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The map label for this gene is dnaX [H]

Identifier: 34497065

GI number: 34497065

Start: 1737175

End: 1739094

Strand: Direct

Name: dnaX [H]

Synonym: CV_1610

Alternate gene names: 34497065

Gene position: 1737175-1739094 (Clockwise)

Preceding gene: 34497064

Following gene: 34497066

Centisome position: 36.56

GC content: 69.95

Gene sequence:

>1920_bases
ATGAGCTATCAAGTCCTTGCCCGCAAGTGGCGCCCCAAACGCTTCGCCGACCTGGTCGGCCAGGAGCACGTGGTGCGCGC
CCTCTCCAACGCCCTGAAAGAGCAGCGGCTTCACCACGCCTACCTGCTGACCGGCACCCGGGGCGTCGGCAAGACCACCA
TCGCCCGCATTCTGGCCAAAAGCCTGAACTGCGAGACCGGCACCACGGCCGAGCCCTGCGGCGAATGCCAGGCCTGCCGC
CAGATCGACAGCGGCCGCTTCGTCGACCTCTTGGAGATCGACGCCGCGTCCAACACCGGCATCGACAACATCCGCGAAGT
GCTGGAAAACGCCCAGTACGCGCCTACGATGGGCCGCTTCAAGGTCTACATCATCGACGAAGTGCACATGCTGTCGAAGA
GCGCGTTCAACGCGATGCTGAAGACGCTGGAAGAGCCGCCCGGCCACGTCAAGTTCATCCTGGCCACCACCGATCCGCAG
AAGGTTCCGGTGACGGTGCTGTCCCGCTGCCTGCAGTTTTCCTTGCGCAACATGACGCCGCAGCAGGTGTCCAGCCACCT
GGCCCACATGCTGGACATCGAAGGCATCCATTACGAGGCGCCGGCGCTGGCCTTGCTGGGCCGCGCGGCGTCCGGCTCGA
TGCGCGACGCGCAGTCGCTGCTGGACCAAGCCATCGCCTACGGCCTGGGCGAGGTCAAGGAAGACGGCGTGCGCGCGATG
CTGGGCGCGGTGGACCGCCGCTACCTGTTCACCCTGCTGCAGGCGCTGGCCGCGTCCGACGGCCCGGCGCTGATGGCCGA
GGCCGACAGGCTGGCCGAGCGCGGCGTCAGCTTCGATTCCGCGCTGTCCGAACTGGCGGTGCTGCTGCAGCAGCTGGCAT
TGGCGCAGACGGTGCCGGCGGCGCTGGCGGCCGACGAGCCCGAGCGCGACACGCTGTTCGCGCTGGCCGACGCCATCGCG
CCGCAGGACGTGCAGCTGTACTACCAGATCGCCATCCACGGCCGCAAGGACCTGGCCTTGGCGCCGGATGAACACGCCGG
CTTCAATATGACCCTGCTGCGCATGCTGGCCTTCCATCCGGCCAACGCGCCGGCGCAGACCGCCGCGCCCGCGCGCCCGG
CCGCGGCGGTCCAGCCGCGGCCCGTGGCCGCATCGGCGGCCGCCGTCGCCAGCGTCTCGGTGCCGGCGGAGCGGGGCATG
TCGCCGGCCGCGCGCGCGTTGCAGGCCGCGGGCCTCGGCGCGCAAGCGCAAGGCAAGCCCCGCGCGGCGGAACCGTCCCC
GGCCGCCGAGCCGGAACCCGAGCCCGCGCCACTGCCGTCCGCCGTGGTTTCGGCTGTGTCGGAACCGTCAAAGCCCGCGC
CGAGCCCGCAGCCGGCTCCGGCGCTGGCCGCGCCGGTGTCCGAGCCGGCTGCGCAGGATGACGAGGACGAGCGCGACGAG
GAAGAGATCGTCGAAGCGCCCTGGTCCGACGACGACGCGATGCCGGCCTACATGCAGCAACCGCCGCTGGAGGACGAGCC
GTCCAGCTATAGCTTCGACGGCGACTGGCAGCGGCTGGTCGCCGACCTGGGCGCCAAGCTCGGCGCGGCGCGGATGCTGG
CGCACAACGCCGTGCTGAAGCGCTGGAGCCAGGACCGCCTGGAACTGGCCGTGCCGGAGAGCTTCCGCCACATGAGCGGA
CGCGACTACCAGGAAAAACTCAAAGCCGCGCTGGCCGAACGCTTCGGCCATCCGGTGGACCTCGCGGTGACGGTGGAGGA
GCTGGGGATGGAAACCCCGGCGATGACCGATGCCAGGCTGCGCCAGGAGCAGCTGGCCGTCGCCCGCGAGTGCATGCAAA
ACGATCCGGTGGTGCAGCAGATGGTACGCGAATTCGGCGCCACGCTGCTCATCGAGACCATTCAACCCGTACAGGAGTGA

