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The map label for this gene is lysR [H]

Identifier: 34499211

GI number: 34499211

Start: 4054331

End: 4055248

Strand: Reverse

Name: lysR [H]

Synonym: CV_3756

Alternate gene names: 34499211

Gene position: 4055248-4054331 (Counterclockwise)

Preceding gene: 34499213

Following gene: 34499210

Centisome position: 85.35

GC content: 69.61

Gene sequence:

>918_bases
ATGTCCATCAGCTTGCGCCATATCGAAGTGTTCCGGGCGGTGATGACCTGCGGCAGCGTCAGCGGCGCCGCGCGTTTGCT
GCACACGTCCCAGCCTACGGTCAGCCGCGAGCTGGCGCGTTGCGAGCAATTGCTGGGCATGGCGCTGTTCGAGCGCGGCC
ATGGCCGCTTGCGTCCCACCCAGCAGGCGCTGCAGCTGTTCGCCGAAGTGGAGCGCAGCTTCGTCGGGCTGGAGCGCATC
GTCGCCAGCGCGGATGCGATCCGGCAGTTCGCCGGCGGCCAACTGGCCGTCGCTTGCCTGCCGGTATTCGCGCAGGCGCT
GCTGCCGGGGGCCTGCGCCGATTTCGTCGCCGACTTTCCCGACGTGGGCGTGGACATCAGCCCGCAGGAGTCGCCGTGGC
TGGAGGAGTGGCTGGCCGCGCAGCGCTTCGACCTGGGACTGACCGAGCAGCAGCAGGCGCCGGCCGGCTGCCAGATGCAG
CCGCTGTGGCAGGGCGACGAGCTATGCGTGCTGCCGGCGGGGCATCCGTTGGCGGAGAAGCGCAGGCTGGAGGCGCGCGA
TTTTGACGGTTTGTCCTTCATCAGCCTGGCGGCCAGCGACAGCTACCGGCAGCAGGTGGACGCCTGGTTGGCGCGGGAGG
GCGTGTCGCGCCGTTTGCAGCTGTCGTGCCACAGCGCGGCTTCGGTGTGCGAAATGGTGAGGCTGGGACTGGGCGTGGCC
ATCGTCAACCCGCTGACGGCGCTGGCCGAGGCGGAGAGGGGGCTGGCAGTGCGGCCGCTGGCGGAGTCGATACCGTTTTC
CGTGCAGCTGGTGCTGCCGCAATTCCGTCCGGCATCGCCGCTGCCGGCGCGCTTCATCGCCGCCTTGCGGCGGCGCGTGT
CGGAACTGGATATCAGGCTGTCGGCTTTGCGAGGCTGA

Upstream 100 bases:

>100_bases
TCACACGATGATCCGCTGGCGGGACATAAAAATAAAATAGCAATTTTTAGATCAGTCTTTCATTTATGATATGGATTGGT
TTGAAAGTACGGTGAGGTCC

Downstream 100 bases:

>100_bases
GCGCGGGAGAGTGGTGGTTTGATATAAAAGCAATTAAATTGCTTAAAAATTAAAAATAACAGTATTCTGTCTTTTTTTAA
TCGATTTGCAAGCGTTTTGA

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSISLRHIEVFRAVMTCGSVSGAARLLHTSQPTVSRELARCEQLLGMALFERGHGRLRPTQQALQLFAEVERSFVGLERI
VASADAIRQFAGGQLAVACLPVFAQALLPGACADFVADFPDVGVDISPQESPWLEEWLAAQRFDLGLTEQQQAPAGCQMQ
PLWQGDELCVLPAGHPLAEKRRLEARDFDGLSFISLAASDSYRQQVDAWLAREGVSRRLQLSCHSAASVCEMVRLGLGVA
IVNPLTALAEAERGLAVRPLAESIPFSVQLVLPQFRPASPLPARFIAALRRRVSELDIRLSALRG

Sequences:

>Translated_305_residues
MSISLRHIEVFRAVMTCGSVSGAARLLHTSQPTVSRELARCEQLLGMALFERGHGRLRPTQQALQLFAEVERSFVGLERI
VASADAIRQFAGGQLAVACLPVFAQALLPGACADFVADFPDVGVDISPQESPWLEEWLAAQRFDLGLTEQQQAPAGCQMQ
PLWQGDELCVLPAGHPLAEKRRLEARDFDGLSFISLAASDSYRQQVDAWLAREGVSRRLQLSCHSAASVCEMVRLGLGVA
IVNPLTALAEAERGLAVRPLAESIPFSVQLVLPQFRPASPLPARFIAALRRRVSELDIRLSALRG
>Mature_304_residues
SISLRHIEVFRAVMTCGSVSGAARLLHTSQPTVSRELARCEQLLGMALFERGHGRLRPTQQALQLFAEVERSFVGLERIV
ASADAIRQFAGGQLAVACLPVFAQALLPGACADFVADFPDVGVDISPQESPWLEEWLAAQRFDLGLTEQQQAPAGCQMQP
LWQGDELCVLPAGHPLAEKRRLEARDFDGLSFISLAASDSYRQQVDAWLAREGVSRRLQLSCHSAASVCEMVRLGLGVAI
VNPLTALAEAERGLAVRPLAESIPFSVQLVLPQFRPASPLPARFIAALRRRVSELDIRLSALRG

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=305, Percent_Identity=54.0983606557377, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI157672245, Length=234, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788887, Length=304, Percent_Identity=25.3289473684211, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787530, Length=232, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693105, Length=240, Percent_Identity=22.0833333333333, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790262, Length=264, Percent_Identity=26.8939393939394, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=241, Percent_Identity=26.1410788381743, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33228; Mature: 33097

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50931 HTH_LYSR ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISLRHIEVFRAVMTCGSVSGAARLLHTSQPTVSRELARCEQLLGMALFERGHGRLRPT
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
QQALQLFAEVERSFVGLERIVASADAIRQFAGGQLAVACLPVFAQALLPGACADFVADFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCC
DVGVDISPQESPWLEEWLAAQRFDLGLTEQQQAPAGCQMQPLWQGDELCVLPAGHPLAEK
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHH
RRLEARDFDGLSFISLAASDSYRQQVDAWLAREGVSRRLQLSCHSAASVCEMVRLGLGVA
HHCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
IVNPLTALAEAERGLAVRPLAESIPFSVQLVLPQFRPASPLPARFIAALRRRVSELDIRL
HHHHHHHHHHHHCCCEECCHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
SALRG
HHCCC
>Mature Secondary Structure 
SISLRHIEVFRAVMTCGSVSGAARLLHTSQPTVSRELARCEQLLGMALFERGHGRLRPT
CCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
QQALQLFAEVERSFVGLERIVASADAIRQFAGGQLAVACLPVFAQALLPGACADFVADFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCC
DVGVDISPQESPWLEEWLAAQRFDLGLTEQQQAPAGCQMQPLWQGDELCVLPAGHPLAEK
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHH
RRLEARDFDGLSFISLAASDSYRQQVDAWLAREGVSRRLQLSCHSAASVCEMVRLGLGVA
HHCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
IVNPLTALAEAERGLAVRPLAESIPFSVQLVLPQFRPASPLPARFIAALRRRVSELDIRL
HHHHHHHHHHHHCCCEECCHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
SALRG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]