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The map label for this gene is uraA [H]

Identifier: 34499079

GI number: 34499079

Start: 3928132

End: 3929373

Strand: Direct

Name: uraA [H]

Synonym: CV_3624

Alternate gene names: 34499079

Gene position: 3928132-3929373 (Clockwise)

Preceding gene: 34499078

Following gene: 34499080

Centisome position: 82.68

GC content: 66.99

Gene sequence:

>1242_bases
ATGCAACAACTCAAGCTGGCGGTGTCCGGCGCCCAGATCCTGTTCGTCGCCTTCGGCGCGCTGGTGCTGGTGCCGCTGCT
CACCGGCCTGAATCCGGCGATGGCGCTGTTGGGCGCCGGTCTCGGCACCCTGCTGTTTCAAGCCTGCACCGGCCGCCAAG
TGCCGATTTTTCTCGGCTCCTCCTTCGCCTTCATCGGCCCCATCATCTACTCGATGCACACCTGGGGCCCGGGCGCGACC
ATGTTCGGCCTGTTCGCCGCCGGCTTCATGTATTTCGTGTTCGCCGCCATCGTGCGCTGGCGCGGCATGGCGCTGGTCAA
CAAGCTGCTGCCGCCGGTGGTGATCGGCCCGGTGATCATGATCATCGGCCTGTCGGTCGCCACCGCCGCCTCCGGCATGG
CGATGGGCCAGGCCGGCGGCAAGCAGGTGCTGCCGTACGAGACCTCTCTGTTGCTGGCCGCCATCTCGCTGGCCACCACC
ATCGTCGTCTCCATCTACGCCCGCGGCATGTTCAAGCTGGTACCCATCCTGGCCGGCGTCACCGTCGGCTACATCGCAGC
CGCCTTCCTCGGCGCGGTGGACTTCGCCAAGCTGGCCGCCGCGCCGTGGTTCGCGGCGCCGACCTTCCACAGCCCGGAAG
TCAACTGGGCGGCGGCGGCCTTCATGCTGCCGGTGGCCATCGCCCCGGCCATCGAGCACATCGGCGGCGTGATGGCCATC
GGCGGCGTCACCGGCAAGGATTACACCAAGACCCCCGGCCTGCACCGCACGCTGGCCGGCGACGGACTGGGCGTATGCGT
GGCCGGCCTGATCGGCGGCCCCCCGGTGACCACCTACGCCGAAGTGACCGGCGCGGTGATGATCACCCGCAATTTCAACC
CGGTGACCATGACCTGGGCGGCGGTGTTCGCCATCTGCATGGCTTTCTTCGGCAAATTCAACGCGCTGCTGCAATCCATC
CCGATGCCGGTGATGGGCGGCATCATGGTGCTCTTGTTCGGCACCATCGCCTCCATCGGCCTGAAAACGCTGATCGAGGC
CAAGGTGGACCTGATGGAGCCGCGCAACCTGGTGATCATCTCGGTGGTGCTGACCGCCGGCATCGGCGGCCTGACGCTGA
AACTGGGCGATTTCGCGTTGTCCGGCGTCGGCCTGTGCTCCTTGCTGGCCATCATCCTGAACCTGATCCTGCCGCGCCGG
GCGGCCAGCCACGACGGCATCGTCGAAGGGCAGGATATCTAG

Upstream 100 bases:

>100_bases
GCGGTGGCGGCGGACGTGGACAACACGCTGGCGCAGGCGGTGATGTACTGCGCCGTCTGAACCCGACACGATTACAAAAC
CAAAACAAGGAAGAATGATG

Downstream 100 bases:

>100_bases
CGCGACCTCAGCACATCAACATAAACTATTGAATTTAAAAATCATTCACAACTGAACACACGTCAACGCAACTGACGGGG
TCTACACTGAAGTTCAGCGC

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQQLKLAVSGAQILFVAFGALVLVPLLTGLNPAMALLGAGLGTLLFQACTGRQVPIFLGSSFAFIGPIIYSMHTWGPGAT
MFGLFAAGFMYFVFAAIVRWRGMALVNKLLPPVVIGPVIMIIGLSVATAASGMAMGQAGGKQVLPYETSLLLAAISLATT
IVVSIYARGMFKLVPILAGVTVGYIAAAFLGAVDFAKLAAAPWFAAPTFHSPEVNWAAAAFMLPVAIAPAIEHIGGVMAI
GGVTGKDYTKTPGLHRTLAGDGLGVCVAGLIGGPPVTTYAEVTGAVMITRNFNPVTMTWAAVFAICMAFFGKFNALLQSI
PMPVMGGIMVLLFGTIASIGLKTLIEAKVDLMEPRNLVIISVVLTAGIGGLTLKLGDFALSGVGLCSLLAIILNLILPRR
AASHDGIVEGQDI

Sequences:

>Translated_413_residues
MQQLKLAVSGAQILFVAFGALVLVPLLTGLNPAMALLGAGLGTLLFQACTGRQVPIFLGSSFAFIGPIIYSMHTWGPGAT
MFGLFAAGFMYFVFAAIVRWRGMALVNKLLPPVVIGPVIMIIGLSVATAASGMAMGQAGGKQVLPYETSLLLAAISLATT
IVVSIYARGMFKLVPILAGVTVGYIAAAFLGAVDFAKLAAAPWFAAPTFHSPEVNWAAAAFMLPVAIAPAIEHIGGVMAI
GGVTGKDYTKTPGLHRTLAGDGLGVCVAGLIGGPPVTTYAEVTGAVMITRNFNPVTMTWAAVFAICMAFFGKFNALLQSI
PMPVMGGIMVLLFGTIASIGLKTLIEAKVDLMEPRNLVIISVVLTAGIGGLTLKLGDFALSGVGLCSLLAIILNLILPRR
AASHDGIVEGQDI
>Mature_413_residues
MQQLKLAVSGAQILFVAFGALVLVPLLTGLNPAMALLGAGLGTLLFQACTGRQVPIFLGSSFAFIGPIIYSMHTWGPGAT
MFGLFAAGFMYFVFAAIVRWRGMALVNKLLPPVVIGPVIMIIGLSVATAASGMAMGQAGGKQVLPYETSLLLAAISLATT
IVVSIYARGMFKLVPILAGVTVGYIAAAFLGAVDFAKLAAAPWFAAPTFHSPEVNWAAAAFMLPVAIAPAIEHIGGVMAI
GGVTGKDYTKTPGLHRTLAGDGLGVCVAGLIGGPPVTTYAEVTGAVMITRNFNPVTMTWAAVFAICMAFFGKFNALLQSI
PMPVMGGIMVLLFGTIASIGLKTLIEAKVDLMEPRNLVIISVVLTAGIGGLTLKLGDFALSGVGLCSLLAIILNLILPRR
AASHDGIVEGQDI

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=376, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI44680145, Length=372, Percent_Identity=24.4623655913978, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI44680148, Length=374, Percent_Identity=24.8663101604278, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40316845, Length=374, Percent_Identity=24.8663101604278, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788843, Length=385, Percent_Identity=37.6623376623377, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87081818, Length=409, Percent_Identity=35.9413202933985, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87082181, Length=444, Percent_Identity=27.4774774774775, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790087, Length=361, Percent_Identity=24.3767313019391, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=172, Percent_Identity=30.8139534883721, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17541904, Length=380, Percent_Identity=23.4210526315789, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356175, Length=281, Percent_Identity=26.6903914590747, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 42619; Mature: 42619

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQLKLAVSGAQILFVAFGALVLVPLLTGLNPAMALLGAGLGTLLFQACTGRQVPIFLGS
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCEEEECC
SFAFIGPIIYSMHTWGPGATMFGLFAAGFMYFVFAAIVRWRGMALVNKLLPPVVIGPVIM
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IIGLSVATAASGMAMGQAGGKQVLPYETSLLLAAISLATTIVVSIYARGMFKLVPILAGV
HHHHHHHHHHCCCHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVGYIAAAFLGAVDFAKLAAAPWFAAPTFHSPEVNWAAAAFMLPVAIAPAIEHIGGVMAI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
GGVTGKDYTKTPGLHRTLAGDGLGVCVAGLIGGPPVTTYAEVTGAVMITRNFNPVTMTWA
CCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCHHHHHCCEEEEEECCCCHHHHHH
AVFAICMAFFGKFNALLQSIPMPVMGGIMVLLFGTIASIGLKTLIEAKVDLMEPRNLVII
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SVVLTAGIGGLTLKLGDFALSGVGLCSLLAIILNLILPRRAASHDGIVEGQDI
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQQLKLAVSGAQILFVAFGALVLVPLLTGLNPAMALLGAGLGTLLFQACTGRQVPIFLGS
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCEEEECC
SFAFIGPIIYSMHTWGPGATMFGLFAAGFMYFVFAAIVRWRGMALVNKLLPPVVIGPVIM
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IIGLSVATAASGMAMGQAGGKQVLPYETSLLLAAISLATTIVVSIYARGMFKLVPILAGV
HHHHHHHHHHCCCHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVGYIAAAFLGAVDFAKLAAAPWFAAPTFHSPEVNWAAAAFMLPVAIAPAIEHIGGVMAI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
GGVTGKDYTKTPGLHRTLAGDGLGVCVAGLIGGPPVTTYAEVTGAVMITRNFNPVTMTWA
CCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCHHHHHCCEEEEEECCCCHHHHHH
AVFAICMAFFGKFNALLQSIPMPVMGGIMVLLFGTIASIGLKTLIEAKVDLMEPRNLVII
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SVVLTAGIGGLTLKLGDFALSGVGLCSLLAIILNLILPRRAASHDGIVEGQDI
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]