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The map label for this gene is tppB

Identifier: 34499210

GI number: 34499210

Start: 4052421

End: 4053908

Strand: Reverse

Name: tppB

Synonym: CV_3755

Alternate gene names: 34499210

Gene position: 4053908-4052421 (Counterclockwise)

Preceding gene: 34499211

Following gene: 34499207

Centisome position: 85.33

GC content: 64.52

Gene sequence:

>1488_bases
ATGACGACGTCTGCGCTCAACCCCTTGCGCCAGCCCAAGCCGTTCTACCTGATCTTCTCGATCGAATTCTGGGAGCGTTT
CGGTTTCTATGGCCTGCAGGGCATCCTGGCCGTTTACCTGGTGAAGGCCCTGGGCCTGCGCGAGGCCGACTCCTTCACGC
TGTTCTCCTCCTTCATCGCGCTGGTGTATGGCCTGATCGCCGTCGGCGGCTGGCTGGGCGACAAGGTGCTGGGAACCAAG
CGCACCATCCTGCTGGGCGCGCTGGTGCTGACCGCCGGCTACGCGATGGTGACCGCGTCGTCCGAGCATATCAGCCTGCT
TTACTTGGGCATGGGCACCATCGCGGTGGGCAACGGCCTGTTCAAGGCCAATCCGTCGTCGCTGCTGTCCAAGTGCTACG
AGGAGAACGATCCGCGGCTGGACGGCGCCTTCACCATGTACTACATGGCGATCAACATCGGTTCGCTGCTGTCGATGCTG
GCCACGCCGTGGCTGGCCGACCAGTTCGGCTACGCCCACGCCTTCGCGCTGTCGGTGGTGGGCATGCTGATCACCGTCGC
CAATTTCATCCTGATGCAAGGCTGGGTGAAGAACTACGGTTCCGACGCCGACTTCCGCACGCCCAGGCTGTCCACCTGGC
TGGCGGTGCTGGCCGGCGTGGTGGCCGCCTGCGCCGCCGCCGCGCTGCTGCTCAAGCACGAGATCATCGCCAACGTGGTG
CTGGCCGTGCTGTCGATCGGCGTGGTGGGCCTGTACGTCAAGGAAACGCTGCTGCTGAAAGGCGCGGAGCGCAAGAAGAT
GATCGTGGCCGCCATCCTGATGCTGCAGGCAACCGTGTTCTTCGTGCTGTACAACCAGATGCCGCTGTCGCTGAACTTCT
TCGCCATCCACAACACCGAGCACATGCTGTTCGGCATCCCGGTGCAGCCGGAGCAGTTCCAGTCGCTGAATCCGTTCTGG
ATCATGCTGGCCAGTCCGCTGCTTGCCTTGTGCTACAACAAGCTGGGCAATCGCCTGCCGATGCCGCACAAGTTCGCGAT
CGGCATGGTGCTGTGCGCCGGTGCCTTCCTGGTGCTGCCGCTGGGCGCCAAGTACGCCAACGCGCAGGGCCTGGTGTCGT
CCAACTGGATGGTGCTGAGCTATCTGCTGCAGAGCGTGGGCGAGCTGCTGATCTCGGGCCTGGGGCTGGCGATGGTGGCG
CAGCTGGTGCCGCAGCGTCTGATGGGCTTCATCATGGGCGCCTGGTTCCTGACCTCGGCCGCGTCGTCGGTGATCGCCGG
CTGGGTGGCGGGCCTGACCGCCGCGCCGGACAACGTGACCAACCCGCTGGCCACGCTGGAGATCTACAGCCGCGTGTTCA
CCCAGATCGGCGTGGTGACCGGCGTGATCGCGGTGGTGACCATCATCATCGCGCCGTGGCTGCACCGGATGACGCTGGAC
GAGAAGCCGGCGCATCCTGAACACGAGATGGCGCTGGACGCTCGTTAA

Upstream 100 bases:

>100_bases
ACTGGCGATGGCCGGCGCCCTGGGGGCCTGTCTTTCCGTCATTCCGCCACGCAGGAGCTTTTCCCGGGTCCGCGGCAGTT
CTGATTACAAGGAACCCAAT

Downstream 100 bases:

