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The map label for this gene is fabZ

Identifier: 34497662

GI number: 34497662

Start: 2378583

End: 2379035

Strand: Direct

Name: fabZ

Synonym: CV_2207

Alternate gene names: 34497662

Gene position: 2378583-2379035 (Clockwise)

Preceding gene: 34497661

Following gene: 34497663

Centisome position: 50.06

GC content: 63.13

Gene sequence:

>453_bases
ATGAGTGAACACGCTGTCTCGATCGATGTCCGCGAGATCATGCGCTGCCTGCCGCATCGTTACCCGTTCCTGCTGGTTGA
CCGCGTCACCGAAATGGAGCCCAACGTGCGCATCAAGGCGCTGAAGAACGTCACCATCAACGAGCCGTTCTTCGTCGGCC
ACTTCGAACAATATCCGGTGATGCCGGGCGTGCTGATCATCGAGGCGCTGGCCCAGGCCGCCGGCATCCTGGCGATCAAG
AGCCAGGGCGAACGCTTGGAGAACGAGCTGTACTTCTTCGTCGGCATCGACAACGCCCGCTTCAAGCGCCAGGTGGTGCC
GGGCGACCAACTGGTGTTCGAAGTGACGCAGATGACCGTCAAGCGCGGCATCGGCAAGTACGCCGCGCGCGCGCTGGTGG
ACGGCCAGGTGGCTTGCGAAGCCGAGATCATGTGCGCGCGCCGCGAGGTGTGA

Upstream 100 bases:

>100_bases
TCCAACGCCGTCCACGTGCGTCATCTGGACGATTTCGCCAAGCGCGTGAAGCAGCTTGAGCGGGAACTGGAAACACTGAA
AAAATCGAAGGAAGAACCTC

Downstream 100 bases:

>100_bases
ACATGGCCATTCATCCGACCGCAATCGTAGATCCCAAGGCGCAGATCGCCGACGACGTCGAAATCGGCGCCTATTCCATC
ATCGGCCCCAACGTCAGCAT

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: but-2-enoyl-[acyl-carrier protein]; H2O

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MSEHAVSIDVREIMRCLPHRYPFLLVDRVTEMEPNVRIKALKNVTINEPFFVGHFEQYPVMPGVLIIEALAQAAGILAIK
SQGERLENELYFFVGIDNARFKRQVVPGDQLVFEVTQMTVKRGIGKYAARALVDGQVACEAEIMCARREV

Sequences:

>Translated_150_residues
MSEHAVSIDVREIMRCLPHRYPFLLVDRVTEMEPNVRIKALKNVTINEPFFVGHFEQYPVMPGVLIIEALAQAAGILAIK
SQGERLENELYFFVGIDNARFKRQVVPGDQLVFEVTQMTVKRGIGKYAARALVDGQVACEAEIMCARREV
>Mature_149_residues
SEHAVSIDVREIMRCLPHRYPFLLVDRVTEMEPNVRIKALKNVTINEPFFVGHFEQYPVMPGVLIIEALAQAAGILAIKS
QGERLENELYFFVGIDNARFKRQVVPGDQLVFEVTQMTVKRGIGKYAARALVDGQVACEAEIMCARREV

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=147, Percent_Identity=55.7823129251701, Blast_Score=177, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_CHRVO (Q7NVY3)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901877.1
- ProteinModelPortal:   Q7NVY3
- SMR:   Q7NVY3
- GeneID:   2549205
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2207
- NMPDR:   fig|243365.1.peg.2207
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- PhylomeDB:   Q7NVY3
- ProtClustDB:   PRK00006
- BioCyc:   CVIO243365:CV_2207-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.58

Molecular weight: Translated: 16978; Mature: 16847

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: ACT_SITE 54-54

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHAVSIDVREIMRCLPHRYPFLLVDRVTEMEPNVRIKALKNVTINEPFFVGHFEQYPV
CCCCEEEECHHHHHHHCCCCCCEEEEEHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCC
MPGVLIIEALAQAAGILAIKSQGERLENELYFFVGIDNARFKRQVVPGDQLVFEVTQMTV
CCHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEEECCCCHHHEECCCCHHHHHHHHHHHH
KRGIGKYAARALVDGQVACEAEIMCARREV
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SEHAVSIDVREIMRCLPHRYPFLLVDRVTEMEPNVRIKALKNVTINEPFFVGHFEQYPV
CCCEEEECHHHHHHHCCCCCCEEEEEHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCC
MPGVLIIEALAQAAGILAIKSQGERLENELYFFVGIDNARFKRQVVPGDQLVFEVTQMTV
CCHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEEECCCCHHHEECCCCHHHHHHHHHHHH
KRGIGKYAARALVDGQVACEAEIMCARREV
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxybutanoyl-[acyl-carrier protein]

Specific reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = but-2-enoyl-[acyl-carrier protein] + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782