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The map label for this gene is clpA [H]

Identifier: 34499124

GI number: 34499124

Start: 3969792

End: 3972074

Strand: Direct

Name: clpA [H]

Synonym: CV_3669

Alternate gene names: 34499124

Gene position: 3969792-3972074 (Clockwise)

Preceding gene: 34499123

Following gene: 34499133

Centisome position: 83.56

GC content: 64.7

Gene sequence:

>2283_bases
ATGATTGCCCAGGAGCTTGAAGTAAGCCTGCACATGGCGTTCATGGACGCACGGCGCAAGCGCCACGAGTTCATCAGCGT
GGAGCATCTGCTGCTCGCGATGACCGACAACCCGTCGGCCGCAGAAGTATTGCGGGCCTGCGGCGCCAATATCGACCAAC
TGAAAAAGCAGCTGACCGACTTCATCGACGAGCACACCCCAACCGTGCCCGGCGAAACCGAAGTCGAAACCCAGCCCACC
CTAGGCTTCCAGCGCGTGATTCAACGCGCGATCCTGCACGTGCAGTCGTCGGGCAAGAAGGAGGTGTCCGGCGCCAATAT
CCTGGTCGCCATCTTCGGCGAGAAGGATTCGCACGCGGTGTACTACCTGCACCAGCAGGGCATCTCGCGGCTGGACGTCG
TCAACTTCATCTCGCACGGCATCACCAAGCAGCGGTCGCAGCAGCCGCCGCAGGAGCCGCGCGACAACGGCAACAACGAC
GCCGACAGCGAGGAACAGGCCACCGGTCCGGGCGGGGCGCTGGAGAATTACACCCAGAACCTCAACCAGATGGCGCGCGA
CGGCAAGATCGATCCCTTGATCGGCCGCGAGCACGAGCTTGAGCGCACGGTGCAGATCCTGTGCCGCCGCCGCAAGAACA
ACCCGCTCTTGGTCGGCGAGGCCGGCGTCGGCAAGACCGCGATCGCCGAAGGCCTGGCGCGCCGCATCGTCAACGGCGAG
GTGCCTGAGATCCTGTCCAAGTCCACCGTCTACGCGCTGGACATGGGCGCCCTCTTGGCCGGCACCAAGTACCGCGGCGA
TTTCGAGCAACGGCTGAAGGCGGTGATCAAGCAGCTGACCGACGACACCAACGCCATCCTGTTCATCGACGAGATCCACA
CGCTGATCGGCGCCGGCGCGGCATCGGGCGGCACGCTGGACGCGTCCAACCTGCTGAAGCCGGCGCTGTCCAACGGCAGC
CTGCGCTGCATAGGCGCGACGACGTACAACGAATACCGCGGCATCTTCGAGAAGGACAACGCGCTGTCGCGCCGCTTCCA
GAAGATAGACGTCACCGAGCCGACGGTCGAGCAGACGGTGGAAATCCTGAAGGGGCTGAAATCCCGCTTCGAGGCCCACC
ACGGCGTCAAGTACACGCAGTCGGCGCTGTCCACCGCGGCCGAGCTGTCTGCGCGCTACATCAACGACCGCCACCTGCCG
GACAAGGCCATCGACGTGATCGACGAGGCCGGCGCCGCGCAGAAGATCCTGCCGAAATCGCGGCAGAAGAAGGTGATCAA
CAAGTCGGAGATCGAAGAGATCGTCGCCAAGATCGCCCGCATTCCGCCTAAGACGGTCTCCAGCGACGACAAGAACGTGC
TGAAGAACCTGGAGCGCGATCTGAAGAACGTGGTGTTCGGCCAGGAGAAGGCGATCGAGGGCCTCGCCAGCGCGATCAAG
ATGACCCGCTCCGGCCTGGGCAATCCGCAGAAGCCCATCGGCTCCTTCCTGTTCTCCGGCCCGACCGGCGTCGGCAAGAC
CGAACTGGCGCGCCAGCTGGCCTACATCCTCGGCGTCGAGCTGATCCGCTTCGACATGTCCGAGTACATGGAGCGCCACG
CGGTGTCGCGCCTGATCGGCGCGCCTCCGGGCTATGTCGGCTTCGAGCAGGGCGGCCAGCTGACCGAGGCCATCAACAAG
CATCCGTACGCGGTGGTGCTGCTGGACGAGATCGAGAAGGCGCATCCGGACATCTACAACGTGCTGCTGCAGGTGATGGA
CCACGGCACGCTGACCGACAACAACGGCCGCAAGGCGGACTTCCGCAACGTGGTGCTGATCATGACCACCAACGCGGGCG
CCGAATCCTTGTCCAAGCCGTCTCTGGGCTTCACCCAGACCAAGGCGGCGGGCGACGAGATGGGCGACATCAAGCGCATG
TTCAGCCCCGAGTTCCGCAACCGCCTGGACGCCATCATCCCCTTCGGCATGCTGGACGAGCAGATCATCCTGCAGGTGGT
GGACAAGTTCCTGATGCAGCTGGAACAGCAGCTGGCGGAAAAGCACGTCGACATTCACTTCACCGACGAGCTGCGCCGCT
ACCTGGCGAAGAACGGCTTCGACCCGCTGATGGGCGCGCGGCCGATGGCGCGCCTGATCCAGGACACGCTGCGCAAGGCG
CTGGCCGACGAGCTGCTGTTCGGCCGCCTGGTGGCCGGCGGCGAGGTGACGGTGACGGTGATCGACGACAAGGTGGAGCT
GAAGTTCGACCAGGACGCGCTGGCCGCGGCCGAGCCGGCCTGA

Upstream 100 bases:

>100_bases
GCGTTTATACCAAAGACGTGGCTGCAACGAAGGTCGAGCAGGTGTTGCAATATGCGAAAGCGCATCAGCATCCGCTTCAG
TGCGTAATGGAGGAAAACTG

Downstream 100 bases:

>100_bases
TCCCAGCCAGTCGGAACGAACGCCCGCGCAAGCGGGCGTTTTTGTTTGGACTTTCGTCCCGTTCCAGCCTCAGCCGCGCG
GATGATGGCGCGCGTGCAGT

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MIAQELEVSLHMAFMDARRKRHEFISVEHLLLAMTDNPSAAEVLRACGANIDQLKKQLTDFIDEHTPTVPGETEVETQPT
LGFQRVIQRAILHVQSSGKKEVSGANILVAIFGEKDSHAVYYLHQQGISRLDVVNFISHGITKQRSQQPPQEPRDNGNND
ADSEEQATGPGGALENYTQNLNQMARDGKIDPLIGREHELERTVQILCRRRKNNPLLVGEAGVGKTAIAEGLARRIVNGE
VPEILSKSTVYALDMGALLAGTKYRGDFEQRLKAVIKQLTDDTNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSNGS
LRCIGATTYNEYRGIFEKDNALSRRFQKIDVTEPTVEQTVEILKGLKSRFEAHHGVKYTQSALSTAAELSARYINDRHLP
DKAIDVIDEAGAAQKILPKSRQKKVINKSEIEEIVAKIARIPPKTVSSDDKNVLKNLERDLKNVVFGQEKAIEGLASAIK
MTRSGLGNPQKPIGSFLFSGPTGVGKTELARQLAYILGVELIRFDMSEYMERHAVSRLIGAPPGYVGFEQGGQLTEAINK
HPYAVVLLDEIEKAHPDIYNVLLQVMDHGTLTDNNGRKADFRNVVLIMTTNAGAESLSKPSLGFTQTKAAGDEMGDIKRM
FSPEFRNRLDAIIPFGMLDEQIILQVVDKFLMQLEQQLAEKHVDIHFTDELRRYLAKNGFDPLMGARPMARLIQDTLRKA
LADELLFGRLVAGGEVTVTVIDDKVELKFDQDALAAAEPA

Sequences:

