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The map label for this gene is hydH [C]

Identifier: 34498795

GI number: 34498795

Start: 3637521

End: 3639032

Strand: Direct

Name: hydH [C]

Synonym: CV_3340

Alternate gene names: 34498795

Gene position: 3637521-3639032 (Clockwise)

Preceding gene: 34498794

Following gene: 34498796

Centisome position: 76.56

GC content: 62.76

Gene sequence:

>1512_bases
ATGGCATGGATCACCACCATTCTGGGGACGACCGGACTGTATTTCTACATCCATGACTACAATATCGACCAGAACGACTT
CCAAACCCAACGCGCCGCCGTGCAATCGCGCCTGTCGCTGTCCCTGCCCCACGGCATCTGGCAGCTGGATGACGAGAACG
TCCGCCTGGCGCTGGACAGCGAGCTGAGTTGGCCATCGGTGATCGCCATCAACGTAAAGGGGGAAAGCGGCCTCAACCTG
GGCCGCACCCGCGACGCCAACGGCAATCTGCGCGACATGCTGCCCAACGAGCAGCCCAAGGTCGACGACACCCTCAGCAT
CCCCATCATCTACCAGGGCAAGGAACACCTGGGCACCGCCACCGTCTACCTGTCGCACGACGCGCTGCGCGCGCGCGAAG
ACCAGCACCTGATCACCATCTTCGCCCAGATCATCCTGCTGGACGGCCTGATCTTCTTCATCATGTCGTTCAACCTGCAG
CGCTTCATCTTCCAGCCGCTGTCCAAGCTGCAGCTGGCGCTGAACACCGCGATCCGCGCGCCGGACGCCAGCGGCGCGCA
GATCACCCACCTGGCGGACGACGAGATCGGCGGCATCGTCAACGGCTTCAACCGCATCGTCGCACGCACCGCGGCCGACC
TGGTGAAACGGACGGCGGCCGAGGCCGTCGCGCGCGAGGAAAAGGAAAAGGCGCAACAGGCCTACAGCCAACTGATGGCG
ACGCAGGAAACGCTGGTGGAGGCGGAAAAGATGGCCTCGCTGGGCAGCCTGGTGGCAGGCGTCGCCCACGAGATCAATAC
GCCGGTCGGCATCACGCTGACCGCCGCCTCCCACCTCGGCACCGCCACCTCCCACATCACCGGCAAGTTGGACAGCGGCA
ACATCAAAAAAAGCGACTTCCAGAGCTACCTTGAAACGGCCCAGGAATGCTGCGAGCTGATCCTGGCCAACTCCGAACGC
GCCGCCAACCTGATCCACAGCTTCAAGCAGGTGGCGGTGGACCAGACCAGCGAGGCCCGTCGCAGCTTCCATCTGCACGA
CTACCTGAACGAGGTGATCACCAGCCTGAAACCACGCTTCAAGCACACCAAGGTCGCGATAGACATCCAGTGCGAGGAGG
ACATTCTGCTGGACAGCTATCCCGGCGCGCTGGCCCAGGTGCTGACCAATCTGGTGGTCAACGCGCTGATACACGGCTAT
GAAAGCGGCGAAATTGCTGGCACCATCGTCATCGAGGCCCACCGCAGCGACGCCCAGCACGTGTCGATGACCATCAGCGA
CAGCGGCAAGGGCATTTCGCCGGAAAACCTCGGCCGGGTGTTCGAACCTTTCTTCACCACCCGCCGCGGCAGCGGCGGCA
GCGGTCTTGGCCTCAACATCGTCTACAACATCGTGCGGCAGCGACTGGGCGGCAACATCGAGGTTCACAGCGAAGTTGGA
CAGGGCACCCGATTCACGCTGGACATGCCCTGCATCGCACCCACCGTCCAGCACAAGGAGAATGTGGCATGA

Upstream 100 bases:

>100_bases
CAGCATGGCAATTCCGGCTCCCTCTGCCTACGATTGATTCTGAGGGCACGAGCAAACAGGCACCATGAAAAGCATCAAGA
CAAGGTTAATGTTATGGCTG

Downstream 100 bases:

>100_bases
GCCAACAAGCCTCTCTTCCCGACGACGACAACTGGCTGCTGGAAGATACCGACGGCGACGAAGCCGGACGGCCGTCCGAG
GTGCGCAAGCCCTGGAAAGT

Product: two-component sensor histidine kinase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MAWITTILGTTGLYFYIHDYNIDQNDFQTQRAAVQSRLSLSLPHGIWQLDDENVRLALDSELSWPSVIAINVKGESGLNL
GRTRDANGNLRDMLPNEQPKVDDTLSIPIIYQGKEHLGTATVYLSHDALRAREDQHLITIFAQIILLDGLIFFIMSFNLQ
RFIFQPLSKLQLALNTAIRAPDASGAQITHLADDEIGGIVNGFNRIVARTAADLVKRTAAEAVAREEKEKAQQAYSQLMA
TQETLVEAEKMASLGSLVAGVAHEINTPVGITLTAASHLGTATSHITGKLDSGNIKKSDFQSYLETAQECCELILANSER
AANLIHSFKQVAVDQTSEARRSFHLHDYLNEVITSLKPRFKHTKVAIDIQCEEDILLDSYPGALAQVLTNLVVNALIHGY
ESGEIAGTIVIEAHRSDAQHVSMTISDSGKGISPENLGRVFEPFFTTRRGSGGSGLGLNIVYNIVRQRLGGNIEVHSEVG
QGTRFTLDMPCIAPTVQHKENVA

