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The map label for this gene is gmk

Identifier: 34499225

GI number: 34499225

Start: 4068276

End: 4068908

Strand: Reverse

Name: gmk

Synonym: CV_3770

Alternate gene names: 34499225

Gene position: 4068908-4068276 (Counterclockwise)

Preceding gene: 34499228

Following gene: 34499224

Centisome position: 85.64

GC content: 67.14

Gene sequence:

>633_bases
ATGAACCAGCCCATCGGCAACATTTACATCGTGGTGGCGCCCTCCGGCGCCGGCAAGACCTCGCTGGTGGCAGCGCTGTT
GCAGGCCGAGCCGAGCGTCGAGCTGTCGATTTCCTATAGCACACGCCAGGCGCGCAAGGGCGAGATCGACGGCCAGCATT
ACCACTTCATCGACCGCGCGGCTTTCGAAGAGATGAAGGACCGCGGCGACTTCCTGGAGTGGGCCGAGGTGTACGGCAAC
TGCTACGGCACCAGCGCGCCGTGGATACGCGGCCGCCTGGAGGCCGGCAGGGACATCCTGCTGGAAATCGACTGGCAGGG
CGCCGAGCAGGTGCGCAAGGTTTTTCCGGACGCCATCGGCATCTTCATCGCCCCGCCGTCCATCGAGGAGCTGGAGCGCC
GCCTGCGCGGCCGCGACACCGACACCGAGGAAGTGATCCTGCGCCGGCTGGCCTCGGCCCGCGCCGAGATCGACAAGATC
GCCGAGTACGACTACATCGTGGTCAACGACGACTTCGAGCGCGCGCGGCTGGATCTGATCAGCATCGTGCGCGCTCAGCG
CCTGAGAAGCGCCCCGCAGTGCCGCCGGCTGGCCGACATGTTCCGCCGCATGGGCACCGCCGGCGCGAAATGA

Upstream 100 bases:

>100_bases
AACACCTAAATCTTGACGTGAAAATATGTCATTGCTTAACAATGGCGGTCCCGCTGTGCTATCCTGAAAAATTACTCTTT
GGCAAATGTTGGTAGCTTGC

Downstream 100 bases:

>100_bases
AAATAGTTCCGTCCCGCCGTGCCGGACGGGACGAAAATCGATATAGTGAACCCTGTAACCGTCATTAGCTGAGAGAGATC
ATGGCCCGTATTACCGTTGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNQPIGNIYIVVAPSGAGKTSLVAALLQAEPSVELSISYSTRQARKGEIDGQHYHFIDRAAFEEMKDRGDFLEWAEVYGN
CYGTSAPWIRGRLEAGRDILLEIDWQGAEQVRKVFPDAIGIFIAPPSIEELERRLRGRDTDTEEVILRRLASARAEIDKI
AEYDYIVVNDDFERARLDLISIVRAQRLRSAPQCRRLADMFRRMGTAGAK

Sequences:

>Translated_210_residues
MNQPIGNIYIVVAPSGAGKTSLVAALLQAEPSVELSISYSTRQARKGEIDGQHYHFIDRAAFEEMKDRGDFLEWAEVYGN
CYGTSAPWIRGRLEAGRDILLEIDWQGAEQVRKVFPDAIGIFIAPPSIEELERRLRGRDTDTEEVILRRLASARAEIDKI
AEYDYIVVNDDFERARLDLISIVRAQRLRSAPQCRRLADMFRRMGTAGAK
>Mature_210_residues
MNQPIGNIYIVVAPSGAGKTSLVAALLQAEPSVELSISYSTRQARKGEIDGQHYHFIDRAAFEEMKDRGDFLEWAEVYGN
CYGTSAPWIRGRLEAGRDILLEIDWQGAEQVRKVFPDAIGIFIAPPSIEELERRLRGRDTDTEEVILRRLASARAEIDKI
AEYDYIVVNDDFERARLDLISIVRAQRLRSAPQCRRLADMFRRMGTAGAK

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=174, Percent_Identity=36.7816091954023, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI4504221, Length=174, Percent_Identity=36.7816091954023, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI226874831, Length=174, Percent_Identity=36.7816091954023, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI38570142, Length=189, Percent_Identity=30.6878306878307, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI14780902, Length=200, Percent_Identity=25, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21361598, Length=194, Percent_Identity=26.8041237113402, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI52630447, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI111154074, Length=154, Percent_Identity=31.1688311688312, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=193, Percent_Identity=54.4041450777202, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=37.2222222222222, Blast_Score=129, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=37.2222222222222, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=192, Percent_Identity=36.9791666666667, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=39.1061452513966, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI161077626, Length=186, Percent_Identity=28.494623655914, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640542, Length=186, Percent_Identity=28.494623655914, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007136, Length=186, Percent_Identity=28.494623655914, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI85724806, Length=186, Percent_Identity=28.494623655914, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45554481, Length=186, Percent_Identity=28.494623655914, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45554489, Length=186, Percent_Identity=28.494623655914, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CHRVO (Q7NRL1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903440.1
- ProteinModelPortal:   Q7NRL1
- GeneID:   2548445
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3770
- NMPDR:   fig|243365.1.peg.3770
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q7NRL1
- BioCyc:   CVIO243365:CV_3770-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23758; Mature: 23758

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPIGNIYIVVAPSGAGKTSLVAALLQAEPSVELSISYSTRQARKGEIDGQHYHFIDRA
CCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECHHHHCCCCCCCCHHHHHHHH
AFEEMKDRGDFLEWAEVYGNCYGTSAPWIRGRLEAGRDILLEIDWQGAEQVRKVFPDAIG
HHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHHCHHHHE
IFIAPPSIEELERRLRGRDTDTEEVILRRLASARAEIDKIAEYDYIVVNDDFERARLDLI
EEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHH
SIVRAQRLRSAPQCRRLADMFRRMGTAGAK
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNQPIGNIYIVVAPSGAGKTSLVAALLQAEPSVELSISYSTRQARKGEIDGQHYHFIDRA
CCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECHHHHCCCCCCCCHHHHHHHH
AFEEMKDRGDFLEWAEVYGNCYGTSAPWIRGRLEAGRDILLEIDWQGAEQVRKVFPDAIG
HHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHHCHHHHE
IFIAPPSIEELERRLRGRDTDTEEVILRRLASARAEIDKIAEYDYIVVNDDFERARLDLI
EEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHH
SIVRAQRLRSAPQCRRLADMFRRMGTAGAK
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782