>100_bases
GCCGGCGCGCGAGTAAAAAAACGGAGACCATGCGGCCTCCGTTTTTTTTATCCATCCAGCCGGCGGCTCCAGTCTTCCAG
TTGGCCGCTTTCCAGCCGTT

Product: tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MTTSALNPLRQPKPFYLIFSIEFWERFGFYGLQGILAVYLVKALGLREADSFTLFSSFIALVYGLIAVGGWLGDKVLGTK
RTILLGALVLTAGYAMVTASSEHISLLYLGMGTIAVGNGLFKANPSSLLSKCYEENDPRLDGAFTMYYMAINIGSLLSML
ATPWLADQFGYAHAFALSVVGMLITVANFILMQGWVKNYGSDADFRTPRLSTWLAVLAGVVAACAAAALLLKHEIIANVV
LAVLSIGVVGLYVKETLLLKGAERKKMIVAAILMLQATVFFVLYNQMPLSLNFFAIHNTEHMLFGIPVQPEQFQSLNPFW
IMLASPLLALCYNKLGNRLPMPHKFAIGMVLCAGAFLVLPLGAKYANAQGLVSSNWMVLSYLLQSVGELLISGLGLAMVA
QLVPQRLMGFIMGAWFLTSAASSVIAGWVAGLTAAPDNVTNPLATLEIYSRVFTQIGVVTGVIAVVTIIIAPWLHRMTLD
EKPAHPEHEMALDAR

Sequences:

>Translated_495_residues
MTTSALNPLRQPKPFYLIFSIEFWERFGFYGLQGILAVYLVKALGLREADSFTLFSSFIALVYGLIAVGGWLGDKVLGTK
RTILLGALVLTAGYAMVTASSEHISLLYLGMGTIAVGNGLFKANPSSLLSKCYEENDPRLDGAFTMYYMAINIGSLLSML
ATPWLADQFGYAHAFALSVVGMLITVANFILMQGWVKNYGSDADFRTPRLSTWLAVLAGVVAACAAAALLLKHEIIANVV
LAVLSIGVVGLYVKETLLLKGAERKKMIVAAILMLQATVFFVLYNQMPLSLNFFAIHNTEHMLFGIPVQPEQFQSLNPFW
IMLASPLLALCYNKLGNRLPMPHKFAIGMVLCAGAFLVLPLGAKYANAQGLVSSNWMVLSYLLQSVGELLISGLGLAMVA
QLVPQRLMGFIMGAWFLTSAASSVIAGWVAGLTAAPDNVTNPLATLEIYSRVFTQIGVVTGVIAVVTIIIAPWLHRMTLD
EKPAHPEHEMALDAR
>Mature_494_residues
TTSALNPLRQPKPFYLIFSIEFWERFGFYGLQGILAVYLVKALGLREADSFTLFSSFIALVYGLIAVGGWLGDKVLGTKR
TILLGALVLTAGYAMVTASSEHISLLYLGMGTIAVGNGLFKANPSSLLSKCYEENDPRLDGAFTMYYMAINIGSLLSMLA
TPWLADQFGYAHAFALSVVGMLITVANFILMQGWVKNYGSDADFRTPRLSTWLAVLAGVVAACAAAALLLKHEIIANVVL
AVLSIGVVGLYVKETLLLKGAERKKMIVAAILMLQATVFFVLYNQMPLSLNFFAIHNTEHMLFGIPVQPEQFQSLNPFWI
MLASPLLALCYNKLGNRLPMPHKFAIGMVLCAGAFLVLPLGAKYANAQGLVSSNWMVLSYLLQSVGELLISGLGLAMVAQ
LVPQRLMGFIMGAWFLTSAASSVIAGWVAGLTAAPDNVTNPLATLEIYSRVFTQIGVVTGVIAVVTIIIAPWLHRMTLDE
KPAHPEHEMALDAR

Specific function: Proton-dependent permease that transports di- and tripeptides

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily

Homologues:

Organism=Homo sapiens, GI4827008, Length=390, Percent_Identity=25.8974358974359, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI226371746, Length=369, Percent_Identity=23.3062330623306, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787922, Length=474, Percent_Identity=65.8227848101266, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=492, Percent_Identity=52.2357723577236, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1786927, Length=484, Percent_Identity=30.3719008264463, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1790572, Length=473, Percent_Identity=31.2896405919662, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17541704, Length=367, Percent_Identity=25.0681198910082, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71987453, Length=206, Percent_Identity=29.126213592233, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569141, Length=369, Percent_Identity=24.9322493224932, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639585, Length=350, Percent_Identity=29.4285714285714, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639583, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24639581, Length=345, Percent_Identity=29.2753623188406, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571098, Length=378, Percent_Identity=26.7195767195767, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571102, Length=371, Percent_Identity=26.9541778975741, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571100, Length=371, Percent_Identity=26.9541778975741, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTPA_CHRVO (Q7NRM5)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903425.1
- ProteinModelPortal:   Q7NRM5
- GeneID:   2546864
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3755
- NMPDR:   fig|243365.1.peg.3755
- HOGENOM:   HBG586603
- OMA:   SLNPFWI
- PhylomeDB:   Q7NRM5
- ProtClustDB:   PRK09584
- BioCyc:   CVIO243365:CV_3755-MONOMER
- HAMAP:   MF_01878
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456
- PANTHER:   PTHR11654:SF6
- TIGRFAMs:   TIGR00924

Pfam domain/function: PF00854 PTR2; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 53668; Mature: 53537

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50850 MFS; PS01022 PTR2_1; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13784850)-; HASH(0x135fce74)-; HASH(0x11d15b4c)-; HASH(0x125e0190)-; HASH(0x127c4084)-; HASH(0x136b77b0)-; HASH(0x13777c90)-; HASH(0x136bdaf0)-; HASH(0x1350b6cc)-; HASH(0x1338ce2c)-; HASH(0x136f55d8)-; HASH(0x1328e8a8)-; HASH(0x128eb744)-; HASH(0x136f559c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSALNPLRQPKPFYLIFSIEFWERFGFYGLQGILAVYLVKALGLREADSFTLFSSFIA
CCCCCCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LVYGLIAVGGWLGDKVLGTKRTILLGALVLTAGYAMVTASSEHISLLYLGMGTIAVGNGL
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCHHEEEECCCCEEEEEEECCHHHHCCCC
FKANPSSLLSKCYEENDPRLDGAFTMYYMAINIGSLLSMLATPWLADQFGYAHAFALSVV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GMLITVANFILMQGWVKNYGSDADFRTPRLSTWLAVLAGVVAACAAAALLLKHEIIANVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVLSIGVVGLYVKETLLLKGAERKKMIVAAILMLQATVFFVLYNQMPLSLNFFAIHNTE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
HMLFGIPVQPEQFQSLNPFWIMLASPLLALCYNKLGNRLPMPHKFAIGMVLCAGAFLVLP
EEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LGAKYANAQGLVSSNWMVLSYLLQSVGELLISGLGLAMVAQLVPQRLMGFIMGAWFLTSA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASSVIAGWVAGLTAAPDNVTNPLATLEIYSRVFTQIGVVTGVIAVVTIIIAPWLHRMTLD
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EKPAHPEHEMALDAR
CCCCCCCCCCCCCCH
>Mature Secondary Structure 
TTSALNPLRQPKPFYLIFSIEFWERFGFYGLQGILAVYLVKALGLREADSFTLFSSFIA
CCCCCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LVYGLIAVGGWLGDKVLGTKRTILLGALVLTAGYAMVTASSEHISLLYLGMGTIAVGNGL
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCHHEEEECCCCEEEEEEECCHHHHCCCC
FKANPSSLLSKCYEENDPRLDGAFTMYYMAINIGSLLSMLATPWLADQFGYAHAFALSVV
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GMLITVANFILMQGWVKNYGSDADFRTPRLSTWLAVLAGVVAACAAAALLLKHEIIANVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVLSIGVVGLYVKETLLLKGAERKKMIVAAILMLQATVFFVLYNQMPLSLNFFAIHNTE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
HMLFGIPVQPEQFQSLNPFWIMLASPLLALCYNKLGNRLPMPHKFAIGMVLCAGAFLVLP
EEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LGAKYANAQGLVSSNWMVLSYLLQSVGELLISGLGLAMVAQLVPQRLMGFIMGAWFLTSA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASSVIAGWVAGLTAAPDNVTNPLATLEIYSRVFTQIGVVTGVIAVVTIIIAPWLHRMTLD
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EKPAHPEHEMALDAR
CCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782