Click here to switch to the map view.

The map label for this gene is mvaB [H]

Identifier: 34497214

GI number: 34497214

Start: 1914558

End: 1915451

Strand: Reverse

Name: mvaB [H]

Synonym: CV_1759

Alternate gene names: 34497214

Gene position: 1915451-1914558 (Counterclockwise)

Preceding gene: 34497215

Following gene: 34497213

Centisome position: 40.32

GC content: 69.69

Gene sequence:

>894_bases
ATGCAGAGCGTCAAGATAGTGGAAGTGGGCCCGCGCGACGGGCTGCAGAACGAAAAACGGCCGCTGAGCGCCGAAATCAA
GCTGGAGCTGATCCGCCGCCTGGCCGGAACCGGCCTGTCCGCGATCGAGGCCGGCGCCTTCGTTTCGCCCAAATGGGTGC
CGCAGATGGCGGGCAGCGCCGAAGTGCTGGCCGCGCTCGACACAACCGGCGCCATCGCCTACCCGGTGCTGGTGCCCAAC
GACATGGGCCTGGACGCCGCGCTGGCAGCCGGCGCCCGCGAGATCGCCGTGTTCGGCGCCGCCAGCGAAAGCTTCAGCCA
GAAGAACATCAACGCCAGCATCGCCGAAAGCCTGCAGCGCTTCGCCAGCGTGGCCCGCCGCGCGCTGGACGCAGGCGTCA
AGGTGCGCGGCTACGTGTCCTGCGTGGTCGGCTGCCCTTACGAGGGCCGGATCGCCCCGCACAAGGTGGCCGACGTGGCC
AAGGCGCTGGCGGATCTGGGCTGCTACGAAATCTCGCTGGGCGACACCATAGGCGTGGGCACCCCGGCTTCGGTGCGCGA
GATGCTGGACGCGGTGCTGGACGTCCTGCCGGCCGGGCAGCTGGCCGGCCATTTCCACGACACCTATGGCATGGCCGTCG
CCAACATCCGCGCGGCGCTGGATGTCGGCCTGCGCGTGTTCGACGCTTCGGTGGCGGGACTGGGCGGCTGCCCGTACGCG
CGCGGGGCATCCGGCAACGTCGCCACGGAAGACGTCGCCTATCTGCTGGCCGGCGAGGGCTACCACACTGGCATCGATCT
CACTAAACTGGTGGACGTCGCCTGGTTCATCGCCGACGCGCTGGGCAAGCCCCCCGCCTCCAAATTGGCGCACGCGCTCG
GCCGCCAGGGCTAG

Upstream 100 bases:

>100_bases
CGCATCCTTCGAACGCTACGACGGGCGCTGCGCGCCGGGCCGGGACACGCTGCAGATGGACATCTACATCCCCATCCAGC
CCAAGCGCTGAAGGAAAGCC

Downstream 100 bases:

>100_bases
GCCTGCCGACTCTCGTTCCGCCGCCGCGCGCCGAGCGTTGACGGAGCCCGAATCATACCGGCCGGCTCGCCCTTCCAATC
AAAAAACATCGCGGGCCGCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQSVKIVEVGPRDGLQNEKRPLSAEIKLELIRRLAGTGLSAIEAGAFVSPKWVPQMAGSAEVLAALDTTGAIAYPVLVPN
DMGLDAALAAGAREIAVFGAASESFSQKNINASIAESLQRFASVARRALDAGVKVRGYVSCVVGCPYEGRIAPHKVADVA
KALADLGCYEISLGDTIGVGTPASVREMLDAVLDVLPAGQLAGHFHDTYGMAVANIRAALDVGLRVFDASVAGLGGCPYA
RGASGNVATEDVAYLLAGEGYHTGIDLTKLVDVAWFIADALGKPPASKLAHALGRQG

Sequences:

>Translated_297_residues
MQSVKIVEVGPRDGLQNEKRPLSAEIKLELIRRLAGTGLSAIEAGAFVSPKWVPQMAGSAEVLAALDTTGAIAYPVLVPN
DMGLDAALAAGAREIAVFGAASESFSQKNINASIAESLQRFASVARRALDAGVKVRGYVSCVVGCPYEGRIAPHKVADVA
KALADLGCYEISLGDTIGVGTPASVREMLDAVLDVLPAGQLAGHFHDTYGMAVANIRAALDVGLRVFDASVAGLGGCPYA
RGASGNVATEDVAYLLAGEGYHTGIDLTKLVDVAWFIADALGKPPASKLAHALGRQG
>Mature_297_residues
MQSVKIVEVGPRDGLQNEKRPLSAEIKLELIRRLAGTGLSAIEAGAFVSPKWVPQMAGSAEVLAALDTTGAIAYPVLVPN
DMGLDAALAAGAREIAVFGAASESFSQKNINASIAESLQRFASVARRALDAGVKVRGYVSCVVGCPYEGRIAPHKVADVA
KALADLGCYEISLGDTIGVGTPASVREMLDAVLDVLPAGQLAGHFHDTYGMAVANIRAALDVGLRVFDASVAGLGGCPYA
RGASGNVATEDVAYLLAGEGYHTGIDLTKLVDVAWFIADALGKPPASKLAHALGRQG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=291, Percent_Identity=58.0756013745705, Blast_Score=354, Evalue=4e-98,
Organism=Homo sapiens, GI109150422, Length=289, Percent_Identity=57.7854671280277, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI109150427, Length=289, Percent_Identity=57.7854671280277, Blast_Score=346, Evalue=1e-95,
Organism=Homo sapiens, GI260654708, Length=291, Percent_Identity=39.1752577319588, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17510563, Length=294, Percent_Identity=51.7006802721088, Blast_Score=317, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=59.106529209622, Blast_Score=349, Evalue=2e-96,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30593; Mature: 30593

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSVKIVEVGPRDGLQNEKRPLSAEIKLELIRRLAGTGLSAIEAGAFVSPKWVPQMAGSA
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCCH
EVLAALDTTGAIAYPVLVPNDMGLDAALAAGAREIAVFGAASESFSQKNINASIAESLQR
HHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCCEEEEEECCHHHHHHCCCCHHHHHHHHH
FASVARRALDAGVKVRGYVSCVVGCPYEGRIAPHKVADVAKALADLGCYEISLGDTIGVG
HHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCC
TPASVREMLDAVLDVLPAGQLAGHFHDTYGMAVANIRAALDVGLRVFDASVAGLGGCPYA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RGASGNVATEDVAYLLAGEGYHTGIDLTKLVDVAWFIADALGKPPASKLAHALGRQG
CCCCCCCCHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQSVKIVEVGPRDGLQNEKRPLSAEIKLELIRRLAGTGLSAIEAGAFVSPKWVPQMAGSA
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCCH
EVLAALDTTGAIAYPVLVPNDMGLDAALAAGAREIAVFGAASESFSQKNINASIAESLQR
HHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCCEEEEEECCHHHHHHCCCCHHHHHHHHH
FASVARRALDAGVKVRGYVSCVVGCPYEGRIAPHKVADVAKALADLGCYEISLGDTIGVG
HHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCC
TPASVREMLDAVLDVLPAGQLAGHFHDTYGMAVANIRAALDVGLRVFDASVAGLGGCPYA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RGASGNVATEDVAYLLAGEGYHTGIDLTKLVDVAWFIADALGKPPASKLAHALGRQG
CCCCCCCCHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]