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The map label for this gene is folK [H]

Identifier: 34497088

GI number: 34497088

Start: 1771601

End: 1772113

Strand: Direct

Name: folK [H]

Synonym: CV_1633

Alternate gene names: 34497088

Gene position: 1771601-1772113 (Clockwise)

Preceding gene: 34497087

Following gene: 34497089

Centisome position: 37.29

GC content: 66.86

Gene sequence:

>513_bases
GTGACGCTGGCCTACGTGGCTCTGGGCAGCAATCTGGAGCAGCCTCAGCAGCAAGTCAGGGCCGCTCTTGCGGCCCTTGG
CCATTTGGATGGCGCCACGTTGCTGCGCCATTCCTCGCTCTACCGCACCGCGCCGGTCGGTTACGCCGACCAGCCCGATT
TCATCAACGCGGTGGCCTTGCTGGACACAGAGCTGCCGCCGTTGCGCCTGCTGGACGCGTTATTGGCGCTGGAGCAACGC
TTCGGCCGCCAGCGCAGCTTCCGCAACGCGCCAAGGGTACTGGATCTTGACTTGTTGTATTACGATGGCGTCTTCCTTGA
AGAGCCCCGGCTGATCCTGCCCCATCCGCGCATGCGCGAGCGCGCCTTCGTGATGGTGCCGCTGGCCGAGATCGCCGCCG
GCGCCACGCTGCCGGGCGTCGGCGACATCGCCGCGCTGGCGGCGGACCTGGCCGGTTCCGGCGTGGCGCGCCTGGACGAC
GAGTCCAACCCCAACAAACAGGAACAAGCATGA

Upstream 100 bases:

>100_bases
TCGCCGAAGCCAAGGAAGGCGGCGCCGAGGAGCCCGCCAAGAAGCGCCGCCGCCGGCGCAGCGGCCGCCGCAAGCCCGAG
GGCGCGGGGGAGAGCGCCGA

Downstream 100 bases:

>100_bases
GTCAATTGCGATACGTGGTGGTGGAGGGGCCGATAGGCTCGGGCAAGTCTTCGCTGGCGCGCCGGCTGTCCGAATACTGG
GGCGTGCAGCTGAAGGCCGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTLAYVALGSNLEQPQQQVRAALAALGHLDGATLLRHSSLYRTAPVGYADQPDFINAVALLDTELPPLRLLDALLALEQR
FGRQRSFRNAPRVLDLDLLYYDGVFLEEPRLILPHPRMRERAFVMVPLAEIAAGATLPGVGDIAALAADLAGSGVARLDD
ESNPNKQEQA

Sequences:

>Translated_170_residues
MTLAYVALGSNLEQPQQQVRAALAALGHLDGATLLRHSSLYRTAPVGYADQPDFINAVALLDTELPPLRLLDALLALEQR
FGRQRSFRNAPRVLDLDLLYYDGVFLEEPRLILPHPRMRERAFVMVPLAEIAAGATLPGVGDIAALAADLAGSGVARLDD
ESNPNKQEQA
>Mature_169_residues
TLAYVALGSNLEQPQQQVRAALAALGHLDGATLLRHSSLYRTAPVGYADQPDFINAVALLDTELPPLRLLDALLALEQRF
GRQRSFRNAPRVLDLDLLYYDGVFLEEPRLILPHPRMRERAFVMVPLAEIAAGATLPGVGDIAALAADLAGSGVARLDDE
SNPNKQEQA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=43.8848920863309, Blast_Score=113, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=134, Percent_Identity=33.5820895522388, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18464; Mature: 18333

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAYVALGSNLEQPQQQVRAALAALGHLDGATLLRHSSLYRTAPVGYADQPDFINAVAL
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LDTELPPLRLLDALLALEQRFGRQRSFRNAPRVLDLDLLYYDGVFLEEPRLILPHPRMRE
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHEECCEEECCCEEECCCCCCCC
RAFVMVPLAEIAAGATLPGVGDIAALAADLAGSGVARLDDESNPNKQEQA
CEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
TLAYVALGSNLEQPQQQVRAALAALGHLDGATLLRHSSLYRTAPVGYADQPDFINAVAL
EEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LDTELPPLRLLDALLALEQRFGRQRSFRNAPRVLDLDLLYYDGVFLEEPRLILPHPRMRE
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHEECCEEECCCEEECCCCCCCC
RAFVMVPLAEIAAGATLPGVGDIAALAADLAGSGVARLDDESNPNKQEQA
CEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]