Sequences:

>Translated_503_residues
MAWITTILGTTGLYFYIHDYNIDQNDFQTQRAAVQSRLSLSLPHGIWQLDDENVRLALDSELSWPSVIAINVKGESGLNL
GRTRDANGNLRDMLPNEQPKVDDTLSIPIIYQGKEHLGTATVYLSHDALRAREDQHLITIFAQIILLDGLIFFIMSFNLQ
RFIFQPLSKLQLALNTAIRAPDASGAQITHLADDEIGGIVNGFNRIVARTAADLVKRTAAEAVAREEKEKAQQAYSQLMA
TQETLVEAEKMASLGSLVAGVAHEINTPVGITLTAASHLGTATSHITGKLDSGNIKKSDFQSYLETAQECCELILANSER
AANLIHSFKQVAVDQTSEARRSFHLHDYLNEVITSLKPRFKHTKVAIDIQCEEDILLDSYPGALAQVLTNLVVNALIHGY
ESGEIAGTIVIEAHRSDAQHVSMTISDSGKGISPENLGRVFEPFFTTRRGSGGSGLGLNIVYNIVRQRLGGNIEVHSEVG
QGTRFTLDMPCIAPTVQHKENVA
>Mature_502_residues
AWITTILGTTGLYFYIHDYNIDQNDFQTQRAAVQSRLSLSLPHGIWQLDDENVRLALDSELSWPSVIAINVKGESGLNLG
RTRDANGNLRDMLPNEQPKVDDTLSIPIIYQGKEHLGTATVYLSHDALRAREDQHLITIFAQIILLDGLIFFIMSFNLQR
FIFQPLSKLQLALNTAIRAPDASGAQITHLADDEIGGIVNGFNRIVARTAADLVKRTAAEAVAREEKEKAQQAYSQLMAT
QETLVEAEKMASLGSLVAGVAHEINTPVGITLTAASHLGTATSHITGKLDSGNIKKSDFQSYLETAQECCELILANSERA
ANLIHSFKQVAVDQTSEARRSFHLHDYLNEVITSLKPRFKHTKVAIDIQCEEDILLDSYPGALAQVLTNLVVNALIHGYE
SGEIAGTIVIEAHRSDAQHVSMTISDSGKGISPENLGRVFEPFFTTRRGSGGSGLGLNIVYNIVRQRLGGNIEVHSEVGQ
GTRFTLDMPCIAPTVQHKENVA

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=259, Percent_Identity=28.957528957529, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081816, Length=374, Percent_Identity=27.807486631016, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=184, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788549, Length=261, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788393, Length=303, Percent_Identity=25.0825082508251, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=522, Percent_Identity=23.3716475095785, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55100; Mature: 54969

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWITTILGTTGLYFYIHDYNIDQNDFQTQRAAVQSRLSLSLPHGIWQLDDENVRLALDS
CHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEECCCCEEEEEEC
ELSWPSVIAINVKGESGLNLGRTRDANGNLRDMLPNEQPKVDDTLSIPIIYQGKEHLGTA
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEECCCHHCCEE
TVYLSHDALRAREDQHLITIFAQIILLDGLIFFIMSFNLQRFIFQPLSKLQLALNTAIRA
EEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDASGAQITHLADDEIGGIVNGFNRIVARTAADLVKRTAAEAVAREEKEKAQQAYSQLMA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQETLVEAEKMASLGSLVAGVAHEINTPVGITLTAASHLGTATSHITGKLDSGNIKKSDF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHEEECCCCCCCCHHHH
QSYLETAQECCELILANSERAANLIHSFKQVAVDQTSEARRSFHLHDYLNEVITSLKPRF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
KHTKVAIDIQCEEDILLDSYPGALAQVLTNLVVNALIHGYESGEIAGTIVIEAHRSDAQH
CCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCE
VSMTISDSGKGISPENLGRVFEPFFTTRRGSGGSGLGLNIVYNIVRQRLGGNIEVHSEVG
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
QGTRFTLDMPCIAPTVQHKENVA
CCCEEEEECCCCCCCHHHHCCCC
>Mature Secondary Structure 
AWITTILGTTGLYFYIHDYNIDQNDFQTQRAAVQSRLSLSLPHGIWQLDDENVRLALDS
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEECCCCEEEEEEC
ELSWPSVIAINVKGESGLNLGRTRDANGNLRDMLPNEQPKVDDTLSIPIIYQGKEHLGTA
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEECCCHHCCEE
TVYLSHDALRAREDQHLITIFAQIILLDGLIFFIMSFNLQRFIFQPLSKLQLALNTAIRA
EEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDASGAQITHLADDEIGGIVNGFNRIVARTAADLVKRTAAEAVAREEKEKAQQAYSQLMA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQETLVEAEKMASLGSLVAGVAHEINTPVGITLTAASHLGTATSHITGKLDSGNIKKSDF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHEEECCCCCCCCHHHH
QSYLETAQECCELILANSERAANLIHSFKQVAVDQTSEARRSFHLHDYLNEVITSLKPRF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
KHTKVAIDIQCEEDILLDSYPGALAQVLTNLVVNALIHGYESGEIAGTIVIEAHRSDAQH
CCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCE
VSMTISDSGKGISPENLGRVFEPFFTTRRGSGGSGLGLNIVYNIVRQRLGGNIEVHSEVG
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
QGTRFTLDMPCIAPTVQHKENVA
CCCEEEEECCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]