Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 34499103

GI number: 34499103

Start: 3945061

End: 3946467

Strand: Direct

Name: hemN [H]

Synonym: CV_3648

Alternate gene names: 34499103

Gene position: 3945061-3946467 (Clockwise)

Preceding gene: 34499101

Following gene: 34499104

Centisome position: 83.04

GC content: 59.99

Gene sequence:

>1407_bases
ATGAAAACTACCCACCCCTTCTCTCCCGCCCATTTCGTCTTCGATCGCGAGTTGATCGAAAGGCTGGATGGCGCGGGGCC
TAGATACACATCCTACCCGACGGCAGATCGTTTTACGTCAAATTTCTCGACGCAAGACTATCTGGACAAATTGCGCCAGC
GTCAGATCGGCGCCAACCGCAAGCCTCTATCATTATACGCTCATATACCATTTTGCAACACCATCTGCTATTACTGCGCC
TGCAACAAGATCATCACCAAGGACAGCAGCAAGGCCGACCTGTATTTGGATTATCTGGAGAAGGAAATCAGTCTGGTGTC
CGCGGAGCTGGGTTTCCGGGAAAAAGTGATACAGCTGCACTTCGGCGGCGGCACCCCCACCTTTCTGTCCGATGCCCAGC
TTGAGCGGCTGATGGGCATCCTGGGAACCCATTTCGAATTCATGAGCGACGGAGAATATTCCATAGAGATAGATCCGCGC
AAGGTAAAACGCGAAACCATGCTGAAACTGGCAGATTATGGTTTCAATCGCGTCAGTGTGGGCATACAGGATTTCGATCC
GGCGGTGCAGCAGGCGGTGAACCGGGTGCAGACCGTGGAGGAGACCCGCGCGGTGATCGACGCCGCCCGCGAAGGCGGCT
TCAAGTCGGTCAGCCTGGACCTGATCTACGGTCTGCCGCTGCAAAGCCGCGAGACCATGCGCGACACGCTGCAGAAGGCG
CTGGCGCTGGATCCCGACCGGCTGTCGCTGTACAACTACGCCCATCTGCCCAGCGTGTTCAAGCCGCAGCGCCGCATCAA
CGAGGCCGAGCTGCCCAGCGCCGCGCTCAAGCTGGACATCCTGCAGGACGCGGTGAAGACGCTGACCGACGCCGGCTACG
TGTTCATCGGCATGGACCATTTCGCCAAGCCCGACGACGAACTGGCCGTCGCGCTGCGCCAGGGCCGGCTGCAACGCAAC
TTCCAGGGCTATTCCACGCATGCCGACTGCGACATGCTGGCCTTCGGCGTCTCGTCCATCGGCAAGGTGGGATCCTGTTA
CAGCCAGAACGACAAAACGCTGGAGGGCTACTACGCGGCGCTGGACCAGGGCCGGCTGCCGGTGGTGCGCGGCTTGACGC
TGGACAGCGACGACGTGCTGCGCCGGACCATCATCCAGAGCCTGATGTGCCGCTTCGCGCTGTCGGTGGAGGCCATCGAG
GAGGTCCACGGCATCAACTTCGCCCAGTATTTTGCGGCGGAAATGCCACAGATACGCGAATTCCAGCAGCAGGGACTGTT
GTCCTTCGACGGCGACTTCCTGATGGTGGAGCCCAAGGGCCGCTTCCTGATCCGCAACATCGCGATGATCTTCGACCGCC
ACCTGCGCGAGCGCGAGACCCAAGCCCGCTACTCCAGAACTATCTGA

Upstream 100 bases:

>100_bases
TTTGCTACAAGCCGGCGAAGCTTGACCCTTATCAAGGCGGAATTCACAAGTTTTTCGCAAATTTACCAGTCCTCCAGAAG
TTTTACCATCCGAATACGAC

Downstream 100 bases:

>100_bases
GCCTCTTCCCGGCGGGGTTTCTCCGGCCCCGCCGTTCCCGGCGGAACTGTTCCTAAGGCGGGTAGCGCTTATTTTTCCCT
GCGTGGTAAGCAAAATCACT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKTTHPFSPAHFVFDRELIERLDGAGPRYTSYPTADRFTSNFSTQDYLDKLRQRQIGANRKPLSLYAHIPFCNTICYYCA
CNKIITKDSSKADLYLDYLEKEISLVSAELGFREKVIQLHFGGGTPTFLSDAQLERLMGILGTHFEFMSDGEYSIEIDPR
KVKRETMLKLADYGFNRVSVGIQDFDPAVQQAVNRVQTVEETRAVIDAAREGGFKSVSLDLIYGLPLQSRETMRDTLQKA
LALDPDRLSLYNYAHLPSVFKPQRRINEAELPSAALKLDILQDAVKTLTDAGYVFIGMDHFAKPDDELAVALRQGRLQRN
FQGYSTHADCDMLAFGVSSIGKVGSCYSQNDKTLEGYYAALDQGRLPVVRGLTLDSDDVLRRTIIQSLMCRFALSVEAIE
EVHGINFAQYFAAEMPQIREFQQQGLLSFDGDFLMVEPKGRFLIRNIAMIFDRHLRERETQARYSRTI

