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The map label for this gene is pepA

Identifier: 34498369

GI number: 34498369

Start: 3192639

End: 3194204

Strand: Reverse

Name: pepA

Synonym: CV_2914

Alternate gene names: 34498369

Gene position: 3194204-3192639 (Counterclockwise)

Preceding gene: 34498377

Following gene: 34498368

Centisome position: 67.23

GC content: 66.16

Gene sequence:

>1566_bases
ATGGAATTTAACATAAAAAGCGGCAGCCCGGAGAAGCAGCGCGTCGCCTGCGTGATCGTCGGCGTTTATGAATCGCGCAA
GCTTACCTTCGCCGCGGATCTGCTCGATCGCATCTCCAACGGCTTCATCAGCGACGTGATCCGCCACGGCGACATGGAGG
GCAAGCTGGGCAGCACGCTGGTGCTGCATTCGGTGCCGCACACGCTGTGCGACCGGGTGATGCTGGTCGGCCTGGGCAAG
GAGCGGGATTTCCGCGCCAAGGAATACCGGGAAGCCGTGCGCGCCTCGGTCAAGGCGCTGACCCAGACCTCGGCCAGCGA
GGCCGTCAGCTACCTGTCCGAACTGACCGTCAAGAAGCATGACGTGGAATGGATGATCGAGCAGGCCACCGTAGTGACGC
TGGACGCGTTGTACCGCTTCGACCGCTTCAAGAGCAAACAGGACGAGTCCGTGCGCGAGCCGCGCAAGCTCACGCTGGCG
GTGCCGCGCCGCAGCGATCTGGCCGATGGGGAGAAGGGGCTGCAACGCGGCCTGGCCATCGGCAACGGCATGAAGCTGGC
CAAGGATCTGGGCAACCTGCCAGGCAATGTCTGCACGCCGAGCTACCTGGGCGAGGAGGCGCGCAAGGTCGCCGAAACCT
TCGGCGCAGAAGCCGAGATCCTGGGCCCGCGCGAAATCGCCGAGCTGGGCATGCATTCCTTCCTGTCGGTGGCCAAGGGC
AGCGCGGAAGAGGCCCGCCTGATCGTGCTCAAGCACCACGGCGCCAAGGACAAGAACGACAAGCCCATCGTGCTGGTGGG
CAAGGGCATCACTTTTGATTCCGGCGGCATTTCGCTGAAGCCCGGCGAAGGCATGGACGAGATGAAGTACGACATGTGCG
GCGCCGCCACCGTGCTGGGCGCGTTCCGCGCCGCGGTGGAGATGAATCTGCCGCTGAACGTGATCGCCATCGTGCCGACC
TGCGAAAACATGCCGAACGGCAACGCGGTGAAGCCGGGCGACATCGTCACCTCCATGTCCGGGCAGACCATCGAAATCCT
CAACACCGACGCCGAGGGCCGCCTGATACTGTGCGATGCGCTGACCTATGCCGAGCGCTTCAGCCCGGCCACCGTGATCG
ATGTCGCCACGCTGACCGGCGCCTGCGTGATCGCGCTGGGCCATATCGCCACCGGCCTGTACAGCAACCAGGACAGCCTG
GCGCGCGAGCTGCTGGCCGCCGGGGAAGAAGTGGCCGACCGCGCCTGGCACATGCCGATGTGGGACGAGTACCAGGAGAT
GCTGAAGAGCCCGTTCGCCGACATGGCCAATATCGGCGGCCGTCCGGGCGGCAGCGTCACCGCGGCCTGCTTCCTGTCCC
GCTTCGCCAAGGCCTACGACTGGGCGCACCTGGACATCGCCGGCACCGCCTGGAAGGGCGGCAAGGACAAGGGCGCCACC
GCGCGTCCGGTGCCGCTCCTGGTGCAGTTCCTGCAAGACCGCGCCGACATCGCGCTGGGCAACGTGGTGCGCCGCGGCCG
TCCGCGCCGCGAGGCGCCCGAAGTGGCAGACGATGAGCAGGATTGA

Upstream 100 bases:

>100_bases
ACAATCCTGCGTTCACCGGCGGCCTAGCCGTCCGTCTTCCCCGAGCTTAGACGGCCGTCATGAGGTGGAGCAACGACACT
CGTTCTACAGCGGAGTACCT

Downstream 100 bases:

>100_bases
TTTTTATACCAATGTCGCCGACCCGCAGGCTTTTGCCTGCAGGTTGGCCGATACCGTGCAGCGCAAGAAGGAAAGGTTGC
TGATCTGGCTGGACAGTGAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MEFNIKSGSPEKQRVACVIVGVYESRKLTFAADLLDRISNGFISDVIRHGDMEGKLGSTLVLHSVPHTLCDRVMLVGLGK
ERDFRAKEYREAVRASVKALTQTSASEAVSYLSELTVKKHDVEWMIEQATVVTLDALYRFDRFKSKQDESVREPRKLTLA
VPRRSDLADGEKGLQRGLAIGNGMKLAKDLGNLPGNVCTPSYLGEEARKVAETFGAEAEILGPREIAELGMHSFLSVAKG
SAEEARLIVLKHHGAKDKNDKPIVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAATVLGAFRAAVEMNLPLNVIAIVPT
CENMPNGNAVKPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFSPATVIDVATLTGACVIALGHIATGLYSNQDSL
ARELLAAGEEVADRAWHMPMWDEYQEMLKSPFADMANIGGRPGGSVTAACFLSRFAKAYDWAHLDIAGTAWKGGKDKGAT
ARPVPLLVQFLQDRADIALGNVVRRGRPRREAPEVADDEQD

Sequences:

>Translated_521_residues
MEFNIKSGSPEKQRVACVIVGVYESRKLTFAADLLDRISNGFISDVIRHGDMEGKLGSTLVLHSVPHTLCDRVMLVGLGK
ERDFRAKEYREAVRASVKALTQTSASEAVSYLSELTVKKHDVEWMIEQATVVTLDALYRFDRFKSKQDESVREPRKLTLA
VPRRSDLADGEKGLQRGLAIGNGMKLAKDLGNLPGNVCTPSYLGEEARKVAETFGAEAEILGPREIAELGMHSFLSVAKG
SAEEARLIVLKHHGAKDKNDKPIVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAATVLGAFRAAVEMNLPLNVIAIVPT
CENMPNGNAVKPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFSPATVIDVATLTGACVIALGHIATGLYSNQDSL
ARELLAAGEEVADRAWHMPMWDEYQEMLKSPFADMANIGGRPGGSVTAACFLSRFAKAYDWAHLDIAGTAWKGGKDKGAT
ARPVPLLVQFLQDRADIALGNVVRRGRPRREAPEVADDEQD
>Mature_521_residues
MEFNIKSGSPEKQRVACVIVGVYESRKLTFAADLLDRISNGFISDVIRHGDMEGKLGSTLVLHSVPHTLCDRVMLVGLGK
ERDFRAKEYREAVRASVKALTQTSASEAVSYLSELTVKKHDVEWMIEQATVVTLDALYRFDRFKSKQDESVREPRKLTLA
VPRRSDLADGEKGLQRGLAIGNGMKLAKDLGNLPGNVCTPSYLGEEARKVAETFGAEAEILGPREIAELGMHSFLSVAKG
SAEEARLIVLKHHGAKDKNDKPIVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAATVLGAFRAAVEMNLPLNVIAIVPT
CENMPNGNAVKPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFSPATVIDVATLTGACVIALGHIATGLYSNQDSL
ARELLAAGEEVADRAWHMPMWDEYQEMLKSPFADMANIGGRPGGSVTAACFLSRFAKAYDWAHLDIAGTAWKGGKDKGAT
ARPVPLLVQFLQDRADIALGNVVRRGRPRREAPEVADDEQD

