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The map label for this gene is lpxD

Identifier: 34497661

GI number: 34497661

Start: 2377544

End: 2378590

Strand: Direct

Name: lpxD

Synonym: CV_2206

Alternate gene names: 34497661

Gene position: 2377544-2378590 (Clockwise)

Preceding gene: 34497660

Following gene: 34497662

Centisome position: 50.04

GC content: 65.62

Gene sequence:

>1047_bases
ATGTCCTACACACTCGAACACATCGTAAAGCAACTGGGCGGAGCGCTGCGCGGCCCGAACCGGGAAGTGTCCCGGCTGGC
CCCGCTTGAGCTGGCCGGCGCCGGCGAGATCGCCTTCGTCGCCAGCGCCAAGTTCCGTCGCCAGATGCTGGAAAGCGCGG
CGGACGCGCTGATCGTCACCGAGGCGCTGGCCGCCGAGCTGCCGGACCGCTCGCTGATCGTGGCCGCCGATCCCTATCTG
TATTTCGCGCGGCTGGCGACGCTGTTCCATCCGCCCAAGGCGCCGCGCGCCGGCATCCATCCGCGCGCGGTGGTGGGCGT
GGGCTGCCGGATAGGCGAGAGCAGCGAGATCGCGGCCAACGCGACCATCGGCGACAACGTCGTCATCGGCGAGCGCTGCC
GCCTGATGCCAGGCGTGGTGGTCGGCGACGGCTGCGAGATCGGCGACGACGTCACGCTTTACCCCAATGTCACCATCTAT
CATGACTGCGTGATCGGCAACCGCGTCGGCGTGCACTCGGGCAGCGTGATCGGCGGCGACGGCTTCGGCCTGGCCTGGGA
CAAGGACCACTGGTTCAAGATCCCGCAAACGGGCAGGGTGGTGCTGGAGGACGACGTCGAGATCGGCGCCAACACCACAG
TGGACCGCGGCGCGCTGGTGGATACGGTGATCCGCAAGGGCGCCAAGATAGATAACCTGGTGCAGATTGCCCACAATGTT
GAAATCGGCGAGCATACCGCCATCGCCGGCTGCGTCGGCATCGCCGGCAGCACCAAGATCGGCGCGCGCTGCACCGTCGG
CGGCGCGGCGATGTTCGTCGGCCACATCGAAGTGGCGGACCGCACTCATATCGGCGGCGGCACCCTGGTGTCGAAGTCGA
TCAAGGAGGCCGGCAACTACGCGTCCTCCTACCCGTTGCAAAGCATGAAGGATTGGCTGTCCAACGCCGTCCACGTGCGT
CATCTGGACGATTTCGCCAAGCGCGTGAAGCAGCTTGAGCGGGAACTGGAAACACTGAAAAAATCGAAGGAAGAACCTCA
TGAGTGA

Upstream 100 bases:

>100_bases
CCCCAAGTTCGATCTGACGCCGCAAGTGCTGAAAGAGCTGGACAAGTAATCGTCTCAACCGTCACCGGAGTAAGCCGACC
CCGAGTCGGCTTTGTTTTTG

Downstream 100 bases:

>100_bases
ACACGCTGTCTCGATCGATGTCCGCGAGATCATGCGCTGCCTGCCGCATCGTTACCCGTTCCTGCTGGTTGACCGCGTCA
CCGAAATGGAGCCCAACGTG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSYTLEHIVKQLGGALRGPNREVSRLAPLELAGAGEIAFVASAKFRRQMLESAADALIVTEALAAELPDRSLIVAADPYL
YFARLATLFHPPKAPRAGIHPRAVVGVGCRIGESSEIAANATIGDNVVIGERCRLMPGVVVGDGCEIGDDVTLYPNVTIY
HDCVIGNRVGVHSGSVIGGDGFGLAWDKDHWFKIPQTGRVVLEDDVEIGANTTVDRGALVDTVIRKGAKIDNLVQIAHNV
EIGEHTAIAGCVGIAGSTKIGARCTVGGAAMFVGHIEVADRTHIGGGTLVSKSIKEAGNYASSYPLQSMKDWLSNAVHVR
HLDDFAKRVKQLERELETLKKSKEEPHE

Sequences:

>Translated_348_residues
MSYTLEHIVKQLGGALRGPNREVSRLAPLELAGAGEIAFVASAKFRRQMLESAADALIVTEALAAELPDRSLIVAADPYL
YFARLATLFHPPKAPRAGIHPRAVVGVGCRIGESSEIAANATIGDNVVIGERCRLMPGVVVGDGCEIGDDVTLYPNVTIY
HDCVIGNRVGVHSGSVIGGDGFGLAWDKDHWFKIPQTGRVVLEDDVEIGANTTVDRGALVDTVIRKGAKIDNLVQIAHNV
EIGEHTAIAGCVGIAGSTKIGARCTVGGAAMFVGHIEVADRTHIGGGTLVSKSIKEAGNYASSYPLQSMKDWLSNAVHVR
HLDDFAKRVKQLERELETLKKSKEEPHE
>Mature_347_residues
SYTLEHIVKQLGGALRGPNREVSRLAPLELAGAGEIAFVASAKFRRQMLESAADALIVTEALAAELPDRSLIVAADPYLY
FARLATLFHPPKAPRAGIHPRAVVGVGCRIGESSEIAANATIGDNVVIGERCRLMPGVVVGDGCEIGDDVTLYPNVTIYH
DCVIGNRVGVHSGSVIGGDGFGLAWDKDHWFKIPQTGRVVLEDDVEIGANTTVDRGALVDTVIRKGAKIDNLVQIAHNVE
IGEHTAIAGCVGIAGSTKIGARCTVGGAAMFVGHIEVADRTHIGGGTLVSKSIKEAGNYASSYPLQSMKDWLSNAVHVRH
LDDFAKRVKQLERELETLKKSKEEPHE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=345, Percent_Identity=41.4492753623188, Blast_Score=252, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_CHRVO (Q7NVY4)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901876.1
- ProteinModelPortal:   Q7NVY4
- GeneID:   2549370
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2206
- NMPDR:   fig|243365.1.peg.2206
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   Q7NVY4
- ProtClustDB:   PRK00892
- BioCyc:   CVIO243365:CV_2206-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37121; Mature: 36990

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTLEHIVKQLGGALRGPNREVSRLAPLELAGAGEIAFVASAKFRRQMLESAADALIVT
CCCCHHHHHHHHHHHHCCCCCHHHHCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHH
EALAAELPDRSLIVAADPYLYFARLATLFHPPKAPRAGIHPRAVVGVGCRIGESSEIAAN
HHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECEECCCCCCEEEE
ATIGDNVVIGERCRLMPGVVVGDGCEIGDDVTLYPNVTIYHDCVIGNRVGVHSGSVIGGD
CCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCEEEEEEEEECCCCCCCCCCEECCC
GFGLAWDKDHWFKIPQTGRVVLEDDVEIGANTTVDRGALVDTVIRKGAKIDNLVQIAHNV
CCCEEECCCCCEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
EIGEHTAIAGCVGIAGSTKIGARCTVGGAAMFVGHIEVADRTHIGGGTLVSKSIKEAGNY
CCCCCHHHHHHHCCCCCCCCCCEEEECCEEEEEEEEEECCCEECCCCHHHHHHHHHHCCC
ASSYPLQSMKDWLSNAVHVRHLDDFAKRVKQLERELETLKKSKEEPHE
CCCCCHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SYTLEHIVKQLGGALRGPNREVSRLAPLELAGAGEIAFVASAKFRRQMLESAADALIVT
CCCHHHHHHHHHHHHCCCCCHHHHCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHH
EALAAELPDRSLIVAADPYLYFARLATLFHPPKAPRAGIHPRAVVGVGCRIGESSEIAAN
HHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECEECCCCCCEEEE
ATIGDNVVIGERCRLMPGVVVGDGCEIGDDVTLYPNVTIYHDCVIGNRVGVHSGSVIGGD
CCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCEEEEEEEEECCCCCCCCCCEECCC
GFGLAWDKDHWFKIPQTGRVVLEDDVEIGANTTVDRGALVDTVIRKGAKIDNLVQIAHNV
CCCEEECCCCCEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
EIGEHTAIAGCVGIAGSTKIGARCTVGGAAMFVGHIEVADRTHIGGGTLVSKSIKEAGNY
CCCCCHHHHHHHCCCCCCCCCCEEEECCEEEEEEEEEECCCEECCCCHHHHHHHHHHCCC
ASSYPLQSMKDWLSNAVHVRHLDDFAKRVKQLERELETLKKSKEEPHE
CCCCCHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782