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The map label for this gene is lpxA [H]

Identifier: 34497663

GI number: 34497663

Start: 2379038

End: 2379814

Strand: Direct

Name: lpxA [H]

Synonym: CV_2208

Alternate gene names: 34497663

Gene position: 2379038-2379814 (Clockwise)

Preceding gene: 34497662

Following gene: 34497664

Centisome position: 50.07

GC content: 64.22

Gene sequence:

>777_bases
ATGGCCATTCATCCGACCGCAATCGTAGATCCCAAGGCGCAGATCGCCGACGACGTCGAAATCGGCGCCTATTCCATCAT
CGGCCCCAACGTCAGCATCGGCGCCGGCAGCTGGATAGGCCCGCACGTGGTGATCGAAGGCCATACCGCCATCGGCAAGA
ACAATCGCGTGTTCCAGTTCTGTTCGCTGGGCGCCATCCCGCAGGACTTGAAATACGCCGGCGAGCCGACCCGGCTGGAG
ATAGGCGACAACAACACCATCCGCGAGTTCTGCACCTTCAATACCGGCACGGTGCAGGATGGCGGCGTCACCCGCGTCGG
CAGCGACAACTGGATCATGGCCTATGTGCACATCGCGCACGACTGCCAGGTGGGCAACCACATCATCCTGGCCAATAACG
CCACCCTGGCCGGCCATGTCCACCTCGGTGACTGGGTGTTCCTGGGCGGCTTCACCAGCGTGCACCAGTTCGTCATCGTC
GGCGAGCACGCGATGACCGCCTTCGCCAGCGCGGTGGCGCAGGACATTCCGGCGTATGTGACGGCGCACGGCAACCGCGC
GGTGCCGTCCGGCATCAATGCGGAAGGCATGAAGCGCCGCGGTTTCACGCCCGAGCAGATCCGCCGCGTCCGCAACGCCT
ACAAGACCTTGTATCGCCAGGGCTTGAGCTACGACGAGGCCAAGGCCGCCATTCTGGCCGAAGCGGGCGAAGGCCATGCC
GAGCTGGAGCCGTTCGTGCGCTTCTTCGGACAATCGGCGCGAGGCATCATCCGCTGA

Upstream 100 bases:

>100_bases
CCGTCAAGCGCGGCATCGGCAAGTACGCCGCGCGCGCGCTGGTGGACGGCCAGGTGGCTTGCGAAGCCGAGATCATGTGC
GCGCGCCGCGAGGTGTGAAC

Downstream 100 bases:

>100_bases
GCTTATGAGCGACCAACTGTTCAAGCGCAAGGGGGCCTTGAAGGTTGCCATGGTGGCCGGGGAGGCTTCCGGCGACCTGC
TGGCCGCCCACCTGATGGAT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MAIHPTAIVDPKAQIADDVEIGAYSIIGPNVSIGAGSWIGPHVVIEGHTAIGKNNRVFQFCSLGAIPQDLKYAGEPTRLE
IGDNNTIREFCTFNTGTVQDGGVTRVGSDNWIMAYVHIAHDCQVGNHIILANNATLAGHVHLGDWVFLGGFTSVHQFVIV
GEHAMTAFASAVAQDIPAYVTAHGNRAVPSGINAEGMKRRGFTPEQIRRVRNAYKTLYRQGLSYDEAKAAILAEAGEGHA
ELEPFVRFFGQSARGIIR

Sequences:

>Translated_258_residues
MAIHPTAIVDPKAQIADDVEIGAYSIIGPNVSIGAGSWIGPHVVIEGHTAIGKNNRVFQFCSLGAIPQDLKYAGEPTRLE
IGDNNTIREFCTFNTGTVQDGGVTRVGSDNWIMAYVHIAHDCQVGNHIILANNATLAGHVHLGDWVFLGGFTSVHQFVIV
GEHAMTAFASAVAQDIPAYVTAHGNRAVPSGINAEGMKRRGFTPEQIRRVRNAYKTLYRQGLSYDEAKAAILAEAGEGHA
ELEPFVRFFGQSARGIIR
>Mature_257_residues
AIHPTAIVDPKAQIADDVEIGAYSIIGPNVSIGAGSWIGPHVVIEGHTAIGKNNRVFQFCSLGAIPQDLKYAGEPTRLEI
GDNNTIREFCTFNTGTVQDGGVTRVGSDNWIMAYVHIAHDCQVGNHIILANNATLAGHVHLGDWVFLGGFTSVHQFVIVG
EHAMTAFASAVAQDIPAYVTAHGNRAVPSGINAEGMKRRGFTPEQIRRVRNAYKTLYRQGLSYDEAKAAILAEAGEGHAE
LEPFVRFFGQSARGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=56.25, Blast_Score=299, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27788; Mature: 27657

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHPTAIVDPKAQIADDVEIGAYSIIGPNVSIGAGSWIGPHVVIEGHTAIGKNNRVFQF
CCCCCCEEECCCHHHCCCCCCCEEEEECCCEEECCCCCCCCEEEEECCEEECCCCCEEEE
CSLGAIPQDLKYAGEPTRLEIGDNNTIREFCTFNTGTVQDGGVTRVGSDNWIMAYVHIAH
ECCCCCCHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEE
DCQVGNHIILANNATLAGHVHLGDWVFLGGFTSVHQFVIVGEHAMTAFASAVAQDIPAYV
CCCCCCEEEEECCCEEEEEEEECCEEEECCHHHHEEEEEECHHHHHHHHHHHHHHCCEEE
TAHGNRAVPSGINAEGMKRRGFTPEQIRRVRNAYKTLYRQGLSYDEAKAAILAEAGEGHA
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCCC
ELEPFVRFFGQSARGIIR
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AIHPTAIVDPKAQIADDVEIGAYSIIGPNVSIGAGSWIGPHVVIEGHTAIGKNNRVFQF
CCCCCEEECCCHHHCCCCCCCEEEEECCCEEECCCCCCCCEEEEECCEEECCCCCEEEE
CSLGAIPQDLKYAGEPTRLEIGDNNTIREFCTFNTGTVQDGGVTRVGSDNWIMAYVHIAH
ECCCCCCHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEE
DCQVGNHIILANNATLAGHVHLGDWVFLGGFTSVHQFVIVGEHAMTAFASAVAQDIPAYV
CCCCCCEEEEECCCEEEEEEEECCEEEECCHHHHEEEEEECHHHHHHHHHHHHHHCCEEE
TAHGNRAVPSGINAEGMKRRGFTPEQIRRVRNAYKTLYRQGLSYDEAKAAILAEAGEGHA
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCCC
ELEPFVRFFGQSARGIIR
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA