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The map label for this gene is sdaC [H]

Identifier: 34496864

GI number: 34496864

Start: 1484693

End: 1485991

Strand: Reverse

Name: sdaC [H]

Synonym: CV_1409

Alternate gene names: 34496864

Gene position: 1485991-1484693 (Counterclockwise)

Preceding gene: 34496865

Following gene: 34496863

Centisome position: 31.28

GC content: 62.97

Gene sequence:

>1299_bases
ATGTCTCAAGCAATCGCCTCCACCGCTTCCCGCTCCGGTTCATCCGGCTGGTCCAAGCACGACACCACCTGGATGCTCGG
CCTGTACGGCACCGCCATCGGCGCCGGCGTCCTGTTCCTCCCGATCAACGCCGGCATCGGCGGCCTGTGGCCGCTGATGC
TGATGGCCATCCTGGCCCTGCCGCTGACCTTCTTCGCCCACCGCGGCCTGACCCGCTTCGTGCTGTCCGGCAGCAAGGAA
GGCGCGGACATCACCGAGGTGGTGGAAGAGCACTTCGGTCTCGGCGCCGGCAAGATCATCACCCTGCTGTACTTCTTCGC
CATCTACCCGATCCTGCTGATGTACAGCGTGGCCATCACCAACACGGTGCTGTCCTTCCTGAACAACCAGCTGCACATCG
AAGTGGGCACCGGCATCGCCACCCGCGCCGTGTTCTCGCTGGCGCTGATCCTGGGCCTGATGTCCATCGTGCGCCTGGGC
GGCCAGATGATCGTCAAGGCGATGAGCATCCTGGTGTACCCGTTCGTGGTGGTGCTGATGCTGCTGGCGCTGTACCTGAT
CCCGCAATGGAGCGATACCGCCATCCGCCACGCCGGCAGCCTGGGCGACGCGCTGTCCAGCGGCGCCTTCTACAAGACGC
TGTGGCTGGCCATCCCGGTGATGGTGTTCTCGTTCAACCACTCGCCGATCATCTCGTCCTTCTCCGTCGACCAGCGCAAG
CTTCACGGCGATGACGCCGAGCCGGCCTCCAGCCGCGTGCTGATTCGCGCCCACACCATGATGGTGCTGACCGTGATGTT
CTTCGTGTTCAGCTGCGTGTTCAGCCTGAGCCCGGCCGACCTGGCCGCCGCCAAGGCCCAGAACATCTCCATCCTGTCCT
ACCTGGCCAACCACTTCCAAAACCCGGTGATGGAATGGGTTGCCCCGATCATCGCCATGGTCGCCATCAGCAAGTCCTTC
CTGGGCCACTACCTGGGCGCCAAGGAAGGCTTCAACGGCCTGGTGATCAAGCAGCTGCGCCAGAACGGCAAGAGCATCGA
ATCGTCCAAGCTGGACCGCTACACCGCCATCTTCATGATCGTCACCTGCTGGATCATCGCCACCATCAACCCGTCCATCC
TGGGCATGATCGAAACCCTGGGCGGCCCGGTGATCGCGATGCTGCTGTTCCTGATGCCGATGTACGCGATCCAGAAAGTG
CCGGCGATGAAGAAGTACTCCGGCGCCGCCAGCAACATCTTCGTGACGCTGATCGGCCTGATCGCCATCTCCGCCATCTT
CTACGATCTGATCGCCTGA

Upstream 100 bases:

>100_bases
GTCAGAACAGCTTTCTCCCGATGGCCTGTTTCCAACGACAAAGGCGCAGGGCATCGGACCCAGTAATTGCGAATATTTCG
TTTTGTAAAAGGCACCTATC

Downstream 100 bases:

>100_bases
TCGTAAGCCAGCGGACCGCGCCTGCTCTCCCTCCCGTCCGGCGAGACCGTCTTGCCGGACAAGCAGGGACTCCCGCGGCC
CCGAACACAGCCATGAGGAG

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSQAIASTASRSGSSGWSKHDTTWMLGLYGTAIGAGVLFLPINAGIGGLWPLMLMAILALPLTFFAHRGLTRFVLSGSKE
GADITEVVEEHFGLGAGKIITLLYFFAIYPILLMYSVAITNTVLSFLNNQLHIEVGTGIATRAVFSLALILGLMSIVRLG
GQMIVKAMSILVYPFVVVLMLLALYLIPQWSDTAIRHAGSLGDALSSGAFYKTLWLAIPVMVFSFNHSPIISSFSVDQRK
LHGDDAEPASSRVLIRAHTMMVLTVMFFVFSCVFSLSPADLAAAKAQNISILSYLANHFQNPVMEWVAPIIAMVAISKSF
LGHYLGAKEGFNGLVIKQLRQNGKSIESSKLDRYTAIFMIVTCWIIATINPSILGMIETLGGPVIAMLLFLMPMYAIQKV
PAMKKYSGAASNIFVTLIGLIAISAIFYDLIA

