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The map label for this gene is purM

Identifier: 34499070

GI number: 34499070

Start: 3920022

End: 3921059

Strand: Direct

Name: purM

Synonym: CV_3615

Alternate gene names: 34499070

Gene position: 3920022-3921059 (Clockwise)

Preceding gene: 34499064

Following gene: 34499071

Centisome position: 82.51

GC content: 66.57

Gene sequence:

>1038_bases
TTGAACACCACGTCCCTCAGTTACCGTGATGCCGGCGTAGACATCGACGCCGGCGACGCGCTGGTCGAAAACATCAAGCC
GTTTGCCAAGCGCACCATGCGCCCGGAAGTGCTCGGCGGCATCGGCGGTTTCGGCGCACTGGTGGAAATCTCCAAGAAGT
ACAAGGAGCCGGTGCTGGTTTCCGGCACCGACGGCGTGGGCACCAAGCTCAAGCTGGCTTTCGACTGGAACCGCCATGAC
ACCGTCGGCATCGACCTGGTGGCGATGAGCGTCAACGACATCCTGGTGCAGGGTGCCGAGCCGCTGTTCTTCCTCGACTA
CTTCGCCTGCGGCAAGCTGGACGTGGCCCAGGCCACCGAGGTGATCAAGGGCATCGCCGCCGGCTGCGAACAGGCCGGCT
GCGCGCTGACCGGCGGCGAAACCGCCGAGATGCCGGGCATGTACCCGGCCGGCGAATACGACCTGGCCGGCTTCGCCGTC
GGCGTGGTGGAGAAGAGCAAGGTGATCAGCGGCCGCGACATCGTCCCCGGCGACGTGGTGCTGGGCCTGGCGTCCAACGG
CGTGCACTCCAATGGCTACAGCCTGGTGCGCAAGATCATCGACCGCGCTCAGCCTGAGCTGGACGCGCCGTTCGACGGCG
ACAAGACCCTGCGCGACGCGGTGATCGCGCCGACCCGCATCTACGTCAAGCCGTTGCTGAAGCTGATGGAGACGCTGCCG
GTCAAGGGCATGGCCCACATCACCGGCGGCGGCATCACCGAAAACACTCCGCGCGTGCTGCCGGACAACACCGTCGCCCA
GATCGACGCCGCCAGCTGGCAGCTGCCCAAGCTGTTCCAGTGGCTGCAGCGCGAAGGCAATGTGGACATCCAGGAAATGT
ACCGCACCTTCAATTGCGGCATCGGCATGGTGGTGGTGGTCGCGCCCGAGCACGCCGAGCAGGCGCTGGCGCTGCTGCGC
GAGGCCGGCGAGACCGTCTATCGCATCGGCCAGGTGCGCGAGCGCCAGGGCGGCGAGCACCAGACCCAGATAGCCTGA

Upstream 100 bases:

>100_bases
GCGCCAGCCTTTTTGCCGATTTTCAGTTAAAATACAGTGCTTTCGCACCGGCGAAAGCTTGATGTAAAAATATTTCAAGT
TTGCAGAAAGCGAGATTATC

Downstream 100 bases:

>100_bases
GGTTCTTCCGCAGGTAGCGCCCCGCGCCGCTGGCTCCGCCGGCGGCGCTTGTCGTTTATCGCCGGGCGGCGGAACCCAGC
CGGCGCAATCGCAACAAACA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNTTSLSYRDAGVDIDAGDALVENIKPFAKRTMRPEVLGGIGGFGALVEISKKYKEPVLVSGTDGVGTKLKLAFDWNRHD
TVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATEVIKGIAAGCEQAGCALTGGETAEMPGMYPAGEYDLAGFAV
GVVEKSKVISGRDIVPGDVVLGLASNGVHSNGYSLVRKIIDRAQPELDAPFDGDKTLRDAVIAPTRIYVKPLLKLMETLP
VKGMAHITGGGITENTPRVLPDNTVAQIDAASWQLPKLFQWLQREGNVDIQEMYRTFNCGIGMVVVVAPEHAEQALALLR
EAGETVYRIGQVRERQGGEHQTQIA

