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The map label for this gene is aphA [H]

Identifier: 34499013

GI number: 34499013

Start: 3865541

End: 3866572

Strand: Reverse

Name: aphA [H]

Synonym: CV_3558

Alternate gene names: 34499013

Gene position: 3866572-3865541 (Counterclockwise)

Preceding gene: 34499014

Following gene: 34499012

Centisome position: 81.38

GC content: 67.64

Gene sequence:

>1032_bases
ATGCTCACCGTCTACTCCGATTCCCACCGTCTGCAGCATGGCCAGGCCGAGCTGATAGACGGCACCCTCAAGCCCTGTTT
CGAAACCCCGTCCCGCGCCGACATGGTGCTGGCCGCCGTGCGCGACCGCGAGCTCGGCGACGTGATCCATCCGCGCCGCC
ACGGGCTGGACCCCATCTTGCGCGTGCACGACGCCGGCTATGTCAGGTTCCTGGAAACCGCCTGGCGGCGTTGGACGGAA
ATGGGGCGCGACTATGACGCGCTGCCCAAGATGTGGCAGGTCCGCCGGCTGCGCGAAGCCATTCCCGAGCACGTGGAAGG
CCAGCTCTGCTATTACTCGATGGATTGCGGCACGCCTGTCACTTCCGGAACCTGGCAGGCGGCGAGCGCGGCCGCCGACA
CCGCGCTGACCGGGGCCGACCGGCTGATCGGCGGCGAGCGCGCGGTGTTTGCGCTGACCCGGCCGCCCGGCCATCACGCG
GCCTTCGACTATTGCGGCGGCTACTGCTTCCTCAACAACGCCGCCATCGCCGCCCAGGCGCTCCGCGACCACGGCATGCG
CAAGGTGGCGGTGCTGGACGTCGACTACCATCACGGTAACGGCACCCAGGACATCTTCTACCGCCGCGCCGACGTGCTGT
TTTTGTCGATACATGGCGATCCGCGCACCGAATACCCGTTCTTCCTCGGCTTCGCCGACGAAAAGGGCGAAGGAGAGGGG
CTGGGCTACAACTTCAATTTCCCGCTGGCGGCCGGGTCCTGCGTCAGCACCTGGTTCGTCGCGCTGGACTGCGCGCTGGA
GCAGATCGCCCGTTTCGGCGCCGAGGCGCTGGTGGTGTCGCTGGGCGTGGACACGTTCCAAGGCGATCCGATCTCGCGCT
TCCAGCTCGACTCCCCCGACTTCGTCACCCTGGGCGCGCGGCTGGCGGGGCTGAAGCTGCCGACGCTGTTCTGCCTGGAA
GGCGGGTACGCGGTGGAGCCGATAGGCACCAACGTGGTTAACGTGCTGGCTGGTTTCGAGGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
GCCTGAGCGGCGCTTGTCCTGGCGCAAGTTCGCGCCCATCAATGTTTGACCCGGCAGGCCCATGGCGGGAGCATGGAGTT
TTCCCACGCCGGAAAACATC

Downstream 100 bases:

>100_bases
CGCGGTTTTTTGATGGGCTTTGGCCTATGCTCAAAGAGTCTTTCGCCGCCATCACGGCGGGCGCCGTAGGCGCGGAAGCG
GATATGGAGAAGGCGATGGG

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MLTVYSDSHRLQHGQAELIDGTLKPCFETPSRADMVLAAVRDRELGDVIHPRRHGLDPILRVHDAGYVRFLETAWRRWTE
MGRDYDALPKMWQVRRLREAIPEHVEGQLCYYSMDCGTPVTSGTWQAASAAADTALTGADRLIGGERAVFALTRPPGHHA
AFDYCGGYCFLNNAAIAAQALRDHGMRKVAVLDVDYHHGNGTQDIFYRRADVLFLSIHGDPRTEYPFFLGFADEKGEGEG
LGYNFNFPLAAGSCVSTWFVALDCALEQIARFGAEALVVSLGVDTFQGDPISRFQLDSPDFVTLGARLAGLKLPTLFCLE
GGYAVEPIGTNVVNVLAGFEARG

Sequences:

>Translated_343_residues
MLTVYSDSHRLQHGQAELIDGTLKPCFETPSRADMVLAAVRDRELGDVIHPRRHGLDPILRVHDAGYVRFLETAWRRWTE
MGRDYDALPKMWQVRRLREAIPEHVEGQLCYYSMDCGTPVTSGTWQAASAAADTALTGADRLIGGERAVFALTRPPGHHA
AFDYCGGYCFLNNAAIAAQALRDHGMRKVAVLDVDYHHGNGTQDIFYRRADVLFLSIHGDPRTEYPFFLGFADEKGEGEG
LGYNFNFPLAAGSCVSTWFVALDCALEQIARFGAEALVVSLGVDTFQGDPISRFQLDSPDFVTLGARLAGLKLPTLFCLE
GGYAVEPIGTNVVNVLAGFEARG
>Mature_343_residues
MLTVYSDSHRLQHGQAELIDGTLKPCFETPSRADMVLAAVRDRELGDVIHPRRHGLDPILRVHDAGYVRFLETAWRRWTE
MGRDYDALPKMWQVRRLREAIPEHVEGQLCYYSMDCGTPVTSGTWQAASAAADTALTGADRLIGGERAVFALTRPPGHHA
AFDYCGGYCFLNNAAIAAQALRDHGMRKVAVLDVDYHHGNGTQDIFYRRADVLFLSIHGDPRTEYPFFLGFADEKGEGEG
LGYNFNFPLAAGSCVSTWFVALDCALEQIARFGAEALVVSLGVDTFQGDPISRFQLDSPDFVTLGARLAGLKLPTLFCLE
GGYAVEPIGTNVVNVLAGFEARG