Sequences:

>Translated_432_residues
MSQAIASTASRSGSSGWSKHDTTWMLGLYGTAIGAGVLFLPINAGIGGLWPLMLMAILALPLTFFAHRGLTRFVLSGSKE
GADITEVVEEHFGLGAGKIITLLYFFAIYPILLMYSVAITNTVLSFLNNQLHIEVGTGIATRAVFSLALILGLMSIVRLG
GQMIVKAMSILVYPFVVVLMLLALYLIPQWSDTAIRHAGSLGDALSSGAFYKTLWLAIPVMVFSFNHSPIISSFSVDQRK
LHGDDAEPASSRVLIRAHTMMVLTVMFFVFSCVFSLSPADLAAAKAQNISILSYLANHFQNPVMEWVAPIIAMVAISKSF
LGHYLGAKEGFNGLVIKQLRQNGKSIESSKLDRYTAIFMIVTCWIIATINPSILGMIETLGGPVIAMLLFLMPMYAIQKV
PAMKKYSGAASNIFVTLIGLIAISAIFYDLIA
>Mature_431_residues
SQAIASTASRSGSSGWSKHDTTWMLGLYGTAIGAGVLFLPINAGIGGLWPLMLMAILALPLTFFAHRGLTRFVLSGSKEG
ADITEVVEEHFGLGAGKIITLLYFFAIYPILLMYSVAITNTVLSFLNNQLHIEVGTGIATRAVFSLALILGLMSIVRLGG
QMIVKAMSILVYPFVVVLMLLALYLIPQWSDTAIRHAGSLGDALSSGAFYKTLWLAIPVMVFSFNHSPIISSFSVDQRKL
HGDDAEPASSRVLIRAHTMMVLTVMFFVFSCVFSLSPADLAAAKAQNISILSYLANHFQNPVMEWVAPIIAMVAISKSFL
GHYLGAKEGFNGLVIKQLRQNGKSIESSKLDRYTAIFMIVTCWIIATINPSILGMIETLGGPVIAMLLFLMPMYAIQKVP
AMKKYSGAASNIFVTLIGLIAISAIFYDLIA

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=428, Percent_Identity=72.4299065420561, Blast_Score=593, Evalue=1e-171,
Organism=Escherichia coli, GI1789504, Length=447, Percent_Identity=48.5458612975391, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789211, Length=426, Percent_Identity=35.4460093896714, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI145693183, Length=424, Percent_Identity=27.3584905660377, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789961, Length=398, Percent_Identity=24.6231155778894, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46761; Mature: 46630

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAIASTASRSGSSGWSKHDTTWMLGLYGTAIGAGVLFLPINAGIGGLWPLMLMAILAL
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHH
PLTFFAHRGLTRFVLSGSKEGADITEVVEEHFGLGAGKIITLLYFFAIYPILLMYSVAIT
HHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NTVLSFLNNQLHIEVGTGIATRAVFSLALILGLMSIVRLGGQMIVKAMSILVYPFVVVLM
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLALYLIPQWSDTAIRHAGSLGDALSSGAFYKTLWLAIPVMVFSFNHSPIISSFSVDQRK
HHHHHHCCCCCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
LHGDDAEPASSRVLIRAHTMMVLTVMFFVFSCVFSLSPADLAAAKAQNISILSYLANHFQ
HCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHC
NPVMEWVAPIIAMVAISKSFLGHYLGAKEGFNGLVIKQLRQNGKSIESSKLDRYTAIFMI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VTCWIIATINPSILGMIETLGGPVIAMLLFLMPMYAIQKVPAMKKYSGAASNIFVTLIGL
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
IAISAIFYDLIA
HHHHHHHHHHHC
>Mature Secondary Structure 
SQAIASTASRSGSSGWSKHDTTWMLGLYGTAIGAGVLFLPINAGIGGLWPLMLMAILAL
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHH
PLTFFAHRGLTRFVLSGSKEGADITEVVEEHFGLGAGKIITLLYFFAIYPILLMYSVAIT
HHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NTVLSFLNNQLHIEVGTGIATRAVFSLALILGLMSIVRLGGQMIVKAMSILVYPFVVVLM
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLALYLIPQWSDTAIRHAGSLGDALSSGAFYKTLWLAIPVMVFSFNHSPIISSFSVDQRK
HHHHHHCCCCCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
LHGDDAEPASSRVLIRAHTMMVLTVMFFVFSCVFSLSPADLAAAKAQNISILSYLANHFQ
HCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHC
NPVMEWVAPIIAMVAISKSFLGHYLGAKEGFNGLVIKQLRQNGKSIESSKLDRYTAIFMI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VTCWIIATINPSILGMIETLGGPVIAMLLFLMPMYAIQKVPAMKKYSGAASNIFVTLIGL
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
IAISAIFYDLIA
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]