Sequences:

>Translated_345_residues
MNTTSLSYRDAGVDIDAGDALVENIKPFAKRTMRPEVLGGIGGFGALVEISKKYKEPVLVSGTDGVGTKLKLAFDWNRHD
TVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATEVIKGIAAGCEQAGCALTGGETAEMPGMYPAGEYDLAGFAV
GVVEKSKVISGRDIVPGDVVLGLASNGVHSNGYSLVRKIIDRAQPELDAPFDGDKTLRDAVIAPTRIYVKPLLKLMETLP
VKGMAHITGGGITENTPRVLPDNTVAQIDAASWQLPKLFQWLQREGNVDIQEMYRTFNCGIGMVVVVAPEHAEQALALLR
EAGETVYRIGQVRERQGGEHQTQIA
>Mature_345_residues
MNTTSLSYRDAGVDIDAGDALVENIKPFAKRTMRPEVLGGIGGFGALVEISKKYKEPVLVSGTDGVGTKLKLAFDWNRHD
TVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATEVIKGIAAGCEQAGCALTGGETAEMPGMYPAGEYDLAGFAV
GVVEKSKVISGRDIVPGDVVLGLASNGVHSNGYSLVRKIIDRAQPELDAPFDGDKTLRDAVIAPTRIYVKPLLKLMETLP
VKGMAHITGGGITENTPRVLPDNTVAQIDAASWQLPKLFQWLQREGNVDIQEMYRTFNCGIGMVVVVAPEHAEQALALLR
EAGETVYRIGQVRERQGGEHQTQIA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=52.463768115942, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=52.463768115942, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=52.463768115942, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=61.7210682492582, Blast_Score=423, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=45.5331412103746, Blast_Score=295, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=48.8165680473373, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI24582400, Length=279, Percent_Identity=48.7455197132617, Blast_Score=257, Evalue=6e-69,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_CHRVO (Q7NS12)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903285.1
- ProteinModelPortal:   Q7NS12
- SMR:   Q7NS12
- GeneID:   2548266
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3615
- NMPDR:   fig|243365.1.peg.3615
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   Q7NS12
- ProtClustDB:   PRK05385
- BioCyc:   CVIO243365:CV_3615-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36998; Mature: 36998

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTSLSYRDAGVDIDAGDALVENIKPFAKRTMRPEVLGGIGGFGALVEISKKYKEPVLV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCEEE
SGTDGVGTKLKLAFDWNRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATE
ECCCCCCCEEEEEEECCCCCCCEEEEEEEEHHHHHHCCCCCEEEEHHHHCCCCCHHHHHH
VIKGIAAGCEQAGCALTGGETAEMPGMYPAGEYDLAGFAVGVVEKSKVISGRDIVPGDVV
HHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCEE
LGLASNGVHSNGYSLVRKIIDRAQPELDAPFDGDKTLRDAVIAPTRIYVKPLLKLMETLP
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCC
VKGMAHITGGGITENTPRVLPDNTVAQIDAASWQLPKLFQWLQREGNVDIQEMYRTFNCG
CCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
IGMVVVVAPEHAEQALALLREAGETVYRIGQVRERQGGEHQTQIA
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNTTSLSYRDAGVDIDAGDALVENIKPFAKRTMRPEVLGGIGGFGALVEISKKYKEPVLV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCEEE
SGTDGVGTKLKLAFDWNRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATE
ECCCCCCCEEEEEEECCCCCCCEEEEEEEEHHHHHHCCCCCEEEEHHHHCCCCCHHHHHH
VIKGIAAGCEQAGCALTGGETAEMPGMYPAGEYDLAGFAVGVVEKSKVISGRDIVPGDVV
HHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCEE
LGLASNGVHSNGYSLVRKIIDRAQPELDAPFDGDKTLRDAVIAPTRIYVKPLLKLMETLP
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCC
VKGMAHITGGGITENTPRVLPDNTVAQIDAASWQLPKLFQWLQREGNVDIQEMYRTFNCG
CCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
IGMVVVVAPEHAEQALALLREAGETVYRIGQVRERQGGEHQTQIA
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782