>Translated_760_residues
MIAQELEVSLHMAFMDARRKRHEFISVEHLLLAMTDNPSAAEVLRACGANIDQLKKQLTDFIDEHTPTVPGETEVETQPT
LGFQRVIQRAILHVQSSGKKEVSGANILVAIFGEKDSHAVYYLHQQGISRLDVVNFISHGITKQRSQQPPQEPRDNGNND
ADSEEQATGPGGALENYTQNLNQMARDGKIDPLIGREHELERTVQILCRRRKNNPLLVGEAGVGKTAIAEGLARRIVNGE
VPEILSKSTVYALDMGALLAGTKYRGDFEQRLKAVIKQLTDDTNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSNGS
LRCIGATTYNEYRGIFEKDNALSRRFQKIDVTEPTVEQTVEILKGLKSRFEAHHGVKYTQSALSTAAELSARYINDRHLP
DKAIDVIDEAGAAQKILPKSRQKKVINKSEIEEIVAKIARIPPKTVSSDDKNVLKNLERDLKNVVFGQEKAIEGLASAIK
MTRSGLGNPQKPIGSFLFSGPTGVGKTELARQLAYILGVELIRFDMSEYMERHAVSRLIGAPPGYVGFEQGGQLTEAINK
HPYAVVLLDEIEKAHPDIYNVLLQVMDHGTLTDNNGRKADFRNVVLIMTTNAGAESLSKPSLGFTQTKAAGDEMGDIKRM
FSPEFRNRLDAIIPFGMLDEQIILQVVDKFLMQLEQQLAEKHVDIHFTDELRRYLAKNGFDPLMGARPMARLIQDTLRKA
LADELLFGRLVAGGEVTVTVIDDKVELKFDQDALAAAEPA
>Mature_760_residues
MIAQELEVSLHMAFMDARRKRHEFISVEHLLLAMTDNPSAAEVLRACGANIDQLKKQLTDFIDEHTPTVPGETEVETQPT
LGFQRVIQRAILHVQSSGKKEVSGANILVAIFGEKDSHAVYYLHQQGISRLDVVNFISHGITKQRSQQPPQEPRDNGNND
ADSEEQATGPGGALENYTQNLNQMARDGKIDPLIGREHELERTVQILCRRRKNNPLLVGEAGVGKTAIAEGLARRIVNGE
VPEILSKSTVYALDMGALLAGTKYRGDFEQRLKAVIKQLTDDTNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSNGS
LRCIGATTYNEYRGIFEKDNALSRRFQKIDVTEPTVEQTVEILKGLKSRFEAHHGVKYTQSALSTAAELSARYINDRHLP
DKAIDVIDEAGAAQKILPKSRQKKVINKSEIEEIVAKIARIPPKTVSSDDKNVLKNLERDLKNVVFGQEKAIEGLASAIK
MTRSGLGNPQKPIGSFLFSGPTGVGKTELARQLAYILGVELIRFDMSEYMERHAVSRLIGAPPGYVGFEQGGQLTEAINK
HPYAVVLLDEIEKAHPDIYNVLLQVMDHGTLTDNNGRKADFRNVVLIMTTNAGAESLSKPSLGFTQTKAAGDEMGDIKRM
FSPEFRNRLDAIIPFGMLDEQIILQVVDKFLMQLEQQLAEKHVDIHFTDELRRYLAKNGFDPLMGARPMARLIQDTLRKA
LADELLFGRLVAGGEVTVTVIDDKVELKFDQDALAAAEPA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=324, Percent_Identity=32.0987654320988, Blast_Score=167, Evalue=5e-41,
Organism=Escherichia coli, GI1787109, Length=750, Percent_Identity=63.2, Blast_Score=987, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=399, Percent_Identity=45.3634085213033, Blast_Score=312, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6320464, Length=262, Percent_Identity=55.7251908396947, Blast_Score=287, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=354, Percent_Identity=42.090395480226, Blast_Score=271, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83811; Mature: 83811