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=505, Percent_Identity=37.6237623762376, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI47155554, Length=348, Percent_Identity=33.0459770114943, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=55.9356136820926, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI87082123, Length=291, Percent_Identity=38.8316151202749, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=295, Percent_Identity=35.9322033898305, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=280, Percent_Identity=30.3571428571429, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129969, Length=497, Percent_Identity=32.5955734406439, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI161077148, Length=496, Percent_Identity=31.6532258064516, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI20130057, Length=496, Percent_Identity=31.6532258064516, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24662227, Length=495, Percent_Identity=31.1111111111111, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21355725, Length=478, Percent_Identity=31.3807531380753, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24661038, Length=505, Percent_Identity=29.9009900990099, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21355645, Length=498, Percent_Identity=30.7228915662651, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24662223, Length=498, Percent_Identity=30.7228915662651, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129963, Length=512, Percent_Identity=30.859375, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19922386, Length=506, Percent_Identity=31.6205533596838, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI21357381, Length=325, Percent_Identity=32.6153846153846, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=325, Percent_Identity=32.6153846153846, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379062, Length=325, Percent_Identity=32.6153846153846, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646701, Length=396, Percent_Identity=24.4949494949495, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646703, Length=396, Percent_Identity=24.4949494949495, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358201, Length=396, Percent_Identity=24.4949494949495, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CHRVO (Q7NTY9)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902584.1
- ProteinModelPortal:   Q7NTY9
- SMR:   Q7NTY9
- MEROPS:   M17.003
- GeneID:   2548593
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2914
- NMPDR:   fig|243365.1.peg.2914
- HOGENOM:   HBG742580
- OMA:   SEGMGEM
- PhylomeDB:   Q7NTY9
- ProtClustDB:   PRK00913
- BioCyc:   CVIO243365:CV_2914-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 56444; Mature: 56444

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 280-280 ACT_SITE 354-354

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFNIKSGSPEKQRVACVIVGVYESRKLTFAADLLDRISNGFISDVIRHGDMEGKLGSTL
CEECCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VLHSVPHTLCDRVMLVGLGKERDFRAKEYREAVRASVKALTQTSASEAVSYLSELTVKKH
EEHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DVEWMIEQATVVTLDALYRFDRFKSKQDESVREPRKLTLAVPRRSDLADGEKGLQRGLAI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GNGMKLAKDLGNLPGNVCTPSYLGEEARKVAETFGAEAEILGPREIAELGMHSFLSVAKG
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCC
SAEEARLIVLKHHGAKDKNDKPIVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAATVLG
CCCCCEEEEEEECCCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHH
AFRAAVEMNLPLNVIAIVPTCENMPNGNAVKPGDIVTSMSGQTIEILNTDAEGRLILCDA
HHHHHHEECCCEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEEH
LTYAERFSPATVIDVATLTGACVIALGHIATGLYSNQDSLARELLAAGEEVADRAWHMPM
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCC
WDEYQEMLKSPFADMANIGGRPGGSVTAACFLSRFAKAYDWAHLDIAGTAWKGGKDKGAT
HHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCC
ARPVPLLVQFLQDRADIALGNVVRRGRPRREAPEVADDEQD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEFNIKSGSPEKQRVACVIVGVYESRKLTFAADLLDRISNGFISDVIRHGDMEGKLGSTL
CEECCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VLHSVPHTLCDRVMLVGLGKERDFRAKEYREAVRASVKALTQTSASEAVSYLSELTVKKH
EEHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DVEWMIEQATVVTLDALYRFDRFKSKQDESVREPRKLTLAVPRRSDLADGEKGLQRGLAI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GNGMKLAKDLGNLPGNVCTPSYLGEEARKVAETFGAEAEILGPREIAELGMHSFLSVAKG
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCC
SAEEARLIVLKHHGAKDKNDKPIVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAATVLG
CCCCCEEEEEEECCCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHH
AFRAAVEMNLPLNVIAIVPTCENMPNGNAVKPGDIVTSMSGQTIEILNTDAEGRLILCDA
HHHHHHEECCCEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEEH
LTYAERFSPATVIDVATLTGACVIALGHIATGLYSNQDSLARELLAAGEEVADRAWHMPM
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCC
WDEYQEMLKSPFADMANIGGRPGGSVTAACFLSRFAKAYDWAHLDIAGTAWKGGKDKGAT
HHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCC
ARPVPLLVQFLQDRADIALGNVVRRGRPRREAPEVADDEQD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782