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The map label for this gene is gcp

Identifier: 34498212

GI number: 34498212

Start: 2992415

End: 2993440

Strand: Direct

Name: gcp

Synonym: CV_2757

Alternate gene names: 34498212

Gene position: 2992415-2993440 (Clockwise)

Preceding gene: 34498210

Following gene: 34498213

Centisome position: 62.98

GC content: 67.64

Gene sequence:

>1026_bases
ATGCTGGTACTTGGCATTGAATCCTCCTGCGACGAAACCGGCGTCGCGCTGTACGACACCGAACGCGGCCTGCTGGCCCA
TCAGCTGCATACTCAAATGGCGATGCACGCCGAGTACGGCGGCGTGGTGCCCGAGCTGGCCAGCCGCGACCACATCCGCC
GCGCCATCCCGCTGACCGAAGCCTGCCTCTCCGAGGCGGGCAAGAAACTCGCCGATCTGGACGCCATCGCCTACACCCAG
GGCCCTGGCCTGGGCGGCGCGCTGATGGTGGGCGCCAGCATGGCCAATGCGCTGGCCTTCGGCCTGAATATTCCCGTCAT
CCCGGTACACCACCTGGAAGGCCATCTGCTGTCGCCGCTGCTGGCCGATCCCAAGCCGGAATTCCCCTTCCTGGCGCTGC
TGGTTTCCGGCGGACACACCCAGTTGATGGCGGTGCGCGGCGTCGGCGACTACGAAATCCTCGGCGAGACCGTGGACGAC
GCCGCCGGCGAGGCCTTCGACAAAACCGCCAAGCTGCTGGGCCTGCCCTACCCTGGCGGCCCGCTGCTGTCCAGGCTGGC
GGAATCCGGCAGCCCGGACCGCTTCACGCTGCCGCGGCCCATGCTGCACTCAGGCAATCTGGACATGAGCTTCTCCGGCC
TGAAGACGGCGGTGCTGACGCTGGTGCGCCAGCAGGAGTCCGCGCAGGGCGAGCTGGACGAACAGACGCGGATGGATATC
TGCCGCGCCTTCCAGGAAGCCATCGTAGAGGTGCTGGTGAAAAAGTCCCTCGCCGCGATGAGGCAGGCCGGCATGAAGCG
GCTGGTGGTGGCCGGCGGCGTCGGCGCCAACAAGCAGCTGCGCGCCGCGCTCAACGACGCCGCCGCGCGCAAGCGTTTCG
ACGTGTTCTACCCGCCCTTGGCGCTGTGCACCGACAACGGCGCGATGATCGCCTTCGCCGGCGCCATGCGCCTGAAATTC
GCGGAGCCGGCCGGCGGCTTCACCATCAAGCCGCGCTGGGATTTGTCCAGCCTGCCGGCAGTATAA

Upstream 100 bases:

>100_bases
TTTGATCAAAAATGTTCATCAGACTAACACTGCCGATTTGGGCGGACAAAGATTCACCGGTAGAATAGAAAGATTGTCCC
GTTATATCCGAGCTGCACCC

Downstream 100 bases:

>100_bases
ACGCATCCATGCCGCCGGTCCCGGGCCGCGCGGCCAGAAAATCAATATGATCCAACTGAAAAATCTGAGCCTGCGCCGCG
GCCTGAAGGAATTGCTGATC

Product: DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLVLGIESSCDETGVALYDTERGLLAHQLHTQMAMHAEYGGVVPELASRDHIRRAIPLTEACLSEAGKKLADLDAIAYTQ
GPGLGGALMVGASMANALAFGLNIPVIPVHHLEGHLLSPLLADPKPEFPFLALLVSGGHTQLMAVRGVGDYEILGETVDD
AAGEAFDKTAKLLGLPYPGGPLLSRLAESGSPDRFTLPRPMLHSGNLDMSFSGLKTAVLTLVRQQESAQGELDEQTRMDI
CRAFQEAIVEVLVKKSLAAMRQAGMKRLVVAGGVGANKQLRAALNDAAARKRFDVFYPPLALCTDNGAMIAFAGAMRLKF
AEPAGGFTIKPRWDLSSLPAV

Sequences:

>Translated_341_residues
MLVLGIESSCDETGVALYDTERGLLAHQLHTQMAMHAEYGGVVPELASRDHIRRAIPLTEACLSEAGKKLADLDAIAYTQ
GPGLGGALMVGASMANALAFGLNIPVIPVHHLEGHLLSPLLADPKPEFPFLALLVSGGHTQLMAVRGVGDYEILGETVDD
AAGEAFDKTAKLLGLPYPGGPLLSRLAESGSPDRFTLPRPMLHSGNLDMSFSGLKTAVLTLVRQQESAQGELDEQTRMDI
CRAFQEAIVEVLVKKSLAAMRQAGMKRLVVAGGVGANKQLRAALNDAAARKRFDVFYPPLALCTDNGAMIAFAGAMRLKF
AEPAGGFTIKPRWDLSSLPAV
>Mature_341_residues
MLVLGIESSCDETGVALYDTERGLLAHQLHTQMAMHAEYGGVVPELASRDHIRRAIPLTEACLSEAGKKLADLDAIAYTQ
GPGLGGALMVGASMANALAFGLNIPVIPVHHLEGHLLSPLLADPKPEFPFLALLVSGGHTQLMAVRGVGDYEILGETVDD
AAGEAFDKTAKLLGLPYPGGPLLSRLAESGSPDRFTLPRPMLHSGNLDMSFSGLKTAVLTLVRQQESAQGELDEQTRMDI
CRAFQEAIVEVLVKKSLAAMRQAGMKRLVVAGGVGANKQLRAALNDAAARKRFDVFYPPLALCTDNGAMIAFAGAMRLKF
AEPAGGFTIKPRWDLSSLPAV

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=336, Percent_Identity=36.6071428571429, Blast_Score=187, Evalue=8e-48,
Organism=Homo sapiens, GI8923380, Length=316, Percent_Identity=31.3291139240506, Blast_Score=121, Evalue=7e-28,
Organism=Escherichia coli, GI1789445, Length=341, Percent_Identity=58.9442815249267, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17557464, Length=333, Percent_Identity=34.8348348348348, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71995670, Length=324, Percent_Identity=31.4814814814815, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320099, Length=371, Percent_Identity=32.6145552560647, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322891, Length=358, Percent_Identity=27.3743016759777, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129063, Length=338, Percent_Identity=34.6153846153846, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21357207, Length=323, Percent_Identity=32.1981424148607, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_CHRVO (Q7NUE3)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902427.1
- ProteinModelPortal:   Q7NUE3
- SMR:   Q7NUE3
- MEROPS:   M22.001
- GeneID:   2548829
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2757
- NMPDR:   fig|243365.1.peg.2757
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q7NUE3
- ProtClustDB:   PRK09604
- BioCyc:   CVIO243365:CV_2757-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36204; Mature: 36204

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLGIESSCDETGVALYDTERGLLAHQLHTQMAMHAEYGGVVPELASRDHIRRAIPLTE
CEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
ACLSEAGKKLADLDAIAYTQGPGLGGALMVGASMANALAFGLNIPVIPVHHLEGHLLSPL
HHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
LADPKPEFPFLALLVSGGHTQLMAVRGVGDYEILGETVDDAAGEAFDKTAKLLGLPYPGG
HCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHCCHHHHHCCHHHHHHHHHHCCCCCCC
PLLSRLAESGSPDRFTLPRPMLHSGNLDMSFSGLKTAVLTLVRQQESAQGELDEQTRMDI
HHHHHHHHCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
CRAFQEAIVEVLVKKSLAAMRQAGMKRLVVAGGVGANKQLRAALNDAAARKRFDVFYPPL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCE
ALCTDNGAMIAFAGAMRLKFAEPAGGFTIKPRWDLSSLPAV
EEEECCCCEEEEEEEEEEEEECCCCCEEECCCCCHHCCCCC
>Mature Secondary Structure
MLVLGIESSCDETGVALYDTERGLLAHQLHTQMAMHAEYGGVVPELASRDHIRRAIPLTE
CEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
ACLSEAGKKLADLDAIAYTQGPGLGGALMVGASMANALAFGLNIPVIPVHHLEGHLLSPL
HHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
LADPKPEFPFLALLVSGGHTQLMAVRGVGDYEILGETVDDAAGEAFDKTAKLLGLPYPGG
HCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHCCHHHHHCCHHHHHHHHHHCCCCCCC
PLLSRLAESGSPDRFTLPRPMLHSGNLDMSFSGLKTAVLTLVRQQESAQGELDEQTRMDI
HHHHHHHHCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
CRAFQEAIVEVLVKKSLAAMRQAGMKRLVVAGGVGANKQLRAALNDAAARKRFDVFYPPL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCE
ALCTDNGAMIAFAGAMRLKFAEPAGGFTIKPRWDLSSLPAV
EEEECCCCEEEEEEEEEEEEECCCCCEEECCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782