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMDARRKRHEFISVEHLLLAMTDNPSAAEVLRACGANIDQLKKQLTD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCHHHHHHHHHH
FIDEHTPTVPGETEVETQPTLGFQRVIQRAILHVQSSGKKEVSGANILVAIFGEKDSHAV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YYLHQQGISRLDVVNFISHGITKQRSQQPPQEPRDNGNNDADSEEQATGPGGALENYTQN
EEEEHHCCHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHH
LNQMARDGKIDPLIGREHELERTVQILCRRRKNNPLLVGEAGVGKTAIAEGLARRIVNGE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
VPEILSKSTVYALDMGALLAGTKYRGDFEQRLKAVIKQLTDDTNAILFIDEIHTLIGAGA
HHHHHCCCCCCEEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCC
ASGGTLDASNLLKPALSNGSLRCIGATTYNEYRGIFEKDNALSRRFQKIDVTEPTVEQTV
CCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHH
EILKGLKSRFEAHHGVKYTQSALSTAAELSARYINDRHLPDKAIDVIDEAGAAQKILPKS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCH
RQKKVINKSEIEEIVAKIARIPPKTVSSDDKNVLKNLERDLKNVVFGQEKAIEGLASAIK
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MTRSGLGNPQKPIGSFLFSGPTGVGKTELARQLAYILGVELIRFDMSEYMERHAVSRLIG
HHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGFEQGGQLTEAINKHPYAVVLLDEIEKAHPDIYNVLLQVMDHGTLTDNNGRKAD
CCCCCCCCCCCCHHHHHHCCCCEEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
FRNVVLIMTTNAGAESLSKPSLGFTQTKAAGDEMGDIKRMFSPEFRNRLDAIIPFGMLDE
CCCEEEEEECCCCHHHCCCCCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCH
QIILQVVDKFLMQLEQQLAEKHVDIHFTDELRRYLAKNGFDPLMGARPMARLIQDTLRKA
HHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LADELLFGRLVAGGEVTVTVIDDKVELKFDQDALAAAEPA
HHHHHHHHHHCCCCEEEEEEECCCEEEEECCHHHHCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFMDARRKRHEFISVEHLLLAMTDNPSAAEVLRACGANIDQLKKQLTD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCHHHHHHHHHH
FIDEHTPTVPGETEVETQPTLGFQRVIQRAILHVQSSGKKEVSGANILVAIFGEKDSHAV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YYLHQQGISRLDVVNFISHGITKQRSQQPPQEPRDNGNNDADSEEQATGPGGALENYTQN
EEEEHHCCHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHH
LNQMARDGKIDPLIGREHELERTVQILCRRRKNNPLLVGEAGVGKTAIAEGLARRIVNGE
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
VPEILSKSTVYALDMGALLAGTKYRGDFEQRLKAVIKQLTDDTNAILFIDEIHTLIGAGA
HHHHHCCCCCCEEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCC
ASGGTLDASNLLKPALSNGSLRCIGATTYNEYRGIFEKDNALSRRFQKIDVTEPTVEQTV
CCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHH
EILKGLKSRFEAHHGVKYTQSALSTAAELSARYINDRHLPDKAIDVIDEAGAAQKILPKS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCH
RQKKVINKSEIEEIVAKIARIPPKTVSSDDKNVLKNLERDLKNVVFGQEKAIEGLASAIK
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MTRSGLGNPQKPIGSFLFSGPTGVGKTELARQLAYILGVELIRFDMSEYMERHAVSRLIG
HHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGFEQGGQLTEAINKHPYAVVLLDEIEKAHPDIYNVLLQVMDHGTLTDNNGRKAD
CCCCCCCCCCCCHHHHHHCCCCEEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
FRNVVLIMTTNAGAESLSKPSLGFTQTKAAGDEMGDIKRMFSPEFRNRLDAIIPFGMLDE
CCCEEEEEECCCCHHHCCCCCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCH
QIILQVVDKFLMQLEQQLAEKHVDIHFTDELRRYLAKNGFDPLMGARPMARLIQDTLRKA
HHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LADELLFGRLVAGGEVTVTVIDDKVELKFDQDALAAAEPA
HHHHHHHHHHCCCCEEEEEEECCCEEEEECCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]