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The map label for this gene is fkpA [H]

Identifier: 34497817

GI number: 34497817

Start: 2548833

End: 2549246

Strand: Direct

Name: fkpA [H]

Synonym: CV_2362

Alternate gene names: 34497817

Gene position: 2548833-2549246 (Clockwise)

Preceding gene: 34497816

Following gene: 34497823

Centisome position: 53.65

GC content: 62.08

Gene sequence:

>414_bases
ATGTTTTCCACACGAATGATTTCCGCCCTGGCCCTGCTGGCCTGCGCGAGCGGCGCGCAGGCCGCGAATGCCCCGGCAGC
GCAAACCCTGTCTTCCGGCGTCAAGATCGAGGTGTTGGTCGCGGGCAAGGGCGTGAAGCCCTCCAGCGGCGATACCGTCA
AGGTCAATTACCGCGGCACGTTCAAGGATGGCAAGGAGTTCGACAGCTCCTACAAGAATGGCGGACCGATCAGCTTCCCG
CTGAATCGCGTGATCCCGTGCTGGACCCAGGGCGTCAGCGCGTTGACGGTCGGCAGCAAGGCCAAACTGTATTGCCCGGC
CAATACCGCATATGGCAGCCGTGGCGTGCCGGGCGTGATTCCGCCTGATACGCCGCTGTATTTCGAAGTGGAACTGCTGT
CCATCCAGAAGTAG

Upstream 100 bases:

>100_bases
TGACCAATCCGGACCTGCGCAAGGAATTTCTGTCCTTGATGCGGAAGTGAGCGGGCGGCATAGGGCCGGACGCGCAGCAT
TTACTTGAATGAAAGAGCCT

Downstream 100 bases:

>100_bases
CATTCGCAGGCGGACAGAAAAACAGGCCCGATATTTCGGGCCTGTTTCACACAGTTTGCCTGCATTCAGCCGGCTGGGGC
GAATAGTCCGGCGAGCGGCG

Product: fkbp-type peptidyl-prolyl cis-trans isomerase fkpA

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MFSTRMISALALLACASGAQAANAPAAQTLSSGVKIEVLVAGKGVKPSSGDTVKVNYRGTFKDGKEFDSSYKNGGPISFP
LNRVIPCWTQGVSALTVGSKAKLYCPANTAYGSRGVPGVIPPDTPLYFEVELLSIQK

Sequences:

>Translated_137_residues
MFSTRMISALALLACASGAQAANAPAAQTLSSGVKIEVLVAGKGVKPSSGDTVKVNYRGTFKDGKEFDSSYKNGGPISFP
LNRVIPCWTQGVSALTVGSKAKLYCPANTAYGSRGVPGVIPPDTPLYFEVELLSIQK
>Mature_137_residues
MFSTRMISALALLACASGAQAANAPAAQTLSSGVKIEVLVAGKGVKPSSGDTVKVNYRGTFKDGKEFDSSYKNGGPISFP
LNRVIPCWTQGVSALTVGSKAKLYCPANTAYGSRGVPGVIPPDTPLYFEVELLSIQK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.9906542056075, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.9906542056075, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=41.1214953271028, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI206725530, Length=136, Percent_Identity=38.2352941176471, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI17149844, Length=136, Percent_Identity=38.2352941176471, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI17149842, Length=136, Percent_Identity=38.2352941176471, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI4503729, Length=138, Percent_Identity=35.5072463768116, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI192448443, Length=88, Percent_Identity=40.9090909090909, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI224809329, Length=92, Percent_Identity=40.2173913043478, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI224809327, Length=92, Percent_Identity=40.2173913043478, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI4758384, Length=92, Percent_Identity=40.2173913043478, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI224809331, Length=92, Percent_Identity=40.2173913043478, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=38.3838383838384, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI8923659, Length=112, Percent_Identity=40.1785714285714, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI33469985, Length=89, Percent_Identity=38.2022471910112, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=115, Percent_Identity=50.4347826086956, Blast_Score=108, Evalue=9e-26,
Organism=Escherichia coli, GI87082390, Length=116, Percent_Identity=42.2413793103448, Blast_Score=98, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=45.2830188679245, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=139, Percent_Identity=35.2517985611511, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=95, Percent_Identity=45.2631578947368, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=95, Percent_Identity=51.5789473684211, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324194, Length=113, Percent_Identity=40.7079646017699, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323566, Length=119, Percent_Identity=36.1344537815126, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=114, Percent_Identity=38.5964912280702, Blast_Score=72, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=43.2692307692308, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363946, Length=136, Percent_Identity=36.0294117647059, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17352457, Length=136, Percent_Identity=36.0294117647059, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647110, Length=122, Percent_Identity=40.9836065573771, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356629, Length=129, Percent_Identity=41.0852713178295, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 14272; Mature: 14272

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSTRMISALALLACASGAQAANAPAAQTLSSGVKIEVLVAGKGVKPSSGDTVKVNYRGT
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEEEC
FKDGKEFDSSYKNGGPISFPLNRVIPCWTQGVSALTVGSKAKLYCPANTAYGSRGVPGVI
CCCCHHHHHCCCCCCCEEECHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCC
PPDTPLYFEVELLSIQK
CCCCCEEEEEEEEEECC
>Mature Secondary Structure
MFSTRMISALALLACASGAQAANAPAAQTLSSGVKIEVLVAGKGVKPSSGDTVKVNYRGT
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEEEC
FKDGKEFDSSYKNGGPISFPLNRVIPCWTQGVSALTVGSKAKLYCPANTAYGSRGVPGVI
CCCCHHHHHCCCCCCCEEECHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCC
PPDTPLYFEVELLSIQK
CCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]