Upstream 100 bases:

>100_bases
GTAAGGCCGGGCCCGCGCAACCGGCCACCGGCGCCGCCCGCGCGGCCGCGCCGGTGAAACCTGTCGCCTTGCGCGGCAAT
TCCCGTTAAAATCCGCCCCC

Downstream 100 bases:

>100_bases
CCGCGATGTTCGGTAAAGCTGGTATCGCCGGCCTGATGAAACAGGCCCAGCAAATGCAGGAAAACATGAAGAAGGCCCAG
GAAGAGCTGGCCAAGGTGGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MSYQVLARKWRPKRFADLVGQEHVVRALSNALKEQRLHHAYLLTGTRGVGKTTIARILAKSLNCETGTTAEPCGECQACR
QIDSGRFVDLLEIDAASNTGIDNIREVLENAQYAPTMGRFKVYIIDEVHMLSKSAFNAMLKTLEEPPGHVKFILATTDPQ
KVPVTVLSRCLQFSLRNMTPQQVSSHLAHMLDIEGIHYEAPALALLGRAASGSMRDAQSLLDQAIAYGLGEVKEDGVRAM
LGAVDRRYLFTLLQALAASDGPALMAEADRLAERGVSFDSALSELAVLLQQLALAQTVPAALAADEPERDTLFALADAIA
PQDVQLYYQIAIHGRKDLALAPDEHAGFNMTLLRMLAFHPANAPAQTAAPARPAAAVQPRPVAASAAAVASVSVPAERGM
SPAARALQAAGLGAQAQGKPRAAEPSPAAEPEPEPAPLPSAVVSAVSEPSKPAPSPQPAPALAAPVSEPAAQDDEDERDE
EEIVEAPWSDDDAMPAYMQQPPLEDEPSSYSFDGDWQRLVADLGAKLGAARMLAHNAVLKRWSQDRLELAVPESFRHMSG
RDYQEKLKAALAERFGHPVDLAVTVEELGMETPAMTDARLRQEQLAVARECMQNDPVVQQMVREFGATLLIETIQPVQE

Sequences:

>Translated_639_residues
MSYQVLARKWRPKRFADLVGQEHVVRALSNALKEQRLHHAYLLTGTRGVGKTTIARILAKSLNCETGTTAEPCGECQACR
QIDSGRFVDLLEIDAASNTGIDNIREVLENAQYAPTMGRFKVYIIDEVHMLSKSAFNAMLKTLEEPPGHVKFILATTDPQ
KVPVTVLSRCLQFSLRNMTPQQVSSHLAHMLDIEGIHYEAPALALLGRAASGSMRDAQSLLDQAIAYGLGEVKEDGVRAM
LGAVDRRYLFTLLQALAASDGPALMAEADRLAERGVSFDSALSELAVLLQQLALAQTVPAALAADEPERDTLFALADAIA
PQDVQLYYQIAIHGRKDLALAPDEHAGFNMTLLRMLAFHPANAPAQTAAPARPAAAVQPRPVAASAAAVASVSVPAERGM
SPAARALQAAGLGAQAQGKPRAAEPSPAAEPEPEPAPLPSAVVSAVSEPSKPAPSPQPAPALAAPVSEPAAQDDEDERDE
EEIVEAPWSDDDAMPAYMQQPPLEDEPSSYSFDGDWQRLVADLGAKLGAARMLAHNAVLKRWSQDRLELAVPESFRHMSG
RDYQEKLKAALAERFGHPVDLAVTVEELGMETPAMTDARLRQEQLAVARECMQNDPVVQQMVREFGATLLIETIQPVQE
>Mature_638_residues
SYQVLARKWRPKRFADLVGQEHVVRALSNALKEQRLHHAYLLTGTRGVGKTTIARILAKSLNCETGTTAEPCGECQACRQ
IDSGRFVDLLEIDAASNTGIDNIREVLENAQYAPTMGRFKVYIIDEVHMLSKSAFNAMLKTLEEPPGHVKFILATTDPQK
VPVTVLSRCLQFSLRNMTPQQVSSHLAHMLDIEGIHYEAPALALLGRAASGSMRDAQSLLDQAIAYGLGEVKEDGVRAML
GAVDRRYLFTLLQALAASDGPALMAEADRLAERGVSFDSALSELAVLLQQLALAQTVPAALAADEPERDTLFALADAIAP
QDVQLYYQIAIHGRKDLALAPDEHAGFNMTLLRMLAFHPANAPAQTAAPARPAAAVQPRPVAASAAAVASVSVPAERGMS
PAARALQAAGLGAQAQGKPRAAEPSPAAEPEPEPAPLPSAVVSAVSEPSKPAPSPQPAPALAAPVSEPAAQDDEDERDEE
EIVEAPWSDDDAMPAYMQQPPLEDEPSSYSFDGDWQRLVADLGAKLGAARMLAHNAVLKRWSQDRLELAVPESFRHMSGR
DYQEKLKAALAERFGHPVDLAVTVEELGMETPAMTDARLRQEQLAVARECMQNDPVVQQMVREFGATLLIETIQPVQE

