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The map label for this gene is adh [H]

Identifier: 34497506

GI number: 34497506

Start: 2238036

End: 2239112

Strand: Direct

Name: adh [H]

Synonym: CV_2051

Alternate gene names: 34497506

Gene position: 2238036-2239112 (Clockwise)

Preceding gene: 34497502

Following gene: 34497513

Centisome position: 47.11

GC content: 66.48

Gene sequence:

>1077_bases
ATGAGCAGCATGAAAGCAACGGTATTCGTCGGACCCGGCAGGATAGAGCTGAGGGAGAAGCCGATTCCGGCAGTCGGCCC
CGGCGACGCGCTGGTGAAAATCACCACCACCACCATCTGCGGCACCGACGTGCACATTCTCAAGGGCGAGTATCCGGTGG
CGTCCGGCCTGACGATAGGGCACGAGCCGGTGGGCGTGATCGAGAAATTGGGCGCGGACGTCAAGGGCTACCGCGAGGGG
CAGCGGGTGATCGCCGGCGCGATCTGTCCCAGCTTCACTTCTTACGGCTGCCAGGACGGCCATCCGGCGCAGGACGGCGG
CTGCGAATGCCACGGCTACAAGCCGATGGGCGGCTGGCGTTTCGGCAACACCATAGACGGCACCCAAGCCGAGTACGTGC
TGGTGCCGGACGCCCAGGCGAACCTGGCGCCGATCCCCGACGGGCTGAGCGACGAGCAGGTGCTGATGTGTCCGGACATC
ATGTCCACCGGCTTCGCCGGCGCGGAGGCGGCCAATATCAGGATAGGCGACGTGGTGGTGGTGTTCGCCCAGGGGCCGAT
CGGCCTGTGCGCGGTGGCCGGCGCCAGGCTGCGCGGCGCTTCGTGCATCATCGCGGTGGACGGGCTGGACGAACGCTTGG
GCATTTCCCGCCGGCTGGGCGCCGACGTCACGCTCAATTTCAAACAAGTGGACGTGATCGCCGAGATCATGAAGCTGACC
GGCGGGCGCGGCGTCGACGCCTCCATCGAGGCGTTGGGCACCCAGGGGACGTTCGAGTCGGCGCTCAGGGTGTTGAAGCC
GGGCGGCACGCTGTCCAGCCTGGGCGTGTACTCGAGCGATCTGAGGATTCCGCTGGACGCGTTCAACGCCGGGCTCGGCG
ACAAGCGCATCGTGTCCTCGCTGTGCCCGGGCGGCAAGGAGAGGATGCGGCGGCTGATGAACGTGCTGGAGAGCGACAGG
CTGGACCTGTCGCCGCTGGTCACGCATCGCTACAAGCTGGACCAGATCGTCGAGGCTTACGACCTGTTCTCGCATCAGCG
CGACGGCGTGCTGAAGGTGGCGATCCAGCCTTTCTAG

Upstream 100 bases:

>100_bases
CCGCCGGTTTGCGGCCTAGTGTTAAGGATGCGTTTCGTTTCCATCCTGGAGCCGGTTGCGGTCATGGCCGGGCGGGCTCC
GCCACGACAGGAGGCAAGCC

Downstream 100 bases:

>100_bases
CCATTCGCGGCAAGGAGCCGGGTCAGATCGCCTGTCCCGGCTCCAGCAGCTCCACGCCGTCGTTTTCCGACAGCGTCAGG
TAGACGGTGGACTGCAAAGC

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSSMKATVFVGPGRIELREKPIPAVGPGDALVKITTTTICGTDVHILKGEYPVASGLTIGHEPVGVIEKLGADVKGYREG
QRVIAGAICPSFTSYGCQDGHPAQDGGCECHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPIPDGLSDEQVLMCPDI
MSTGFAGAEAANIRIGDVVVVFAQGPIGLCAVAGARLRGASCIIAVDGLDERLGISRRLGADVTLNFKQVDVIAEIMKLT
GGRGVDASIEALGTQGTFESALRVLKPGGTLSSLGVYSSDLRIPLDAFNAGLGDKRIVSSLCPGGKERMRRLMNVLESDR
LDLSPLVTHRYKLDQIVEAYDLFSHQRDGVLKVAIQPF

Sequences:

>Translated_358_residues
MSSMKATVFVGPGRIELREKPIPAVGPGDALVKITTTTICGTDVHILKGEYPVASGLTIGHEPVGVIEKLGADVKGYREG
QRVIAGAICPSFTSYGCQDGHPAQDGGCECHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPIPDGLSDEQVLMCPDI
MSTGFAGAEAANIRIGDVVVVFAQGPIGLCAVAGARLRGASCIIAVDGLDERLGISRRLGADVTLNFKQVDVIAEIMKLT
GGRGVDASIEALGTQGTFESALRVLKPGGTLSSLGVYSSDLRIPLDAFNAGLGDKRIVSSLCPGGKERMRRLMNVLESDR
LDLSPLVTHRYKLDQIVEAYDLFSHQRDGVLKVAIQPF
>Mature_357_residues
SSMKATVFVGPGRIELREKPIPAVGPGDALVKITTTTICGTDVHILKGEYPVASGLTIGHEPVGVIEKLGADVKGYREGQ
RVIAGAICPSFTSYGCQDGHPAQDGGCECHGYKPMGGWRFGNTIDGTQAEYVLVPDAQANLAPIPDGLSDEQVLMCPDIM
STGFAGAEAANIRIGDVVVVFAQGPIGLCAVAGARLRGASCIIAVDGLDERLGISRRLGADVTLNFKQVDVIAEIMKLTG
GRGVDASIEALGTQGTFESALRVLKPGGTLSSLGVYSSDLRIPLDAFNAGLGDKRIVSSLCPGGKERMRRLMNVLESDRL
DLSPLVTHRYKLDQIVEAYDLFSHQRDGVLKVAIQPF