Sequences:

>Translated_468_residues
MKTTHPFSPAHFVFDRELIERLDGAGPRYTSYPTADRFTSNFSTQDYLDKLRQRQIGANRKPLSLYAHIPFCNTICYYCA
CNKIITKDSSKADLYLDYLEKEISLVSAELGFREKVIQLHFGGGTPTFLSDAQLERLMGILGTHFEFMSDGEYSIEIDPR
KVKRETMLKLADYGFNRVSVGIQDFDPAVQQAVNRVQTVEETRAVIDAAREGGFKSVSLDLIYGLPLQSRETMRDTLQKA
LALDPDRLSLYNYAHLPSVFKPQRRINEAELPSAALKLDILQDAVKTLTDAGYVFIGMDHFAKPDDELAVALRQGRLQRN
FQGYSTHADCDMLAFGVSSIGKVGSCYSQNDKTLEGYYAALDQGRLPVVRGLTLDSDDVLRRTIIQSLMCRFALSVEAIE
EVHGINFAQYFAAEMPQIREFQQQGLLSFDGDFLMVEPKGRFLIRNIAMIFDRHLRERETQARYSRTI
>Mature_468_residues
MKTTHPFSPAHFVFDRELIERLDGAGPRYTSYPTADRFTSNFSTQDYLDKLRQRQIGANRKPLSLYAHIPFCNTICYYCA
CNKIITKDSSKADLYLDYLEKEISLVSAELGFREKVIQLHFGGGTPTFLSDAQLERLMGILGTHFEFMSDGEYSIEIDPR
KVKRETMLKLADYGFNRVSVGIQDFDPAVQQAVNRVQTVEETRAVIDAAREGGFKSVSLDLIYGLPLQSRETMRDTLQKA
LALDPDRLSLYNYAHLPSVFKPQRRINEAELPSAALKLDILQDAVKTLTDAGYVFIGMDHFAKPDDELAVALRQGRLQRN
FQGYSTHADCDMLAFGVSSIGKVGSCYSQNDKTLEGYYAALDQGRLPVVRGLTLDSDDVLRRTIIQSLMCRFALSVEAIE
EVHGINFAQYFAAEMPQIREFQQQGLLSFDGDFLMVEPKGRFLIRNIAMIFDRHLRERETQARYSRTI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=241, Percent_Identity=25.3112033195021, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI87082341, Length=455, Percent_Identity=48.7912087912088, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1789325, Length=395, Percent_Identity=27.0886075949367, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53142; Mature: 53142

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTHPFSPAHFVFDRELIERLDGAGPRYTSYPTADRFTSNFSTQDYLDKLRQRQIGANR
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCC
KPLSLYAHIPFCNTICYYCACNKIITKDSSKADLYLDYLEKEISLVSAELGFREKVIQLH
CCEEEEEECCHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FGGGTPTFLSDAQLERLMGILGTHFEFMSDGEYSIEIDPRKVKRETMLKLADYGFNRVSV
ECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCEEEE
GIQDFDPAVQQAVNRVQTVEETRAVIDAAREGGFKSVSLDLIYGLPLQSRETMRDTLQKA
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LALDPDRLSLYNYAHLPSVFKPQRRINEAELPSAALKLDILQDAVKTLTDAGYVFIGMDH
HCCCCCHHHHHHHHHCCHHHCHHHHCCHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECHH
FAKPDDELAVALRQGRLQRNFQGYSTHADCDMLAFGVSSIGKVGSCYSQNDKTLEGYYAA
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LDQGRLPVVRGLTLDSDDVLRRTIIQSLMCRFALSVEAIEEVHGINFAQYFAAEMPQIRE
HCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
FQQQGLLSFDGDFLMVEPKGRFLIRNIAMIFDRHLRERETQARYSRTI
HHHCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTTHPFSPAHFVFDRELIERLDGAGPRYTSYPTADRFTSNFSTQDYLDKLRQRQIGANR
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCC
KPLSLYAHIPFCNTICYYCACNKIITKDSSKADLYLDYLEKEISLVSAELGFREKVIQLH
CCEEEEEECCHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FGGGTPTFLSDAQLERLMGILGTHFEFMSDGEYSIEIDPRKVKRETMLKLADYGFNRVSV
ECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCEEEE
GIQDFDPAVQQAVNRVQTVEETRAVIDAAREGGFKSVSLDLIYGLPLQSRETMRDTLQKA
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LALDPDRLSLYNYAHLPSVFKPQRRINEAELPSAALKLDILQDAVKTLTDAGYVFIGMDH
HCCCCCHHHHHHHHHCCHHHCHHHHCCHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECHH
FAKPDDELAVALRQGRLQRNFQGYSTHADCDMLAFGVSSIGKVGSCYSQNDKTLEGYYAA
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LDQGRLPVVRGLTLDSDDVLRRTIIQSLMCRFALSVEAIEEVHGINFAQYFAAEMPQIRE
HCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
FQQQGLLSFDGDFLMVEPKGRFLIRNIAMIFDRHLRERETQARYSRTI
HHHCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]