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The map label for this gene is mmsB [H]

Identifier: 34497536

GI number: 34497536

Start: 2266746

End: 2267636

Strand: Reverse

Name: mmsB [H]

Synonym: CV_2081

Alternate gene names: 34497536

Gene position: 2267636-2266746 (Counterclockwise)

Preceding gene: 34497537

Following gene: 34497535

Centisome position: 47.73

GC content: 67.79

Gene sequence:

>891_bases
ATGGAAAACATCGCCTTCATCGGCCTGGGCAATATGGGCGGGCCGATGGCCGTCAATCTGCTGAACAAGGGCTTCAAGGT
CAGCGCCTTCGACTTGTCGGCCGACGCGCTGGCCAAGGTGGCCGCCGCCGGCGGCCGCGCCGCGTCCAGCGCCGCCGACG
CGGCCGAGAGCGCAAGCGTGGTGATTTCCATGCTGCCGGCCGGCAAGCACGTGGCCGGCCTGTATCTGGGCGATAACGGC
CTGTTCGCCAGGCTGCCCAAGGGCGCGCTGGTCATCGACTGCAGCACCATAGACGCCGGCACCGCGCGCAAAGTCGCCGA
AGGCGCGCGGGAAAAAGGCCTGTCCATGCTGGACGCGCCGGTCTCCGGCGGCACCGCCGGCGCCGCCGCCGGCACGCTGA
CCTTCATCGTCGGCGGCGCGGCGGAAGACCTGGCCCACGCCCGCCCGGTGCTGGAGGCGATGGGCAAGAATATCTTCCAT
GCCGGCGGCGCCGGCGCCGGCCAGACCGCCAAGATCTGCAACAACATGCTGCTGGGCATCCTGATGGCCGGCACCGCCGA
GGCGCTGGCGCTGGGCGTCAAGAACGGCCTGGACCCGAAAGTGCTGTCCGAGATCATCAGCAAGAGCTCGGGCCGCAACT
GGGCGACCGAGCTCTACAACCCCTGGCCCGGCGTAATGGACAACACGCCGGCCAGCCGCGGCTACGCCGGCGGCTTCATG
TCCGAGCTGATGCTGAAGGATCTGGGCTTGGCCGAGGAAACCGCACTGCAGAGCCACGCCGCCAATCCGCTGGGCGCGCT
GGCGCGCAATCTGTATGAGGAGCACGTGCACCAGGGCAACGGCAAGCTGGACTTTTCCAGCATCGTCAAACACTTTCACT
CGCTGAATTGA

Upstream 100 bases:

>100_bases
ATCGACCAGGCCTGGGTGGACGGGCATTTCGAATCGCCGTGGCGCGAGGCCGACCACCCGCTGGCGGGATTGAAATAACA
AGCATACAGAGGAGAACAGC

Downstream 100 bases:

>100_bases
AACAGGTCCAGATAACTGCCACAGCGATATGACATGTGATAAATTCATGTCATGTCTGCGACAGGGAGGGCGCTCAGGCG
CCCTCCTTTCTTGTTTCGGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MENIAFIGLGNMGGPMAVNLLNKGFKVSAFDLSADALAKVAAAGGRAASSAADAAESASVVISMLPAGKHVAGLYLGDNG
LFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDAPVSGGTAGAAAGTLTFIVGGAAEDLAHARPVLEAMGKNIFH
AGGAGAGQTAKICNNMLLGILMAGTAEALALGVKNGLDPKVLSEIISKSSGRNWATELYNPWPGVMDNTPASRGYAGGFM
SELMLKDLGLAEETALQSHAANPLGALARNLYEEHVHQGNGKLDFSSIVKHFHSLN

Sequences:

>Translated_296_residues
MENIAFIGLGNMGGPMAVNLLNKGFKVSAFDLSADALAKVAAAGGRAASSAADAAESASVVISMLPAGKHVAGLYLGDNG
LFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDAPVSGGTAGAAAGTLTFIVGGAAEDLAHARPVLEAMGKNIFH
AGGAGAGQTAKICNNMLLGILMAGTAEALALGVKNGLDPKVLSEIISKSSGRNWATELYNPWPGVMDNTPASRGYAGGFM
SELMLKDLGLAEETALQSHAANPLGALARNLYEEHVHQGNGKLDFSSIVKHFHSLN
>Mature_296_residues
MENIAFIGLGNMGGPMAVNLLNKGFKVSAFDLSADALAKVAAAGGRAASSAADAAESASVVISMLPAGKHVAGLYLGDNG
LFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDAPVSGGTAGAAAGTLTFIVGGAAEDLAHARPVLEAMGKNIFH
AGGAGAGQTAKICNNMLLGILMAGTAEALALGVKNGLDPKVLSEIISKSSGRNWATELYNPWPGVMDNTPASRGYAGGFM
SELMLKDLGLAEETALQSHAANPLGALARNLYEEHVHQGNGKLDFSSIVKHFHSLN

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=290, Percent_Identity=45.8620689655172, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI40556376, Length=291, Percent_Identity=24.7422680412371, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=38.4353741496599, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=35.4948805460751, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=31.1418685121107, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789092, Length=300, Percent_Identity=32, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=269, Percent_Identity=45.3531598513011, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655230, Length=287, Percent_Identity=44.9477351916376, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19922568, Length=287, Percent_Identity=44.9477351916376, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28574115, Length=191, Percent_Identity=27.2251308900524, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30051; Mature: 30051

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIAFIGLGNMGGPMAVNLLNKGFKVSAFDLSADALAKVAAAGGRAASSAADAAESASV
CCCEEEEEECCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
VISMLPAGKHVAGLYLGDNGLFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDAP
HEEECCCCCCEEEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEECCC
VSGGTAGAAAGTLTFIVGGAAEDLAHARPVLEAMGKNIFHAGGAGAGQTAKICNNMLLGI
CCCCCCHHHHHEEEEEECCCHHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHH
LMAGTAEALALGVKNGLDPKVLSEIISKSSGRNWATELYNPWPGVMDNTPASRGYAGGFM
HHHCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHH
SELMLKDLGLAEETALQSHAANPLGALARNLYEEHVHQGNGKLDFSSIVKHFHSLN
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MENIAFIGLGNMGGPMAVNLLNKGFKVSAFDLSADALAKVAAAGGRAASSAADAAESASV
CCCEEEEEECCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
VISMLPAGKHVAGLYLGDNGLFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDAP
HEEECCCCCCEEEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEECCC
VSGGTAGAAAGTLTFIVGGAAEDLAHARPVLEAMGKNIFHAGGAGAGQTAKICNNMLLGI
CCCCCCHHHHHEEEEEECCCHHHHHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHH
LMAGTAEALALGVKNGLDPKVLSEIISKSSGRNWATELYNPWPGVMDNTPASRGYAGGFM
HHHCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHH
SELMLKDLGLAEETALQSHAANPLGALARNLYEEHVHQGNGKLDFSSIVKHFHSLN
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]