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The map label for this gene is guaC

Identifier: 34498377

GI number: 34498377

Start: 3202077

End: 3203027

Strand: Reverse

Name: guaC

Synonym: CV_2922

Alternate gene names: 34498377

Gene position: 3203027-3202077 (Counterclockwise)

Preceding gene: 34498378

Following gene: 34498369

Centisome position: 67.42

GC content: 64.35

Gene sequence:

>951_bases
ATGATCAAGACCGAACTCAACTACGGCGACGTATACCTGGTGCCGAAGAAAACCGTGGTGGACAGCCGCAAGGAGTGCGA
CACCTCCGTGCAGTTCGGCCCGCGCCGCTTCGCGATGCCGGTCTACCCGTCCAATATGAAGTCGGTGGTTTCGGCCGAAA
CCTGCGAGCTGTTCGCCCGCGAAGGCTGGTTCTACACCCTGCACCGCTTCAATGTCGACGCGGTGGCCTTCACCCGCTAC
ATGCAGGAGCAGGGCCTGTTCGCGTCGATCAGCGTCGGCGTCAACGACGACACCTACGAGCAGCTGGACGCGCTGAAAGC
CGCCGGCCTGAGCCCCGAATACATGACGCTCGACATCGCTAACGCCTGGTGCGTGAAGGCGGAGCGCATGATCAAGCACA
TCAAGCAGCATTTCCCCAACACCTTCCTGATCGGCGGCAACGTCGCCACCGCCGAAGCCGCGCGCGACCTCGAGGCCTGG
GGCTGCGACGCGATCAAGGCCGGCATCGCCGGCGGCCGCGTCTGCATCACCAAGAACAAGACCGGCTTCCATCGCCCGAT
GGTCTCCACCGTGCGCGACTGCGTGGCCGCGGTGACGATCCCGGTGATCGCCGACGGCGGCATCGTCGAGCACGGCGACA
TCGCCAAGGCGCTGGTCTGCGGCGCGACCATGGTGATGGCCGGTTCGCTGTTCGCCGGCTATGACGAGTCGGCGGGCGAC
ATCGTCGAGATCGCGGGCAAGCACTACAAGGAATACTTCGGCAGCGCCTCGCAGTTCAACAAGGGCGCCTACGTCAACGT
CGAGGGCAAGAAGATCCTGGTCGAGTACAAGGGCAGCATGGGCAAGCTGCTGCGTGAACTGCAGGAGGACCTGCAGTCTT
CGGTCAGCTACGCCGGCGGCACCACGCTGGCCGCGCTGCGCGAGGTGGAGATGATCCAGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
GGCGTCGCAGGGGTAGCTGCAAATGGGAGCCTATACGGCTCCCGTCTTTGTTTGGGGCCCCTGTTTTTTCATCCAAACCT
GTTTTTGTGGGAGCACACGC

Downstream 100 bases:

>100_bases
GCCGACATCTGAAACGACAAACGGCCGCGGGCTTGCGCTGCGCGGCCGTTTTCATGCCTGCTGTTACTTGGCGCCGGCCA
ATTCCGGCGCGGCGGCCTCG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIKTELNYGDVYLVPKKTVVDSRKECDTSVQFGPRRFAMPVYPSNMKSVVSAETCELFAREGWFYTLHRFNVDAVAFTRY
MQEQGLFASISVGVNDDTYEQLDALKAAGLSPEYMTLDIANAWCVKAERMIKHIKQHFPNTFLIGGNVATAEAARDLEAW
GCDAIKAGIAGGRVCITKNKTGFHRPMVSTVRDCVAAVTIPVIADGGIVEHGDIAKALVCGATMVMAGSLFAGYDESAGD
IVEIAGKHYKEYFGSASQFNKGAYVNVEGKKILVEYKGSMGKLLRELQEDLQSSVSYAGGTTLAALREVEMIQVYR

Sequences:

>Translated_316_residues
MIKTELNYGDVYLVPKKTVVDSRKECDTSVQFGPRRFAMPVYPSNMKSVVSAETCELFAREGWFYTLHRFNVDAVAFTRY
MQEQGLFASISVGVNDDTYEQLDALKAAGLSPEYMTLDIANAWCVKAERMIKHIKQHFPNTFLIGGNVATAEAARDLEAW
GCDAIKAGIAGGRVCITKNKTGFHRPMVSTVRDCVAAVTIPVIADGGIVEHGDIAKALVCGATMVMAGSLFAGYDESAGD
IVEIAGKHYKEYFGSASQFNKGAYVNVEGKKILVEYKGSMGKLLRELQEDLQSSVSYAGGTTLAALREVEMIQVYR
>Mature_316_residues
MIKTELNYGDVYLVPKKTVVDSRKECDTSVQFGPRRFAMPVYPSNMKSVVSAETCELFAREGWFYTLHRFNVDAVAFTRY
MQEQGLFASISVGVNDDTYEQLDALKAAGLSPEYMTLDIANAWCVKAERMIKHIKQHFPNTFLIGGNVATAEAARDLEAW
GCDAIKAGIAGGRVCITKNKTGFHRPMVSTVRDCVAAVTIPVIADGGIVEHGDIAKALVCGATMVMAGSLFAGYDESAGD
IVEIAGKHYKEYFGSASQFNKGAYVNVEGKKILVEYKGSMGKLLRELQEDLQSSVSYAGGTTLAALREVEMIQVYR