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=356, Percent_Identity=25.8426966292135, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=27.1739130434783, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=27.1739130434783, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71565152, Length=344, Percent_Identity=28.1976744186047, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI34577061, Length=334, Percent_Identity=27.8443113772455, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501929, Length=336, Percent_Identity=26.1904761904762, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI71743840, Length=334, Percent_Identity=26.9461077844311, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262073058, Length=334, Percent_Identity=26.9461077844311, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71565154, Length=336, Percent_Identity=27.6785714285714, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501933, Length=339, Percent_Identity=26.8436578171091, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI22538446, Length=251, Percent_Identity=26.2948207171315, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI22538444, Length=251, Percent_Identity=26.2948207171315, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=30.1020408163265, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=29.7376093294461, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082125, Length=367, Percent_Identity=28.3378746594005, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788075, Length=360, Percent_Identity=28.8888888888889, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787863, Length=353, Percent_Identity=26.0623229461756, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=27.1929824561404, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788073, Length=365, Percent_Identity=24.6575342465753, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788407, Length=349, Percent_Identity=27.7936962750716, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=28.9256198347107, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081918, Length=288, Percent_Identity=26.7361111111111, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790718, Length=285, Percent_Identity=25.2631578947368, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787572, Length=134, Percent_Identity=41.7910447761194, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=363, Percent_Identity=31.129476584022, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=29.9168975069252, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25146526, Length=344, Percent_Identity=26.453488372093, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=364, Percent_Identity=25.5494505494505, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=283, Percent_Identity=27.9151943462898, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=351, Percent_Identity=29.3447293447293, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=351, Percent_Identity=29.3447293447293, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=27.8688524590164, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320033, Length=352, Percent_Identity=27.5568181818182, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=317, Percent_Identity=26.813880126183, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=319, Percent_Identity=25.0783699059561, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319520, Length=266, Percent_Identity=25.5639097744361, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=280, Percent_Identity=25.3571428571429, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=321, Percent_Identity=25.2336448598131, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=395, Percent_Identity=24.5569620253165, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137530, Length=361, Percent_Identity=27.9778393351801, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737897, Length=359, Percent_Identity=27.5766016713092, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17737895, Length=334, Percent_Identity=28.4431137724551, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37806; Mature: 37675

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSMKATVFVGPGRIELREKPIPAVGPGDALVKITTTTICGTDVHILKGEYPVASGLTIG
CCCCEEEEEECCCEEEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCEEC
HEPVGVIEKLGADVKGYREGQRVIAGAICPSFTSYGCQDGHPAQDGGCECHGYKPMGGWR
CCCHHHHHHHCCCCCCHHCCHHEEEHHHCCCHHHCCCCCCCCCCCCCCEECCCCCCCCCC
FGNTIDGTQAEYVLVPDAQANLAPIPDGLSDEQVLMCPDIMSTGFAGAEAANIRIGDVVV
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCCCCCEEEECEEEE
VFAQGPIGLCAVAGARLRGASCIIAVDGLDERLGISRRLGADVTLNFKQVDVIAEIMKLT
EEECCCCCEEHHCCCCCCCCEEEEEECCCHHHHCCHHHCCCCEEEEHHHHHHHHHHHHHC
GGRGVDASIEALGTQGTFESALRVLKPGGTLSSLGVYSSDLRIPLDAFNAGLGDKRIVSS
CCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHCCCCCHHHHHHH
LCPGGKERMRRLMNVLESDRLDLSPLVTHRYKLDQIVEAYDLFSHQRDGVLKVAIQPF
HCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
SSMKATVFVGPGRIELREKPIPAVGPGDALVKITTTTICGTDVHILKGEYPVASGLTIG
CCCEEEEEECCCEEEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCEEC
HEPVGVIEKLGADVKGYREGQRVIAGAICPSFTSYGCQDGHPAQDGGCECHGYKPMGGWR
CCCHHHHHHHCCCCCCHHCCHHEEEHHHCCCHHHCCCCCCCCCCCCCCEECCCCCCCCCC
FGNTIDGTQAEYVLVPDAQANLAPIPDGLSDEQVLMCPDIMSTGFAGAEAANIRIGDVVV
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCCCCCEEEECEEEE
VFAQGPIGLCAVAGARLRGASCIIAVDGLDERLGISRRLGADVTLNFKQVDVIAEIMKLT
EEECCCCCEEHHCCCCCCCCEEEEEECCCHHHHCCHHHCCCCEEEEHHHHHHHHHHHHHC
GGRGVDASIEALGTQGTFESALRVLKPGGTLSSLGVYSSDLRIPLDAFNAGLGDKRIVSS
CCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHCCCCCHHHHHHH
LCPGGKERMRRLMNVLESDRLDLSPLVTHRYKLDQIVEAYDLFSHQRDGVLKVAIQPF
HCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]