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795202, Length=256, Percent_Identity=31.640625, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI30795204, Length=256, Percent_Identity=31.640625, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI13128864, Length=218, Percent_Identity=33.0275229357798, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI17158039, Length=258, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI20070354, Length=221, Percent_Identity=35.7466063348416, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI153085395, Length=188, Percent_Identity=33.5106382978723, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI148539870, Length=170, Percent_Identity=35.8823529411765, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI169234807, Length=170, Percent_Identity=35.8823529411765, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI8923769, Length=302, Percent_Identity=26.4900662251656, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI226529806, Length=132, Percent_Identity=40.1515151515151, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI62750347, Length=212, Percent_Identity=32.5471698113208, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI62750349, Length=212, Percent_Identity=32.5471698113208, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073088, Length=169, Percent_Identity=28.9940828402367, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI13128860, Length=287, Percent_Identity=21.9512195121951, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI262073092, Length=230, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI293336691, Length=255, Percent_Identity=22.3529411764706, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17540334, Length=238, Percent_Identity=31.5126050420168, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=238, Percent_Identity=31.5126050420168, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=238, Percent_Identity=31.5126050420168, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17537347, Length=243, Percent_Identity=32.0987654320988, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193209491, Length=220, Percent_Identity=28.6363636363636, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17508561, Length=286, Percent_Identity=25.1748251748252, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25154020, Length=214, Percent_Identity=31.7757009345794, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=179, Percent_Identity=31.8435754189944, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561978, Length=238, Percent_Identity=26.0504201680672, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17534739, Length=299, Percent_Identity=24.0802675585284, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=320, Percent_Identity=28.4375, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=219, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325141, Length=98, Percent_Identity=38.7755102040816, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281360899, Length=216, Percent_Identity=37.5, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642146, Length=216, Percent_Identity=37.5, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642142, Length=216, Percent_Identity=37.5, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642144, Length=216, Percent_Identity=37.5, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360799, Length=216, Percent_Identity=35.1851851851852, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360801, Length=216, Percent_Identity=35.1851851851852, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24641720, Length=216, Percent_Identity=35.1851851851852, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644244, Length=246, Percent_Identity=25.609756097561, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24657891, Length=288, Percent_Identity=22.9166666666667, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37717; Mature: 37717

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVYSDSHRLQHGQAELIDGTLKPCFETPSRADMVLAAVRDRELGDVIHPRRHGLDPIL
CEEEECCCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHCCHHHHHCCCHHCCCCHHE
RVHDAGYVRFLETAWRRWTEMGRDYDALPKMWQVRRLREAIPEHVEGQLCYYSMDCGTPV
EECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHCCCEEEEEEECCCCCC
TSGTWQAASAAADTALTGADRLIGGERAVFALTRPPGHHAAFDYCGGYCFLNNAAIAAQA
CCCCCCHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCCCCHHHHCCCEEEECCHHHHHHH
LRDHGMRKVAVLDVDYHHGNGTQDIFYRRADVLFLSIHGDPRTEYPFFLGFADEKGEGEG
HHHCCCEEEEEEEEEEECCCCCHHHHEEEEEEEEEEEECCCCCCCCEEEEECCCCCCCCC
LGYNFNFPLAAGSCVSTWFVALDCALEQIARFGAEALVVSLGVDTFQGDPISRFQLDSPD
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCCCCCEEECCCCC
FVTLGARLAGLKLPTLFCLEGGYAVEPIGTNVVNVLAGFEARG
EEEECCCCCCCCCCEEEEECCCEEECCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MLTVYSDSHRLQHGQAELIDGTLKPCFETPSRADMVLAAVRDRELGDVIHPRRHGLDPIL
CEEEECCCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHCCHHHHHCCCHHCCCCHHE
RVHDAGYVRFLETAWRRWTEMGRDYDALPKMWQVRRLREAIPEHVEGQLCYYSMDCGTPV
EECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHCCCEEEEEEECCCCCC
TSGTWQAASAAADTALTGADRLIGGERAVFALTRPPGHHAAFDYCGGYCFLNNAAIAAQA
CCCCCCHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCCCCHHHHCCCEEEECCHHHHHHH
LRDHGMRKVAVLDVDYHHGNGTQDIFYRRADVLFLSIHGDPRTEYPFFLGFADEKGEGEG
HHHCCCEEEEEEEEEEECCCCCHHHHEEEEEEEEEEEECCCCCCCCEEEEECCCCCCCCC
LGYNFNFPLAAGSCVSTWFVALDCALEQIARFGAEALVVSLGVDTFQGDPISRFQLDSPD
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCCCCCEEECCCCC
FVTLGARLAGLKLPTLFCLEGGYAVEPIGTNVVNVLAGFEARG
EEEECCCCCCCCCCEEEEECCCEEECCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]