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The map label for this gene is cobW [H]

Identifier: 34497016

GI number: 34497016

Start: 1673287

End: 1674393

Strand: Reverse

Name: cobW [H]

Synonym: CV_1561

Alternate gene names: 34497016

Gene position: 1674393-1673287 (Counterclockwise)

Preceding gene: 34497017

Following gene: 34497015

Centisome position: 35.24

GC content: 70.19

Gene sequence:

>1107_bases
ATGAGCGCGCCGCGCCTTCCCGTCACCGTGTTGACCGGTTTCCTCGGCGCCGGCAAGACCACGCTGCTGTCCAAGCTGCT
GGAGAACAACAAGCAGCGGCGGCTGGCGATACTGGTAAACGAGTTCGGCGAGGTGTCGATAGACGGCGGCCTGCTGCGCG
ACGGCGAGAACCAGGGCGTCGAGATCCACGACCTGGCCAACGGCCTGGTCGCCTACGACGACGACGCCGACTTCCTGCCC
ACCATGCTGGCGCTGTGGCAGCGCCGCCAGCAGATCGACCACGTGCTGATCGAAACCTCCGGCCTCGCGCTGCCCAGCGC
GGTGATGGCCCAGCTGCAAAGCGAGGCGCTGGCGCCCTATTTCGTGCTGGACGCGACGCTGGCGGTGGTCGACACCCCGC
TGCTGCTGGCCGGGCACTTCGCGCCGGCCGGAGACGGCGGCAAGACCGACGCGGTGGCGGCGCTGTTCGACCAGCAACTG
GGCCACGCCGACATCGTGGTGCTGAACAAGATAGACGCGCTGTCCGCCGACCAGCTGCTGGCGGCGGAGGAAGCCGTGCG
CAAGCAAGCGCCGTCGATCCGCTTCATCGAGCTGGCCTATGAGGCCAAGCTGGACACCCGGCTGACGCTGGGCCTGCATC
TGCACGAGGCCTCGCCGGCCGCGCACCGCCATTACGGCCCGGTGGCCAGCATGCCAGGGCTGGCGATGCGGCCGCTGGCC
AACCAAACGCTGTTGGACGGCCACAGCCACGGCGGCCAGGCGGCGCACAGCCACGGCCTGGCCACCCACAAGCATTTCCA
CGAGCAGGACCCGGGCTGGCAATCGTTCATGATCCGCAGCAAGGAGCCGCAGTGCGCCGACAAGCTGGCCGCCGCGCTGC
AGGCCATCGCCCGCGAGGAGCCGCTGCTGCGCATCAAGGGCTTCGCCGCCTGCGCCGACAGTCCTGGCCGGCTGCTGGCC
CAGGGCGTGCGCAGCCGTATCGAGCTGAGCCGCGACGACACGCTGGCCGCGCCGCGCCAGGCGCAGCTGGTCTTCATCGG
CTACCACCCCAGCCGCCCGCGCGTGGTGGCCTTGCTGCGCGACATCACCGGCGCGCACTGGAGTTAG

Upstream 100 bases:

>100_bases
GCATTCCCTTCATCGTCATCGACCGCCCGCAACTGGATTATCCGCAGGCCTTCGGCGACTTCGCCTCGCTGCTGGCGGCC
TTGCCCAAGGGAGAACAAGC

Downstream 100 bases:

>100_bases
CCGGTGAGCGCATTGGAACTCTGCGGCCTGGACTGGTCGCCCGACGCCGCGACCGCGCCTGAGGCCAGGCTGCTGCGCGA
CATCGCGCTGACTGTCCGGC

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSAPRLPVTVLTGFLGAGKTTLLSKLLENNKQRRLAILVNEFGEVSIDGGLLRDGENQGVEIHDLANGLVAYDDDADFLP
TMLALWQRRQQIDHVLIETSGLALPSAVMAQLQSEALAPYFVLDATLAVVDTPLLLAGHFAPAGDGGKTDAVAALFDQQL
GHADIVVLNKIDALSADQLLAAEEAVRKQAPSIRFIELAYEAKLDTRLTLGLHLHEASPAAHRHYGPVASMPGLAMRPLA
NQTLLDGHSHGGQAAHSHGLATHKHFHEQDPGWQSFMIRSKEPQCADKLAAALQAIAREEPLLRIKGFAACADSPGRLLA
QGVRSRIELSRDDTLAAPRQAQLVFIGYHPSRPRVVALLRDITGAHWS

Sequences:

>Translated_368_residues
MSAPRLPVTVLTGFLGAGKTTLLSKLLENNKQRRLAILVNEFGEVSIDGGLLRDGENQGVEIHDLANGLVAYDDDADFLP
TMLALWQRRQQIDHVLIETSGLALPSAVMAQLQSEALAPYFVLDATLAVVDTPLLLAGHFAPAGDGGKTDAVAALFDQQL
GHADIVVLNKIDALSADQLLAAEEAVRKQAPSIRFIELAYEAKLDTRLTLGLHLHEASPAAHRHYGPVASMPGLAMRPLA
NQTLLDGHSHGGQAAHSHGLATHKHFHEQDPGWQSFMIRSKEPQCADKLAAALQAIAREEPLLRIKGFAACADSPGRLLA
QGVRSRIELSRDDTLAAPRQAQLVFIGYHPSRPRVVALLRDITGAHWS
>Mature_367_residues
SAPRLPVTVLTGFLGAGKTTLLSKLLENNKQRRLAILVNEFGEVSIDGGLLRDGENQGVEIHDLANGLVAYDDDADFLPT
MLALWQRRQQIDHVLIETSGLALPSAVMAQLQSEALAPYFVLDATLAVVDTPLLLAGHFAPAGDGGKTDAVAALFDQQLG
HADIVVLNKIDALSADQLLAAEEAVRKQAPSIRFIELAYEAKLDTRLTLGLHLHEASPAAHRHYGPVASMPGLAMRPLAN
QTLLDGHSHGGQAAHSHGLATHKHFHEQDPGWQSFMIRSKEPQCADKLAAALQAIAREEPLLRIKGFAACADSPGRLLAQ
GVRSRIELSRDDTLAAPRQAQLVFIGYHPSRPRVVALLRDITGAHWS

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=362, Percent_Identity=27.6243093922652, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI126722884, Length=362, Percent_Identity=27.3480662983425, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI148727351, Length=364, Percent_Identity=27.4725274725275, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI146231952, Length=364, Percent_Identity=27.1978021978022, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI223941779, Length=356, Percent_Identity=27.247191011236, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI223941776, Length=351, Percent_Identity=26.4957264957265, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI119120938, Length=134, Percent_Identity=35.8208955223881, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788499, Length=168, Percent_Identity=35.7142857142857, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082430, Length=353, Percent_Identity=26.3456090651558, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324356, Length=198, Percent_Identity=29.7979797979798, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39673; Mature: 39542

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPRLPVTVLTGFLGAGKTTLLSKLLENNKQRRLAILVNEFGEVSIDGGLLRDGENQGV
CCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCEEECCCCCCE
EIHDLANGLVAYDDDADFLPTMLALWQRRQQIDHVLIETSGLALPSAVMAQLQSEALAPY
EHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCC
FVLDATLAVVDTPLLLAGHFAPAGDGGKTDAVAALFDQQLGHADIVVLNKIDALSADQLL
HHHHHHHHHHCCCHHEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
AAEEAVRKQAPSIRFIELAYEAKLDTRLTLGLHLHEASPAAHRHYGPVASMPGLAMRPLA
HHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCC
NQTLLDGHSHGGQAAHSHGLATHKHFHEQDPGWQSFMIRSKEPQCADKLAAALQAIAREE
CCCEECCCCCCCCHHHHCCCHHHHHHCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHCCC
PLLRIKGFAACADSPGRLLAQGVRSRIELSRDDTLAAPRQAQLVFIGYHPSRPRVVALLR
CCEEEECCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHH
DITGAHWS
HHCCCCCC
>Mature Secondary Structure 
SAPRLPVTVLTGFLGAGKTTLLSKLLENNKQRRLAILVNEFGEVSIDGGLLRDGENQGV
CCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCEEECCCCCCE
EIHDLANGLVAYDDDADFLPTMLALWQRRQQIDHVLIETSGLALPSAVMAQLQSEALAPY
EHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCC
FVLDATLAVVDTPLLLAGHFAPAGDGGKTDAVAALFDQQLGHADIVVLNKIDALSADQLL
HHHHHHHHHHCCCHHEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
AAEEAVRKQAPSIRFIELAYEAKLDTRLTLGLHLHEASPAAHRHYGPVASMPGLAMRPLA
HHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCC
NQTLLDGHSHGGQAAHSHGLATHKHFHEQDPGWQSFMIRSKEPQCADKLAAALQAIAREE
CCCEECCCCCCCCHHHHCCCHHHHHHCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHCCC
PLLRIKGFAACADSPGRLLAQGVRSRIELSRDDTLAAPRQAQLVFIGYHPSRPRVVALLR
CCEEEECCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHH
DITGAHWS
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]