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily

Homologues:

Organism=Homo sapiens, GI50541956, Length=331, Percent_Identity=31.1178247734139, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI50541954, Length=331, Percent_Identity=31.1178247734139, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI50541952, Length=331, Percent_Identity=31.1178247734139, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI50541948, Length=331, Percent_Identity=31.1178247734139, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI156104880, Length=328, Percent_Identity=30.1829268292683, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI66933016, Length=239, Percent_Identity=33.8912133891213, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI217035152, Length=256, Percent_Identity=32.421875, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156616279, Length=256, Percent_Identity=32.421875, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI34328930, Length=256, Percent_Identity=32.421875, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217035146, Length=256, Percent_Identity=32.421875, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI34328928, Length=256, Percent_Identity=32.421875, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI217035148, Length=256, Percent_Identity=32.421875, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI217035150, Length=256, Percent_Identity=32.421875, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786293, Length=320, Percent_Identity=27.1875, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788855, Length=225, Percent_Identity=37.3333333333333, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560440, Length=320, Percent_Identity=30, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=242, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994389, Length=211, Percent_Identity=27.4881516587678, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323585, Length=244, Percent_Identity=33.6065573770492, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323464, Length=244, Percent_Identity=34.0163934426229, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322012, Length=175, Percent_Identity=35.4285714285714, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6319352, Length=129, Percent_Identity=34.8837209302326, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641071, Length=245, Percent_Identity=31.0204081632653, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24641073, Length=245, Percent_Identity=31.0204081632653, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571163, Length=245, Percent_Identity=31.0204081632653, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_CHRVO (Q7NTY1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902592.1
- HSSP:   Q81JJ9
- ProteinModelPortal:   Q7NTY1
- SMR:   Q7NTY1
- GeneID:   2547468
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2922
- NMPDR:   fig|243365.1.peg.2922
- HOGENOM:   HBG298985
- OMA:   PDYITID
- ProtClustDB:   PRK05458
- BioCyc:   CVIO243365:CV_2922-MONOMER
- BRENDA:   1.7.1.7
- HAMAP:   MF_01511
- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF036500

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 34582; Mature: 34582

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTELNYGDVYLVPKKTVVDSRKECDTSVQFGPRRFAMPVYPSNMKSVVSAETCELFAR
CCEEECCCCCEEEECCHHHHCCHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
EGWFYTLHRFNVDAVAFTRYMQEQGLFASISVGVNDDTYEQLDALKAAGLSPEYMTLDIA
CCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEC
NAWCVKAERMIKHIKQHFPNTFLIGGNVATAEAARDLEAWGCDAIKAGIAGGRVCITKNK
CHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHCCCHHHHHCCCCCEEEEECCC
TGFHRPMVSTVRDCVAAVTIPVIADGGIVEHGDIAKALVCGATMVMAGSLFAGYDESAGD
CCCCCHHHHHHHHHHHHHHHEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
IVEIAGKHYKEYFGSASQFNKGAYVNVEGKKILVEYKGSMGKLLRELQEDLQSSVSYAGG
HHHHHHHHHHHHCCCHHHCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
TTLAALREVEMIQVYR
HHHHHHHHHHHHEECC
>Mature Secondary Structure
MIKTELNYGDVYLVPKKTVVDSRKECDTSVQFGPRRFAMPVYPSNMKSVVSAETCELFAR
CCEEECCCCCEEEECCHHHHCCHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
EGWFYTLHRFNVDAVAFTRYMQEQGLFASISVGVNDDTYEQLDALKAAGLSPEYMTLDIA
CCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEC
NAWCVKAERMIKHIKQHFPNTFLIGGNVATAEAARDLEAWGCDAIKAGIAGGRVCITKNK
CHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHCCCHHHHHCCCCCEEEEECCC
TGFHRPMVSTVRDCVAAVTIPVIADGGIVEHGDIAKALVCGATMVMAGSLFAGYDESAGD
CCCCCHHHHHHHHHHHHHHHEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
IVEIAGKHYKEYFGSASQFNKGAYVNVEGKKILVEYKGSMGKLLRELQEDLQSSVSYAGG
HHHHHHHHHHHHCCCHHHCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
TTLAALREVEMIQVYR
HHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782