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=297, Percent_Identity=25.2525252525253, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI194306571, Length=300, Percent_Identity=25, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI194306567, Length=300, Percent_Identity=25, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI31563534, Length=232, Percent_Identity=26.7241379310345, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786676, Length=656, Percent_Identity=42.9878048780488, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1787341, Length=138, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787119, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=309, Percent_Identity=26.2135922330097, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=247, Percent_Identity=23.8866396761134, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324478, Length=234, Percent_Identity=26.4957264957265, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=218, Percent_Identity=24.3119266055046, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17647857, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859927, Length=223, Percent_Identity=27.3542600896861, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921076, Length=301, Percent_Identity=24.5847176079734, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 68889; Mature: 68758

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPKRFADLVGQEHVVRALSNALKEQRLHHAYLLTGTRGVGKTTIARILAK
CCHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
SLNCETGTTAEPCGECQACRQIDSGRFVDLLEIDAASNTGIDNIREVLENAQYAPTMGRF
HCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYIIDEVHMLSKSAFNAMLKTLEEPPGHVKFILATTDPQKVPVTVLSRCLQFSLRNMTP
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
QQVSSHLAHMLDIEGIHYEAPALALLGRAASGSMRDAQSLLDQAIAYGLGEVKEDGVRAM
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGAVDRRYLFTLLQALAASDGPALMAEADRLAERGVSFDSALSELAVLLQQLALAQTVPA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAADEPERDTLFALADAIAPQDVQLYYQIAIHGRKDLALAPDEHAGFNMTLLRMLAFHP
HHHCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCC
ANAPAQTAAPARPAAAVQPRPVAASAAAVASVSVPAERGMSPAARALQAAGLGAQAQGKP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCC
RAAEPSPAAEPEPEPAPLPSAVVSAVSEPSKPAPSPQPAPALAAPVSEPAAQDDEDERDE
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCH
EEIVEAPWSDDDAMPAYMQQPPLEDEPSSYSFDGDWQRLVADLGAKLGAARMLAHNAVLK
HHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RWSQDRLELAVPESFRHMSGRDYQEKLKAALAERFGHPVDLAVTVEELGMETPAMTDARL
HHCHHHHEEECCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCCHHHH
RQEQLAVARECMQNDPVVQQMVREFGATLLIETIQPVQE
HHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCC
>Mature Secondary Structure 
SYQVLARKWRPKRFADLVGQEHVVRALSNALKEQRLHHAYLLTGTRGVGKTTIARILAK
CHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
SLNCETGTTAEPCGECQACRQIDSGRFVDLLEIDAASNTGIDNIREVLENAQYAPTMGRF
HCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYIIDEVHMLSKSAFNAMLKTLEEPPGHVKFILATTDPQKVPVTVLSRCLQFSLRNMTP
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
QQVSSHLAHMLDIEGIHYEAPALALLGRAASGSMRDAQSLLDQAIAYGLGEVKEDGVRAM
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGAVDRRYLFTLLQALAASDGPALMAEADRLAERGVSFDSALSELAVLLQQLALAQTVPA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAADEPERDTLFALADAIAPQDVQLYYQIAIHGRKDLALAPDEHAGFNMTLLRMLAFHP
HHHCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCC
ANAPAQTAAPARPAAAVQPRPVAASAAAVASVSVPAERGMSPAARALQAAGLGAQAQGKP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCC
RAAEPSPAAEPEPEPAPLPSAVVSAVSEPSKPAPSPQPAPALAAPVSEPAAQDDEDERDE
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCH
EEIVEAPWSDDDAMPAYMQQPPLEDEPSSYSFDGDWQRLVADLGAKLGAARMLAHNAVLK
HHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RWSQDRLELAVPESFRHMSGRDYQEKLKAALAERFGHPVDLAVTVEELGMETPAMTDARL
HHCHHHHEEECCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCCHHHH
RQEQLAVARECMQNDPVVQQMVREFGATLLIETIQPVQE
HHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]