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The map label for this gene is cobL [H]

Identifier: 34497023

GI number: 34497023

Start: 1681415

End: 1682116

Strand: Reverse

Name: cobL [H]

Synonym: CV_1568

Alternate gene names: 34497023

Gene position: 1682116-1681415 (Counterclockwise)

Preceding gene: 34497024

Following gene: 34497022

Centisome position: 35.4

GC content: 67.09

Gene sequence:

>702_bases
ATGATCATCTGCATAGGCGCCGGCCCCGGCGACATCGGCTACCTGCCGCAGCGCTCGGCCCAACTGATACGCGAGGCCGA
CGTGGTGGCCGGCTTCAACGCGGTGGTGGACGTGGTCCGCCCGCTGATCCCGGACAGCGCCGAAGTGATACAGATGGGCT
ACCGCGACCAGGTGGCCCAGCTGGACATCGTCGCCGAGCGCCACCATGCCGGCAAGAAGTGCGTGGTGGTGTTCATGGGC
GACATCCACTTCAGCGGCTTCCAGTACCTGGAGCGGGTGGAGCGCGCCTGCGGCCACCCGGTGGAGACGATACCGGGCAT
CTCCTCGGCGCAGATACTGGCCTCGCGCGGCAAGGTGTGCTTCGACGAGACCAGCTTCATCACCTTCCACCGCCGCGGCG
ACCTGACCCCGTTCAAGCGCCACCTGGTGCACGTGCTGCAGGACGGCCGCAACGCCATCGTGATCCCCTGCCCGTGGGAC
GAGGCGCGCTCCTTCATGCCCTGGCATATCGCCGCCTACCTGCTGGAAAACGGCATCCCGGCCGGCCAGCCGGTGGAAGT
GTGGGAAAACCTGACCCGCAACGAGGCGGAATGGCGCGGCACGCTGGCCGAGTGCGCCGAGCAGCGCTTCTCCGACATGA
GCATCATGCTGATCCGCACGCTCGCGCCGATGGACAGCCAGATCGAGCCGACCCACAAATGA

Upstream 100 bases:

>100_bases
CAAGATGGCTGCCGACTGAACTCGCACAATGAAGAGGCCCGGCTTTGCCGGGTCCTGTAGAACAGAATCGAATGACTACA
TTGCAGCCAAAGGAATACGC

Downstream 100 bases:

>100_bases
GCCAGCCAGACTACGCCATCGTGCTGGCCGGCCACGGCAGCCGCGACCCGGACGGGGTCAACGAGTTCATGCAGCTGGTG
GACGCGCTGAAGGCGCGCGC

Product: cobalt-precorrin-6Y C(5)-methyltransferase

Products: tetrahydrofolate; L-methionine

Alternate protein names: Cobalt-precorrin-6 methyltransferase; Cobalt-precorrin-6Y methylase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MIICIGAGPGDIGYLPQRSAQLIREADVVAGFNAVVDVVRPLIPDSAEVIQMGYRDQVAQLDIVAERHHAGKKCVVVFMG
DIHFSGFQYLERVERACGHPVETIPGISSAQILASRGKVCFDETSFITFHRRGDLTPFKRHLVHVLQDGRNAIVIPCPWD
EARSFMPWHIAAYLLENGIPAGQPVEVWENLTRNEAEWRGTLAECAEQRFSDMSIMLIRTLAPMDSQIEPTHK

Sequences:

>Translated_233_residues
MIICIGAGPGDIGYLPQRSAQLIREADVVAGFNAVVDVVRPLIPDSAEVIQMGYRDQVAQLDIVAERHHAGKKCVVVFMG
DIHFSGFQYLERVERACGHPVETIPGISSAQILASRGKVCFDETSFITFHRRGDLTPFKRHLVHVLQDGRNAIVIPCPWD
EARSFMPWHIAAYLLENGIPAGQPVEVWENLTRNEAEWRGTLAECAEQRFSDMSIMLIRTLAPMDSQIEPTHK
>Mature_233_residues
MIICIGAGPGDIGYLPQRSAQLIREADVVAGFNAVVDVVRPLIPDSAEVIQMGYRDQVAQLDIVAERHHAGKKCVVVFMG
DIHFSGFQYLERVERACGHPVETIPGISSAQILASRGKVCFDETSFITFHRRGDLTPFKRHLVHVLQDGRNAIVIPCPWD
EARSFMPWHIAAYLLENGIPAGQPVEVWENLTRNEAEWRGTLAECAEQRFSDMSIMLIRTLAPMDSQIEPTHK

Specific function: Probably catalyzes the methylation of C-5 in cobalt- precorrin-6Y to form cobalt-precorrin-7W-a [H]

COG id: COG2241

COG function: function code H; Precorrin-6B methylase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR012818 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: 2.1.1.13

Molecular weight: Translated: 26029; Mature: 26029

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIICIGAGPGDIGYLPQRSAQLIREADVVAGFNAVVDVVRPLIPDSAEVIQMGYRDQVAQ
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHH
LDIVAERHHAGKKCVVVFMGDIHFSGFQYLERVERACGHPVETIPGISSAQILASRGKVC
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHCCCEE
FDETSFITFHRRGDLTPFKRHLVHVLQDGRNAIVIPCPWDEARSFMPWHIAAYLLENGIP
ECCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCC
AGQPVEVWENLTRNEAEWRGTLAECAEQRFSDMSIMLIRTLAPMDSQIEPTHK
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIICIGAGPGDIGYLPQRSAQLIREADVVAGFNAVVDVVRPLIPDSAEVIQMGYRDQVAQ
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHH
LDIVAERHHAGKKCVVVFMGDIHFSGFQYLERVERACGHPVETIPGISSAQILASRGKVC
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHCCCEE
FDETSFITFHRRGDLTPFKRHLVHVLQDGRNAIVIPCPWDEARSFMPWHIAAYLLENGIP
ECCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCC
AGQPVEVWENLTRNEAEWRGTLAECAEQRFSDMSIMLIRTLAPMDSQIEPTHK
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-methyltetrahydrofolate; L-homocysteine

Specific reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]