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The map label for this gene is serC

Identifier: 34497756

GI number: 34497756

Start: 2489033

End: 2490121

Strand: Direct

Name: serC

Synonym: CV_2301

Alternate gene names: 34497756

Gene position: 2489033-2490121 (Clockwise)

Preceding gene: 34497755

Following gene: 34497761

Centisome position: 52.39

GC content: 62.99

Gene sequence:

>1089_bases
ATGGCCAAGGTGTACAACTTTTCCGCCGGTCCCGCCGTATTGCCGCACCAGGTGCTGGCCGAGGCGCAAAGCGAGTTGCT
GGATTGGCACGGCTCCGGCATGAGCGTGATGGAGATGAGCCATCGCGGCAAGGAGTTCATGGAGATCATCCATGACGCCG
AGCAGGACCTGCGCCAGCTGATGGGCATTCCCGCCGGCTACAAGGTGCTGTTCCTGCAAGGCGGCGCGTCGCTGCAGTTC
GCGATGGCCCCGCTGAATCTGCTGGGCGACAAGGACAGCATCGACATCGTCAATACCGGCCACTGGTCCAAGCTGGCGAT
CAAGGAGGCTAAGCGCTACGCCAAGGTCAATGTGGTGGCCAGCAGCGAAGACCGCAACTTCTGTTACGTCCCGGAAGAGG
CCGCCTGGCAGCGCGACCCGAATGCCGCCTATCTGCACTACACCTCGAACGAGACCATCGGCGGCCTGCAGTTCCCCTAC
ATCCCGGCCGAGCAGCACGGCGTGCCCCTGGTCTGCGACATGTCGTCCGACTTCCTGTCGCGCGAGGTGGACGTCAGCCG
CTTCGGCATGATCTATGCCGGCGCGCAGAAGAACATCGGCCCGTCGGGGCTGACCGTGCTGCTGATCCGCGAGGATCTGC
TGGGCAAGGCGCGAGCCGACATCCCCACCATGCTGAACTACCAGGTTCACGCCGACGCCGACTCGATGTACAACACGCCG
GGCACTTACCCGATCTACATCGCCGGCCTGGTGTTCAAGTGGTTGAAGGAGCAGGGCGGCGTCAAGGGCATCGCCACCCG
CAACGAGGAAAAAGCCGGCCTGCTGTACCACGTGATCGACAGCAGCGGCGGCTTCTACTCCACCCACATCGAACAGCCGT
TCCGTTCCAAGATGAATGTGGTGTTCAAGCTGAGGGATGAGGCGCTGGACGAGATCTTCCTGCTGGAGGCGCGCAAGAAC
GGCCTGGCGCAGCTGAAGGGCCACCGCGCGGTGGGCGGCATGCGCGCTTCCATCTACAACGCGATGCCGATCGAAGGGGT
GAAGTCTCTGGTGAACTTCATGCAGGACTTCGCGCGGCAATACGGCTGA

Upstream 100 bases:

>100_bases
CGGCGCATCCCTGGCGGGAGACGCCGGTTTTTTTATACACTCGTAGCGACGCAGCCCGGAGCAGGCTGACCCGATACACG
CAAAGACACAGAGGATAGAC

Downstream 100 bases:

>100_bases
TCATCATTGCCGCAGGGGGAGCGCCGGTCTGGCCGGGGCTCCTTTTTTTATCCGCTCCGCGGCGCGGCCTAGGCGGCAGC
CGGCTTGGGCAGCTCGACGC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MAKVYNFSAGPAVLPHQVLAEAQSELLDWHGSGMSVMEMSHRGKEFMEIIHDAEQDLRQLMGIPAGYKVLFLQGGASLQF
AMAPLNLLGDKDSIDIVNTGHWSKLAIKEAKRYAKVNVVASSEDRNFCYVPEEAAWQRDPNAAYLHYTSNETIGGLQFPY
IPAEQHGVPLVCDMSSDFLSREVDVSRFGMIYAGAQKNIGPSGLTVLLIREDLLGKARADIPTMLNYQVHADADSMYNTP
GTYPIYIAGLVFKWLKEQGGVKGIATRNEEKAGLLYHVIDSSGGFYSTHIEQPFRSKMNVVFKLRDEALDEIFLLEARKN
GLAQLKGHRAVGGMRASIYNAMPIEGVKSLVNFMQDFARQYG

Sequences:

>Translated_362_residues
MAKVYNFSAGPAVLPHQVLAEAQSELLDWHGSGMSVMEMSHRGKEFMEIIHDAEQDLRQLMGIPAGYKVLFLQGGASLQF
AMAPLNLLGDKDSIDIVNTGHWSKLAIKEAKRYAKVNVVASSEDRNFCYVPEEAAWQRDPNAAYLHYTSNETIGGLQFPY
IPAEQHGVPLVCDMSSDFLSREVDVSRFGMIYAGAQKNIGPSGLTVLLIREDLLGKARADIPTMLNYQVHADADSMYNTP
GTYPIYIAGLVFKWLKEQGGVKGIATRNEEKAGLLYHVIDSSGGFYSTHIEQPFRSKMNVVFKLRDEALDEIFLLEARKN
GLAQLKGHRAVGGMRASIYNAMPIEGVKSLVNFMQDFARQYG
>Mature_361_residues
AKVYNFSAGPAVLPHQVLAEAQSELLDWHGSGMSVMEMSHRGKEFMEIIHDAEQDLRQLMGIPAGYKVLFLQGGASLQFA
MAPLNLLGDKDSIDIVNTGHWSKLAIKEAKRYAKVNVVASSEDRNFCYVPEEAAWQRDPNAAYLHYTSNETIGGLQFPYI
PAEQHGVPLVCDMSSDFLSREVDVSRFGMIYAGAQKNIGPSGLTVLLIREDLLGKARADIPTMLNYQVHADADSMYNTPG
TYPIYIAGLVFKWLKEQGGVKGIATRNEEKAGLLYHVIDSSGGFYSTHIEQPFRSKMNVVFKLRDEALDEIFLLEARKNG
LAQLKGHRAVGGMRASIYNAMPIEGVKSLVNFMQDFARQYG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=46.814404432133, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=42.296918767507, Blast_Score=298, Evalue=4e-81,
Organism=Escherichia coli, GI1787136, Length=363, Percent_Identity=53.7190082644628, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17506897, Length=358, Percent_Identity=42.1787709497207, Blast_Score=316, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324758, Length=384, Percent_Identity=36.1979166666667, Blast_Score=255, Evalue=8e-69,
Organism=Drosophila melanogaster, GI21356589, Length=362, Percent_Identity=48.3425414364641, Blast_Score=355, Evalue=2e-98,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_CHRVO (Q7NVP1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901971.1
- ProteinModelPortal:   Q7NVP1
- SMR:   Q7NVP1
- GeneID:   2549777
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2301
- NMPDR:   fig|243365.1.peg.2301
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   Q7NVP1
- ProtClustDB:   PRK05355
- BioCyc:   CVIO243365:CV_2301-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40160; Mature: 40029

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 152-152 BINDING 173-173 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYNFSAGPAVLPHQVLAEAQSELLDWHGSGMSVMEMSHRGKEFMEIIHDAEQDLRQL
CCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
MGIPAGYKVLFLQGGASLQFAMAPLNLLGDKDSIDIVNTGHWSKLAIKEAKRYAKVNVVA
HCCCCCCEEEEEECCCCEEEEECCHHHCCCCCCEEEEECCCCHHHHHHHHHHHEEEEEEE
SSEDRNFCYVPEEAAWQRDPNAAYLHYTSNETIGGLQFPYIPAEQHGVPLVCDMSSDFLS
CCCCCCEEECCCHHHCCCCCCCEEEEEECCCCCCCEECCCCCCCCCCCCEEEECCHHHHH
REVDVSRFGMIYAGAQKNIGPSGLTVLLIREDLLGKARADIPTMLNYQVHADADSMYNTP
HCCCHHHHCEEEECCCCCCCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCHHHCCCC
GTYPIYIAGLVFKWLKEQGGVKGIATRNEEKAGLLYHVIDSSGGFYSTHIEQPFRSKMNV
CCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCEEEHHCCCHHHHHHHE
VFKLRDEALDEIFLLEARKNGLAQLKGHRAVGGMRASIYNAMPIEGVKSLVNFMQDFARQ
EEEEHHHHHHHEEEEHHCCCCHHHHCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
YG
CC
>Mature Secondary Structure 
AKVYNFSAGPAVLPHQVLAEAQSELLDWHGSGMSVMEMSHRGKEFMEIIHDAEQDLRQL
CEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
MGIPAGYKVLFLQGGASLQFAMAPLNLLGDKDSIDIVNTGHWSKLAIKEAKRYAKVNVVA
HCCCCCCEEEEEECCCCEEEEECCHHHCCCCCCEEEEECCCCHHHHHHHHHHHEEEEEEE
SSEDRNFCYVPEEAAWQRDPNAAYLHYTSNETIGGLQFPYIPAEQHGVPLVCDMSSDFLS
CCCCCCEEECCCHHHCCCCCCCEEEEEECCCCCCCEECCCCCCCCCCCCEEEECCHHHHH
REVDVSRFGMIYAGAQKNIGPSGLTVLLIREDLLGKARADIPTMLNYQVHADADSMYNTP
HCCCHHHHCEEEECCCCCCCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCHHHCCCC
GTYPIYIAGLVFKWLKEQGGVKGIATRNEEKAGLLYHVIDSSGGFYSTHIEQPFRSKMNV
CCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCEEEHHCCCHHHHHHHE
VFKLRDEALDEIFLLEARKNGLAQLKGHRAVGGMRASIYNAMPIEGVKSLVNFMQDFARQ
EEEEHHHHHHHEEEEHHCCCCHHHHCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
YG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782