQGQDAVNTAKAFNEAL
PLTGVILTKMDGDSRGGAALSVRHVTGKPIKFIGVGEKVAAIEPFHPDRIASRILGMGDVLSLIEEVQKGIDQKEAEAMA
KKLKSGKGFDLEDFKAQMQQMKKMGGMANLLEKMPGQLGEMAKGVQGAEAEKAMRRVEGIINSMTPEERRKPELLKASRK
RRIAAGSGVTVQEVNRLLNQFEQMQKMMKQFSSKGGMMKMMRGMKGMMPGM
>Mature_451_residues
MLDNLTSRLSGVMKTLRGNARLTESNIQDAMREVRMALLEADVALPVVKTFIAQVKERALGQDVMGSLTPGQALVGVVNE
ELVKLMGDKNDELNLAAVPPAIVLMAGLQGAGKTTTVGKLAKRLKETQKKKVLVVSADVYRPAAIEQLKLLASQVGVEWF
PSDEKQKPVDIARAAIDHARRHFFDVLLVDTAGRLAIDEAMMEEIKALHAAINPVETLFVVDAMQGQDAVNTAKAFNEAL
PLTGVILTKMDGDSRGGAALSVRHVTGKPIKFIGVGEKVAAIEPFHPDRIASRILGMGDVLSLIEEVQKGIDQKEAEAMA
KKLKSGKGFDLEDFKAQMQQMKKMGGMANLLEKMPGQLGEMAKGVQGAEAEKAMRRVEGIINSMTPEERRKPELLKASRK
RRIAAGSGVTVQEVNRLLNQFEQMQKMMKQFSSKGGMMKMMRGMKGMMPGM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=462, Percent_Identity=32.2510822510823, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI226371618, Length=380, Percent_Identity=33.9473684210526, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=38.3647798742138, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=27.9220779220779, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=27.9220779220779, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788963, Length=449, Percent_Identity=68.3741648106904, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=34.7169811320755, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=31.1659192825112, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI193206261, Length=295, Percent_Identity=30.5084745762712, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=455, Percent_Identity=34.2857142857143, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=325, Percent_Identity=27.0769230769231, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17647949, Length=447, Percent_Identity=30.8724832214765, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.5454545454545, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49099; Mature: 49099

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTSRLSGVMKTLRGNARLTESNIQDAMREVRMALLEADVALPVVKTFIAQVKERAL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQDVMGSLTPGQALVGVVNEELVKLMGDKNDELNLAAVPPAIVLMAGLQGAGKTTTVGKL
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCCCCCHHHHHH
AKRLKETQKKKVLVVSADVYRPAAIEQLKLLASQVGVEWFPSDEKQKPVDIARAAIDHAR
HHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
RHFFDVLLVDTAGRLAIDEAMMEEIKALHAAINPVETLFVVDAMQGQDAVNTAKAFNEAL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLTGVILTKMDGDSRGGAALSVRHVTGKPIKFIGVGEKVAAIEPFHPDRIASRILGMGDV
CCHHEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEEVQKGIDQKEAEAMAKKLKSGKGFDLEDFKAQMQQMKKMGGMANLLEKMPGQLGE
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHH
MAKGVQGAEAEKAMRRVEGIINSMTPEERRKPELLKASRKRRIAAGSGVTVQEVNRLLNQ
HHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FEQMQKMMKQFSSKGGMMKMMRGMKGMMPGM
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLDNLTSRLSGVMKTLRGNARLTESNIQDAMREVRMALLEADVALPVVKTFIAQVKERAL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQDVMGSLTPGQALVGVVNEELVKLMGDKNDELNLAAVPPAIVLMAGLQGAGKTTTVGKL
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCCCCCHHHHHH
AKRLKETQKKKVLVVSADVYRPAAIEQLKLLASQVGVEWFPSDEKQKPVDIARAAIDHAR
HHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
RHFFDVLLVDTAGRLAIDEAMMEEIKALHAAINPVETLFVVDAMQGQDAVNTAKAFNEAL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHC
PLTGVILTKMDGDSRGGAALSVRHVTGKPIKFIGVGEKVAAIEPFHPDRIASRILGMGDV
CCHHEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEEVQKGIDQKEAEAMAKKLKSGKGFDLEDFKAQMQQMKKMGGMANLLEKMPGQLGE
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHH
MAKGVQGAEAEKAMRRVEGIINSMTPEERRKPELLKASRKRRIAAGSGVTVQEVNRLLNQ
HHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FEQMQKMMKQFSSKGGMMKMMRGMKGMMPGM
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]