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The map label for this gene is lrp [H]

Identifier: 34497368

GI number: 34497368

Start: 2078652

End: 2079140

Strand: Reverse

Name: lrp [H]

Synonym: CV_1913

Alternate gene names: 34497368

Gene position: 2079140-2078652 (Counterclockwise)

Preceding gene: 34497371

Following gene: 34497367

Centisome position: 43.76

GC content: 57.67

Gene sequence:

>489_bases
ATGAAGTCAATTTCCGCCTCCGCCAAAGCGCTGGACAAGATGGACCGCAAGATCCTGCGCATCCTGCAGAAAAACGGCCG
CATCGCCATGACCGAGCTGGCCGAAAAAGTGGGGCTGTCCACCACCCCCTGCACCGAACGGGTGAGGCGCATGGAACGCG
ACGGCATCATCGAAGGCTATTACGCCCGCCTCAATCCCCACGCGCTGGGCGGCTCTCTGCTGGTATTCGTGGAGATCAAG
CTGGAAGCCAAGTCCGGCAATATCTTCGACGCCTTTCGCCGCGAGATCATGAGCATTCCGGAAATCCTGGAATGCCATCT
GGTGTCAGGCGATTTCGATTACCTGATCAAGGCGCGCATCCCGGACATGTCGATGTACCGCAAGTTGCTGGGAGACATTC
TGCTGCAACTGCCGTCGGCGAAAGAGTCGAAAAGCTATGTAGTGATGGAGGAAGTCAAGGAGACCCTGTCGCTGCCGCTG
GAGGATTGA

Upstream 100 bases:

>100_bases
GAATTCCGCTAGTATATGCATTGACATCTGGTTTTTTTCACTGAAATTGATGAGAATCAAATGATCATTCTCAAATCTTT
CGCACATAAACAGTGAAAAC

Downstream 100 bases:

>100_bases
ATTCCCCTTTAAAATCAACGCAGAAGACTTGACCAAAGCCTAGAAAAAGCTTGCTTTTATGTCCTGAGTCAACCAAACCC
AAAATAACTACACCAGTAGA

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKSISASAKALDKMDRKILRILQKNGRIAMTELAEKVGLSTTPCTERVRRMERDGIIEGYYARLNPHALGGSLLVFVEIK
LEAKSGNIFDAFRREIMSIPEILECHLVSGDFDYLIKARIPDMSMYRKLLGDILLQLPSAKESKSYVVMEEVKETLSLPL
ED

Sequences:

>Translated_162_residues
MKSISASAKALDKMDRKILRILQKNGRIAMTELAEKVGLSTTPCTERVRRMERDGIIEGYYARLNPHALGGSLLVFVEIK
LEAKSGNIFDAFRREIMSIPEILECHLVSGDFDYLIKARIPDMSMYRKLLGDILLQLPSAKESKSYVVMEEVKETLSLPL
ED
>Mature_162_residues
MKSISASAKALDKMDRKILRILQKNGRIAMTELAEKVGLSTTPCTERVRRMERDGIIEGYYARLNPHALGGSLLVFVEIK
LEAKSGNIFDAFRREIMSIPEILECHLVSGDFDYLIKARIPDMSMYRKLLGDILLQLPSAKESKSYVVMEEVKETLSLPL
ED

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=59.4594594594595, Blast_Score=190, Evalue=4e-50,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=37.0860927152318, Blast_Score=114, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18334; Mature: 18334

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSISASAKALDKMDRKILRILQKNGRIAMTELAEKVGLSTTPCTERVRRMERDGIIEGY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHH
YARLNPHALGGSLLVFVEIKLEAKSGNIFDAFRREIMSIPEILECHLVSGDFDYLIKARI
HHHCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHEEEEECC
PDMSMYRKLLGDILLQLPSAKESKSYVVMEEVKETLSLPLED
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKSISASAKALDKMDRKILRILQKNGRIAMTELAEKVGLSTTPCTERVRRMERDGIIEGY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHH
YARLNPHALGGSLLVFVEIKLEAKSGNIFDAFRREIMSIPEILECHLVSGDFDYLIKARI
HHHCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHEEEEECC
PDMSMYRKLLGDILLQLPSAKESKSYVVMEEVKETLSLPLED
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]