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The map label for this gene is tdk

Identifier: 34497797

GI number: 34497797

Start: 2528359

End: 2528913

Strand: Reverse

Name: tdk

Synonym: CV_2342

Alternate gene names: 34497797

Gene position: 2528913-2528359 (Counterclockwise)

Preceding gene: 34497799

Following gene: 34497794

Centisome position: 53.23

GC content: 62.16

Gene sequence:

>555_bases
ATGGCCAAACTGTTTTTCCGATACGCCGCGATGAACAGCGGCAAGAGCACCCAGCTGCTGCAGATCGCCAACAACTACGA
ATCGATGGACAAGAAGGTGGCCCTGTACACCAGCGCCATCGACGACCGCTACGGCGTGGGCATGATCACCTCGCGGCTGA
ATATCCAGCGCGAATCCAACACCTTCGACGCCGGCTTCGATTTCCTGGCTCACGATTACGGCGACACCGCATGCGTGCTG
GTGGATGAAGCCCAGTTCATGACGCCCGAGCAGGCGCAGCAGCTGCACCGACTGGCCCACAAGCGCAATATTCCGGTGAT
CTGTTTTGGCCTGCGCACCGACTTCCAGGGCCATCCCTTCCCGGGCTCAGCCTGGCTGCTGTCGCTGGCGGACGACGTCG
AAGAGATCAAAACCATCTGCCACTGCGGCCGCAAGGCGACGATGCATATCCGCATCGACGGCGACGGCCGCCGCGTCAAG
GAAGGCCCTCAGGTGGAAATCGGCGGCGAGGCGCGCTACCGCGCCGTATGCGGCCGCTGTTTCCACCACGACTAA

Upstream 100 bases:

>100_bases
GATATCGGCAAAAAGCCGCTGGGCGAGATCGCCAGCTTCTACTGAGCGCGCCGGCCATGGTATGCTGCGCGCCCCGGCAA
CGTCCTTCGCGCCCAGCACC

Downstream 100 bases:

>100_bases
GCCCGCGCGGCAGCCAACATTCCAGAGCCGGCCAAAACCGGCTCGTTTTCATTCCGTGCGCACATAGGCCCGCAAGCGGT
GCCCATCCGGGTCCAGCGCT

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MAKLFFRYAAMNSGKSTQLLQIANNYESMDKKVALYTSAIDDRYGVGMITSRLNIQRESNTFDAGFDFLAHDYGDTACVL
VDEAQFMTPEQAQQLHRLAHKRNIPVICFGLRTDFQGHPFPGSAWLLSLADDVEEIKTICHCGRKATMHIRIDGDGRRVK
EGPQVEIGGEARYRAVCGRCFHHD

Sequences:

>Translated_184_residues
MAKLFFRYAAMNSGKSTQLLQIANNYESMDKKVALYTSAIDDRYGVGMITSRLNIQRESNTFDAGFDFLAHDYGDTACVL
VDEAQFMTPEQAQQLHRLAHKRNIPVICFGLRTDFQGHPFPGSAWLLSLADDVEEIKTICHCGRKATMHIRIDGDGRRVK
EGPQVEIGGEARYRAVCGRCFHHD
>Mature_183_residues
AKLFFRYAAMNSGKSTQLLQIANNYESMDKKVALYTSAIDDRYGVGMITSRLNIQRESNTFDAGFDFLAHDYGDTACVLV
DEAQFMTPEQAQQLHRLAHKRNIPVICFGLRTDFQGHPFPGSAWLLSLADDVEEIKTICHCGRKATMHIRIDGDGRRVKE
GPQVEIGGEARYRAVCGRCFHHD

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=182, Percent_Identity=46.7032967032967, Blast_Score=174, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_CHRVO (Q7NVK0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902012.1
- ProteinModelPortal:   Q7NVK0
- SMR:   Q7NVK0
- GeneID:   2547205
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2342
- NMPDR:   fig|243365.1.peg.2342
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- PhylomeDB:   Q7NVK0
- ProtClustDB:   PRK04296
- BioCyc:   CVIO243365:CV_2342-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 20746; Mature: 20615

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 83-83

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLFFRYAAMNSGKSTQLLQIANNYESMDKKVALYTSAIDDRYGVGMITSRLNIQRESN
CCHHEEEEECCCCCCCCEEEEEHHCHHHHHHEEEEEEHHCCCCCCCEEEEHEEEEEECCC
TFDAGFDFLAHDYGDTACVLVDEAQFMTPEQAQQLHRLAHKRNIPVICFGLRTDFQGHPF
CCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
PGSAWLLSLADDVEEIKTICHCGRKATMHIRIDGDGRRVKEGPQVEIGGEARYRAVCGRC
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHH
FHHD
HCCC
>Mature Secondary Structure 
AKLFFRYAAMNSGKSTQLLQIANNYESMDKKVALYTSAIDDRYGVGMITSRLNIQRESN
CHHEEEEECCCCCCCCEEEEEHHCHHHHHHEEEEEEHHCCCCCCCEEEEHEEEEEECCC
TFDAGFDFLAHDYGDTACVLVDEAQFMTPEQAQQLHRLAHKRNIPVICFGLRTDFQGHPF
CCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
PGSAWLLSLADDVEEIKTICHCGRKATMHIRIDGDGRRVKEGPQVEIGGEARYRAVCGRC
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHH
FHHD
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782