Click here to switch to the map view.

The map label for this gene is xerC

Identifier: 34497827

GI number: 34497827

Start: 2556799

End: 2557698

Strand: Reverse

Name: xerC

Synonym: CV_2372

Alternate gene names: 34497827

Gene position: 2557698-2556799 (Counterclockwise)

Preceding gene: 34497828

Following gene: 34497822

Centisome position: 53.83

GC content: 66.11

Gene sequence:

>900_bases
ATGGACGAGGCCATCCGCCGCTTCATCGAGCATCTGGCCGTCGCCGGCCGCAGCCCGCACACGCTCGCAGCCTACCGGGC
CGACATCGAACTGCTGGAAAACATGATGCAGGCCAAATCCGCTCGCGACGCCACCGCCGCGGAATTGCGCAAGGCGCTGG
CCAAATTGCACGCGCAAGGATTGAGCAGCCGCAGCCTGGCGCGGCGGCTGTCCTCGTGGCGGCAGTTCTACCATTGGCTG
CAGCGCAACGGAGAGCGCGAGGACAACCCTGCCGCCGGGCTGTACGCCCCCAAGCGAGACAAGTTGCTGCCCAAGGCATT
GCCGGTCGACGGCACGGCAGCGCTGCTCGACCGGATAGAAGGCGAAAGCGAACTGGATGCCCGCGACCGCGCGATATTCG
AGCTGGTTTACAGCTGCGGCCTCCGGCTGTCGGAAACCGTGGCGCTGAATCTGGACGACGTGGACTTTTCCGACAGTCTG
CTGCGCATCCGCGGCAAGGGCGGCAAGGAGAGGCTGGTGCCCATCGGCGCCGAAGCCATGCTCAGACTGCGGACCTGGCT
GGGCGAACGCTCGGCGGGAATGGATGAGCCGGCGCTGTTTCTGGGCCGGCACGGCCACCGGCTGGGAGGCCGCCAGGTGG
AAAAACGATTGCGCGACTGGGCGATCAAGACCGGGGCCGGCCAGCATGTCCACCCGCACATGCTGCGCCACTCGTTCGCC
TCCCACATGCTGCAATCATCAGGCGATCTGCGCGCGGTGCAGGAACTGCTGGGCCACGCCAACCTGTCCAGCACCCAGAT
TTACACCGCGCTGGACTTCCAGCACCTGGCCAAGGTGTATGACGGCGCGCATCCGCGCGCGCGCAAGCGCGGCAAGCCGG
ACGACGAAAACAAATCATAA

Upstream 100 bases:

>100_bases
AACGCGCCGCCGCCCCTGGCCGGCGCGCTGCTGAAGAACGAGCAGGATCTGCAGCTGTTCGAGCGGCTGATGCAGATGGC
GCGCCTGCGCCGCAACTGAG

Downstream 100 bases:

>100_bases
AACCGGCAGCGGCCATCAGCCGCCCTTGTGCACGTCGCGGCATAGCAACATCGCATGGATGTTGTCCGCCTTGTCGGCAT
CGAAGCCCAGGCGCGCCACT

Product: integrase/recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDEAIRRFIEHLAVAGRSPHTLAAYRADIELLENMMQAKSARDATAAELRKALAKLHAQGLSSRSLARRLSSWRQFYHWL
QRNGEREDNPAAGLYAPKRDKLLPKALPVDGTAALLDRIEGESELDARDRAIFELVYSCGLRLSETVALNLDDVDFSDSL
LRIRGKGGKERLVPIGAEAMLRLRTWLGERSAGMDEPALFLGRHGHRLGGRQVEKRLRDWAIKTGAGQHVHPHMLRHSFA
SHMLQSSGDLRAVQELLGHANLSSTQIYTALDFQHLAKVYDGAHPRARKRGKPDDENKS

Sequences:

>Translated_299_residues
MDEAIRRFIEHLAVAGRSPHTLAAYRADIELLENMMQAKSARDATAAELRKALAKLHAQGLSSRSLARRLSSWRQFYHWL
QRNGEREDNPAAGLYAPKRDKLLPKALPVDGTAALLDRIEGESELDARDRAIFELVYSCGLRLSETVALNLDDVDFSDSL
LRIRGKGGKERLVPIGAEAMLRLRTWLGERSAGMDEPALFLGRHGHRLGGRQVEKRLRDWAIKTGAGQHVHPHMLRHSFA
SHMLQSSGDLRAVQELLGHANLSSTQIYTALDFQHLAKVYDGAHPRARKRGKPDDENKS
>Mature_299_residues
MDEAIRRFIEHLAVAGRSPHTLAAYRADIELLENMMQAKSARDATAAELRKALAKLHAQGLSSRSLARRLSSWRQFYHWL
QRNGEREDNPAAGLYAPKRDKLLPKALPVDGTAALLDRIEGESELDARDRAIFELVYSCGLRLSETVALNLDDVDFSDSL
LRIRGKGGKERLVPIGAEAMLRLRTWLGERSAGMDEPALFLGRHGHRLGGRQVEKRLRDWAIKTGAGQHVHPHMLRHSFA
SHMLQSSGDLRAVQELLGHANLSSTQIYTALDFQHLAKVYDGAHPRARKRGKPDDENKS

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4973

COG function: function code L; Site-specific recombinase XerC

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=295, Percent_Identity=48.4745762711864, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789261, Length=295, Percent_Identity=35.5932203389831, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790768, Length=159, Percent_Identity=32.7044025157233, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790767, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_CHRVO (Q7NVH1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902042.1
- HSSP:   P0A8P8
- ProteinModelPortal:   Q7NVH1
- SMR:   Q7NVH1
- GeneID:   2546987
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2372
- NMPDR:   fig|243365.1.peg.2372
- HOGENOM:   HBG727654
- OMA:   DININQK
- PhylomeDB:   Q7NVH1
- BioCyc:   CVIO243365:CV_2372-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33497; Mature: 33497

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: ACT_SITE 142-142 ACT_SITE 166-166 ACT_SITE 233-233 ACT_SITE 236-236 ACT_SITE 259-259 ACT_SITE 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEAIRRFIEHLAVAGRSPHTLAAYRADIELLENMMQAKSARDATAAELRKALAKLHAQG
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
LSSRSLARRLSSWRQFYHWLQRNGEREDNPAAGLYAPKRDKLLPKALPVDGTAALLDRIE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHC
GESELDARDRAIFELVYSCGLRLSETVALNLDDVDFSDSLLRIRGKGGKERLVPIGAEAM
CCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHEEECCCCCCCEEECCHHHH
LRLRTWLGERSAGMDEPALFLGRHGHRLGGRQVEKRLRDWAIKTGAGQHVHPHMLRHSFA
HHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SHMLQSSGDLRAVQELLGHANLSSTQIYTALDFQHLAKVYDGAHPRARKRGKPDDENKS
HHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MDEAIRRFIEHLAVAGRSPHTLAAYRADIELLENMMQAKSARDATAAELRKALAKLHAQG
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
LSSRSLARRLSSWRQFYHWLQRNGEREDNPAAGLYAPKRDKLLPKALPVDGTAALLDRIE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHC
GESELDARDRAIFELVYSCGLRLSETVALNLDDVDFSDSLLRIRGKGGKERLVPIGAEAM
CCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHEEECCCCCCCEEECCHHHH
LRLRTWLGERSAGMDEPALFLGRHGHRLGGRQVEKRLRDWAIKTGAGQHVHPHMLRHSFA
HHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SHMLQSSGDLRAVQELLGHANLSSTQIYTALDFQHLAKVYDGAHPRARKRGKPDDENKS
HHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782